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Journal of Thermal Science 2025年第1期34卷 34-49页

作者： WANG Shuang MU lin LI Xue XIE Jun DONG ming School of Energy and Power Engineering Dalian University of Technology School of Optical Information and Energy Engineering Wuhan Institute of Technology School of Energy and Environment Shenyang Aerospace University

Turbulent agglomeration is viewed as a promising technology for enhancing fine particle removal *** better understand particle transport,agglomeration behaviors,and fluid-particle interactions,we numerically explored these phenomena under cylindrical vortex wake influence using a coupled large eddy simulation and discrete element method（LES-DEM） *** validity of the LES approach was verified by comparison with available direct numerical simulation（DNS） *** adopted the Johnson-Kendall-Roberts（JKR） contact model for particle-particle *** particle dispersion and agglomeration characteristics of particles with different diameters（dp=2-20 μm） in the laminar and transition of shear layer（TrSL） flow regimes were *** particles were concentrated at the vortex centers,while larger particles accumulated around the *** agglomeration efficiency exhibited an M-shaped profile spanwise（y-direction）.With increasing Reynolds number,the agglomeration efficiency and turbulence intensity *** particle agglomeration efficiency peaks at a certain Reynolds ***,at higher Reynolds numbers,reducing the residence time of particles in the flow field decreases the agglomeration efficiency.

关键词： discrete element method large eddy simulation microparticle particle agglomeration

High-dense nanocrystalline W-based alloy prepared by hot isostatic pressing with uniform microstructure, ultrahigh hardness and good thermal stability

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Tungsten 2025年第1期7卷 120-136页

作者： Zao-ming Wu lin He lin-Sen Ye Xiao-Feng Yang Jia-Jia Zhang Hong-Bo Lei Institute of Materials China Academy of Engineering Physics

High-density uniform microstructure nanocrystalline W-10wt.% Cr-5wt.% Y（W-10Cr-5Y） alloy with an average grain size of 85 nm and a relative density of 99.8% was successfully prepared.W-Cr-Y alloys with different amounts of second-phase particles were prepared by high-energy ball milling and hot isostatic pressing *** effects of composition design,ball milling parameters,and sintering parameters on the microstructure of W-Cr-Y alloys were studied.A feasible technology for controlling the synthesis of high-density nanocrystalline W-based alloys has been *** microstructure analysis of nanocrystalline W-10Cr-5Y alloy shows that there are two types of doping in the second phase:intergranular doping and intragranular *** "uniform distribution YOx-rich particles" effectively suppresses the grain growth of W and leads to the formation of nanocrystalline W-10Cr-5Y alloy.W-10Cr-5Y has an ultra-high hardness,with a Vickers hardness of 1312±12 kgf·***-temperature annealing treatment shows that W-10Cr-5Y has good thermal stability at 1000 and1100℃,as demonstrated by the comparison of Vickers hardness and grain size between annealed and unannealed alloys.

关键词： Hot isostatic pressing Microstructure Nanocrystalline tungsten Thermal stability Vickers hardness

表面微织构涂层-基体系统重载弹流润滑性能分析

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表面技术 2020年第7期49卷 159-167页

作者：肖洋轶罗静石万凯康明林华中农业大学工学院武汉430070 农业农村部长江中下游农业装备重点实验室武汉430070 重庆大学机械传动国家重点实验室重庆400044 重庆阳江机械制造有限公司重庆400000

目的研究表面涂层与织构化协同作用时摩擦副的重载弹流润滑性能,为重载传动的摩擦学设计提供参考。方法基于广义Reynolds方程、线弹性方程以及载荷平衡方程,建立表面微织构涂层-基体系统的弹流润滑模型,并无量纲化,然后运用Full-system... 详细信息

目的研究表面涂层与织构化协同作用时摩擦副的重载弹流润滑性能,为重载传动的摩擦学设计提供参考。方法基于广义Reynolds方程、线弹性方程以及载荷平衡方程,建立表面微织构涂层-基体系统的弹流润滑模型,并无量纲化,然后运用Full-system有限元法编程求解,探讨涂层的弹性模量以及三角形织构深度、宽度、密度对系统弹流响应的影响。结果载荷一定时,薄膜涂层(2μm)的弹性模量变化(50~500 GPa)对油膜压力整体分布影响较小,但二次压力峰在硬质涂层上更为显著。在涂层与基体存在弹性模量差时,其上由微织构引起的集中应力是无涂层的2~3倍。最小油膜厚度随着涂层弹性模量的增大而增大。随着织构深度的增大(0~5μm),油膜压力和厚度波动更加明显,最小油膜厚度随之减小,系统最大等效应力也显著增大。当织构宽度增大(10~20μm)时,油膜压力和厚度波动减弱,最小油膜厚度先减小后增大。如果织构密度增大(0.5~2),油膜压力波动更为剧烈,油膜厚度波动变化不大,但其波动周期变化明显,最小油膜厚度先减小后增大。膜基界面最大剪应力出现在二次压力峰附近,织构化表面油膜压力波动越大,膜基界面剪应力波动也越大。结论存在一个最优的织构深度、宽度和密度,使得镀膜齿轮的承载能力最佳。合理的涂层选配和微织构设计,可以有效地提高齿轮的摩擦学性能,提前预防膜基系统失效。

关键词：表面织构涂层齿轮弹流润滑有限元

Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran kang Renwen Wan Fangqi Li Weiwei lin Zhihua Han Beijie Qi Jinrong lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-kang Chen ming-ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期68卷 233-240页

作者： Peipei Liu Yantong Li Meng-Xiang Wu Hao kang Xiao-Li Zhao lin Xu linlin Liu Xiaodong Li Junfeng Fang Zhiwei Fang Ya Cheng Hai-Bo Yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

关键词： double carbohelicene optical resolution organic laser isomerization X-ray diffraction

Application of community-based and integrated strategy to reduce malaria disease burden in southern Tanzania:the study protocol of China-UK-Tanzania pilot project on malaria control

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Infectious Diseases of Poverty 2019年第1期8卷 91-96页

作者： Duoquan Wang Prosper Chaki Yeromin Mlacha Tegemeo Gavana Mihayo Gabriel Michael Rashid Khatibu Jun Feng Zheng-Bin Zhou kang-ming lin Shang Xia He Yan Deus Ishengoma Susan Rumisha Sigbert Mkude Renata Mandike Frank Chacky Charles Dismasi Salim Abdulla Honorati Masanja Ning Xiao Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionShanghai 200025People's Republic of China Ifakara Health Institute Dar es SalaamDares SalaamUnited Republic of Tanzania Guangxi Center for Disease Control and Prevention NaningPeople's Republic of China National Institute for Medical Research Dares SalaamUnited Republic of Tanzania National Malaria Control Programme Ministry of HealthCommunity DevelopmentGenderElderly and ChildrenDares SalaamUnited Republic of Tanzania

Background:During the past six decades,remarkable success on malaria control has been made in *** major experience could be shared with other malaria endemic countries including Tanzania with high malaria ***,China’s 1-3-7 model for malaria elimination is one of the most important refined experiences from many years’efforts and key innovation measures for malaria elimination in ***:The China-UK-Tanzania pilot project on malaria control was implemented from April,2015 to June,2018,which was an operational research with two communities receiving the proposed interventions and two comparable communities serving as control *** World Health Organization"Test,Treat,Track"(WHO-T3)Initiative,which calls for every suspected case to receive a diagnostic test,every confirmed case to be treated,and for the disease to be tracked,was integrated with Chinese experiences on malaria control and elimination for exploration of a proper model tailored to the local *** of China’s 1-3-7 model integrating with WHO-T3 initiative and local resources aiming at reducing the burden of malaria in terms of morbidity and mortality by 30%in the intervention communities in comparison with that at the baseline ***:The China-UK-Tanzania pilot project on malaria control was that at China’s first pilot project on malaria control in Africa,exploring the feasibility of Chinese experiences by China-Africa collaboration,which is expected that the strategies and approaches used in this project could be potential for scaling up in Tanzania and African countries,and contribute to the acceleration of malaria control and elimination in Africa.

关键词： Malaria Community-based Chinese experiences WHO-T3 initiative Tanzania Pilot Protocol

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU kang WANG YUANHONG PENG MENG CHEN lin ZHONG LUJI HUANG FU CHENG XINDAN SHENG XIN YANG MANZHAO OUYANG GEORGE A.CAlin ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

Numerical Simulation of Peen Forming

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上海交通大学学报 2004年第Z2期38卷 73-78页

作者： kang Xiaoming Ma Zeen Gu lin Chen ming School of Mechanical Engineering Shanghai Jiaotong University Shanghai200030 China Department of Aircraft Manufacturing Engineering Northwestern Polytechnical UniversityXi''an710072China School of Mechanical Engineering Shanghai Jiaotong University Shanghai200030 China School of Mechanical Engineering Shanghai Jiaotong University Shanghai200030 China

Peen forming is the most important process for the manufacturing of integral wing skin panels. In order to determine peening parameters, an equivalent deformation theory was proposed in which peening parameters are transformed into equivalent nodal forces. In this study, a linear elastic shell finite element method is adopted. Other related problems such as wing skin panel modeling and peening scheme analysis were also outlined. The method has been applied to manufacturing panels of a certain Chinese aircraft and was proved to be effective in reducing peening experimental tests and improving products quality.

关键词： peen forming wing skin panel equivalent deformation theory numerical simulation

Membrane enhanced COD degradation of pulp wastewater using Cu_2O/H_2O_2 heterogeneous Fenton process

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Chinese Journal of Chemical Engineering 2018年第9期26卷 1896-1903页

作者： Hongjia Zhou lin kang ming Zhou Zhaoxiang Zhong Weihong Xing State Key Laboratory of Materials-Oriented Chemical Engineering National Engineering Research Center for Special Separation Membrane Nanjing Tech University

Both activity and stability of the catalyst can be improved in heterogeneous Fenton reaction,in particular,with no limitation for the working p H and no production of the *** this work,a combination of catalyst Cu_2O and pore-channel-dispersed H_2O_2is proposed to treat the pulp *** degree of CODs in the wastewater was up to 77%in the ceramic membrane reactor using Cu_2O powder(2.0 g·L^(-1))and membranefeeding H_2O_2(0.8 ml·L^(-1))within 60 *** of·OH radical formation in the advanced oxidation process was analyzed with a fluorescent *** efficiency of H_2O_2was successfully enhanced by 10%with the membrane *** on,the catalyst recyclability was evaluated in a five-cycle *** concentration of copper ions being dissolved in the treated water was monitored with *** Cu_2O/H_2O_2(membrane)treatment the effluent is qualified to discharge with COD concentration lower than 15 mg·L^(-1)with regard to the national standard GB25467-2010.

关键词： Pulp wastewater Heterogeneous Fenton Membrane Cu2O Advanced oxidation