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“Yin-Yang philosophy” for the design of anticancer drug delivery nanoparticles

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Biomaterials Translational 2024年第2期5卷 144-156页

作者： Ai Y. Tian Y. Qiao j. Wang C. Li H. School of Lifesciences Shanghai University Shanghai China

Understanding the in vivo transport process provides guidelines for designing ideal nanoparticles (NPs) with higher efficacy and fewer off-target effects. Many factors, such as particle size, morphology, surface potential, structural stability, and etc., may influence the delivering process of NPs due to the existence of various physiological barriers within the body. Herein, we summarise the distinct influences of NP physicochemical properties on the four consecutive in vivo transport steps: (1) navigating with bloodstream within blood vessels, (2) transport across vasculature walls into tumour tissues, (3) intratumoural transport through the interstitial space, and (4) cellular uptake & intracellular delivery by cancerous cells. We found that the philosophy behind the current consensus for NP design has certain similarities to the “Yin-Yang” theory in traditional Chinese culture. Almost all physicochemical properties, regardless of big or small sizes, long or short length, positive or negative zeta potentials, are double-edged swords. The balance of potential benefits and side effects, drug selectivity and accessibility should be fully considered when optimising particle design, similar to the “Yin-Yang harmony”. This paper presents a comprehensive review of the advancements in NPs research, focusing on their distinct features in tumour targeting, drug delivery, and cell uptake. Additionally, it deliberates on future developmental trends and potential obstacles, thereby aiming to uncover the ways these characteristics influence the NPs’ biological activity and provide theoretical guidance for the targeted delivery of NPs. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： in vivo drug delivery nanoparticle design on-demand drug release targeting strategy “Yin-Yang harmony”

Leptin Modulates the Differentiation of Keratinocytes via Autophagy in Psoriasis Patients with Metabolic Syndrome

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International j.urnal of Dermatology and Venereology 2024年第3期7卷 121-130页

作者： Song C.-H. Wang R. Zhao Z.-K. Zhang Y. Sun j. Zhang X. Ding X.-Y. Bai j. Liang X.-Q. Wei X.-j. Liu X.-L. Yang T. Liang X.-L. Li C.-X. Lin B.-W. Department of Dermatology PLA General Hospital Beijing 100853 China Department of Clinical Laboratory PLA General Hospital Beijing 100853 China Department of Dermatology Southern Medical University Guangdong Guangzhou 510515 China

Obj.ctive: Psoriasis is associated with a high prevalence of metabolic syndrome (MS), and patients with concomitant psoriasis and MS are more severely affected and less responsive to treatment. However, the molecular mechanisms behind these effects are unknown. Recent studies have shown that leptin may serve as a molecular link between psoriasis and MS, suggesting that high leptin concentrations may exacerbate psoriasis. However, the molecular mechanism of this effect is still unclear. We aimed to investigate the effect of leptin on autophagy in patients with psoriasis. Methods: From j.nuary 2021 to j.ne 2022 in PLA General Hospital, we enrolled 51 patients with psoriasis, including 21 patients with MS and 30 without MS, and 30 healthy controls who had undergone nevus surgery. We measured the epidermal leptin, P62, and LC3B concentrations of patients by immunohistochemistry, and measured the serum leptin concentration by enzyme-linked immunosorbent assay. We then performed correlation analyses to compare these proteins' concentrations between patients with concomitant psoriasis and MS, patients with psoriasis alone, and healthy control groups. Additionally, we performed western blotting after in vitro culture of HaCaT cells with different concentrations of leptin and measured the expression levels of the autophagy markers Beclin1, LC3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling pathway-related proteins of HaCat cells. Next, we transfected ATG5 into HaCaT cells to revert autophagy and used the specific PI3K inhibitor LY294002 to block PI3K/AKT/mTOR signaling. The expression levels of K10, K16, and K17 of HaCat cells were again measured. One-way analysis of variance was used for the comparison of means of multiple samples, and LSD-t post hoc test was used for comparison between the 2 groups. The counting data were analyzed by the chi-square test. Correlations were evaluated by Pearson correlation analysis. Results: The serum l

关键词： autophagy keratinocyte differentiation leptin metabolic syndrome PI3K/AKT/mTOR psoriasis signal pathway

Generalized Hopf Bifurcation in a Delay Model of Neutrophil Cells Model

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International j.urnal of Modern Nonlinear Theory and Application 2024年第2期13卷 11-28页

作者： Suqi Ma S. j. Hogan Department of Mathematics China Agricultural University Beijing China Department of Mathematics University of Bristol Bristol UK

The DDE-Biftool software is applied to solve the dynamical stability and bifurcation problem of the neutrophil cells model. Based on Hopf point finding with the stability property of the equilibrium solution loss, the continuation of the bifurcating periodical solution starting from Hopf point is exploited. The generalized Hopf point is tracked by seeking for the critical value of free parameter of the switching phenomena of the open loop, which describes the lineup of bifurcating periodical solutions from Hopf point. The normal form near the generalized Hopf point is computed by Lyapunov-Schimdt reduction scheme combined with the center manifold analytical technique. The near dynamics is classified by geometrically different topological phase portraits.

关键词： Generalized Hopf Bifurcation DDE-Biftool Software Norm Form

Effects of different ratios of soluble to insoluble dietary fiber on growth performance and intestinal health of piglets

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ANIMAL NUTRITION 2024年第3期18卷 257-271页

作者： Feng, Luya Luo, Zhenfu Wang, j.ng Wu, Kunfu Wang, Wenliang Liu, Zhimou Wen, j.ping Wang, Zhenbin Duns, Gregory j. Ma, Xiaokang Tan, Bi'e Hunan Agr Univ Coll Anim Sci & Technol Hunan Prov Key Lab Prod Qual Regulat Livestock & P Changsha 410128 Peoples R China Yuelushan Lab Changsha 410128 Peoples R China Hunan Nuoze Biol Technol Co Ltd Yiyang 413001 Peoples R China

This study investigated the impact of different ratios of soluble to insoluble dietary fiber (SDF:IDF) formulations by sugar beet pulp (SBP) supplementation on piglet growth performance, nutrient digestibility, immune function, intestinal morphology, intestinal microbiota and intestinal health. A total of 60 crossbred piglets (Duroc x [Landrace x Yorkshire]) at 40 d old with body weight of 10.0 +/- 0.3 kg were randomly assigned to 5 treatments with 6 replicates per treatment and 2 piglets per replicate in a 21d trial. The dietary treatments included a corn-soybean meal diet (0% SBP supplementation; CON), and diets supplemented with 2%, 4%, 6%, and 8% SBP, representing different SDF:IDF ratios at 10.16%, 13.53%, 16.79%, 19.86%, and 24.81%, respectively. The results indicated that the 8% SBP treatment had a negative effect on feed-to-gain ratio (linear, P = 0.009) compared with the CON treatment (P = 0.021). The apparent total tract digestibility (ATTD) of crude protein was lower in treatments supplemented with SBP (P = 0.002) and showed a linear decrease (P = 0.001), while the ATTD of IDF showed a linear increase (P = 0.037) in four SBP treatments compared to the CON treatment. The 4% SBP treatment increased serum concentrations of triglyceride (quadratic, P = 0.019) and K (linear, P < 0.0037), and decreased alanine transaminase concentration (quadratic, P = 0.015) compared with the CON treatment. The concentrations of Cit, Cys, Ile, Leu, Orn, Arg, taurine, urea, 1-methylhistidine, a-aminoadipic acid, aaminobutyric acid and cystathionine in the 4% SBP treatment were highest among all treatments (P < 0.05). The serum concentrations of interleukin-6, interleukin-8, interleukin-10, transforming growth factor-b, and tumor necrosis factor-a in the 6% SBP treatment were higher than those in the CON treatment (P < 0.05), which also increased mucin-2 and G protein-coupled receptor 41 mRNA expression (P < 0.05) in colonic mucosa compared with the CON treatment and improved th

关键词： Soluble dietary fiber Insoluble dietary fiber Sugar beet pulp Growth performance Intestinal health Piglet SUGAR-BEET PULP CHAIN FATTY-ACIDS NUTRIENT DIGESTIBILITY MICROBIOTA COMPOSITION FECAL MICROBIOTA BARRIER FUNCTION WEANING STRESS AMINO-ACIDS WHEAT METABOLISM

The Oral Health Status of Person with Special Needs in Kumasi

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Open j.urnal of Stomatology 2024年第1期14卷 14-31页

作者： Ama Agyeibea Amuasi Alexander Oti-Acheampong Victoria N. A. Boadu Lord j. j. Gowans The Department Child Oral Health & Orthodontics School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana The Department of Oral & Maxillofacial Sciences School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana The Department of Community Dentistry School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana

Background: The most prevalent non-communicable disease worldwide is oral health-related disease, with dental caries and periodontal conditions being common. Oral health status significantly impacts overall health and quality of life. Barriers to dental care affect children with special needs. This study evaluates the oral health status and treatment requirements of people with special needs. Methodology: This descriptive cross-sectional study in Kumasi, Ghana examined oral health status among people, 121 children with special needs over two months, in j.ne-j.ly 2022. Dental caries, periodontal changes, malocclusion, and trauma were assessed. The data was analyzed using SPSS 20.0. Results: The oral health status among people with special needs in this study was generally moderate, with a range from very good to very poor. The prevalence of dental caries was 37%, with a mean DMFT score of 2.82. Periodontal health showed unsatisfactory indicators such as mobile teeth, poor gingival health, high plaque scores, and the presence of halitosis. Conclusion: This descriptive study aimed to provide baseline data on the oral health status of special needs students in Kumasi, addressing the lack of knowledge in this area. It highlighted the importance of dental care in maintaining good oral health and overall well-being in individuals with special needs. Coordinated efforts by dental professionals are needed to provide dental health education and preventive interventions for these children.

关键词： Special Needs Oral Health Dental Caries Periodontal Diseases Malocclusion

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德国历史哲学传统中的理念论及其批判

世界哲学 2024年第4期 54-62页

作者：尉佩云 [德]j.吕森山西大学历史文化学院埃森高等人文研究所

在德国的学术传统中,历史哲学具有漫长的学术历程,它伴随着历史学职业化的过程而形成、发展。在初创及此后的语境中,它成为一种思考过去的全新的学术领域和学术形式。在德国历史哲学开端之处,理念论便主导了这个思想传统,这种影响一直... 详细信息

在德国的学术传统中,历史哲学具有漫长的学术历程,它伴随着历史学职业化的过程而形成、发展。在初创及此后的语境中,它成为一种思考过去的全新的学术领域和学术形式。在德国历史哲学开端之处,理念论便主导了这个思想传统,这种影响一直延续至今。我们可以从四个方面来审视理念论在德国历史哲学中的影响,以启蒙运动之后的德国历史哲学演变的四个先后相序的阶段或形式为题,这分别是理念论的历史哲学,理念论的历史方法论,理念论的历史认识论和理念论视角下诗性与修辞的历史书写。在今天,理念论失去了在方法论上的合理性,但如果历史学还是建立在人类生活形式的解释学基础之上的学科,那么理念论的学术思考就仍然有必要进行批判性反思。将人类受难等现实主义思考纳入其中,在我们将这种现实主义进行人文化的时候,理念论在当下语境中应该获得进一步批判性思考。

关键词：理念论历史哲学史学职业化历史认识论诗性史学

Full Dynamic Model for Liquid Sloshing Simulation in Cylindrical Tank Shape

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World j.urnal of Mechanics 2024年第4期14卷 55-72页

作者： Omar Noui Mohamed Bouazara Marc j. Richard Department of Applied Science University of Quebec at Chicoutimi Chicoutimi Canada Department of Mechanical Engineering Laval University Quebec Canada

This study presents a comprehensive full dynamic model designed for simulating liquid sloshing behavior within cylindrical tank structures. The model employs a discretization approach, representing the liquid as a network of interconnected spring-damper-mass systems. Key aspects include the adaptation of liquid discretization techniques to cylindrical lateral cross-sections and the calculation of stiffness and damping coefficients. External forces, simulating various vehicle maneuvers, are also integrated into the model. The resulting system of equations is solved using Maple Software with the Runge-Kutta-Fehlberg method. This model enables accurate prediction of liquid displacement and pressure forces, offering valuable insights for tank design and fluid dynamics applications. Ongoing refinement aims to broaden its applicability across different liquid types and tank geometries.

关键词： Fluid-Structure Interaction Equivalent Mechanical Model Liquid Discretization Spring-Mass Model Spring-Mass Network Liquid Simulation

Kikuchi-Fuj.moto Disease: A Case of Lymphadenitis Following COVID-19 Infection

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Open j.urnal of Rheumatology and Autoimmune Diseases 2024年第3期14卷 118-124页

作者： j.spreet Dhillon Bhagvat j. Maheta Neeladri Misra Department of Internal Medicine Sutter Roseville Medical Center Roseville CA USA California Northstate University College of Medicine Elk Grove CA USA

Introduction: Kikuchi-Fuj.moto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare disease of uncertain origin proposed to be secondary to viral or autoimmune causes. It presents as unilateral cervical lymphadenopathy and fever, typically resolving within a few months, however, it mimics malignant lymphoma, leading to extensive work-up fearing malignancy. Case History: A 33-year-old female with a history of Sj.gren’s syndrome, rheumatoid arthritis (not on immunosuppressive therapy) and recent COVID-19 infection two months ago presented with episodes of flu-like symptoms;fever (101˚F), chills, and myalgias for two months. Upon evaluation, she had leukopenia (WBC 1.8 k/uL), neutropenia (1.0 k/uL), elevated CRP (134 mg/L), and CT neck demonstrated multiple enlarged cervical lymph nodes with necrosis. The patient was started on Cefdinir and doxycycline for a possible atypical infection given neutropenic fevers and the patient continued to have fevers. A biopsy showed focal necrosis with no evidence of malignancy, suggesting KFD that was likely triggered by a recent COVID infection. She was treated with Prednisone and naproxen, which led to an improvement in symptoms and recovery of her pancytopenia. Discussion: This case is unique since the patient’s recent infection with COVID-19 may have triggered the clinical manifestations of KFD. There have been a few case reports of children who were diagnosed with KFD after a COVID-19 infection and adults diagnosed with KFD following COVID vaccinations;however, this is the first case report involving a young adult in her thirties who was diagnosed with KFD two months after COVID-19.

关键词： Kikuchi-Fuj.moto Disease COVID-19 Rheumatology

Cluster Modulation: A Generalized Modulation Scheme Leading to NOMA or Adaptive Modulation

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j.urnal of Computer and Communications 2024年第7期12卷 12-22页

作者： j.mal S. Rahhal Suliman j. Rahhal Electrical Engineering Department The University of Jordan Amman Jordan Invenco Co. Tampa USA

The need for higher data rate and higher systems capacity leads to several solutions including higher constellation size, spatial multiplexing, adaptive modulation and Non-Orthogonal Multiple Access (NOMA). Adaptive Modulation makes use of the user’s location from his base station, such that, closer users get bigger constellation size and hence higher data rate. A similar idea of adaptive modulation that makes use of the user’s locations is the NOMA technique. Here the base station transmits composite signals each for a different user at a different distance from the base station. The transmitted signal is formed by summing different user’s constellations with different weights. The closer the users the less average power constellation is used. This will allow the closer user to the base station to distinguish his constellation and others constellation. The far user will only distinguish his constellation and other user’s data will appear as a small interference added to his signal. In this paper, it is shown that the Adaptive modulation and the NOMA are special cases of the more general Cluster Modulation technique. Therefore, a general frame can be set to design both modulation schemes and better understanding is achieved. This leads to designing a multi-level NOMA and/or flexible adaptive modulation with combined channel coding.

关键词： Cluster Modulation Adaptive Modulation NOMA