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Roles of endoplasmic reticulum stress and apoptosis signaling pathways in gynecologic tumor cells：A systematic review

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Oncology and Translational Medicine 2017年第3期3卷 131-135页

作者： kangsheng liu Weimin Fang Erhu Sun Yajun Chen Department of Clinical Laboratory Nanjing Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210029 China Department of Obstetrics and Gynecology Nanjing Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210029 China

Efficient functioning of the endoplasmic reticulum(ER) is very important for most cellular activities, such as protein folding and modification. The ER closely interacts with other organelles, including the Golgi body, endosome, membrane, and mitochondria, providing lipids and proteins for the repair of these organelles. ER stress can be induced by various abnormal materials in the cell. ER stress is a compensatory intracellular environment disorder that occurs during areaction. ER can sense the stress and respond to it through translational attenuation, upregulation of the genes for ER chaperones and related proteins, and degradation of unfolded proteins by a quality-control system, but excessive ER activation can cause cell death. The Pubmed and Web of Science databases were searched for full-text articles, and the terms "endoplasmic reticulum stress/unfolded protein response/gynecologic tumor cell apoptosis" were used as key words. Thirty-five studies of ER stress and unfolded protein response published from 2000 to 2016 were analyzed. Stress triggers apoptosis through a variety of signaling pathways. Increasing evidence has shown that the ER plays an important role in tumor cell diseases. The present review discusses the molecular mechanisms underlying unfolded protein response and its ability to promote survival and proliferation in gynecologic tumor cells.

关键词： endoplasmic reticulum(ER) unfolded protein response(UPR) inositol-requiring-JNK(IRE1-JNK) caspase CCAAT-enhancer-binding protein homologous protein(CHOP) gynecologic tumor cell

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian Li Xueer liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen kangsheng Li Jiangtao Sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

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我国中小企业电子商务的发展现状与对策研究

中国市场 2008年第41期 63-64页

作者：刘康胜江西应用技术职业学院

电子商务的出现为广大的中小企业带来了更为广阔的发展空间,在我国中小企业发展电子商务的过程中面临着诸多的问题,正确认识到这些问题并加以解决与改正,明确中小企业发展电子商务的现状与对策将是中小企业在未来取得长足发展的必由之路。

关键词：中小企业电子商务现状对策

On Exact Controllability of Linear PDEs:Frequency Domain Characterization and Piecewise Multiplier Techniques

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On Exact Controllability of Linear PDEs:Frequency Domain Cha...

1997年中国控制会议

作者： liu kangsheng Department of Applied Mathematics Zhejiang University, Hangzhou, 310027

＜正＞This paper is a summary account of research results on exact controllability of linoar partial differential equations, which are proved by means of a frequency domain characterization and/or a piecewise multipli... 详细信息

关键词： exact controllability wave equation moving control unique continuation exponential stabilizability

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线性控制系统对小时滞的鲁棒能控性

数学年刊（A辑） 2007年第2期28卷 151-158页

作者：于欣刘康生浙江大学宁波理工学院信息与优化技术研究所浙江宁波315100 浙江大学数学系杭州310027

对于在Banach空间中线性控制系统对时滞的鲁棒能控性．给出一个充分条件,在这个条件下,证明对一个能控的线性系统施加某个小的时滞扰动之后,其能控性保持不变．

关键词： C0-半群能控性 X-能控性鲁棒性时滞

Exact Internal Controllability of The Kirchhoff Plate-Like Equation

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Exact Internal Controllability of The Kirchhoff Plate-Like E...

基于GA-LSTM的高层建筑结构地震响应的分散控制研究

1998年中国控制会议

作者： liu kangsheng and YU Xinhui Department of Applied Mathematics Zhejiang University, Hangzhou, 310027, China.

＜正＞When the rotatory inertia is taken into account, vibrations of a linear plate can be described by the Kirchhoff plate equation. Consider this equation with locally distributed control forces and some boundary condition which is the simply supported boundary condition for a rectangular plate. In this paper, we establish exact controllability of the system in terms of the equivalence to exact internal controllability of the wave equation, by means of a frequency domain characterization of exact controllability introduced recently in liu [1].

关键词： Kirchhoff plate equation locally distributed control exact controllability wave equation frequency domain condition

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振动与冲击 2021年第10期40卷 114-122页

作者：高经纬涂建维刘康生李召武汉理工大学道路桥梁与结构工程湖北省重点实验室武汉430070

高层建筑结构复杂,自由度数庞大,采用主动抗震控制方法时结构的精确模型无法建立,整体控制目标也难以获取。为此,将长短时记忆(LSTM)网络理论和大系统分散控制理论结合,提出一种基于LSTM的智能分散控制方法;利用LSTM深度学习框架构建不... 详细信息

高层建筑结构复杂,自由度数庞大,采用主动抗震控制方法时结构的精确模型无法建立,整体控制目标也难以获取。为此,将长短时记忆(LSTM)网络理论和大系统分散控制理论结合,提出一种基于LSTM的智能分散控制方法;利用LSTM深度学习框架构建不同类型的分散控制器,并根据Lyapunov稳定性理论推导分散控制器稳定的充分条件,运用遗传算法(GA)对LSTM框架的初始学习率进行优化,提高分散控制器的收敛速度和预测精度。以20层Benchmark模型作为被控对象,研究GA-LSTM分散控制方法的控制性能,并与集中控制效果进行对比分析。结果表明,基于GA-LSTM的智能分散控制方法可以简化控制器结构,对比集中控制可能产生的整体失效现象,具有更高的可靠性和更好的控制效果。

关键词：分散控制长短时记忆(LSTM)网络 Lyapunov稳定性理论遗传算法(GA) 结构振动控制