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Three-dimensional kagome structures in a PCL/HA-based hydrogel scaffold to lead slow BMP-2 release for effective bone regeneration

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Bio-Design and Manufacturing 2023年第1期6卷 12-25页

作者： Se-Hwan lee kang-gon lee Jaeyeon lee Yong Sang Cho Min-Soo Ghim Soojin Kim Su-Jin Heo Yongdoo Park Young-Sam Cho Bu-Kyu lee McKay Orthopaedic Research Laboratory Department of Orthopaedic SurgeryPerelman School of MedicineUniversity of Pennsylvania36th Street and Hamilton WalkPhiladelphiaPA 19104USA Department of Biomedical Sciences College of MedicineKorea University73Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Medical Device Development Center Daegu-Gyeongbuk Medical Innovation Foundation(K-MEDI hub)80Cheombok-roDong-guDaegu 41061Republic of Korea Department of Mechanical Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea Biomedical Engineering Research Center Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea Department of Mechanical Design Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea MECHABIO Group Wonkwang University460Iksan-daeroIksan 54538Republic of Korea Department of Oral and Maxillofacial Surgery Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea

Osteoconductive function is remarkably low in bone disease in the absence of bone tissue surrounding the grafting site,or if the bone tissue is in poor ***,an effective bone graft in terms of both osteoconductivity and osteoinductivity is required for clinical ***,the three-dimensional(3D)kagome structure has been shown to be advantageous for bone tissue regeneration due to its mechanical *** this study,a polycaprolactone(PCL)kagome-structure scaffold containing a hyaluronic acid(HA)-based hydrogel was fabricated using a 3D printing *** retention capacity of the hydrogel in the scaffold was assessed in vivo with a rat calvaria subcutaneous model for 3 weeks,and the results were compared with those obtained with conventional 3D-printed PCL grid-structure scaffolds containing HA-based hydrogel and bulk-type HA-based *** retained hydrogel in the kagome-structure scaffold was further evaluated by in vivo imaging system *** further reinforce the osteoinductivity of the kagome-structure scaffold,a PCL kagome-structure scaffold with bone morphogenetic protein-2(BMP-2)containing HA hydrogel was fabricated and implanted in a calvarial defect model of rabbits for 16 *** bone regeneration characteristics were evaluated with hematoxylin and eosin(H&E),Masson’s trichrome staining,and micro-CT image analysis.

关键词： Kagome-structure scaffold Retention capacity Biomimetic hydrogel Bone morphogenetic protein-2(BMP-2)

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Dynamic observation of dendrite growth on lithium metal anode during battery charging/discharging cycles

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npj Computational Materials 2022年第1期8卷 960-972页

作者： Hae gon lee Se Young Kim Joon Sang lee Next Generation Battery Research Center Korea Electrotechnology Research Institute(KERI)12Jeongiui-gilSeongsan-guChangwon-siGyeongsangnam-do51543Republic of Korea Department of Mechanical Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul03722Republic of Korea

Lithium metal is considered one of the most promising anode materials for application in next-generation ***,despite decades of research,practical application of lithium metal batteries has not yet been achieved because the fundamental interfacial mechanism of lithium dendrite growth is not yet fully *** this study,a series of reactive molecular dynamics (MD) simulations was performed to investigate the electrochemical dynamic reactions at the electrode/electrolyte *** allows quantitative characterization of morphological phenomena and real-time interfacial visualization of the dynamic growth of dead lithium and dendrites during repeated *** computational protocol was utilized to investigate the dendrite mitigation mechanism when an electrolyte additive (hydrogen fluoride) is dissolved in an organic ethylene carbonate (EC) electrolyte *** was confirmed that beneficial decomposition reactions between electrolyte components form a protective film on the anode surface,suppressing large interphase volume changes and unnecessary degradation reactions.

关键词： battery lithium electrolyte

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Efficient L-band ASE Generation Using a C/L-Band Coupler, an Optical Mirror and a FBG

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光学学报 2003年第S1期23卷 495-496页

作者： Seungtaek Kim Heuiseok kang kang-Won lee Yong-gon Seo Youngjune Cho Korea Institute of Industrial Technology 35-3 IbJang HongCheon CheonAn ChungNam ROKKorea Institute of Industrial Technology 35-3 IbJang HongCheon CheonAn ChungNam ROKKorea Institute of Industrial Technology 35-3 IbJang HongCheon CheonAn ChungNam ROKKorea Electronics Technology Institute Pyungtaek KyungGi ROKKorea Institute of Industrial Technology 35-3 IbJang HongCheon CheonAn ChungNam ROK

A new structure for efficient and cost-effective L-band amplified spontaneous emission (ASE) generation was experimentally investigated and demonstrated using a C/L-band coupler, an optical mirror, and a fiber Bragg grating (FBG). The proposed structure has about 1.5 dB increase of the power around 1570 nm compared with conventional one. Various structures for power enhancement were also considered.

关键词： ASE EDF of into as In Efficient L-band ASE Generation Using a C/L-Band Coupler an Optical Mirror and a FBG

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A study on neural mechanism of face processing based on fMRI

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Progress in Natural Science:Materials International 2008年第2期18卷 201-207页

作者： kang lee Canada Institute of Child Study University of Toronto

Recently,there were debates about the specificity of lateral middle fusiform in face processing. The debates focused on whether these areas were specialized in face processing or involved in processing of visual expertise and categorization at individual level. The present study aims to investigate the neural mechanism of face processing,using Chinese characters as comparison stimuli. Chinese characters are greatly similar to faces on a variety of dimensions,among which the most significant one is that both faces and Chinese characters not only are extremely familiar to literate Chinese adults but also are processed at individual level. In the present study,faces and Chinese characters activated bilateral middle fusiform with great correlation. Greater activities were observed in the right fusiform face area (FFA) for faces than for Chinese characters. These results demonstrate that FFA is specialized in face processing per se rather than the processing of visual expertise and categorization at individual level.

关键词： Face processing Chinese characters Fusiform gyrus fMRI

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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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Attribute of Big Data Analytics Quality Affecting Business Performance

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Journal of Social Computing 2023年第4期4卷 357-381页

作者： Sangjae lee Byung gon Kim the College of Business Administration Sejong UniversitySeoul 05006Republic of Korea the Department of Digital Business Administration Namseoul UniversityCheonan 31020Republic of Korea

With an accelerating increase of business benefits produced from big data analytics (if used appropriately and intelligently by businesses in the private and public sectors), this study focused on empirically identifying the big data analytics (BDA) attributes. These attributes were classified into four groups (i.e., value innovation, social impact, precision, and completeness of BDA quality) and were found to influence the decision-making performance and business performance outcomes. A structural equation modeling analysis using 382 responses from a BDA related to practitioners indicated that the attributes of representativeness, predictability, interpretability, and innovativeness as related to value innovation greatly enhanced the decision-making confidence and effectiveness of decision makers who make decisions using big data. In addition, individuality, collectivity, and willfulness, which are related to social impact, also greatly improved the decision-making confidence and effectiveness of the same decision makers. This shows that the value innovation and social impact, which have received relatively less attention in previous studies, are the crucial attributes for BDA quality as they influence the decision-making performance. Comprehensiveness, factuality, and realism, which are linked to completeness, also have similar results. Furthermore, the higher the decision-making confidence of the decision makers who used big data was, the higher the financial performance of their companies. In addition, high decision-making confidence using big data was found to improve the nonfinancial performance metrics such as customer satisfaction and quality levels as well as product development capabilities. High decision-making effectiveness with big data was also shown to improve the nonfinancial performance metrics.

关键词： big data analytics(BDA) attribute of BDA quality decision-making confidence decisionmaking effectiveness financial business performance nonfinancial business performance

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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Synthesis,Properties,and Biological Application of Perfect Crystal Gold Nanowires:A Review

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Journal of Materials Science & Technology 2015年第6期31卷 573-580页

作者： Mijeong kang Hyoban lee Taejoon kang Bongsoo Kim Department of Chemistry KAISTDaejeon 305-701Korea BioNanotechnology Research Center and BioNano Health Guard Research Center

In the last decade,numerous kinds of nanoscale materials have been *** characteristics are critically influenced by their synthetic or fabrication *** this review article,we introduce perfect crystal gold nanowires(Au NWs) synthesized by vapor transport method and summarize their material properties and biological ***-crystalline Au NWs having no defects or twins show unique mechanical,electrical,and electrochemical ***,they are exceptionally competent in penetrating cells or tissues with minimum biological damage and in the electrical analysis and manipulation of biological activities in the cells and/or *** is expected that the Au NWs would give us technological breakthrough in diverse applications such as nanoscale functional components as well as new insights in fundamental material science.

关键词： Nanomaterials Nanostructured metallic materials Na

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Successful treatment of relapsed acute promyelocytic leukemia with arsenic trioxide in a hemodialysis-dependent patient: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5347-5352页

作者： Hee Jeong lee Sang-gon Park Department of Hemato-Oncology Chosun University HospitalGwang-ju 501-717South Korea Department of Internal Medicine Hemato-oncologyChosun University HospitalGwangju 61453South Korea

BACKGROUND Arsenic trioxide(ATO)is recommended for patients who do not achieve molecular remission or who have molecular or morphologic ***,there are no guidelines for adjusting ATO dosage in patients with severe renal failure or on ***,we report the successful treatment of relapsed acute promyelocytic leukemia(APL)in a patient on hemodialysis with ATO single agent and review the cases in *** SUMMARY A 46-year-old woman who has been on hemodialysis to chronic glomerulonephritis for 15 years visited our hospital for *** had been seen for pancytopenia 3 years ago and had been diagnosed with *** also received chemotherapy for APL but unfortunately was lost to follow-up after her second consolidation *** was noted to have pancytopenia by her nephrologist during hemodialysis 1 mo *** marrow biopsy and reverse transcriptase-polymerase chain reaction(RT-PCR)tests revealed a diagnosis of relapsed *** for relapsed APL with ATO single agent was started and she achieved molecular remission after administering 24 doses of *** far,four consolidation therapies have been performed with the ATO single agent,and,to date,the molecular remission has been maintained as negative promyelocytic leukemia/retinoic acid receptor-αfusion gene as confirmed by RTPCR testing for two *** This is a rare case of relapsed APL successfully treated with the single agent ATO in a patient on hemodialysis.

关键词： Arsenic trioxide Acute promyelocytic leukemia Pancytopenia Hemodialysis Promyelocytic leukemia/retinoic acid receptor-αfusion gene Case report

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