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Methanol extract of Codium fragile inhibits tumor necrosis factor-ɑ-induced matrix metalloproteinase-9 and invasiveness of MDA-MB-231 cells by suppressing nuclear factor-κB activation

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 520-525页

作者： Matharage Gayani Dilshara Rajapaksha Gedara Prasad Tharanga Jayasooriya Chang-Hee kang Yung-Hyun choi Gi-Young Kim Department of Marine Life Sciences Jeju National University Nakdonggang National Institute of Biological Resource Department of Biochemistry College of Oriental Medicine Dong-Eui University

Objective:To evaluate whether the methanol extract of Codium fragile(MECF) regulates tumor necrosis factor-α(TNF-α)-induced invasion of human breast cancer MDA-MB-231 cells by suppressing matrix metalloproteinase-9(MMP-9).Methods:Reverse transcriptionpolymerase chain reaction(RT-PCR) and western blot analysis were performed to analyze the expression of MMP-9 and nuclear factor-κB(NF-κB) subunits,p65 and p50,and IκB in MDA-MB-231 cells.3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide(MTT) assay was used for cell ***-9 activity and invasion were measured by gelatin zymography and a matrigel invasion assay,***- κB activity was measured by an electrophoretic mobility shift assay and luciferase ***:MECF had no effects on cell viability up to a concentration of 100 μg/mL in human breast cancer MDA-MB-231 cells regardless of the presence of TNF-α.MDA-MB-231 cells that were stimulated with TNF-α showed a marked increase of invasion compared to the untreated control,whereas pretreatment with MECF downregulated the TNF-α-induced invasion of MDA-MB-231 ***,zymography,western blot analysis,and reverse transcriptase-polymerase chain reaction(RT-PCR) confirmed that MECF decreased TNF-α-induced MMP-9 expression and activity which is a key regulator for cancer *** to an electrophoretic morbidity shift assay,pretreatment with MECF in MDA-MB-231 cells significantly decreased the TNF-α-induced DNA-binding activity of nuclear factor- κB(NF- κB),which is an important transcription factor for regulating cancer invasion-related genes such as ***,treatment with MECF sustained the expression of p65 and p50 in response to TNF-α in the cytosolic *** luciferase assay demonstrated that MECF attenuated TNF-α-induced NF- κB luciferase ***:MECF exhibited its antiinvasive capability by downregulating TNF-α-induced MMP-9 expression,resulting from the suppression of NF- κB activi

关键词： Codium fragile Invasion Nuclear factor-κB Matrix metalloproteinase-9 Tumor necrosis factor-α

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Physicochemical properties of cricket (Gryllus bimaculatus) gel fraction with soy protein isolate for 3D printing-based meat analogue

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FOOD BIOSCIENCE 2023年第3期53卷 3001-3010页

作者： Nam, Hyong Kyong kang, Tae Wan Kim, In-Woo choi, Ra-Yeong Kim, Hyun Woo Park, Hyun Jin Korea Univ Coll Life Sci & Biotechnol Dept Biotechnol Seoul 02841 South Korea Rural Dev Adm Dept Agr Biol Natl Inst Agr Sci Wonju 55365 South Korea

Cricket (Gryllus bimaculatus) gel was fractionated and mixed with different soybean protein isolate (SPI) concentrations, and its characteristics were evaluated to determine its potential use as a meat analog. Crushed crickets were separated into the filtrate, supernatant, and pellet fractions by centrifugation and freeze-drying, and powdered and mixed with 18% SPI at different concentrations (5%-20%). The filtrate fraction had the lowest protein content and the highest fat and carbohydrate content among the nutrient fractions. Conversely, the supernatant and pellet fractions had high protein, low fat, and low carbohydrate content. SDS-PAGE detected relatively low-molecular weight proteins. Numerous muscle proteins were identified, including actin, myosin, and hemocyanin, a protein that transports oxygen in insects. Regarding the rheological characteristics of the cricket fraction, the entire fraction exhibited G'>G" in both the frequency and the temperature sweep tests, revealing a tendency for gel-like viscosity. In all cricket fractions, both G' and G" increased with increasing fraction powder concentration. When printed, supernatant fractions had no structural stability, pellet fractions had 5%-15% stability, and filtrate fractions had 5%-20% stability. The three interval thixotropy test revealed that the pellet fraction had a recovery rate of over 90% after high shear deformation. Texture profile analysis showed an increase in both hardness and chewability. After heat treatment, cohesiveness was higher than adhesiveness, indicating greater elasticity. Field-emission scanning electron microscopy results revealed that the pellet fraction was denser than the other fractions, particularly at higher concentrations. Based on the overall characteristics, 15% pellets were found to be the most appropriate fraction and concentration.

关键词： 3D printing Soy protein isolate G bimaculatus Edible insect Meat analogue

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The Influence of Knowledge,Trust,and Perceived Risk on Firefighters'Preparedness and Willingness to Respond to Nuclear Emergencies:The Case of South Korea

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International Journal of Disaster Risk Science 2022年第4期13卷 536-548页

作者： Jongan choi Sangkyu Lee HaeYoun choi Department of Psychology Kangwon National UniversityChuncheon 24341Korea Department of Reactor System Evaluation Korea Institute of Nuclear SafetyDaejon 34142Korea Department of Psychology Chungbuk National UniversityCheongju 28644Korea

At the site of nuclear accidents,fjrefjghters situated near nuclear power plants(NPPs)assume responsibility for suppressing fjres and rescuing workers from leaked *** timely responses to nuclear emergencies can prevent or minimize the catastrophic impacts of these *** their important role in nuclear emergency management,little is known about the factors that influence fjrefjghters'nuclear emergency *** recruited 179 Korean fjrefjghters(96%male)situated near *** examined whether and how knowledge regarding nuclear accidents and trust in the authorities operating nuclear power plants were related to fjrefjghters'risk perceptions of nuclear accidents to predict their preparedness and willingness to respond to nuclear *** results indicate that trust moderated the effect of knowledge on the perceived risk of nuclear accidents,and that the perceived risk mediated the relationship between knowledge and fjrefjghters'preparedness and willingness to respond to nuclear *** results revealed a pattern of moderated mediation,in which perceived risk mediated the indirect effect of knowledge on preparedness and willingness when the fjrefjghters'trust was low,but not when it was high.

关键词： Firefjghters Knowledge of nuclear accidents Nuclear emergencies Risk perception South Korea Trust of authorities

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Unraveling the Harmonious Coexistence of Ruthenium States on a Self-Standing Electrode for Enhanced Hydrogen Evolution Reaction

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Energy & Environmental Materials 2024年第6期7卷 303-311页

作者： Joonhee Ma Jin Hyuk Cho Chaehyeon Lee Moon Sung kang Sungkyun choi Ho Won Jang Sang Hyun Ahn Seoin Back Soo Young Kim Department of Materials Science and Engineering Korea UniversitySeoul 02841Korea Department of Chemical and Biomolecular Engineering Institute of Emergent MaterialsSogang UniversitySeoul 04107Korea Department of Cogno-Mechatronics Engineering College of Nanoscience and NanotechnologyPusan National UniversityBusan 46241Korea Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Korea School of Chemical Engineering and Material Science Chung-Ang UniversitySeoul 06974Korea

The development of cost-effective,highly efficient,and durable electrocatalysts has been a paramount pursuit for advancing the hydrogen evolution reaction(HER).Herein,a simplified synthesis protocol was designed to achieve a self-standing electrode,composed of activated carbon paper embedded with Ru single-atom catalysts and Ru nanoclusters(ACP/Ru_(SAC+C))via acid activation,immersion,and high-temperature *** initio molecular dynamics(AIMD)calculations are employed to gain a more profound understanding of the impact of acid activation on carbon ***,the coexistence states of the Ru atoms are confirmed via aberration-corrected scanning transmission electron microscopy(AC-STEM),X-ray photoelectron spectroscopy(XPS),and X-ray absorption spectroscopy(XAS).Experimental measurements and theoretical calculations reveal that introducing a Ru single-atom site adjacent to the Ru nanoclusters induces a synergistic effect,tuning the electronic structure and thereby significantly enhancing their catalytic ***,the ACP/Ru_(SAC+C)exhibits a remarkable turnover frequency(TOF)of 18 s^(−1)and an exceptional mass activity(MA)of 2.2 A mg^(−1),surpassing the performance of conventional Pt *** self-standing electrode,featuring harmoniously coexisting Ru states,stands out as a prospective choice for advancing HER catalysts,enhancing energy efficiency,productivity,and selectivity.

关键词： electrocatalysis electronic coupling effect hydrogen evolution reaction selfstanding electrode

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Intraoperative optical coherence tomography findings during surgery for optic disc pit-associated maculopathy

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 684-686页

作者： Hyun Goo kang Sung Eun Park Eun Young choi Sung Chul Lee Min Kim Department of Ophthalmology Institute of Vision ResearchGangnam Severance HospitalYonsei University College of Medicine211 EonjuroGangnam-guSeoul 06273Republic of Korea Department of Ophthalmology Institute of Vision ResearchSeverance HospitalYonsei University College of Medicine134 Shinchon-dongSeodaemun-guSeoul 06273Republic of Korea

Dear Editor,We report our experience using a continuous intraoperative optical coherence tomography(OCT)-enabled microscope system for real-time anatomical evaluation of the optic pit during surgery in an 8-year-old girl who presented with symptomatic optic disc pit(ODP) maculopathy. ODP is an extremely rare congenital anomaly secondary to colobomatous malformation of the optic nerve head, with a reported incidence of 0.00009%[1]. Although patients are frequently asymptomatic, approximately 40%-50% of patients experience visual symptoms because of subretinal fluid(SRF) accumulation beneath the macula.

关键词： surgery maculopathy congenital

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Advantage of endoscopic mucosal resection with a cap for rectal neuroendocrine tumors

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World Journal of Gastroenterology 2015年第31期21卷 9387-9393页

作者： Su Bum Park Hyung Wook Kim Dae Hwan kang Cheol Woong choi Su Jin Kim Hyeong Seok Nam Department of Internal Medicine Pusan National University School of Medicine Research institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital

AIM: To compare the outcomes of endoscopic mucosal resection with a cap(EMR-C) with those of endoscopic submucosal dissection(ESD) for the resection of rectal neuroendocrine ***: One hundred and sixteen lesions in 114 patients with rectal neuroendocrine tumor(NET) resected with EMR-C or ESD were included in the study. This study was performed at Pusan National University Yangsan Hospital between July 2009 and August 2014. We analyzed endoscopic complete resection rate,pathologic complete resection rate,procedure time,and adverse events in the EMR-C(n = 65) and ESD(n = 51) groups. We also performed a subgroup analysis by tumor ***: Mean tumor size was 4.62 ± 1.66 mm in the EMR-C group and 7.73 ± 3.14 mm in the ESD group(P < 0.001). Endoscopic complete resection rate was 100% in both groups. Histologic complete resection rate was significantly greater in the EMR-C group(92.3%) than in the ESD group(78.4%)(P = 0.042). Mean procedure time was significantly longer in the ESD group(14.43 ± 7.26 min) than in the EMR-C group(3.83 ± 1.17 min)(P < 0.001). Rates of histologic complete resection without complication were similar for tumor diameter ≤ 5 mm(EMR-C,96%; ESD,100%,P = 0.472) as well as in cases of 5 mm < tumor diameter ≤ 10 mm(EMR-C,80%; ESD,71.0%,P = 0.524).CONCLUSION: EMR-C may be simple,faster,and more effective than ESD in removing rectal NETs and may be preferable for resection of small rectal NETs.

关键词： Neuroendocrine tumor Endoscopic mucosal resection

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Unexpected Li displacement and suppressed phase transition enabling highly stabilized oxygen redox in P3-type Na layered oxide cathode

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Journal of Energy Chemistry 2023年第10期85卷 144-153,I0006页

作者： Myungeun choi Hobin Ahn Hyunyoung Park Yongseok Lee Jinho Ahn Bonyoung Ku Junseong Kim Wonseok Ko Jungmin kang Jung-Keun Yoo Duho Kim Jongsoon Kim Department of Energy Science Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea Carbon Composites Department Korea Institute of Materials Science(KIMS)Changwon 51508Republic of Korea Department of Mechanical Engineering(Integrated Engineering Program) Kyung Hee University1732Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 17104Republic of Korea Department of KHU-KIST Convergence Science and Technology Kyung Hee University23Kyunghee-daero Dongdaemun-guSeoul 02447Republic of Korea

Oxygen redox is considered a new paradigm for increasing the practical capacity and energy density of the layered oxide cathodes for Na-ion batteries. However, severe local structural changes and phase transitions during anionic redox reactions lead to poor electrochemical performance with sluggish ***, we propose a synergy of Li-Cu cations in harnessing the full potential of oxygen redox, through Li displacement and suppressed phase transition in P3-type layered oxide cathode. P3-type Na_(0.7)[Li_(0.1)Cu_(0.2)Mn_(0.7)]O_(2) cathode delivers a large specific capacity of ~212 mA h g^(-1)at 15 mA g^(-1). The discharge capacity is maintained up to ~90% of the initial capacity after 100 cycles, with stable occurrence of the oxygen redox in the high-voltage region. Through advanced experimental analyses and first-principles calculations, it is confirmed that a stepwise redox reaction based on Cu and O ions occurs for the charge-compensation mechanism upon charging. Based on a concrete understanding of the reaction mechanism, the Li displacement by the synergy of Li-Cu cations plays a crucial role in suppressing the structural change of the P3-type layered material under the oxygen redox reaction, and it is expected to be an effective strategy for stabilizing the oxygen redox in the layered oxides of Na-ion batteries.

关键词： Layered oxide cathode Oxygen redox reaction Structural stability Li displacement No phase transition

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Bimodal grain structures and tensile properties of a biomedical Co-20Cr-15W-10Ni alloy with different pre-strains

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Rare Metals 2021年第1期40卷 20-30页

作者： Cheng-Lin Li Seong-Woo choi Jeong Mok Oh Jae-Keun Hong Jong-Taek Yeom Joo-Hee kang Qing-Song Mei Chan Hee Park Department of Materials Engineering School of Power and Mechanical EngineeringWuhan UniversityWuhan 430072China Advanced Metals Division.Korea Institute of Materials Science Changwon 51508Republic of Korea Materials Testing&Reliability Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

The influence of pre-strain on the formation of bimodal grain structures and tensile properties of a Co-20 Cr-15 W-10 Ni alloy was *** bimodal grain structures consist of fine grains(FGs;2-3μm in diameter)and coarse grains(CGs;8-16μm in diameter),which can be manipulated by changing the pre-strain(ε=0.3-0.7)and annealing temperatures(1000-1100℃).High pre-strain applied in the samples can intensify the plasticity heterogeneity through increasing the total dislocation density and the local volumes of high-density *** can essentially result in finer FGs,a higher FG volume fraction,and overall grain refinement in the samples after ***-temperature essentially increases both the size and volume fraction of CGs,leading to an increase in the average grain *** tensile test suggests that the bimodal grain structured samples exhibited both high strength and ductility,yield strengths of621-877 MPa and ultimate tensile strengths of1187-1367 MPa with uniform elongations of 55.0%-71.4%.The superior strength-ductility combination of the samples arises from the specific deformation mechanisms of the bimodal grain *** tensile properties strongly depend on the size ratio and volume fraction of FGs/CGs in addition to the average grain size in the bimodal grain *** grain structures can be modified via changing the pre-strain and annealing temperature.

关键词： Biomaterials Bimodal grain structure Deformation heterogeneity Pinning High strength/ductility

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Investigation of fatigue resistance of fillet-welded tube connection details for sign support structures

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Frontiers of Structural and Civil Engineering 2020年第1期14卷 199-214页

作者： Hyungjoo choi Husam NAJM Titan Engineers PC UnionNJ 08854USA Department of Civil and Environmental Engineering Rutgersthe State University of New JerseyPiscatawayNJ 08853USA

Stiffened and unstiffened fillet-welded tube-to-transverse plate connection details are widely used for mast-arm and base-plate connections for highway sign ***,due to repetitive wind loads,cyclic fatigue stresses are induced and they are the primary source of failure in welded connections at these *** resistance of fatigue critical details has been an on-going research topic because of limited experimental results and the variability in existing fatigue testing *** main objective of this study is to evaluate fatigue resistance of fillet-welded tube connection details by utilizing the advanced fatigue tool in ANSYS Workbench *** Element(FE)models development and model validation using existing test data was *** resulting fatigue resistance from FE analysis was expressed in terms of fatigue life,fatigue damage,and fatigue safety factor to determine the fatigue performance of fillet-welded *** fatigue test data was grouped to perform a synthetic analysis and then analysis results were provided to determine input data and fatigue limit for the fatigue *** local stress level at fatigue critical locations was evaluated using a static FE model for different number of stiffeners and boundary *** results of this investigation provides fatigue resistance of fillet-welded connection details in the form of fatigue life,fatigue damage and safety factor for various connection parameters and structural conditions.

关键词： fatigue weld connections base plate fillet welds

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Diagnosis of building energy consumption in the 2012 CBECS data using heterogeneous effect of energy variables:A recursive partitioning approach

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Building Simulation 2021年第6期14卷 1737-1755页

作者： Doowon choi Chul Kim Department of Industrial and Systems Engineering College of EngineeringTexas A&M UniversityCollege StationTX 77843USA Indoor Air Quality Research Center Korea Institute of Civil Engineering and Building TechnologyGoyang-Si10223R.O.Korea

Numerous previous literature has attempted to apply machine learning techniques to analyze relationships between energy variables in energy ***,most machine learning methods are primarily used for prediction through complicated learning processes at the expense of *** methods have difficulties in evaluating the effect of energy variables on energy consumption and especially capturing their heterogeneous ***,to identify the energy consumption of the heterogeneous relationships in actual buildings,this study applies the MOdel-Based recursive partitioning(MOB)algorithm to the 2012 CBECS survey data,which would offer representative information about actual commercial building characteristics and energy *** resultant tree-structured subgroups,the MOB tree reveals the heterogeneous effect of energy variables and mutual influences on building energy *** results of this study would provide insights for architects and engineers to develop energy conservative design and retrofit in *** buildings.

关键词： CBECS,commercial building decision tree analysis MOdel-Based recursive partitioning(MOB)algorithm recursive partitioning subgroup identification

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