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Eye-shaped keyboard for dual-hand text entry in virtual reality

Virtual Reality & Intelligent Hardware 2023年第5期5卷 451-469页

作者： kangyu wang Yangqiu YAN Hao ZHANG Xiaolong LIU Lili wang State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100083China Peng Cheng Laboratory Shenzhen 518000China

We propose an eye-shaped keyboard for high-speed text entry in virtual reality (VR), having the shape of dual eyes with characters arranged along the curved eyelids, which ensures low density and short spacing of the keys. The eye-shaped keyboard references the QWERTY key sequence, allowing the users to benefit from their experience using the QWERTY keyboard. The user interacts with an eye-shaped keyboard using rays controlled with both the hands. A character can be entered in one step by moving the rays from the inner eye regions to regions of the characters. A high-speed auto-complete system was designed for the eye-shaped keyboard. We conducted a pilot study to determine the optimal parameters, and a user study to compare our eye-shaped keyboard with the QWERTY and circular keyboards. For beginners, the eye-shaped keyboard performed significantly more efficiently and accurately with less task load and hand movement than the circular keyboard. Compared with the QWERTY keyboard, the eye-shaped keyboard is more accurate and significantly reduces hand translation while maintaining similar efficiency. Finally, to evaluate the potential of eye-shaped keyboards, we conducted another user study. In this study, the participants were asked to type continuously for three days using the proposed eye-shaped keyboard, with two sessions per day. In each session, participants were asked to type for 20min, and then their typing performance was tested. The eye-shaped keyboard was proven to be efficient and promising, with an average speed of 19.89 words per minute (WPM) and mean uncorrected error rate of 1.939%. The maximum speed reached 24.97 WPM after six sessions and continued to increase.

关键词： Virtual reality Human computer interaction Text entry Shaped keyboard QWERTY-like key sequence Dual-hand cooperation

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Lineaperpetua ***.:a new diatom genus in the Thalassiosirales supported by morphology and molecular data

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Journal of Oceanology and Limnology 2024年第1期42卷 277-290页

作者： Pan YU Lin YANG Qingmin YOU John Patrick KOCIOLEK kangyu wang Yonghong BI Quanxi wang College of Life Sciences Shanghai Normal UniversityShanghai 200234China Institute of Hydrobiology Chinese Academy of SciencesWuhan 430072China Museum of Natural History and Department of Ecology and Evolutionary Biology University of ColoradoUCB 218Boulder CO 80309USA

Based on a combination of morphology and molecular data of ribosomal DNA genes,a new diatom genus Lineaperpetua ***,You,Kociolek&wang is *** features that help define Lineaperpetua at the level of genus include:a tangentially undulated valve face;continuous cribra areolae on the valve interior consisting of pores arranged as strips;single rimoportula located inside the ring of marginal ***,phylogenetic analysis based on nuclear small subunit(SSU)rDNA sequences and nuclear large subunit(LSU)rDNA gene placed the three strains of *** in a single,monophyletic clade at a considerable sequence distance from the other genera(Thalassiosira,Conticribra,Planktoniella,Shinodiscus,and other genera)belonging to *** the similarities with some species of Thalassiosira,Conticribra,and Spicaticribra,the suite of features found in Lineaperpetua differentiate it from these other *** molecular data and morphological characters suggest an affinity of the new genus to the Thalassiosiraceae.

关键词： diatom morphology new genus phylogeny taxonomy Thalassiosiraceae

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Transcriptome-Wide Identification and Functional Analysis of PgSQE08-01 Gene in Ginsenoside Biosynthesis in Panax ginseng ***.

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Phyton-International Journal of Experimental Botany 2024年第2期93卷 313-327页

作者： Lei Zhu Lihe Hou Yu Zhang Yang Jiang Yi wang Meiping Zhang Mingzhu Zhao kangyu wang College of Life Science Jilin Agricultural UniversityChangchun130118China Jilin Engineering Research Center Ginseng Genetic Resources Development and Utilization Changchun130118China Jilin Academy of Vegetable and Flower Sciences Changchun130033China

Panax ginseng *** an important plant species used in traditional Chinese medicine,whose primary active ingredient is a *** biosynthesis is not only regulated by transcription factors but also controlled by a variety of structural ***,the molecular mechanism underlying ginsenoside biosynthesis has always been a topic in the discussion of ginseng secondary *** epoxidase(SQE)is a key enzyme in the mevalonic acid pathway,which affects the biosynthesis of secondary metabolites such as *** ginseng transcriptome,expression,and ginsenoside content databases,this study employed bioinformatic methods to systematically analyze the genes encoding SQE in *** first selected six PgSQE candidates that were closely involved in ginsenoside biosynthesis and then identified PgSQE08-01 to be highly associated with ginsenoside ***,we constructed the overexpression vector pCAMBIA3301-PgSQE08-01 and the RNAi vector pART27-PgSQE08-01 and transformed ginseng adventitious roots using Agrobacterium rhizogenes,to obtain positive hairy-root ***,quantitative reverse transcriptionpolymerase chain reaction and high-performance liquid chromatography were used to determine the expression of relevant genes and ginsenoside content,***,we focused on the function of PgSQE08-01 gene,which was noted to be involved in ginsenoside ***,these findings not only provided a molecular basis for the identification of important functional genes in ginseng but also enriched genetic resources for the biosynthesis of ginsenosides using synthetic biology.

关键词： Panax ginseng pgSQE08-01 gene squalene epoxidase ginsenoside ginseng hairy roots

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Network pharmacology and experimental validation of Maxing Shigan decoction in the treatment of influenza virus-inducedferroptosis

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Chinese Journal of Natural Medicines 2023年第10期21卷 775-788页

作者： HUANG Jiawang MA Xinyue LIAO Zexuan LIU Zhuolin wang kangyu FENG Zhiying NING Yi LU Fangguo LI Ling College of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208China College of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208China The Medicine School of Hunan University of Chinese Medicine Changsha 410208China Hunan Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208China

Influenza is an acute viral respiratory infection that has caused high morbidity and mortality *** A virus(IAV)has been found to activate multiple programmed cell death pathways,including *** is a novel form of programmed cell death in which the accumulation of intracellular iron promotes lipid peroxidation,leading to cell ***,little is known about how influenza viruses induce ferroptosis in the host *** this study,based on network pharmacology,we predicted the mechanism of action of Maxing Shigan decoction(MXSGD)in IAV-induced ferroptosis,and found that this process was related to biological processes,cellular components,molecular function and multiple signaling pathways,where the hypoxia inducible factor-1(HIF-1)signaling pathway plays a significant ***,we constructed the mouse lung epithelial(MLE-12)cell model by IAV-infected in vitro cell experiments,and revealed that IAV infection induced cellular ferroptosis that was characterized by mitochondrial damage,increased reactive oxygen species(ROS)release,increased total iron and iron ion contents,decreased expression of ferroptosis marker gene recombinant glutathione peroxidase 4(GPX4),increased expression of acyl-CoA synthetase long chain family member 4(ACSL4),and enhanced activation of hypoxia inducible factor-1α(HIF-1α),induced nitric oxide synthase(iNOS)and vascular endothelial growth factor(VEGF)in the HIF-1 signaling *** with MXSGD effectively reduced intracellular viral load,while reducing ROS,total iron and ferrous ion contents,repairing mitochondrial results and inhibiting the expression of cellular ferroptosis and the HIF-1 signaling ***,based on animal experiments,it was found that MXSGD effectively alleviated pulmonary congestion,edema and inflammation in IAV-infected mice,and inhibited the expression of ferroptosis-related protein and the HIF-1 signaling pathway in lung tissues.

关键词： Network pharmacology Experimental validation Maxing Shigan decoction Influenza Ferroptosis HIF-1 signaling pathway

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Response of the Ginseng C_(2)H_(2)-Type Zinc Finger Protein Family PgZFPs Gene to Methyl Jasmonate Regulation

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Phyton-International Journal of Experimental Botany 2024年第11期93卷 3055-3071页

作者： Yue Jiang Lingyu Liu kangyu wang Mingzhu Zhao Ping Chen Jun Lei Yanfang wang Meiping Zhang Yi wang Guang Chen College of Life Science Jilin Agricultural UniversityChangchun130118China Research Center for Ginseng Genetic Resources Development and Utilization Jilin ProvinceJilin Agricultural UniversityChangchun130118China College of Chinese Medicinal Materials Jilin Agricultural UniversityChangchun130118China

The main active components of ginseng are ginsenosides,which play signiﬁcant roles in treating cardiovascular diseases,cancer,and providing antioxidant *** are primarily synthesized through the mevalo-nate pathway and the methylerythritol phosphate *** key enzyme genes involved in this biosynthetic process have been cloned and validated,yet the regulatory functions of transcription factors remain *** C_(2)H_(2)-type zincﬁnger protein family,one of the largest families of transcription factors,is crucial in plant growth and development,response to biotic and abiotic stresses,and regulation of secondary *** study,based on the ginseng transcriptome database from Jilin,conducted a correlation analysis between the expression levels of PgZFPs genes in the Jilin ginseng C_(2)H_(2)-type zincﬁnger protein family and ginsenoside content,a gen-ome-wide association study of PgZFPs,and co-expression analysis of PgZFPs with validated key enzyme ***,ﬁve candidate genes involved in ginsenoside biosynthesis were identiﬁ*** involvement of PgZFP27 and PgZFP-59-02 genes from the PgZFPs family in the biosynthesis of ginsenosides was validated through in vitro methyl jasmonate(MeJA)induction *** result provides new genetic resources for the biosynthesis of ginsenosides.

关键词： Ginsenosides C_(2)H_(2)-type zincﬁnger protein family MeJA induction functional study SIT SITIENS FLC FLACCA MVA Mevalonate MEP 2-C-methyl-D-erythritol 4-phosphate GWAS Genome-wide association studies HPLC High-performance liquid chromatography

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移动荷载作用下结构弹塑性安定分析方法及其应用研究

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湖南大学学报（自然科学版） 2018年第7期45卷 93-102页

作者：庄妍王孟王康宇东南大学土木工程学院江苏南京210096 河海大学岩土工程科学研究所江苏南京210098

为了研究移动荷载作用下结构的安定性问题,以Melan静力型安定定理为基础,通过构造满足静力平衡条件的最佳残余应力场,并求解移动荷载作用下结构中的真实弹性应力场,发展了一种弹塑性安定性计算方法.该方法摆脱了传统安定性分析方法中的... 详细信息

为了研究移动荷载作用下结构的安定性问题,以Melan静力型安定定理为基础,通过构造满足静力平衡条件的最佳残余应力场,并求解移动荷载作用下结构中的真实弹性应力场,发展了一种弹塑性安定性计算方法.该方法摆脱了传统安定性分析方法中的数学规划运算,解决了计算中维数障碍的问题.通过与前人研究结果对比,说明本方法的正确性.基于此方法,研究了列车荷载直接作用下路基的静力安定极限的第一类上限kI和静力安定极限kSD,进行轮载间距L和铁轨间距B对路基安定极限的敏感性分析,发现当轮载间距L和铁轨间距B大于等于10a时,轮载间距L和铁轨间距B对路基安定极限不再产生影响;通过分析材料泊松比v和内摩擦角φ对安定极限的影响,表明安定极限随着路基泊松比的增大略有减小,但随着内摩擦角的增大而有明显增加;并提出了一种基于安定极限荷载包络图的路基安定性评价方法和设计方法,据此可对铁路路基进行设计指导和安全性评价.

关键词：安定分析铁路赫兹荷载 Melan静力安定定理移动荷载弹塑性材料

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Plasma SNORD83A as a potential biomarker for early diagnosis of non-small cell lung cancer

Plasma SNORD83A as a potential biomarker for early diagnosis...

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2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： kangyu wang Xingguo Song Li Xie Xianrang Song Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences

Background: Despite decades of efforts, non-small-cell lung cancer(NSCLC) remains the leading cause of global cancer mortality primarily due to the challenge in early detection of the cancer. The present study aimed to validate plasma snoRNAs as biomarkers for diagnosing early-stage *** and Methods: Differential levels of snoRNAs were screened and validated in NSCLC tissues and normal tissues by TCGA and snoRNAs databases, then SNORD83 A was selected and further verified in FFPE samples including 48 NSCLC tissues and 48 adjacent normal tissues, as well as in plasma from 150 NSCLC patients and 150 health donors. Then, the diagnostic efficiency of plasma SNORD83 A, as well as combined with CEA was determined by receiver operating characteristic(ROC) ***: SNORD83 A was significantly upregulated in tissues and plasma samples of NSCLC patients, as well as early-stage NSCLC patients compared to those of healthy donors. Plasma SNORD83 A was capable to act as the promising diagnostic biomarker for NSCLC and early-stage NSCLC. The combination of CEA and SNORD83 A provided a more accurate diagnostic efficiency than CEA alone for early-stage NSCLC. The expression levels of plasma SNORD83 A was significantly decreased ***: SNORD83 A is significantly upregulated in NSCLC patients, and can serve as the promising and non-invasive diagnostic biomarker for NSCLC and early-stage NSCLC.

关键词： SnoRNAs SNORD83A biomarker NSCLC diagnosis

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基于Von-Mises屈服准则的结构安定性研究

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地下空间与工程学报 2016年第S1期12卷 170-174,191页

作者：庄妍王康宇河海大学岩土力学与堤坝工程教育部重点实验室南京210098 河海大学岩土工程科学研究所南京210098

基于静力安定定理提出了一种服从Von-mises屈服准则的静力安定分析方法。该方法将经典的安定理论与有限元方法相结合,通过构造自平衡的残余应力场,并利用有限元程序求解弹性应力场,避免了线性规划方法的维度障碍。将车辆与路面的接触应... 详细信息

基于静力安定定理提出了一种服从Von-mises屈服准则的静力安定分析方法。该方法将经典的安定理论与有限元方法相结合,通过构造自平衡的残余应力场,并利用有限元程序求解弹性应力场,避免了线性规划方法的维度障碍。将车辆与路面的接触应力简化为三种荷载分布形式:Hertz荷载、均布荷载和梯形荷载,研究了荷载形式和路面材料参数对结构安定行为的影响。研究结果表明,路面摩擦系数和材料屈服应力对结构安定极限的影响较大,摩擦系数越大,安定极限值越小;安定极限随着材料的屈服应力基本呈线性增长。当摩擦系数相对较小时,Hertz荷载下的安定极限值最大,而梯形分布荷载下的安定极限值最小。研究结果可为路面结构的设计提供一定的参考价值。

关键词：安定分析 Von-mises屈服准则 Hertz荷载静力安定定理

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多个列车轮载作用下铁路道床结构安定性分析

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中南大学学报（自然科学版） 2020年第8期51卷 2343-2352页

作者：王康宇庄妍张占荣张升浙江工业大学土木工程学院浙江杭州310014 东南大学土木工程学院混凝土及预应力混凝土结构教育部重点实验室江苏南京211189 长沙理工大学公路养护技术国家工程实验室湖南长沙410114 中铁第四勘察设计院集团有限公司湖北武汉430063 中南大学土木工程学院高速铁路建造技术国家工程实验室湖南长沙410075

为了更全面地了解铁路道床结构的安定行为,根据列车轮载作用下于Winkler连续均匀弹性地基上的钢轨竖向挠曲变形规律,采用基于Gauss函数的轨枕荷载分担比的近似计算方法,确定单个和多个轮载作用于不同位置处的轨枕荷载分担比。基于BOUSSI... 详细信息

为了更全面地了解铁路道床结构的安定行为,根据列车轮载作用下于Winkler连续均匀弹性地基上的钢轨竖向挠曲变形规律,采用基于Gauss函数的轨枕荷载分担比的近似计算方法,确定单个和多个轮载作用于不同位置处的轨枕荷载分担比。基于BOUSSINESQ和CERRUTI解答,推导竖向和水平均布荷载作用下半无限空间结构中的弹性应力场的解析表达,并结合Melan静力安定定理,提出多个列车轮载作用下铁路道床结构的安定性分析方法,通过与已有文献计算结果的对比,对推导的弹性应力场解析方法及静力安定分析方法的可行性和计算结果的准确性进行验证。基于铁路道床结构的安定性分析方法,研究多个列车轮载作用下道床材料参数对其安定荷载的影响规律。研究结果表明:对于和谐号CRH3型电力动车组高速列车,其轨枕荷载分担仅在1个转向架的2个轮轴荷载之间存在叠加影响,且在其影响范围内轨枕荷载分担比呈现“M”形分布;道床结构的静力安定荷载随内摩擦角增大而增大,尽管泊松比是影响结构弹性应力场的重要参数,但其对道床安定荷载的影响较小;在满足经济性的前提下,适当选用高强度的材料,能有效提高给定摩擦因数下道床结构的承载能力。

关键词：多列车轮载铁路道床 Gauss函数安定分析弹性应力场

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循环荷载作用下土拱效应的离散元研究

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建筑科学与工程学报 2023年第3期40卷 152-160页

作者：曹军王康宇骆大江浙江工业大学土木工程学院浙江杭州310014 杭州众邦基础工程有限公司浙江杭州310000

基于室内Trapdoor模型试验,采用PFC2D研究了循环荷载作用下不同路堤高度的土拱效应,从力链和位移的角度对路堤内土拱结构、填料移动的变化规律进行了宏观和微观分析。结果表明:抗扭转模型可以较好地模拟以铝棒相似土作为填料的Trapdoor... 详细信息

基于室内Trapdoor模型试验,采用PFC2D研究了循环荷载作用下不同路堤高度的土拱效应,从力链和位移的角度对路堤内土拱结构、填料移动的变化规律进行了宏观和微观分析。结果表明:抗扭转模型可以较好地模拟以铝棒相似土作为填料的Trapdoor试验;在循环荷载作用下路堤内形成的土拱结构发生破坏,土拱效应得到削弱,土拱结构的破坏主要发生在初始加载阶段,并且在这个阶段高路堤底部土拱结构比低路堤受到外部荷载的影响要小;随着加载的进行,路堤内部形成了新的稳定受力结构并基本保持不变;在循环加载过程中低路堤加载板两侧的力链结构受到的影响和扰动比高路堤的大;在循环荷载作用下,路堤表面发生了沉降,其中塑性位移主要发生在初始加载阶段,之后产生的几乎是弹性位移;高路堤加载板两侧土体相较于低路堤在第一次加载时更不容易产生横向位移被挤向两端,加载板的竖向位移减少,从而减少加载板对底部土体的影响,使得路堤底部的土拱结构更不容易被影响。

关键词：土拱效应离散元循环荷载 Trapdoor试验力链

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