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Anti-bacterial activity and brine shrimp lethality bioassay of methanolic extracts of fourteen different edible vegetables from Bangladesh

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Asian Pacific Journal of Tropical Biomedicine 2013年第1期3卷 1-7页

作者： M.Obayed Ullah Mahmuda Haque kaniz fatima urmi Abu Hasanat Md.Zulfiker Elichea Synthi Anita Momtaj Begum Kaiser Hamid School of Chemistry and Molecular Biosciences University of Queensland Department of Pharmacy Southeast University Department of Pharmacy Jahangirnagar University Department of Pharmacy East West University

Objective:To investigate the antibacterial and cytotoxic activity of fourteen different edible vegetables methanolic extract from ***:The antibacterial activity was evaluated using disc diffusion assay method against 12 bacteria(both gram positive and gram negative).The plant extracts were also screened for cytotoxic activity using the brine shrimp lethality bioassay method and the lethal concentrations(LC_(50))were determined at confidence intervals by analyzing the data on a computer loaded with"Finney Programme??Results:All the vegetable extracts showed low to elevated levels of antibacterial activity against most of the tested strains(zone of inhibition=5-28 mm).The most active extract against all bacterial strains was from Xanthium indicum which showed remarkable antibacterial activity having the diameter of growth inhibition zone ranging from 12 to 28 mm followed by Alternanthera sessilis(zone of inhibition=6-21 mm).All extracts exhibited considerable general toxicity towards brine *** LC_(50)value of the tested extracts was within the range of 8.447 to 60.323μg/mL with respect to the positive control(vincristine sulphate)which was 0.91μg/*** all studied extracts,Xanthium indicum displayed the highest cytotoxic effect with LC_(50)value of 8.447μg/***:The results of the present investigation suggest that most of the studied plants are potentially good source of antibacterial and anticancer agents.

关键词： Bangladeshi vegetables Antibacterial Disc diffusion Brine shrimp lethality

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Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

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Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： fatima Aldali Chunchu Deng Mingbo Nie Hong Chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

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Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5686-5726页

作者： Priyanka Dey Talukdar urmi Chatterji Cancer Research Laboratory Department of ZoologyUniversity of Calcutta35 Ballygunge Circular RoadKolkata 700019 West BengalIndia

Specific cell states in metazoans are established by the symphony of gene expression programs that necessitate intricate synergic interactions between transcription factors and the *** of these regulatory molecules is associated with cell state transitions,which in turn is accountable for diverse maladies,including developmental disorders,metabolic disorders,and most significantly,cancer.A decade back most transcription factors,the key enablers of disease development,were historically viewed as‘undruggable’;however,in the intervening years,a wealth of literature validated that they can be targeted indirectly through transcriptional co-activators,their confederates in various physiological and molecular *** co-activators,along with transcription factors,have the ability to initiate and modulate transcription of diverse genes necessary for normal physiological functions,whereby,deregulation of such interactions may foster tissue-specific disease ***,it is essential to analyze how these co-activators modulate specific multilateral processes in coordination with other *** proposed review attempts to elaborate an in-depth account of the transcription co-activators,their involvement in transcription regulation,and context-specific contributions to pathophysiological *** review also addresses an issue that has not been dealt with in a comprehensive manner and hopes to direct attention towards future research that will encompass patient-friendly therapeutic strategies,where drugs targeting co-activators will have enhanced benefits and reduced side *** insights into currently available therapeutic interventions and the associated constraints will eventually reveal multitudes of advanced therapeutic targets aiming for disease amelioration and good patient prognosis.

关键词： therapeutic eventually potential

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Cloning,expression,purification and bioinformatic analysis of 2-methylcitrate synthase from Mycobacterium tuberculosis

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Asian Pacific Journal of Tropical Medicine 2015年第1期8卷 19-23页

作者： Kasamy Eniyan urmi Bajpai Department of Biomedical Science Acharya Narendra Dev College(University of Delhi)

Objective:To clone,express and purify 2—methylcitrale synthase(Rv1131) gene of Mycobacterium tuberculosis(***) and to study its structural characteristics using various bioinformatics ***:Rv1131 gene was amplified In polymerase chain reaction using *** H37 Rv genomic DNA and cloned into pGEM-T easy vector and *** gene was sub-cloned in pET28 c vector,expressed in Escherichia coli RL22(*** BL21)(DE3) cells and the recombinant protein was identified by Western *** protein was purified using Nickel affinity chromatography and the structural characteristics like sub-cellular *** of transmembrane helices and secondary structure of the protein were predicted by bioinformaties *** structure of the protein and phylogenetic analysis was aiso established by in silico ***:The expression of the recombinant protein(Rv1131) was confirmed by western blotting using anti-HIS antibodies and the protein was purified from the soluble *** silico analysis showed that the protein contains no signal peptide and transmembrane helices,Active site prediction showed that the protein has histidine and aspartie acid residues at 242.281 & 332 positions *** analysis showed100%homology with major mycobacterial *** structure predicts 2-methyleitrate synthase contain 51.9%;alpha-helk.8.7%extended strand and 39.4%random *** structure of the protein was also ***:The enzyme 2-methylcitrate synthase from *** H37 Rv has been successfully expressed and *** purified protein will further be utilized to develop assay methods lor screening new inhibitors.

关键词： Mycobacterium tuberculosis 2-methylcitrate synthase Propionyl-CoA Expression Purification

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Impact of Metabolic disrupting chemicals on redox homeostasis,energy sensors,receptor modulation,and hormone metabolism:A comparative account in Teleost and mammalian model organisms

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Aquaculture and Fisheries 2024年第3期9卷 455-485页

作者： urmi Mukherjee Sudipta Maitra Molecular and Cellular Endocrinology Laboratory Department of ZoologyVisva-Bharati UniversitySantiniketan731235India

Endocrine-disrupting chemicals(EDCs)may mimic the endogenous neuroendocrine and endocrine messengers and interfere with developmental,reproductive,immune,metabolic and other physiological *** of basal metabolic rate,energy metabolism,food intake and engorgement by endocrine disruptors may lead to loss of metabolic ***-induced loss of metabolic homeostasis and obesity gave rise to the concept of metabolic-disrupting chemicals(MDC)and environmental *** oxidative stress,alterations in the circadian clock,and energy-sensing homeostasis are some of the major pathophysiological conditions implicated in promoting metabolic ***,fish are the most vulnerable candidate due to their direct exposure to metabolic disruptors in aquatic *** limited,studies conducted using piscine models have helped to identify MDCs in the aquatic ***,the molecular mechanisms through which MDCs can negatively influence the metabolism of hormones,epigenetic alteration,gut dysbiosis,and changes in endocrine and metabolic receptor expression and functions have recently gained considerable *** this review,we provide an update on the impact of MDCs on the initiators,cellular mediators,and hormone receptors related to the maintenance of metabolic homeostasis,with particular emphasis on fish models.

关键词： Reactive oxygen species SIRT1/AMPK/PGC PPAR Estrogen receptor Hormone metabolism Metabolic disruption

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孟加拉吉大港土地利用分析

孟加拉吉大港土地利用分析

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作者： kaniz fatima Tonny 厦门大学

学位级别：硕士

像很多其他发展中国家一样,孟加拉国也经历了快速的城市化进程,导致土地占用量增加,土地利用/覆被变化(LULC)显著。然而由于缺乏时间序列的地理数据,目前监测土地利用和土地覆盖对国家环境、天气和生物多样性影响的研究较少。本研究通... 详细信息

像很多其他发展中国家一样,孟加拉国也经历了快速的城市化进程,导致土地占用量增加,土地利用/覆被变化(LULC)显著。然而由于缺乏时间序列的地理数据,目前监测土地利用和土地覆盖对国家环境、天气和生物多样性影响的研究较少。本研究通过最大似然的分类方法提取卫星数据信息,并使用分类后变化的识别策略监测对土地利用的影响。利用空间分辨率均为30m x 30m的 1989年、2004 年 LANDSAT 4-5 TM影像和 2019 年 LANDSAT 8 OLI 影像分析土地利用/覆盖变化特征,从而得到三十年来孟加拉国吉大港城市扩张的时空轨迹。然后通过QGIS中的MOLUSCE功能,通过CA-ANN模型实现对LULC的未来预测。在这期间,吉大港市的建成区面积扩大了 4倍,而农田和丘陵植被的面积分别减少了近3倍和2倍。1989-2019年,农业用地、森林以外的树木和丘陵植被面积分别减少了约23%,16%和6%,而建成区面积增加了约27%。对2034年土地利用变化的未来预测显示,在2019年至2034年期间,耕地,休耕地和林地以外树木的减少将继续,并转换为约16%的建成区。由于城市化进程加快,城市周围的林地、农业用地和树木面临着进一步破坏的严重威胁。由于人口和经济变化,孟加拉国城市化趋势在以往研究有所反映,但从物理或空间维度对未来增长方向的研究却甚少。本研究还从时空变化的角度增强对孟加拉国城市化的认知。研究结果将帮助规划者、利益相关者和政策制定者理解城市发展驱动机制,并将促进城市规划水平,从而减轻城市扩张对环境的影响。

关键词： Landsat影像遥感 MOLUSCE CA-ANN模型 GIS

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Navigating the genomic instability mine field of osteosarcoma to better understand implications of non-coding RNAs

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BIOCELL 2022年第10期46卷 2177-2193页

作者： kaniz FATEMA ZACHARY LARSON JARED BARROTT Biomedical and Pharmaceutical Science Idaho State UniversityPocatello83209USA

Osteosarcoma is one of the most genomically complex cancers and as result,it has been difficult to assign genomic aberrations that contribute to disease progression and patient outcome consistently across *** potential source for correlating osteosarcoma and genomic biomarkers is within the non-coding regions of RNA that are differentially ***,it is unsurprising that a cancer classification that is fraught with genomic instability is likely to have numerous studies correlating non-coding RNA expression and function have been published on the *** review undertakes the formidable task of evaluating the published literature of noncoding RNAs in *** is not the first review on this topic and will certainly not be the *** review is organized with an introduction into osteosarcoma and the epigenetic control of gene expression before reviewing the molecular function and expression of long non-coding RNAs,circular RNAs,and short non-coding RNAs such as microRNAs,piwi RNAs,and short-interfering *** review concludes with a review of the literature and how the biology of non-coding RNAs can be used therapeutically to treat cancers,especially *** conclude that non-coding RNA expression and function in osteosarcoma is equally complex to understanding the expression differences and function of coding RNA and proteins;however,with the added lens of both coding and non-coding genomic sequence,researchers can begin to identify the patterns that consistently associate with aggressive osteosarcoma.

关键词： Osteosarcoma Epigenetics Long non-coding RNA Circular RNA MicroRNA

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Review of MXenes as a component in smart textiles and an adsorbent for textile wastewater remediation

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Chinese Chemical Letters 2024年第2期35卷 208-222页

作者： kaniz Farhana Kumaran Kadirgama Abu Shadate Faisal Mahamude Rajan Jose Department of Apparel Engineering Bangladesh University of TextilesDhaka 1208Bangladesh Faculty of Mechanical and Automotive Engineering Technology Universiti Malaysia Pahang26600 PekanPahangMalaysia Center of Automotive Engineering Universiti Malaysia PahangMalaysia College of Engineering Universiti Malaysia Pahang26300 GambangPahangMalaysia Faculty of Industrial Sciences & Technology Universiti Malaysia Pahang26300 KuantanMalaysia Center of Intelligent Materials Universiti Malaysia Pahang26300 KuantanMalaysia

Two-dimensional(2D)MXenes have emerged as an archetypical layered material combining the properties of an organic-inorganic hybrid offering materials sustainability for a range of *** surface functional groups and the associated chemical properties'tailorability through functionalizing MXenes with other materials as well as hydrophilicity and high conductivity enable them to be the best successor for various applications in textile industries,especially in the advancement of smart textiles and remediation of textile ***-based textile composite performs superb smartness in high-performance wearables as well as in the reduction of textile dyes from *** article critically reviews the significance of MXenes in two sectors of the textile ***,we review the improvement of textile raw materials such as fiber,yarn,and fabric by using MXene as electrodes in supercapacitors,pressure ***,we review advancements in the removal of dyes from textile wastewater utilizing MXene as an absorbent by the adsorption ***-based textiles demonstrated superior strength through the strong bonding between MXene and textile structures as well as the treatment of adsorbate by adsorbent(MXene in the adsorption process).We identify critical gaps for further research to enable their real-life applications.

关键词： Textile fibers Industrial wastewater treatment MAX phases Hybrid electrodes Adsorption

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Comparative Study of Entanglement and Wigner Function for Multi-Qubit GHZ-Squeezed State

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Communications in Theoretical Physics 2017年第12期67卷 729-734页

作者： fatima-Zahra Siyouri Laboratoire de Physique Thèorique Département de Physique Faculté des Sciences Université Mohammed Ⅴ-Agdal

In this paper we address the possibility of using the Wigner function to capture the quantum entanglement present in a multi-qubit system. For that purpose, we calculate both the degree of entanglement and the Wigner function for mixed tripartite squeezed states of Greenberger–Horne–Zeilinger(GHZ) type then we compare their behaviors. We show that the role of Wigner function in detecting and quantifying bipartite quantum correlation [Int. J. Mod. Phys. B30(2016) 1650187] may be generalized to the multipartite case.

关键词： negativity of Wigner function entanglement squeezed states tripartite GHZ non-classicality

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Biodiesel synthesis via metal oxides and metal chlorides catalysis from marine alga Melanothamnus afaqhusainii

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Chinese Journal of Chemical Engineering 2016年第3期24卷 388-393页

作者： Abdul Majeed Khan Noureen fatima Research Laboratory of Bioenergy Department of ChemistryFederal Urdu University of ArtsSdence and TechnologyCulshan-e-lqbal CampusUniversity RoadKarachi-75300Pakistan

This research article demonstrates the most comprehensive comparative catalytic study of different metal oxides and metal chlorides towards the methanolysis of triglycerides of marine red macroalga Melanothamnus alhqhusainii. CaO was found to be the most reactive metal oxide that yielded 80% biodiesel while ZnCI2 was the most reactive metal chloride that produced 60% biodiesel by mechanical stirring for 6 h at 100-110 ℃. The overall reactivity order of the catalysts was found to be CaO 〉 MgO 〉 Pb02 〉 ZnC12 〉 TIC14 〉 PbO 〉 HgC12 〉 ZnO 〉 AIC13 〉 SnCI2 〉 TiO2 whereas, CaCI2, MgCI2, A1203, HgO, PbCI2, MnO2, MnC12, Fe203 and FeCI3 were found to be non-reactive for transesterification of triglycerides. In addition, a detailed study of the screening of mobile phases and spraying reagents was conducted which showed that petroleum ether ： chloroform ： toluene （7：2：1 ） is the best mobile phase, whereas iodine crystals/silica gel is the best visualizing agent for the thin layer chroma- tography （TLC） examination ofbiodiesel. Biodiesel production was confirmed by comparative TLC examination. It was further supported by the determination of fuel properties of biodiesel, which were found to be similar to the standard limits of American Society for Testing and Materials （ASTM）,

关键词： Biomass Methanolysis Triglycerides Biodiesel Catalysts

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