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甲状腺球蛋白基因对CH患儿诊断、早期干预疗效及影响因素分析

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中国计划生育学杂志 2020年第8期28卷 1258-1261页

作者：唐华周莹郑康宁王华喻容湖南省妇幼保健院长沙410008 湖南省长沙市中心医院

目的:探究甲状腺球蛋白基因(TG)筛查对先天性甲状腺功能低下(CH)患儿诊断并早期干预疗效,分析患病影响因素。方法:本院出生后确诊为先天性甲状腺功能减低症43例患儿,根据治疗时机不同分为0.05),但0.05)。多因素分析,孕妇年龄≥35岁、妊... 详细信息

目的:探究甲状腺球蛋白基因(TG)筛查对先天性甲状腺功能低下(CH)患儿诊断并早期干预疗效,分析患病影响因素。方法:本院出生后确诊为先天性甲状腺功能减低症43例患儿,根据治疗时机不同分为0.05),但0.05)。多因素分析,孕妇年龄≥35岁、妊娠期并发甲状腺疾病、甲状腺家族史以及用药史均为CH患病主要危险因素。结论:TG基因突变在CH患儿中检出率较高,可帮助CH患儿病因诊断。早期治疗干预有助于患儿生长发育。孕妇年龄、妊娠期并发甲状腺疾病、甲状腺家族史以及用药史等为CH患病主要危险因素。

关键词：先天性甲状腺功能低下患儿甲状腺球蛋白基因诊断早期干预发育商甲状腺激素影响因素

阿司匹林联合氯吡格雷对缺血性轻度颈动脉狭窄患者脑卒中二级预防的作用

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第三军医大学学报 2015年第9期37卷 925-929页

作者：蒲明军陈军杨伟业张超周振华史树贵陈康宁第三军医大学西南医院神经内科重庆400038

目的对比阿司匹林联合氯吡格雷与单用阿司匹林或氯吡格雷对症状性轻度颈动脉狭窄患者脑卒中二级预防的疗效及安全性。方法纳入本科2009年1月至2013年8月诊断为症状性轻度颈动脉狭窄的患者,所有患者行全脑血管造影术(DSA)检查确诊狭窄率... 详细信息

目的对比阿司匹林联合氯吡格雷与单用阿司匹林或氯吡格雷对症状性轻度颈动脉狭窄患者脑卒中二级预防的疗效及安全性。方法纳入本科2009年1月至2013年8月诊断为症状性轻度颈动脉狭窄的患者,所有患者行全脑血管造影术(DSA)检查确诊狭窄率≤50%,给所有患者服用他汀类药物,联合服用抗血小板聚集药物阿司匹林和氯吡格雷的患者归为双联抗血小板药物组(双抗组),单用阿司匹林或氯吡格雷的患者归为单联抗血小板药物组(单抗组)。搜集入院时改良Rankin评分(mRS评分)、美国国立卫生研究院卒中神经功能残损量评分(NIHSS评分)及电话随访患者出院后1年内mRS评分情况、卒中复发及不良血管事件发生情况。结果共搜集151例症状性轻度颈动脉狭窄患者,其中单抗组及双抗组分别为52、99例,排除10例失访患者,最终分别纳入48、93例患者进入分析。通过比较发现单抗组与双抗组同侧卒中复发率(分别为8.3%、2.1%)、非同侧卒中复发率(分别是2.1%、1.1%)、病死率(分别为4.1%、2.1%)无明显差异(P>0.05),出血发生率(分别为0%、11.8%)有统计学差异(P0.05)。结论对颈动脉狭窄≤50%的症状性轻度颈动脉狭窄患者单用阿司匹林或氯吡格雷进行脑卒中二级预防可能更安全。

关键词：脑卒中抗血小板聚集颈动脉狭窄

Transcranial magnetic stimulation combined with transcranial direct current stimulation in patients with chronic insomnia: A case report

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Transcranial magnetic stimulation combined with transcranial...

Altered Motor-Striatal Plasticity and Cortical Functioning in Patients with Schizophrenia

中国睡眠研究会第十四届全国学术年会

作者： Qi zhou Dongsheng zhou Ningbo kangning Hospital

Background: Long-term insomnia affects the normal life and work of individuals and increases the risk of various health problems, including mental illness. Therefore, there is an urgent need for an efficient and safe treatment for improving sleep. We hypothesize that sleep can be improved by modulating the excitability of the cerebral cortex in an individual, but since physical therapy techniques are not widely used in sleep disorders, the optimal regimen for improving sleep is ***: In this study, we report the case a 52-year-old woman who received rTMS combined with tDCS after agreeing to publish her case. In order to evaluate the quality of sleep and the stability of emotional symptoms, clinical evaluations were conducted at baseline, after 10 treatment sessions, after 20 treatment sessions, and one month after the end of treatment. Assessments included the Pittsburgh Sleep Quality Index(PSQI), Hamilton Depression Scale(HAMD), and Hamilton Anxiety Scale(HAMA).Results: After completing rTMS combined with tDCS, the patient showed an overall clinical improvement, with clinical changes mainly observed in the PSQI, HAMD, and HAMA scale scores, and this improvement was maintained one month after the ***:This case provides the first evidence for the feasibility, tolerability, and safety of combined rTMS and tDCS in a patient with chronic insomnia. Our exploratory research provides a new perspective for the treatment of patients with simple insomnia so that follow-up research can further replicate this intervention.

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来源： cnki会议评论

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cnki会议

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Neuroscience Bulletin 2017年第3期33卷 307-311页

作者： Dongsheng zhou Feng Pang Shiyan Liu Ying Shen Lingjiang Liu Zezhong Fang Chuang Wang Zhenyu Hu Ti-Fei Yuan Ningbo kangning Hospital Ningbo Key Laboratory of Behavioral Neuroscience School of Psychology Nanjing Normal University Rehabilitation Medicine Center First Affiliated Hospital of Nanjing Medical University Ningbo Key Laboratory of Behavioral Neuroscience Ningbo University School of Medicine

Patients with schizophrenia undergo changes in brain plasticity. In the present study, we characterized motor cortical-striatal plasticity in such patients. Compared with the potentiation following high-frequency repetitive transcranial magnetic stimulation in the control group, the patients demonstrated impaired plasticity of corticostriatal motor-evoked potentials recorded from hand ***, the loss of cortical plasticity was correlated with impaired motor learning in a rotary pursuit task. Moreover,the loss of plasticity was correlated with the symptoms of schizophrenia. The results suggest that the progression of schizophrenia is accompanied by altered cortical plasticity and functioning.

关键词： Schizophrenia Cortical plasticity Motor learning human

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光电式数字日照计在气象观测中的应用评估

气象水文海洋仪器 2022年第3期39卷 80-82,86页

作者：杨炳玉舒康宁陈焘徐非周群云南省气象信息中心昆明520034 大理州气象局大理671000

文章利用云南省125个国家地面观测站2019年4—6月平行观测期间暗筒式日照计(人工观测)和DFC2型光电式数字日照计(自动观测)日照资料,1991—2020年历年日照数据以及2020年光电式数字日照计自动观测日照资料,探究了平行观测期间数据的一致... 详细信息

文章利用云南省125个国家地面观测站2019年4—6月平行观测期间暗筒式日照计(人工观测)和DFC2型光电式数字日照计(自动观测)日照资料,1991—2020年历年日照数据以及2020年光电式数字日照计自动观测日照资料,探究了平行观测期间数据的一致性,分析了2020年自动观测日照时数月、年总量以及数据异常偏高的原因。所得结果以期为气候分析、资源开发等提供准确的日照数据,同时为更好地推进气象现代化提供参考。

关键词： DFC2型光电式数字日照计暗筒式日照计日照时数应用评估

丁丙诺啡成瘾患者多药联用致呼吸衰竭1例分析

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中国药物依赖性杂志 2024年第2期33卷 174-177页

作者：蔡丹丹桂冬辉黄燕燕周文华宁波大学附属康宁医院宁波315201 宁波市康宁医院宁波315201

探讨1例丁丙诺啡依赖患者在戒断过程中多药联用导致呼吸衰竭发生的情况、诊治经过和转归。分析引起呼吸衰竭的相关因素、发生机制和预防措施。值得引起临床医生的重视和借鉴,从而提高临床对阿片类及镇静催眠类药物使用的安全意识,保障... 详细信息

探讨1例丁丙诺啡依赖患者在戒断过程中多药联用导致呼吸衰竭发生的情况、诊治经过和转归。分析引起呼吸衰竭的相关因素、发生机制和预防措施。值得引起临床医生的重视和借鉴,从而提高临床对阿片类及镇静催眠类药物使用的安全意识,保障患者健康和医疗安全。

关键词：丁丙诺啡奥氮平联合用药艾司唑仑呼吸衰竭

Functional near-infrared spectroscopy in elderly patients with four types of dementia

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World Journal of Psychiatry 2023年第5期13卷 203-214页

作者： Xi Mei Chen-Jun Zou Jun Hu Xiao-Li Liu Cheng-Ying Zheng Dong-Sheng zhou Key Lab Ningbo Kangning HospitalNingbo 315201Zhejiang ProvinceChina Department of Geriatric Ningbo Kangning HospitalNingbo 315201Zhejiang ProvinceChina

BACKGROUND Functional near-infrared spectroscopy(fNIRS)is commonly used to study human brain function by measuring the hemodynamic signals originating from cortical activation and provides a new noninvasive detection method for identifying *** To investigate the fNIRS imaging technique and its clinical application in differential diagnosis of subtype dementias including frontotemporal lobe dementia,Lewy body dementia,Parkinson’s disease dementia(PDD)and Alzheimer’s disease(AD).METHODS Four patients with different types of dementia were examined with fNIRS during two tasks and a resting *** adopted the verbal fluency task,working memory task and resting state *** patient was compared on the same *** conducted and analyzed the fNIRS data using a general linear model and Pearson’s correlation *** Compared with other types of dementias,fNIRS showed the left frontotemporal and prefrontal lobes to be poorly activated during the verbal fluency task in frontotemporal *** Lewy body dementia,severe asymmetry of prefrontal lobes appeared during both verbal fluency and working memory tasks,and the patient had low functional connectivity during a resting *** PDD,the patient’s prefrontal cortex showed lower excitability than the temporal lobe during the verbal fluency task,while the prefrontal cortex showed higher excitability during the working memory *** patient with AD showed poor prefrontal and temporal activation during the working memory task,and more activation of frontopolar instead of the dorsolateral prefrontal *** Different hemodynamic characteristics of four types of dementia(as seen by fNIRS imaging)provides evidence that fNIRS can serve as a potential tool for the diagnosis between dementia subtypes.

关键词： diagnosis patients Functional

维普期刊数据库评论

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浅析枳实益气之效

新中医 2021年第16期53卷 125-126页

作者：刘康宁周陈聪华智超叶海勇浙江中医药大学浙江杭州310053

枳实以其破气消积、化痰散痞之力为众所熟知,而诸医鲜有议其益气升清之力,枳实益气之力不可忽视。现考历代医家之言,循有效配伍之方,遵当代名医之案,浅论枳实益气之功,阐明其中要义。

关键词：枳实益气医案

The prevalence and related factors of depressive episodes in patients with chronic insomnia disorder

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The prevalence and related factors of depressive episodes in...