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Journal of Iron and Steel Research International 2024年第3期31卷 608-621页

作者： zhe Wang Qi-long Wei Cheng-bin Shi Zhan-cheng Guo State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The effect of Al_(2)O_(3)/SiO_(2) mass ratio and cao content on the viscosity and structure of the cao-Al_(2)O_(3)-SiO_(2)-6MgO-1.5ZrO_(2)-1.5CeO_(2) slag was *** results show that with the increase in Al_(2)O_(3)/SiO_(2) mass ratio,the viscous flow units within the slag gradually change from Si-O-Si to Al-O-Al and ***,the substitution of Al_(2)O_(3) for SiO_(2) leads to the transformation of Si-O bonds towards weaker Al-O bonds,which weaken the bond strength of the aluminosilicate networks,thus leading to a decrease in the viscosity of *** increase in cao content effectively promotes the depolymerization of the aluminosilicate networks,resulting in a significant decrease in the viscosity of the *** slag with Al_(2)O_(3)/SiO_(2) of 0.7-1.5 and cao of 30 wt.%shows promise as the reference slag system for the Fe-collection smelting of spent automotive catalysts due to its good comprehensive performance.

关键词： Aluminosilicate slag Al_(2)O_(3)/SiO_(2)mass ratio cao content Viscosity Slag structure

The appearance of cytoplasmic cytochrome C precedes apoptosis during Drosophila salivary gland degradation

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Insect Science 2024年第1期31卷 157-172页

作者： Shihui Long Wenxin cao Yongyu Qiu Ruohan Deng Jiali Liu Lidan Zhang Renke Dong Fengxin Liu Sheng Li Haigang Zhao Na Li kang Li Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhouChina Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouGuangdong ProvinceChina School of Food Science and Engineering South China University of TechnologyGuangzhouChina ChemPartner PharmaTech Co. LtdJiangmenGuangdong ProvinceChina

Apoptosis is an important process for organism development that functions to eliminate cell damage,maintain homeostasis,and remove obsolete tissues during *** mammals,apoptosis is accompanied by the release of cytochrome C(Cyt-c)from mitochondria to the ***,whether this process is conserved in the fruit fly,Drosophila melanogaster,remains *** this study,we discovered that during the degradation of Drosophila salivary gland,the transcription of mitochondria apoptosis factors(MAPFs),Cyt-c,and death-associated APAF1-related killer(Dark)encoding genes are all upregulated antecedent to initiator and effector caspases encoding *** proteins Cyt-c and the active caspase 3 appear gradually in the cytoplasm during salivary gland ***,the Cyt-c protein colocates with mito-GFP,the marker indicating cytoplasmic mitochondria,and the change in mitochondrial membrane potential coincides with the appearance of Cyt-c in the ***,impeding or promoting 20E-induced transcription factor E93 suppresses or enhances the staining of Cyt-c and the active caspase 3 in the cytoplasm of salivary gland,and accordingly decreases or increases the mitochondrial membrane potential,*** research provides evidence that cytoplasmic Cyt-c appears before apoptosis during Drosophila salivary gland degradation,shedding light on partial conserved mechanism in apoptosis between insects and mammals.

关键词： active caspase 3 apoptosis Cyt-c Drosophila salivary gland

Perinatal prevalence of birth defects in the Mainland of China,2000–2021:a systematic review and meta-analysis

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World Journal of Pediatrics 2024年第7期20卷 669-681页

作者： Liang-Yu kang Zi-Rui Guo Wei-Jing Shang Gui-Ying cao Yi-Ping Zhang Qiao-Mei Wang Hai-Ping Shen Wan-Nian Liang Min Liu Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityNo.38Xueyuan RoadHaidian DistrictBeijing100191China Vanke School of Public Health Tsinghua UniversityNo.1Tsinghua GardenHaidian DistrictBeijing100084China Department of Maternal and Child Health National Health Commission of the People’s Republic of ChinaNo.1Xizhimenwai South RoadXicheng DistrictBeijingChina Institute of Healthy China Tsinghua UniversityNo.1Tsinghua GardenHaidian DistrictBeijing100084China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of Education BeijingNo.38Xueyuan RoadHaidian DistrictBeijing100191China

Background Although birth defects are of great concern globally,the latest national prevalence has not yet been quantified in *** conducted a systematic review and meta-analysis to estimate the perinatal prevalence of birth defects in the Mainland of China between 2000 and *** We performed a systematic literature search of six databases for relevant articles published between January 1,2000,and March 1,*** included published studies that reported data on the perinatal prevalence of birth defects in the Mainland of *** DerSimonian and Laird random-effects models were used to estimate the pooled prevalence and its 95%confidence interval(CI).We also conducted subgroup analyses and univariable meta-regressions to explore differences in prevalence by time period,geographic region,and other *** We included 254 studies reporting the perinatal prevalence of birth defects and 86 studies reporting only the prevalence of specific types of birth *** on 254 studies covering 74,307,037 perinatal births and 985,115 cases with birth defects,the pooled perinatal prevalence of birth defects was 122.54(95%CI 116.20–128.89)per 10,000 perinatal births in the Mainland of China during 2000–***,the perinatal prevalence of birth defects increased from 95.60(86.51–104.69)per 10,000 in 2000–2004 to 208.94(175.67–242.22)per 10,000 in 2020–*** were also significant disparities among different geographical *** heart defects(33.35 per 10,000),clefts of the lip and/or palate(13.52 per 10,000),polydactyly(12.82 per 10,000),neural tube defects(12.82 per 10,000),and inborn errors of metabolism(11.41 per 10,000)were the five most common types of birth *** perinatal prevalence among males was significantly higher than that among females(β=2.44×10^(−3),P=0.003);a higher perinatal prevalence of birth defects was observed among perinatal births whose mothers were≥35 years(β=4.34×10^(−3),P<0.001).Conclusion Compreh

关键词： Birth defects China Perinatal Prevalence

Evolutionary Decision-Making and Planning for Autonomous Driving Based on Safe and Rational Exploration and Exploitation

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Engineering 2024年第2期33卷 108-120页

作者： kang Yuan Yanjun Huang Shuo Yang Zewei Zhou Yulei Wang Dongpu cao Hong Chen College of Electronic and Information Engineering Tongji UniversityShanghai 201804China Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghai 201210China School of Automotive Studies Tongji UniversityShanghai 201804China School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China

Decision-making and motion planning are extremely important in autonomous driving to ensure safe driving in a real-world *** study proposes an online evolutionary decision-making and motion planning framework for autonomous driving based on a hybrid data-and model-driven ***,a data-driven decision-making module based on deep reinforcement learning(DRL)is developed to pursue a rational driving performance as much as ***,model predictive control(MPC)is employed to execute both longitudinal and lateral motion planning *** constraints are defined according to the vehicle’s physical limit to meet the driving task ***,two principles of safety and rationality for the self-evolution of autonomous driving are proposed.A motion envelope is established and embedded into a rational exploration and exploitation scheme,which filters out unreasonable experiences by masking unsafe actions so as to collect high-quality training data for the DRL *** with a high-fidelity vehicle model and MATLAB/Simulink co-simulation environment are conducted,and the results show that the proposed online-evolution framework is able to generate safer,more rational,and more efficient driving action in a real-world environment.

关键词： Autonomous driving Decision-making Motion planning Deep reinforcement learning Model predictive control

Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1380-1399页

作者： Yixian Li Peng Yang Ran Meng Shuting Xu Lingling Zhou kang Qian Pengzhen Wang Yunlong Cheng Dongyu Sheng Minjun Xu Tianying Wang Jing Wu Jinxu cao Qizhi Zhang Key Laboratory of Smart Drug Delivery Ministry of EducationSchool of PharmacyFudan UniversityShanghai 201203China

Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer’s disease(AD)collectively culminate in neuronal *** the context of AD,autophagy dysfunction,a multi-link obstacle involving autophagy downregulation and lysosome defects in neurons/microglia is highly implicated in intra/extraneuronal pathological ***,multidimensional autophagy regulation strategies co-manipulating“autophagy induction”and“lysosome degradation”in dual targets(neuron and microglia)are more reliable for AD ***,we designed an RP-1 peptide-modified reactive oxygen species(ROS)-responsive micelles(RT-NM)loading rapamycin or gypenoside *** by RP-1 peptide,the ligand of receptor for advanced glycation end products(RAGE),RT-NM efficiently targeted neurons and microglia in AD-affected *** nanocombination therapy activated the whole autophagy-lysosome pathway by autophagy induction(rapamycin)and lysosome improvement(gypenoside XVII),thus enhancing autophagic degradation of neurotoxic aggregates and inflammasomes,and promoting Aβ ***,it decreased aberrant protein burden,alleviated neuroinflammation,and eventually ameliorated memory defects in 3×Tg-AD transgenic *** research developed a multidimensional autophagy nano-regulator to boost the efficacy of autophagy-centered AD therapy.

关键词： Autophagy-lysosome pathway Alzheimer’s disease Proteostasis Neuroinflammation Multi-target therapy Rapamycin Gypenoside XVII Cascade dual-targeting

基于NSGA-Ⅲ的桥梁网络多目标维修决策优化研究

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土木工程学报 2024年第5期57卷 41-52页

作者：戴理朝康哲陈瑞王磊长沙理工大学湖南长沙410114

桥梁网络维护方案的制定需权衡多个决策目标以保障其运营安全。为推动桥梁网络维护的低碳化,考虑桥梁网络在运营和维护期间的碳排放,以桥梁网络整体性能最优、碳排放量和维修总成本最小为目标,以桥梁个体满足最低性能要求为约束条件,构... 详细信息

桥梁网络维护方案的制定需权衡多个决策目标以保障其运营安全。为推动桥梁网络维护的低碳化,考虑桥梁网络在运营和维护期间的碳排放,以桥梁网络整体性能最优、碳排放量和维修总成本最小为目标,以桥梁个体满足最低性能要求为约束条件,构建桥梁网络多目标维修决策优化模型,并率先将NSGA-Ⅲ算法应用到桥梁网络维修决策领域,通过其参考点策略从大量的非支配解集中筛选更优的桥梁网络维修方案,以实现网络性能、维护成本和低碳环境的综合考量。模型求解过程中,从收敛性能、解集分布和目标函数性能分析三方面,研究多目标下NSGA-Ⅱ和NSGA-Ⅲ的求解效果。研究结果表明:NSGA-Ⅱ在求解桥梁网络双目标维修决策优化问题上要优于NSGA-Ⅲ,而NSGA-Ⅲ更适合求解目标个数为3个及以上的桥梁网络维修决策多目标优化问题;对于桥梁网络性能-成本-环境的多目标优化,NSGA-Ⅲ可获得更低的成本、更低的碳排放量和更高的网络性能,这表明NSGA-Ⅲ是求解桥梁网络多目标维修决策优化问题非常有效的工具。

关键词：桥梁工程桥梁网络多目标优化碳排放 NSGA-Ⅲ算法 NSGA-Ⅱ算法

Fanlian Huazhuo Formula alleviates high-fat diet-induced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway

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World Journal of Gastroenterology 2024年第30期30卷 3584-3608页

作者： Meng-Yuan Niu Geng-Ting Dong Yi Li Qing Luo Liu cao Xi-Min Wang Qi-Wen Wang Yi-Ting Wang zhe Zhang Xi-Wen Zhong Wei-Bo Dai Le-Yu Li Pharmacology Laboratory Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina Department of Endocrinology Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina

BACKGROUND Fanlian Huazhuo Formula(FLHZF)has the functions of invigorating spleen and resolving phlegm,clearing heat and purging *** has been identified to have therapeutic effects on type 2 diabetes mellitus(T2DM)in clinical ***-alcoholic fatty liver disease(NAFLD)is frequently diagnosed in patients with ***,the therapeutic potential of FLHZF on NAFLD and the underlying mechanisms need further *** To elucidate the effects of FLHZF on NAFLD and explore the underlying hepatoprotective mechanisms in vivo and in *** HepG2 cells were treated with free fatty acid for 24 hours to induce lipid accumulation cell ***,experiments were conducted with the different concentrations of freeze-dried powder of FLHZF for 24 hours.C57BL/6 mice were fed a high-fat diet for 8-week to establish a mouse model of NAFLD,and then treated with the different concentrations of FLHZF for 10 *** FLHZF had therapeutic potential against lipid accumulation and abnormal changes in biochemical indicators in vivo and in *** experiments verified that FLHZF alleviated abnormal lipid metabolism might by reducing oxidative stress,regulating the AMPKα/SREBP-1C signaling pathway,activating autophagy,and inhibiting hepatocyte *** FLHZF alleviates abnormal lipid metabolism in NAFLD models by regulating reactive oxygen species,autophagy,apoptosis,and lipid synthesis signaling pathways,indicating its potential for clinical application in NAFLD.

关键词： Fanlian Huazhuo Formula Nonalcoholic fatty liver disease Autophagy Apoptosis AMPKα/SREBP-1C signal pathway Oxidative stress

Annealing-induced long-range charge density wave order in magnetic kagome FeGe:Fluctuations and disordered structure

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 112-121页

作者： Chenfei Shi Yi Liu Bishal Baran Maity Qi Wang Surya Rohith Kotla Sitaram Ramakrishnan Claudio Eisele Harshit Agarwal Leila Noohinejad Qian Tao Baojuan kang zhefeng Lou Xiaohui Yang Yanpeng Qi Xiao Lin Zhu-An Xu Arumugam Thamizhavel Guang-Han cao Sander Van Smaalen Shixun cao Jin-Ke Bao Department of Physics Materials Genome InstituteInstitute for Quantum Science and TechnologyShanghai UniversityShanghai 200444China Key Laboratory of Quantum Precision Measurement of zhejiang Province School of PhysicsZhejiang University of TechnologyHangzhou 310023China School of Physics Zhejiang UniversityHangzhou 310027China Department of Condensed Matter Physics and Materials Science Tata Institute of Fundamental ResearchMumbai 400005India School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China Laboratory of Crystallography University of BayreuthBayreuth 95447Germany Department of Quantum Matter AdSEHiroshima UniversityHigashi-Hiroshima 739-8530Japan P24 PETRA IIIDeutsches Elektronen-Synchrotron DESYHamburg 22607Germany Key Laboratory for Quantum Materials of zhejiang Province School of ScienceWestlake UniversityHangzhou 310024China Department of Physics China Jiliang UniversityHangzhou 310018China Shanghai Key Laboratory of High-resolution Electron Microscopy ShanghaiTech UniversityShanghai 201210China Collaborative Innovation Centre of Advanced Microstructures Nanjing UniversityNanjing 210093China Shanghai Key Laboratory of High Temperature Superconductors Shanghai UniversityShanghai 200444China School of Physics Hangzhou Normal UniversityHangzhou 311121China

Charge density wave(CDW) in kagome materials with the geometric frustration is able to carry unconventional ***, a CDW has been observed below the antiferromagnetic order in kagome FeGe, in which magnetism and CDW are intertwined to form an emergent quantum ground state. However, the CDW is only short-ranged and the structural modulation originating from it has yet to be determined experimentally. Here we realize a long-range CDW order by post-annealing process,and resolve the structure model through single crystal X-ray diffraction. Occupational disorder of Ge resulting from short-range CDW correlations above T_(CDW) is identified from structure refinements. The partial dimerization of Ge along the c axis is unveiled to be the dominant distortion for the CDW. Occupational disorder of Ge is also proved to exist in the CDW phase due to the random selection of partially dimerized Ge sites. Our work provides useful insights for understanding the unconventional nature of the CDW in FeGe.

关键词： charge density wave kagome disordered structure fluctuations

Effects of Different Exogenous Substances on Seed Germination of Isatis indigotica Under Drought Stress and Chemical Composition of Isatis indigotica leaves

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Journal of Northeast Agricultural University(English Edition) 2024年第2期31卷 66-75页

作者： Wang Hao Qin Jingjing Shi zhe Song Jiayao Ma Wuqiong Wang Huimin cao Jinjun Department of Pharmacy Changzhi Medical CollegeChangzhi 046000ShanxiChina Millet Research Institute Shanxi Agricultural UniversityChangzhi 046000ShanxiChina

This study was to investigate the effects of three exogenous substances on chemical constituents of Isatis indigotica leavesand their efficacy in alleviating drought stress, and explore the methods of applying exogenous substances to efficient cultivationof Isatis indigotica. Polyethylene glycol (PEG) was used to simulate drought stress to deal with seeds of Isatis indigotica at thegermination stage (concentration: 0, 10%, 15%, and 20%). Simultaneous operation of exogenous growth regulators [microbialinoculum (MI), γ-aminobutyric acid (GABA) and salicylic acid (SA)] and PEG were implemented in seeds of Isatis *** effects of drought stress and the mitigation of exogenous substances were observed by statistics of seed germination potential,germination rate, hypocotyl length, and radicle length of each treatment. The effects of exogenous substances on the content ofalkaloids, crude protein and free amino acids in the leaves of Isatis indigotica grown in a greenhouse were determined after sprayingexogenous substances on the plants. The differences of germination potential, germination rate, hypocotyl length, and radicle lengthamong 15% PEG stress treatment, 10% PEG stress treatment and the control were significant (P<0.05). According to the predesignedgermination standard, the seeds did not germinate under 20% PEG stress treatment. When the PEG concentration was 15%, the resultsof seed germination potential and germination rate after adding MI were significantly different from those under stress alone (P<0.05).When exposed to 10% PEG stress, the supplementation of GABA led to a notable increase in radicle length of Isatis indigotica seeds,showing significant differences compared to other three treatments. The application of MI and GABA under 15% PEG stress resultedin a significant increase in the radicle and hypocotyl length of Isatis indigotica seeds compared to other two treatments. The contentof the total alkaloids in leaves of Isatis indigotica was signif

关键词： Isatis indigotica Fort. exogenous growth regulator drought stress chemical composition leaves of Isatis indigotica

基于优化A-BiLSTM的滚动轴承故障诊断

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吉林大学学报（工学版） 2024年第8期54卷 2156-2166页

作者：余萍赵康曹洁兰州理工大学电气工程与信息工程学院兰州730050 甘肃省工业过程控制重点实验室兰州730050 兰州理工大学电气与控制工程国家级实验教学示范中心兰州730050

为提高超参数设置的效率及其与模型的适配性,改善人工设置模型参数的高成本和低效率问题,提出一种基于蜜獾算法(Honey badger algorithm,HBA)优化注意力双向长短时记忆网络(HBA-A-BiLSTM)的滚动轴承故障诊断方法。首先,通过HBA对A-BiLST... 详细信息

为提高超参数设置的效率及其与模型的适配性,改善人工设置模型参数的高成本和低效率问题,提出一种基于蜜獾算法(Honey badger algorithm,HBA)优化注意力双向长短时记忆网络(HBA-A-BiLSTM)的滚动轴承故障诊断方法。首先,通过HBA对A-BiLSTM模型进行最优超参数组合搜寻,然后基于最优超参数下的A-BiLSTM模型进行故障诊断性能测试。最后,基于不同工况的数据集进行模型泛化能力测试。采用CWRU数据集对所提方法的故障诊断效果进行验证,利用诊断精度以及混淆矩阵进行评价。实验结果表明,与其他群智能优化算法相比,蜜獾算法搜索全局性能好,收敛速度快,优化后的最终模型的故障诊断准确率达到了99.5%,具有良好的效果,且在不同工况下能够实现稳定、准确的故障诊断性能,泛化能力强。

关键词：故障诊断蜜獾算法参数优化双向长短时记忆网络注意力机制