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基于优先使用权的温贮备可修重试系统可靠性与期望成本模型

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控制与决策 2024年第4期39卷 1351-1360页

作者：康佳胡林敏王妍燕山大学理学院河北秦皇岛066004

针对具有两种不同类型部件的温贮备可修系统,基于优先使用权规则,将部件的重试特性和不可靠修理设备引入系统,建立一种新的系统可靠性和成本模型.失效部件由一个不可靠修理设备维修,当正常的修理设备维修失效部件时会发生不完全故障,此... 详细信息

针对具有两种不同类型部件的温贮备可修系统,基于优先使用权规则,将部件的重试特性和不可靠修理设备引入系统,建立一种新的系统可靠性和成本模型.失效部件由一个不可靠修理设备维修,当正常的修理设备维修失效部件时会发生不完全故障,此时,它或以一定的概率立即被维修,或以一定的概率继续低效维修失效部件.在不完全故障下,修理设备有可能发生完全性故障,完全性故障后会立即被维修.鉴于维修环境的随机波动性,利用PH分布对修理设备的修理时间进行建模,这在一定程度上拓展了模型的适用性.通过概率讨论得到稳态下系统的一些主要性能指标,构建单位时间的总期望成本函数,并就总期望成本关于各参数的敏感性进行分析.通过数值实例展示系统参数对系统稳态性能指标和系统成本的影响,为系统可靠性设计者和决策者提供理论支撑和参考.

关键词：重试不可靠修理设备 PH分布稳态指标期望成本

Structured-illumination reflectance imaging for the evaluation of microorganism contamination in pork: Effects of spectral and imaging features on its prediction performance

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Food Science and Human Wellness 2024年

作者： Binjing Zhou Xiaohua Liu yan Ge kang Tu Jing Peng Juan Francisco García-Martín Jie Wu Weijie Lan Leiqing Pan The Academy of Science， Nanjing Agricultural University College of Engineering， Nanjing Agricultural University College of Food Science and Technology， Nanjing Agricultural University School of Food and Biological Engineering， Bengbu University Departamento de Ingeniería Química， Facultad de Química， Universidad de Sevilla

Structured-illumination reflectance imaging provides a new means for food quality detection. This original work investigated the capability of Structured-illumination reflectance imaging technique coupled with multivariate chemometrics to evaluate the microbial contamination in pork inoculated with Pseudomonas fluorescens and Brochothrix thermosphacta during storage at different temperatures. The prediction performances based on different spectrum and the textural features of direct component and amplitude component images demodulated from the SIRI pattern images， as well as their data fusion were comprehensively compared. Based on the full wavelength spectrum (420 – 700) nm of amplitude component images， the orthogonal signal correction coupled with support vector machine regression provided the best predictions of the number of Pseudomonas fluorescens and Brochothrix thermosphacta in pork， with the Rp2values of 0.870 and 0.906， respectively. Besides， the prediction models based on the amplitude component or direct component image textural features and the data fusion models using spectrum and textural features from direct component and amplitude component images cannot significantly improve their prediction accuracy. Consequently， structured-illumination reflectance imaging can be further considered as a potential technique for the rapid evaluation of microbial contaminations in pork meat.

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Association between the frontoparietal network,clinical symptoms and treatment response in individuals with untreated anorexia nervosa

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General Psychiatry 2024年第3期37卷 364-374页

作者： Qianqian He Hui Zheng Jialin Zhang Ling Yue Qing kang Cheng Lian Lei Guo yan Chen yanran Hu Yuping Wang Sufang Peng Zhen Wang Qiang Liu Jue Chen Department of Clinical Psychology Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Clinical Psychology Shanghai Pudong New Area Mental Health CenterTongji University School of MedicineShanghaiChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research Bejing Normal UniversityBeijingChina

Background Anorexia nervosa(AN)has been characterised as a psychiatric disorder associated with increased ***,it remains difficult to predict treatment response in patients with *** cognitive abilities are known to be resistant to *** has been established that the frontoparietal control network(FPCN)is the direct counterpart of the executive control ***,the resting-state brain activity of the FPCN may serve as a biomarker to predict treatment response in *** The study aimed to investigate the association between resting-state functional connectivity(RSFC)of the FPCN,clinical symptoms and treatment response in patients with *** In this case-control study,79 female patients with AN and no prior treatment from the Shanghai Mental Health Center and 40 matched healthy controls(HCs)were recruited from January 2015 to March *** participants completed the Questionnaire Versionof the Eating Disorder Examination(version 6.0)to assess the severity of their eating disorder ***,RSFC data were obtained from all participants at baseline by functional magnetic resonance *** with AN underwent routine outpatient treatment at the 4th and 12th week,during which time their clinical symptoms were evaluated using the same measures as at *** Among the 79 patients,40 completed the 4-week follow-up and 35 completed the 12-week *** RSFC from the right posterior parietal cortex(PPC)and dorsolateral prefrontal cortex(diPFC)increased in 79 patients with AN vs 40 HCs after controlling for depression and anxiety *** multiple linear regression,the RSFC of the PPC to the inferior frontal gyrus was found to be a significant factor for self-reported eating disorder symptoms at baseline and the treatment response to cognitive preoccupations about eating and body image,after controlling for age,age of onset and body mass *** RSFC in the dIPFC to the middle temporal gyrus and the

关键词： symptoms routine prevention

基于Nrf2/HO-1信号通路探究胃复春胶囊辅助治疗重症肺炎合并应激性胃溃疡临床研究

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世界华人消化杂志 2024年第3期32卷 228-235页

作者：苗燕燕孙康舟山市中医医院急诊科浙江省舟山市316000

背景重症肺炎合并应激性溃疡发病机制并未完全阐述,尚无特效治疗方案,预后普遍较差,明确其发病机制,确定治疗靶点有望控制病情进展,促使疾病转归.目的探讨基于核因子E2相关因子2/血红素氧合酶-1(nuclear factor erythroid 2 related fac... 详细信息

背景重症肺炎合并应激性溃疡发病机制并未完全阐述,尚无特效治疗方案,预后普遍较差,明确其发病机制,确定治疗靶点有望控制病情进展,促使疾病转归.目的探讨基于核因子E2相关因子2/血红素氧合酶-1(nuclear factor erythroid 2 related factor 2/heme oxygenase-1,Nrf2/HO-1)信号通路探究胃复春胶囊辅助治疗重症肺炎合并应激性胃溃疡效果.方法收集2021-01/2023-01舟山市中医医院108例重症肺炎合并应激性胃溃疡患者临床资料进行回顾性分析,根据治疗方案分为对照组(n=54)和研究组(n=54),分别采取奥美拉唑、奥美拉唑+胃复春胶囊,连续治疗1 wk.统计2组治疗总有效率、临床症状缓解时间、不良反应、复发率及治疗前后生长抑素(somatostatin,SS)、血管活性肠肽(vasoactive intestinal peptide,VIP)、胃泌素(gastrin,GAS)、Nrf2/HO-1信号通路相关mRNA、蛋白表达、氧化应激指标[丙二醛(malondialdehyde,MDA)、一氧化氮(nitric oxide,NO)、8-羟基脱氧鸟苷酸(8-Hydroxy-2'-deoxyguanine,8-OHdG)].结果研究组治疗总有效率较对照组高,临床症状缓解时间较对照组短(P<0.05);治疗1 wk后研究组VIP、GAS、SS含量及其差值均高于对照组(P<0.05);治疗1 wk后研究组Nrf2、HO-1 mRNA、蛋白及NO含量均高于对照组,MDA、8-OHdG含量低于对照组,差值均高于对照组(P<0.05);2组不良反应及复发率比较差异无统计学意义.结论胃复春胶囊辅助治疗重症肺炎合并应激性胃溃疡效果确切,有利于增加胃肠激素含量,缩短症状缓解时间,且安全性高,可能机制与上调Nrf2/HO-1信号通路有关.

关键词：重症肺炎应激性胃溃疡胃复春胶囊奥美拉唑 Nrf2/HO-1信号通路

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo Ma yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

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生成式人工智能防沉迷立法问题研究

东北师大学报（哲学社会科学版） 2024年第2期 112-126页

作者：李岩康铭辽宁大学法学院辽宁沈阳110036

既有防沉迷规范的适用范围有限并且没有指出相关主体的具体义务,其难以应对生成式人工智能令人沉迷的风险。从原因视角分析,生成式人工智能令人沉迷的原因在于其生成的虚拟世界更具有吸引力、精准推送产生舒适性、虚拟人物使人产生情感... 详细信息

既有防沉迷规范的适用范围有限并且没有指出相关主体的具体义务,其难以应对生成式人工智能令人沉迷的风险。从原因视角分析,生成式人工智能令人沉迷的原因在于其生成的虚拟世界更具有吸引力、精准推送产生舒适性、虚拟人物使人产生情感依赖。从后果视角分析,人们对生成式人工智能的沉迷容易造成创新能力退化、道德标准僵化与价值导向机械化、审美形式化等问题。基于此,生成式人工智能提供者和开发者首先需要履行审批和披露义务。其次应设置防沉迷层面的算法,包括根据用户的年龄等因素设置相应的防沉迷策略,设置用户偏好推送的限度,履行适当的披露义务并拒绝提供情感慰藉;应当对生成式人工智能在思维认知领域“作为思想生成、创新工具”加以限制;设置道德过滤机制;在特定情形中限制“直接提供成品”的使用频次。再次,定期进行算法检查。最后,生成式人工智能提供者和开发者违反防沉迷、防止依赖义务应当承担行政责任。

关键词：生成式人工智能防沉迷义务行政责任

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生成式人工智能沉迷的法律规制:动因及对策

北京行政学院学报 2024年第1期 118-128页

作者：李岩康铭辽宁大学法学院辽宁沈阳110036

生成式人工智能的蓬勃兴起为经济社会发展注入了新动能,正在深刻改变人们的生产生活方式,同时也容易导致人工智能沉迷问题。这不仅是个体层面的问题,更涉及人的思维自由、行为自由、人的主体地位等更深层次的问题。当前在防范方面还存... 详细信息

生成式人工智能的蓬勃兴起为经济社会发展注入了新动能,正在深刻改变人们的生产生活方式,同时也容易导致人工智能沉迷问题。这不仅是个体层面的问题,更涉及人的思维自由、行为自由、人的主体地位等更深层次的问题。当前在防范方面还存在着对象范围过窄、监管方法不当、防沉迷领域局限以及防范义务不明确且手段单一等问题。应当从法律层面对生成式人工智能的沉迷问题进行规制,明确生成式人工智能提供者的防沉迷义务,转变监管方法,加大监管力度,建立生成式人工智能沉迷防范体系,发挥多元主体协同共治,确保生成式人工智能的使用符合人类整体利益。

关键词：生成式人工智能技术沉迷防沉迷立法人机关系人工智能立法

CGG repeat expansion in LOC642361/NUTM2B-AS1 typically presents as oculopharyngodistal myopathy

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Journal of Genetics and Genomics 2024年第2期51卷 184-196页

作者： yan Shi Chunyan Cao Yiheng Zeng Yuanliang Ding Long Chen Fuze Zheng Xuejiao Chen Fanggui Zhou Xiefeng yang Jinjing Li Liuqing Xu Guorong Xu Minting Lin Hiroyuki Ishiura Shoji Tsuji Ning Wang Zhiqiang Wang Wan-Jin Chen kang yang Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of NeuroscienceFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350005China Department of Neurology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian 350212China The First Affiliated Hospital College of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan 471000China Department of Neurology Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujian 363000China Department of Neurology Jian'ou Municipal Hospital of Fujian ProvinceJian'ouFujian 353100China Department of Radiology First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China Department of Neurology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Neurology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Institute of Medical Genomics International University of Health and WelfareChiba 286-0048Japan

CGG repeat expansions in LOC642361/NUTM2B-AS1 have recently been identified as a cause of oculopharyngeal myopathy with ***,since only three patients from a single family were reported,it remains unknown whether their clinicopathological features are typical for CGG repeat expansions in LOC642361/***,using repeat-primed-polymerase chain reaction and long-read sequencing,we identify 12 individuals from 3 unrelated families with CGG repeat expansions in LOC642361/NUTM2B-AS1,typically presenting with oculopharyngodistal *** CGG repeat expansions range from 161 to 669 repeat *** of the patients present with ptosis,restricted eye movements,dysphagia,dysarthria,and diffuse limb muscle *** one patient shows T2-weighted hyperintensity in the cerebellar white matter surrounding the deep cerebellar nuclei on brain magnetic resonance *** biopsies from three patients show a myopathic pattern and rimmed *** of muscle biopsies suggest that CGG repeat expansions in LOC642361/NUTM2B-AS1 may deleteriously affect aggrephagic capacity,suggesting that RNA toxicity and mitochondrial dysfunction may contribute to *** study thus expands the phenotypic spectrum for the CGG repeat expansion of LOC642361/NUTM2B-AS1 and indicates that this genetic variant typically manifests as oculopharyngodistal myopathy with chronic myopathic changes with rimmed vacuoles and filamentous intranuclear inclusions in muscle fibers.

关键词： Oculopharyngeal myopathy with leukoencephalopathy Oculopharyngodistal myopathy CGG repeat expansion Rimmed vacuoles

Lecithin-cholesterol acyltransferase is a potential tumor suppressor and predictive marker for hepatocellular carcinoma metastasis

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3651-3671页

作者： yan Li Li-Na Jiang Bo-kang Zhao Mei-Ling Li Yi-Yun Jiang Yi-Si Liu Shu-Hong Liu Li Zhu Xin Ye Jing-Min Zhao Department of Pathology and Hepatology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Hepatology Center of Infectious Diseases and Pathogen BiologyThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina First Department of Liver Disease Center Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100190China Department of Pathology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

BACKGROUND Hepatocellular carcinoma(HCC)is a major cause of cancer mortality worldwide,and metastasis is the main cause of early recurrence and poor ***,the mechanism of metastasis remains poorly *** To determine the possible mechanism affecting HCC metastasis and provide a possible theoretical basis for HCC *** The candidate molecule lecithin-cholesterol acyltransferase(LCAT)was screened by gene microarray and bioinformatics *** expression levels of LCAT in clinical cohort samples was detected by quantitative realtime polymerase chain reaction and western *** proliferation,migration,invasion and tumor-forming ability were measured by Cell Counting Kit-8,Transwell cell migration,invasion,and clonal formation assays,*** formation was detected in nude mice after LCAT gene knockdown or *** immunohistochemistry for Ki67,E-cadherin,N-cadherin,matrix metalloproteinase 9 and vascular endothelial growth factor were performed in liver tissues to assess the effect of LCAT on *** set enrichment analysis(GSEA)on various gene signatures were analyzed with GSEA version *** machine-learning algorithms(random forest,support vector machine,and logistic regression)were applied to predict HCC metastasis in The Cancer Genome Atlas and GEO *** LCAT was identified as a novel gene relating to HCC metastasis by using gene microarray in HCC *** was significantly downregulated in HCC tissues,which is correlated with recurrence,metastasis and poor outcome of HCC *** analysis indicated that LCAT inhibited HCC cell proliferation,migration and invasion both in vitro and in *** data showed that LCAT was negatively associated with HCC size and metastasis(HCC size≤3 cm vs 3-9 cm,P9 cm,P<0.01;metastatic-free HCC vs extrahepatic metastatic HCC,P<0.05).LCAT suppressed the growth,migration and invasion of HCC cell lines via PI3K/A

关键词： Lecithin-cholesterol acyltransferase Tumor suppressor gene Hepatocellular carcinoma PI3K/AKT/mTOR Predicting model