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基于跨孔雷达的水工防渗墙无损检测实验系统设计

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实验技术与管理 2024年第5期41卷 9-14页

作者：唐玉康飞宿晓辉张建涛张东昊姚遥大连理工大学建设工程学院辽宁大连116024

水利学科前沿实验是“新工科”人才培养模式下实验教学的重要环节。为丰富前沿实验内容,将科研与教学紧密结合,设计了跨孔雷达检测水工防渗墙隐蔽病害的可视化实验系统。该系统由可视化水箱、可视化模型箱和跨孔雷达系统三部分组成。可... 详细信息

水利学科前沿实验是“新工科”人才培养模式下实验教学的重要环节。为丰富前沿实验内容,将科研与教学紧密结合,设计了跨孔雷达检测水工防渗墙隐蔽病害的可视化实验系统。该系统由可视化水箱、可视化模型箱和跨孔雷达系统三部分组成。可视化水箱尺寸为1.2 m×1.0 m×1.5 m;可视化模型箱尺寸为0.6 m×0.2 m×1.0 m;跨孔雷达系统由网络分析仪和收发天线采集数据,由控制主机存储和显示数据。实验教学表明,该系统能够利用跨孔雷达有效检测出水工防渗墙内部隐蔽病害,具有较强的创新性和前沿性,有助于激发学生的创新思维,提高科研能力,达到以研促教、教研相长的目的。

关键词：实验教学水工防渗墙跨孔雷达无损检测隐蔽病害

High coercivity Pr2Fe14B/α-Fe nanocomposite permanent magnets with Zr addition

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Rare Metals 2020年第1期39卷 41-47页

作者： Mehran Khan Alam Guang-Bing Han Shi-shou kang School of Physics Shandong UniversityJinan250100China

The ingots with nominal composition Pr9.5Fe84-xB6.4P0.1Zrx(x=0,1,2,3)were prepared by an electric arc furnace under purified argon *** ribbons were obtained by melt spinning at a wheel speed of16-33 m·s-1.X-ray diffraction(XRD)results show that P addition decreases crystallinity of hard phase,but further Zr addition increases the amorphous-forming ability of soft *** intrinsic coercivity largely increases from 502(Zr-free)to 945 kA·m-1(2 at%Zr),which is among the highest value reported so far in this poor rare earth nanocomposite *** hysteresis loops of the alloys with addition of 1 at%and 2 at%Zr show good squareness with single-phase characteristic,indicating well exchange coupling between hard and soft magnetic *** electron microscope(TEM)results reveal small grain size and uniformity in the microstructure in the Zradded samples,which is the reason for high coercivity.

关键词： Magnetic properties Coercivity Zr addition Nanocomposite magnets

Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes

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Nuclear Science and Techniques 2024年第4期35卷 208-220页

作者： Ao-Yan Cheng Hao Cai Shi Chen Tian-Lu Chen Xiang Dong You-Liang Feng Qi Gao Quan-Bu Gou Yi-Qing Guo Hong-Bo Hu Ming-Ming kang Hai-Jin Li Chen Liu Mao-Yuan Liu Wei Liu Fang-Sheng Min Chu-Cheng Pan Bing-Qiang Qiao Xiang-Li Qian Hui-Ying Sun Yu-Chang Sun Ao-Bo Wang Xu Wang Zhen Wang Guang-Guang Xin Yu-Hua yao Qiang Yuan Yi Zhang School of Physics and Technology Wuhan UniversityWuhan 430072China School of Physics and Astronomy Yunnan UniversityKunming 650091China Ministry of Education The Key Laboratory of Cosmic Rays(Tibet University)Lhasa 850000China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences 19 A Yuquan RoadShijingshan DistrictBeijing 100049China College of Physics Sichuan UniversityChengdu 610064China School of Intelligent Engineering Shandong Management UniversityJinan 250357China Tsung‑Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China Suzhou Aerospace Information Research Institute Suzhou 215123China College of Physics Chongqing UniversityNo.55 Daxuecheng South RoadHigh‑tech DistrictChongqing 401331China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210008China

The High Altitude Detection of Astronomical Radiation(HADAR)experiment,which was constructed in Tibet,China,combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity advantages of focused Cherenkov *** objective is to observe transient sources such as gamma-ray bursts and the counterparts of gravitational *** study aims to utilize the latest AI technology to enhance the sensitivity of HADAR *** datasets and models with distinctive creativity were constructed by incorporating the relevant physical theories for various *** models can determine the type,energy,and direction of the incident particles after careful *** obtained a background identification accuracy of 98.6%,a relative energy reconstruction error of 10.0%,and an angular resolution of 0.22°in a test dataset at 10 *** findings demonstrate the significant potential for enhancing the precision and dependability of detector data analysis in astrophysical *** using deep learning techniques,the HADAR experiment’s observational sensitivity to the Crab Nebula has surpassed that of MAGIC and *** energies below 0.5 TeV and remains competitive with conventional narrow-field Cherenkov telescopes at higher *** addition,our experiment offers a new approach for dealing with strongly connected,scattered data.

关键词： VHE gamma-ray astronomy HADAR Deep learning Convolutional neural networks

Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo Yi Su Yu-Ya-Nan Zhang Hao Yu Zhe Lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun Li Yun-Dan Liao Zhe-Wei kang Li-Fang Wang Yue Li Ming Li Bing Liu Hai-Liang Huang Lu-Xian Lv Yin yao Yun-Long Tan Gerome Breen Ian Everall Hong-Xing Wang Zhuo Huang Dai Zhang Wei-Hua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

江苏常熟地区汉族人群47个微单倍型的遗传多态性及遗传结构分析

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生物化学与生物物理进展 2024年第2期51卷 423-434页

作者：潘坤鹏冯耀森于文帅刘宗伟姚伊人赵杰康克莱张驰王乐吴坚昆明医科大学法医学院昆明650500 公安部鉴定中心法医遗传学公安部重点实验室现场物证溯源技术国家工程实验室北京100038 中国人民公安大学侦查学院北京100038 江苏省常熟市公安局常熟215500

目的探索江苏常熟地区汉族人群在47个常染色体微单倍型基因座的遗传多态性,评估应用效能及法庭科学参数。方法采用MHSeqTyper47混合DNA鉴定试剂盒进行基因座复合扩增及文库构建,使用MiSeq FGx测序平台进行测序,测得的数据应用MHTyper数... 详细信息

目的探索江苏常熟地区汉族人群在47个常染色体微单倍型基因座的遗传多态性,评估应用效能及法庭科学参数。方法采用MHSeqTyper47混合DNA鉴定试剂盒进行基因座复合扩增及文库构建,使用MiSeq FGx测序平台进行测序,测得的数据应用MHTyper数据分析软件进行分析,对获得的样本遗传信息进行评估,结合千人基因组数据(1000 Genomes Project phase 3,1KG)评估群体间遗传分化指数及遗传距离,并计算法庭科学参数。结果江苏常熟地区汉族人群与1KG中的中国北京群体的遗传分化和遗传距离最小,并得到最接近的有效等位基因数(Ae),累积随机匹配概率(combined matching probability,CMP)与1KG中东亚参考人群的5个群体均接近,为1.25×10^(-36),累积非父排除概率达0.9999999999641。结论本研究报告了47个微单倍型基因座在江苏常熟地区汉族人群中的等位基因频率及遗传多态性信息,为47个微单倍型在法医学应用中提供了数据基础。另外,比较了1KG参考人群与江苏常熟地区汉族人群的多态性差异,并揭示了47个微单倍型在江苏常熟地区汉族人群中的遗传结构。总的来说,1KG中的东亚人群参考数据更符合江苏常熟地区汉族人群的遗传特征。

关键词：法医遗传学微单倍型二代测序

Studies on Non-potentiometric Piezoelectric Sensor System for Determination of Vitamin B_1

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Chemical Research in Chinese Universities 2003年第3期19卷 280-285页

作者： YUAN Jin bin NIE Li hua yao shou zhuo State Key Laboratory of Chemo/Biosensing&Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082P.R.China

A piezoelectric sensor responsive to vitamin B 1 was fabricated based on the vitamin B 1 tetraphenylborate ion pair. The general performance characteristics of the sensor are presented here. The proposed sensor showed a wide working pH range, a good sensitivity and selectivity. The response range is between 1 0×10 -7 -4 9×10 -5 mol/L with a detection limit of 8×10 -8 mol/L at pH 4 0. The selectivity should be attributed to the preferential adsorption of the component ion on the membrane/solution interface. The adsorption behavior of vitamin B 1 on the crystal surface was investigated with a quartz crystal impedance(QCI) system.

关键词： Piezoelectric sensor Vitamin B_(1) Ion-pair complex

体外冲击波结合关节松动术治疗肩袖部分损伤合并肩关节僵硬的短期疗效观察

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海军军医大学学报 2024年第3期45卷 358-363页

作者：邵权威年申生刘康姚盖傅夏威汪滋民上海市杨浦区中心医院康复医学科上海200090 海军军医大学(第二军医大学)第一附属医院骨科上海200433

目的探讨体外冲击波结合关节松动术治疗肩袖部分损伤的治疗效果。方法选取2020年1月至2021年1月在海军军医大学(第二军医大学)第一附属医院就诊的75例肩袖部分损伤合并肩关节僵硬患者作为研究对象,随机分为3组:冲击波组、关节松动术组... 详细信息

目的探讨体外冲击波结合关节松动术治疗肩袖部分损伤的治疗效果。方法选取2020年1月至2021年1月在海军军医大学(第二军医大学)第一附属医院就诊的75例肩袖部分损伤合并肩关节僵硬患者作为研究对象,随机分为3组:冲击波组、关节松动术组和冲击波结合关节松动术组,每组25例。对冲击波组患者予体外冲击波及常规理疗(干扰电、短波等)和运动指导,对关节松动术组患者予关节松动术治疗及常规理疗和运动指导,对冲击波结合关节松动术组患者予冲击波结合关节松动术治疗及常规理疗和运动指导。治疗3周后比较3组患者的临床治疗效果。结果治疗3周后,3组患者视觉模拟量表(VAS)评分均降低,加利福尼亚大学洛杉矶分校(UCLA)肩关节评分均增加,各组与治疗前相比差异均有统计学意义(均P<0.01);冲击波结合关节松动术组患者VAS评分[(1.80±1.08)分]低于冲击波组[(3.08±1.44)分]和关节松动术组[(2.96±1.57)分],UCLA肩关节评分[(27.44±1.96)分]高于冲击波组[(24.76±2.24)分]和关节松动术组[(22.92±3.93)分],差异均有统计学意义(均P<0.05)。冲击波结合关节松动术组的总有效率[92.00%(23/25)]高于冲击波组[72.00%(18/25)]和关节松动术组[76.00%(19/25)],差异均有统计学意义(均P<0.05)。结论体外冲击波结合关节松动术治疗肩袖部分损伤相比单纯冲击波或关节松动术有更好的短期疗效。

关键词：肩袖损伤肩关节僵硬体外冲击波关节松动术

钢纤维增强混凝土动态力学性能及HJC本构模型参数标定

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中国建材科技 2024年第3期33卷 20-25页

作者：宁鹏博刘军赵硕李瑶沈阳建筑大学材料科学与工程学院辽宁沈阳110168 沈阳理工大学材料科学与工程学院辽宁沈阳110159

探讨了不同体积掺量钢纤维和镀铜钢纤维对混凝土动态力学性能的影响,以及标定本构模型参数对钢纤维混凝土和镀铜钢纤维混凝土的适用性。在高强混凝土中掺加0.5%、1%、1.5%体积掺量的钢纤维制备7组试件,分别进行静态力学性能试验和分离... 详细信息

探讨了不同体积掺量钢纤维和镀铜钢纤维对混凝土动态力学性能的影响,以及标定本构模型参数对钢纤维混凝土和镀铜钢纤维混凝土的适用性。在高强混凝土中掺加0.5%、1%、1.5%体积掺量的钢纤维制备7组试件,分别进行静态力学性能试验和分离式霍普金森压杆试验(SHPB),基于静态、动态力学结果修正Holmquist-JohnsonCook(HJC)本构模型参数,并利用有限元分析软件验证HJC模型参数的有效性。结果表明,在0.5%、1%、1.5%体积掺量下,混凝土动态峰值抗压强度随纤维掺量的增加而提高。标定的HJC模型对钢纤维混凝土的动态峰值抗压强度预测效果良好,模拟得到的应力-应变曲线与SHPB试验结果大致吻合。以侵蚀准则模拟得到动态冲击试验试件破坏过程,为钢纤维混凝土的抗冲击设计提供参考。

关键词：钢纤维抗冲击性能分离式霍普金森压杆试验 HJC本构模型

高速铁路路基填料智能振动压实系统研制与试验研究

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铁道学报 2024年第6期46卷 138-147页

作者：谢康陈晓斌肖宪普李泰灃张千里尧俊凯中南大学土木工程学院湖南长沙410075 中国铁道科学研究院集团有限公司铁道建筑研究所北京100081 石家庄铁道大学土木工程学院河北石家庄050043

针对现有振动压实设备的局限性,研制一种振动参数调节广、能够实时监测填料干密度的室内智能振动压实设备,并进一步量化评估填料压实状态动刚度和强度的新指标。基于振动理论,揭示室内振动压实设备稳定工作机制,提出振动参数动态优化方... 详细信息

针对现有振动压实设备的局限性,研制一种振动参数调节广、能够实时监测填料干密度的室内智能振动压实设备,并进一步量化评估填料压实状态动刚度和强度的新指标。基于振动理论,揭示室内振动压实设备稳定工作机制,提出振动参数动态优化方法,基于表面沉降理论提出干密度实时计算方法,结合压密曲线建立压实性能评估方法,分别从滞后角修正刚度理论和相似修正强度理论,提出刚度和强度等力学指标对压实状态进行综合评估方法;研发室内振动压实系统以及数据采集分析软件,分析系统部件的工作性能和指标的测试计算方法;最后,开展室内振动压实试验。研究结果发现,增大容器直径和设备自重可显著提高填料干密度;当系统处于共振频率下,填料动刚度减小,承载能力增大;基于振动参数动态优化方法,能够有效减少30%振动能量输出,进一步提高压实效率,减少压实器械磨损及颗粒破碎。研究成果有助于加深对振动压实成型机理的分析,为振动压实试验方法在高速铁路路基建设中推广应用提供理论基础。

关键词：高速铁路路基振动压实振动理论参数优化表面沉降法压实状态