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Neutrophil-mediated liver injury during hepatic ischemia-reperfusion in rats

Hepatobiliary & Pancreatic Diseases International 2006年第3期5卷 436-442页

作者： Motomichi Sato kanji kawachi Yuji Abe Department of Surgery Ⅱ Ehime University EhimeJapan

BACKGROUND: Neutrophil plays an important role in hepatic ischemia-reperfusion injury. We investigated neutrophil infiltration in liver tissue, Kupffer cells' role in neutrophil accumulation, and apoptosis and regeneration of hepatocytes in liver ischemia-reperfusion injury. METHODS: Vascular microclamps were placed across the pedicles of the median and left lateral lobes for 90 minutes after 30% hepatectomy with the resection of caudate, right lateral and quadrate lobes and papillary process. Gadolinium chloride (GdCl3) was used to destroy Kupffer cells. Neutrophil activity was inhibited with Urge-8, a monoclonal antibody against neutrophil produced in our laboratory. GdCl3 (10 mg/kg) and Urge-8 (50 mg/kg) were given intravenously in respective groups. Ischemia control, GdCl3 and Urge-8 groups were compared. RESULTS: Following hepatic reperfusion, serum interleukin-8 (IL-8) levels and hepatic neutrophil counts peaked at 3 hours, and peak concentrations of alanine aminotransferase (ALT) occurred at 6 hours. Animals of the control group showed increases in neutrophil infiltration in liver tissue, liver enzyme levels, and apoptosis index of hepatocytes and decreases in overall survival rate and proliferating cell nuclear antigen (PCNA) expression of hepatocytes. The survival rates and PCNA proportion of hepatocytes were higher and the levels of hepatic neutrophil infiltration, liver enzymes, and hepatocyte apoptosis after reperfusion were lower in the GdCl3 and Urge-8 groups than those in the ischemia control group. CONCLUSIONS: Blockades of Kupffer cells' activity and neutrophil infiltration by GdCl3 and Urge-8 eliminate neutrophil-mediated hepatic injury and enhance subsequent hepatic regeneration during liver ischemiareperfusion.

关键词： neutrophil liver ischemia-reper fusion injury

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Sigmoid colon endometriosis treated with laparoscopy-assisted sigmoidectomy:Significance of preoperative diagnosis

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World Journal of Gastroenterology 2007年第40期13卷 5400-5402页

作者： Motohira Yoshida Yuji Watanabe Atsushi Horiuchi Yuji Yamamoto Hiroki Sugishita kanji kawachi Department of Organ Regenerative Surgery Ehime University Graduate School of MedicineShitsukawaToonEhime 791-0295Japan

我们在场外科手术前地正确地被诊断并且经历了最低限度地侵略的外科的有 S 字形的结肠子宫内膜增生的一个女病人。她与直肠的流血和便秘进入我们的医院。我们执行了几工作 ups。显示出的 S 字形的冒号狭窄由粘膜下层肿瘤引起了的结肠镜... 详细信息

我们在场外科手术前地正确地被诊断并且经历了最低限度地侵略的外科的有 S 字形的结肠子宫内膜增生的一个女病人。她与直肠的流血和便秘进入我们的医院。我们执行了几工作 ups。显示出的 S 字形的冒号狭窄由粘膜下层肿瘤引起了的结肠镜检查和内视镜的 ultrasonography，和磁性的回声成像揭示了在 T1 加权、 T2 加权的成像上显示信号 hy-pointensity 的一个 S 字形的冒号肿瘤。然而， colonoscopic 帮助 ultrasonography 的针针吸活组织检查不能指定肿瘤特征。从这些考试，当 S 字形的冒号子宫内膜增生和帮助 laparoscopy 的乙状结肠切除术被执行，损害被诊断。从 resected 标本的病理学的诊断与外科手术前的诊断相同，即，结肠的子宫内膜增生。因为肠的子宫内膜增生的鉴别诊断似乎困难，小心的外科手术前的诊断被要求包括最低限度地侵略的外科选择治疗。

关键词：子宫内膜异位手术诊断腹腔镜治疗

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Evaluation of prognostic factors and scoring system in colonic perforation

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World Journal of Gastroenterology 2007年第23期13卷 3228-3231页

作者： Atsushi Horiuchi Yuji Watanabe Takashi Doi Kouichi Sato Syungo Yukumi Motohira Yoshida Yuji Yamamoto Hiroki Sugishita kanji kawachi Department of Surgery 2 Ehime University School of Medicine

AIM: To study the significance of scoring systems assessing severity and prognostic factors in patients with colonic perforation. METHODS: A total of 26 patients (9 men, 17 women; mean age 72.7 ± 11.6 years) underwent emergency operation for colorectal perforation in our institution between 1993 and 2005. Several clinical factors were measured preoperatively and 24 h postoperatively. Acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ), Mannheim peritonitis index (MPI) and peritonitis index of Altona (PIA Ⅱ) scores were calculated preoperatively. RESULTS: Overall postoperative mortality rate was 23.1% (6 patients). Compared with survivors, non- survivors displayed low blood pressure, low serum protein and high serum creatinine preoperatively, and low blood pressure, low white blood cell count, low pH, low PaO2/FiO2, and high serum creatinine postoperatively. APACHE Ⅱ score was significantly lower in survivors than in non-survivors (10.4 ± 3.84 vs 19.3 ± 2.87, P = 0.00003). Non-survivors tended to display high MPI score and low PIA Ⅱ score, but no signif icant difference was identif ied. CONCLUSION: Pre- and postoperative blood pressure and serum creatinine level appear related to prognosis of colonic perforation. APACHE Ⅱ score is most associated with prognosis and scores ≥ 20 are associated with signif icantly increased mortality rate.

关键词：结肠穿孔刮伤系统预兆因子症状

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近代日本作家坪内逍遥、森鸥外和夏目漱石对莎士比亚作品的翻译与解读

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中世纪与文艺复兴研究 2024年第1期 23-44页

作者：川地美子李文超日本庆应义塾大学国际莎士比亚协会浙江大学外国语学院日语所中国日语教育研究会

莎士比亚在明治时期传入日本。当时日本摆脱了长期的民族闭塞,开始吸收西欧文化,开启了现代化进程。本文考察在这样的历史背景下,近代日本作家坪内逍遥、森鸥外和夏目漱石对莎剧的翻译与解读,进而思考日本对莎士比亚的接受与日本的西化... 详细信息

莎士比亚在明治时期传入日本。当时日本摆脱了长期的民族闭塞,开始吸收西欧文化,开启了现代化进程。本文考察在这样的历史背景下,近代日本作家坪内逍遥、森鸥外和夏目漱石对莎剧的翻译与解读,进而思考日本对莎士比亚的接受与日本的西化之间的联系。

关键词：莎士比亚翻译解读日本坪内逍遥森鸥外夏目漱石

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程序化降温保存血管内皮功能的研究

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中国现代普通外科进展 2005年第3期8卷 144-145页

作者：刘毅徐克森河内宽治陈雨信寿楠海山东大学齐鲁医院普外科肝胆血管外科研究所山东济南250012 日本爱媛大学第二外科日本松山7910295

目的探讨程序化降温对体外大鼠血管内皮的影响。方法对大鼠腹主动脉进行0.7℃/min(新鲜血管组和常规方法组)及1℃/min(试验组)程序化降温,低温保存3个月后对比观察血管内皮形态和功能变化。结果试验组的平均收缩张力及非依赖性血管舒张... 详细信息

目的探讨程序化降温对体外大鼠血管内皮的影响。方法对大鼠腹主动脉进行0.7℃/min(新鲜血管组和常规方法组)及1℃/min(试验组)程序化降温,低温保存3个月后对比观察血管内皮形态和功能变化。结果试验组的平均收缩张力及非依赖性血管舒张均较常规组高(P0.05);光镜下试验组血管内皮细胞较常规组完整。结论改良的降温程序能够较好保持内皮的收缩功能以及非内皮依赖性舒张功能,但对内皮依赖性舒张功能效果欠佳。

关键词：低温保存内皮,血管大鼠,Wister

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Optimal resection of gastric bronchogenic cysts based on anatomical continuity with adherent gastric muscular layer: A case report

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1216-1223页

作者： Masayoshi Terayama Koshi Kumagai Hiroshi kawachi Rie Makuuchi Masaru Hayami Satoshi Ida Manabu Ohashi Takeshi Sano Souya Nunobe Department of Gastroenterological Surgery Gastroenterological CenterCancer Institute HospitalJapanese Foundation for Cancer ResearchTokyo 135-8550Japan Department of Pathology Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyo 135-8550Japan

BACKGROUND Bronchogenic cysts are congenital lesions requiring radical resection because of malignant ***,a method for the optimal resection of these cysts has not been completely *** SUMMARY Herein,we presented three patients with bronchogenic cysts that were located adjacent to the gastric wall and resected *** cysts were detected incidentally with no symptoms and the preoperative diagnosis was challenging to obtain via radiological *** on laparoscopic findings,the cyst was attached firmly to the gastric wall and the boundary between the gastric and cyst walls was difficult to ***,resection of cysts alone caused cystic wall injury in Patient ***,the cyst was resected completely along with a part of the gastric wall in Patient *** examination revealed the final diagnosis of bronchogenic cyst and revealed that the cyst wall shared the muscular layer with the gastric wall in Patients 1 and *** Patient 3,the cyst was located adjacent to the gastric wall but histopathologically originated from diaphragm rather than *** the patients were free from *** The findings of this study state that a safe and complete resection of bronchogenic cysts required the adherent gastric muscular layer or full-thickness dissection,if bronchogenic cysts are suspected via pre-and/or intraoperative findings.

关键词： Bronchogenic cysts Laparoscopic resection Gastric wall Muscular layer Case report

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Successful treatment with laparoscopic surgery and sequential multikinase inhibitor therapy for hepatocellular carcinoma:A case report

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World Journal of Gastrointestinal Surgery 2022年第3期14卷 260-267页

作者： Yutaka Endo Motohide Shimazu Tadayuki Sakuragawa Yusuke Uchi Motonori Edanami Ken Sunamura Soji Ozawa Naokazu Chiba Shigeyuki kawachi Department of Surgery Tama Kyuryo HospitalTokyo 1940297Japan Department of Digestive and Transplantation Surgery Tokyo Medical University Hachioji Medical CenterTokyo 1930998Japan

BACKGROUND Hepatocellular carcinoma(HCC)with massive portal vein tumor thrombosis(PVTT)and distant metastasis is considered ***,due to recent developments in systemic chemotherapy,successful cases of conversion therapy for unresectable diseases have been ***,we report a successful multidisciplinary approach for treatment of multi-visceral recurrence with sequential multikinase inhibitor and laparoscopic *** SUMMARY A 63-year-old woman with chronic hepatitis B virus infection was diagnosed with ***,she underwent two rounds of laparoscopic partial hepatectomy,laparoscopic left adrenalectomy,and transcatheter arterial chemoembolization plus sorafenib for *** years after initial hepatectomy,she presented with a 43-mm mass in the spleen and tumor thrombus involving the main portal vein trunk with *** liver function was Child-Pugh B(8),and protein induced by vitamin K absence or antagonist II(PIVKA II)levels were elevated up to 46.291 mAU/*** initial treatment with regorafenib for three months was unsuccessful,the patient was administered *** months post-treatment,there was no contrast enhancement of PVTT or splenic *** was discontinued due to severe ***,splenic metastasis became viable,and PIVKA II ***,hand-assisted laparoscopic splenectomy was *** experienced no clinical recurrence 14 mo after *** Conversion surgery after successful multikinase inhibitor treatment might be considered an effective treatment option for advanced HCC.

关键词： Hepatocellular carcinoma Lenvatinib Portal vein Venous thrombosis Splenic neoplasms Case report

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Clinical features and progress of ischemic gastritis with high fatalities: Seven case reports

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World Journal of Clinical Cases 2022年第24期10卷 8686-8694页

作者： Kento Shionoya Akiko Sasaki Hidekazu Moriya Karen Kimura Takashi Nishino Jun Kubota Chihiro Sumida Junichi Tasaki Chikamasa Ichita Makomo Makazu Sakue Masuda Kazuya Koizumi Jun kawachi ToshitakaTsukiyama Makoto Kako Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of General Internal Medicine Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of General Surgery Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of Radiology Shonan Kamakura General HospitalKamakura 247-8533Japan

BACKGROUND Ischemic gastritis is a clinically rare and highly fatal disease that occurs when the hemodynamics of a patient with vascular risk is *** diagnosis and treatment are possible only with upper endoscopy after symptom *** report seven cases of ischemic gastritis and its clinical features,prognosis,and indicators that may help in early *** SUMMARY Of the seven patients,six had vascular risk and five died within 2 wk of *** symptoms included hematemesis and *** surgery is a choice for radical treatment,not all patients were *** such patients,conservative treatment was selected,but all of them *** contrast,patients who underwent repeat endoscopy showed improved mucosal findings,suggesting that this improvement may not affect *** ischemic changes such as wall thickening,mural emphysema,and fluid retention in the stomach were observed before diagnosis through endoscopy and computed tomography(CT).The CT scan can be effective for early detection,and improvement in circulatory failure and aggressive treatment may save the lives of patients with this *** The characteristic CT findings enable early detection of ischemic *** diagnosis increases the chance of survival if early therapeutic intervention and improvement of circulatory dynamics can be achieved in this highly fatal disease.

关键词： Celiac artery Gastrointestinal bleeding Ischemic gastritis Superior mesenteric artery Vascular risk Case report

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Soft X-ray laser observation of femtosecond-laser-driven ablation of tungsten

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Chinese Optics Letters 2015年第7期13卷 2-4页

作者： Masaharu Nishikino Noboru Hasegawa Masahiko Ishino Yoshihiro Ochi Tetsuya kawachi Mitsuru Yamagiwa Yoshiaki Kato Quantum Beam Science Directorate Kansai Photon Science Institute Japan Atomic Energy Agency Graduate School for the Creation of New Photonics Industries

Ablation dynamics of tungsten irradiated with a 70 fs laser pulse is investigated with X-ray interferometry and X-ray imaging using a 13.9 nm soft X-ray laser of 7 ps pulse duration. The evolution of high-density ablation front of tungsten （i.e., W） is presented. The ablation front expands to ~120 nm above the original target surface at 160 ps after femtosecond-laser irradiation with an expansion speed of approximately 750 m/s. These results will provide important data for understanding ablation properties of W, which is a candidate material of the first wall of magnetic confinement fusion reactors.

关键词： Soft X-ray laser observation of femtosecond-laser-driven ablation of tungsten high

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Examination of in vivo mutagenicity of sodium arsenite and dimethylarsinic acid in gpt delta rats

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Journal of Environmental Sciences 2016年第11期28卷 125-130页

作者： Masaki Fujioka Min Gi Satoko kawachi Kumiko Tatsumi Naomi Ishii Kenichiro Doi Anna Kakehashi Hideki Wanibuchi Department of Molecular Pathology Osaka City University Graduate School of Medicine

Arsenic is a well-known human bladder and liver carcinogen, but its exact mechanism of carcinogenicity is not fully understood. Dimethylarsinic acid（DMAV） is a major urinary metabolite of sodium arsenite（i As~Ⅲ） and induces urinary bladder cancers in rats. DMAVand i As~Ⅲare negative in in vitro mutagenicity tests. However, their in vivo mutagenicities have not been determined. The purpose of present study is to evaluate the in vivo mutagenicities of DMAVand i As~Ⅲin rat urinary bladder epithelium and liver using gpt delta F344 ***-week old male gpt delta F344 rats were randomized into 3 groups and administered 0,92 mg/L DMAV, or 87 mg/L i As~Ⅲ（each 50 mg/L As） for 13 weeks in the drinking water. In the mutation assay, point mutations are detected in the gpt gene by 6-thioguanine selection（gpt assay） and deletion mutations are identified in the red/gam genes by Spi-selection（Spi-assay）. Results of the gpt and Spi-assays showed that DMAVand i As~Ⅲhad no effects on the mutant frequencies or mutation spectrum in urinary bladder epithelium or liver. These findings indicate that DMAVand i As~Ⅲare not mutagenic in urinary bladder epithelium or liver in rats.

关键词： Dimethylarsinic acid Sodium arsenite In vivo mutagenicity Urinary bladder epithelium gpt delta rat

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