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Topological approach of liver segmentation based on 3D visualization technology in surgical planning for split liver transplantation

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World Journal of Gastrointestinal Surgery 2022年第10期14卷 1141-1149页

作者： Dong Zhao kang-jun zhang Tai-Shi Fang Xu Yan Xin Jin Zi-Ming Liang Jian-Xin Tang Lin-Jie Xie Department of Liver Surgery and Organ Transplantation Center The Third People's Hospital of ShenzhenThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518000Guangdong ProvinceChina

BACKGROUND Split liver transplantation(SLT)is a complex *** left-lateral and right tri-segment splits are the most common surgical approaches and are based on the Couinaud liver segmentation ***,the liver surface following right trisegment splits may exhibit different degrees of ischemic changes related to the destruction of the local portal vein blood flow *** is currently no consensus on preoperative evaluation and predictive strategy for hepatic segmental necrosis after *** To investigate the application of the topological approach in liver segmentation based on 3D visualization technology in the surgical planning of *** Clinical data of 10 recipients and 5 donors who underwent SLT at Shenzhen Third People’s Hospital from January 2020 to January 2021 were retrospectively *** surgery,all the donors were subjected to 3D modeling and *** on the 3D-reconstructed models,the liver splitting procedure was simulated using the liver segmentation system described by Couinaud and a blood flow topology liver segmentation(BFTLS)*** addition,the volume of the liver was also *** indexes mainly included the hepatic vasculature and expected volume of split grafts evaluated by 3D models,the actual liver volume,and the ischemia state of the hepatic segments during the actual *** Among the 5 cases of split liver surgery,the liver was split into a left-lateral segment and right trisegment in 4 cases,while 1 case was split using the left and right half liver *** operations were successfully implemented according to the preoperative *** to Couinaud liver segmentation system and BFTLS methods,the volume of the left lateral segment was 359.00±101.57 mL and 367.75±99.73 mL,respectively,while that measured during the actual surgery was 397.50±37.97 *** volume of segment IV(the portion of ischemic liver lobes)allocated to the right tri-segment was 136.31±86.10 mL

关键词： Three-dimensional visualization Couinaud liver segmentation Blood flow topology liver segmentation Split liver transplantation Surgical planning

Reconstructing the portal vein through a posterior pancreatic tunnel:New choice for portal vein thrombosis during liver transplantation

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World Journal of Gastrointestinal Surgery 2022年第10期14卷 1131-1140页

作者： Dong Zhao Yi-Ming Huang Zi-Ming Liang kang-jun zhang Tai-Shi Fang Xu Yan Xin Jin Yi zhang Jian-Xin Tang Lin-Jie Xie Xin-Chen Zeng Department of Liver Surgery and Organ Transplantation Center The Third People’s Hospital of ShenzhenThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518000Guangdong ProvinceChina

BACKGROUND Thrombectomy and anatomical anastomosis(TAA)has long been considered the optimal approach to portal vein thrombosis(PVT)in liver transplantation(LT).However,TAA and the current approach for non-physiological portal reconstructions are associated with a higher rate of complications and mortality in some *** To describe a new choice for reconstructing the portal vein through a posterior pancreatic tunnel(RPVPPT)to address cases of unresectable *** Between August 2019 and August 2021,245 adult LTs were ***-five(18.4%)patients were confirmed to have PVT before surgery,among which seven underwent PV reconstruction via the RPVPPT *** retrospectively analyzed the surgical procedure and postoperative complications of these seven recipients that underwent PV reconstruction due to *** During the procedure,PVT was found in all the seven cases with significant adhesion to the vascular wall and could not be *** portal vein proximal to the superior mesenteric vein was damaged in one case when attempting thrombolectomy,resulting in massive *** was successfully performed in all patients with a mean duration of 585 min(range 491-756 min)and mean intraoperative blood loss of 800 mL(range 500-3000 mL).Postoperative complications consisted of chylous leakage(n=3),insufficient portal venous flow to the graft(n=1),intra-abdominal hemorrhage(n=1),pulmonary infection(n=1),and perioperative death(n=1).The remaining six patients survived at 12-17 mo *** The RPVPPT technique might be a safe and effective surgical procedure during LT for complex ***,follow-up studies with large samples are still warranted due to the relatively small number of cases.

关键词： Liver transplantation Portal vein thrombosis Portal vein reconstruction Retropancreatic tunnel Computer tomography angiography Three-dimensional visualization

Outcomes of ABO-incompatible liver transplantation in end-stage liver disease patients co-infected with hepatitis B and human immunodeficiency virus

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World Journal of Gastroenterology 2023年第11期29卷 1745-1756页

作者： Jian-Xin Tang kang-jun zhang Tai-Shi Fang Rui-Hui Weng Zi-Ming Liang Xu Yan Xin Jin Lin-Jie Xie Xin-Chen Zeng Dong Zhao Department of Liver Surgery and Organ Transplantation Center The Third People's Hospital of Shenzhen(The Second Affiliated Hospital of Southern University of Science and Technology)Shenzhen 518000Guangdong ProvinceChina Department of Neurology The Third People’s Hospital of Shenzhen(The Second Affiliated Hospital of Southern University of Science and Technology)Shenzhen 518000Guangdong ProvinceChina Department of Liver Surgery and Organ Transplantation Center National Clinical Research Center for Infectious DiseaseShenzhen 518000Guangdong ProvinceChina

BACKGROUND Human immunodeficiency virus(HIV)-positive patients coinfected with hepatitis B virus(HBV)are eligible for liver transplantation(LT)in Africa and Southeast Asia,particularly ***,the outcome of HIV-HBV coinfected patients referred for ABO-incompatible LT(ABOi-LT)is *** To clarify the outcome of ABOi-LT for HIV-HBV coinfected patients with endstage liver disease(ESLD).METHODS We report on two Chinese HIV-HBV coinfected patients with ESLD who underwent A to O brain-dead donor LT and reviewed the literature on HIV-HBV coinfected patients treated with ABO-compatible *** pretransplantation HIV viral load was undetectable,with no active opportunistic *** therapy consisted of two sessions of plasmapheresis and a single dose of rituximab in two split doses,followed by an intraoperative regimen of intravenous immunoglobulin,methylprednisolone,and ***-transplant maintenance immunosuppressive agents consisted of tacrolimus and mycophenolate mofetil,and *** At the intermediate-term follow-up,patients showed undetectable HIV viral load,CD4(+)T cell counts greater than 150 cells/μL,no HBV recurrence,and stable liver function.A liver allograft biopsy showed no evidence of acute cellular *** patients survived at 36-42 mo of *** This is the first report of ABOi-LT in HIV-HBV recipients with good intermediate-term outcomes,suggesting that ABOi-LT may be feasible and safe for HIV-HBV coinfected patients with ESLD.

关键词： ABO incompatibility liver transplantation Human immunodeficiency virus Hepatitis B virus End-stage liver disease Immunosuppression

How to apply ex-vivo split liver transplantation safely and feasibly: A three-step approach

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1691-1699页

作者： Dong Zhao Qiu-Hua Xie Tai-Shi Fang kang-jun zhang Jian-Xin Tang Xu Yan Xin Jin Lin-Jie Xie Wen-Gui Xie Department of Liver Surgery and Organ Transplantation Center Shenzhen Third People’s HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen 518112Guangdong ProvinceChina Department of Organ Procurement Organizations Shenzhen Third People’s HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen 518112Guangdong ProvinceChina

BACKGROUND Given the current organ shortage crisis,split liver transplantation(SLT)has emerged as a promising alternative for select end-stage liver disease *** To introduce an ex-vivo liver graft splitting approach and evaluate its safety and feasibility in *** A retrospective analysis was conducted on the liver transplantation data from cases performed at our center between April 1,2022,and May 31,*** study included 25 SLT cases and 81 whole liver transplantation(WLT)*** ex-vivo liver splitting was employed for SLT graft procurement in three *** outcomes were determined,including liver function parameters,postoperative complications,and perioperative *** comparisons for categorical variables were performed using theχ²-*** In the study,postoperative complications in the 25 SLT cases included hepatic artery thrombosis(n=1)and pulmonary infections(n=3),with no perioperative *** contrast,among the 81 patients who underwent WLT,complications included perioperative mortality(n=1),postoperative pulmonary infections(n=8),abdominal infection(n=1),hepatic artery thromboses(n=3),portal vein thrombosis(n=1),and intra-abdominal bleeding(n=5).Comparative analysis demonstrated significant differences in alanine aminotransferase(176.0 vs 73.5,P=0.000)and aspartate aminotransferase(AST)(42.0 vs 29.0,P=0.004)at 1 wk postoperatively,and in total bilirubin(11.8 vs 20.8,P=0.003)and AST(41.5 vs 26.0,P=0.014)at 2 wk ***,the overall incidence of complications was comparable between the two groups(P>0.05).CONCLUSION Our findings suggest that the total ex-vivo liver graft splitting technique is a safe and feasible approach,especially under the expertise of an experienced transplant *** approach developed by our center can serve as a valuable reference for other transplantation centers.

关键词： Split liver transplantation Transplantation Liver splitting Ex-vivo In-situ

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou zhang Shuo Li Fu Tang Jingkai zhang Yuetong kang Hean zhang Lidong Li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua Lu jun Shen Xin zhang Lingcong Chao Liang Chen Ding zhang Tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

Subtoxic concentration of Doxorubicin enhances TRAIL-induced apoptosis in Human prostate cancer cell line LNCaP

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Subtoxic concentration of Doxorubicin enhances TRAIL-induced...

Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

第十三届全国泌尿外科学术会议暨第八届全球华人泌尿外科学术会议

作者： Jian kang, Liang zhang, jun Qi, Fang Chen Department of Urology, Xinhua Hospital, Medical School of Shanghai Jiaotong University

Most tumor cells are sensitive to TRAIL-induced apoptosis but sparing to normal cells, thus providing therapeutic potential for clinical use. Some tumor cells are resistant to TRAIL-induced cell death while the sensit... 详细信息

关键词： TRAIL Doxorubicin LNCaP Apoptosis

来源： cnki会议评论

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 221-232页

作者： Yuanchun zhang Shengtao Gao Xingzhao zhang Dacheng Ma Chuanlei Zhu jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui Wang Hanyue zhang Xiou Wang Sijia Zhou Bo Ma Yan Luan Xin Wang Xinlin Chen Zhichao zhang Qianyan kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells