检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

公共行政的伦理把握及其取向

中山大学学报（社会科学版） 2006年第5期46卷 94-99页

作者：张康之中国人民大学行政学系北京100872

从20世纪后期开始,行政伦理研究成为一种新的学术热潮,这是对近代以来社会发展中的“形式化”以及工具理性进行理论反思的运动,它要求把价值的因素引入到公共行政的重建中来。但是,当我们对公共行政进行伦理把握的时候,需要超越近代以... 详细信息

从20世纪后期开始,行政伦理研究成为一种新的学术热潮,这是对近代以来社会发展中的“形式化”以及工具理性进行理论反思的运动,它要求把价值的因素引入到公共行政的重建中来。但是,当我们对公共行政进行伦理把握的时候,需要超越近代以来所形成的所谓整体主义和个体主义的思维框架,进而根据合作理念和服务精神去重建公共行政。

关键词：公共行政行政伦理整体主义个体主义

在线全文

学校读者我要写书评

暂无评论

论从经验理性出发的社会治理

中国人民大学学报 2016年第1期30卷 81-90页

作者：张康之中国人民大学国家发展与战略研究院北京100872 中国人民大学公共管理学院北京100872

20世纪后期以来,社会显现出了高度复杂性和高度不确定性。如何在这种条件下开展行动?如何在这一条件下开展社会治理?对这些问题的思考最终指向了人的行动中的理性问题。在工业社会中,人的行动以及社会治理基本上是建立在工具理性和技术... 详细信息

20世纪后期以来,社会显现出了高度复杂性和高度不确定性。如何在这种条件下开展行动?如何在这一条件下开展社会治理?对这些问题的思考最终指向了人的行动中的理性问题。在工业社会中,人的行动以及社会治理基本上是建立在工具理性和技术理性的基础上的,排斥了人的情感和道德。人的情感和道德是否在人的行动以及社会治理中发挥作用?这是由理性的性质所决定的。从经验理性的角度看,集体行动的过程中不仅不应排斥人的情感和道德,反而使人的情感和道德的重要性显现出来。在高度复杂性和高度不确定性条件下开展行动和社会治理,需要从经验理性出发。

关键词：经验理性社会治理情感与道德纲要性理性

在线全文

学校读者我要写书评

暂无评论

透气保水喷膜材料研究

功能材料 2011年第3期42卷 391-394页

作者：张增志侯亮张大伟中国矿业大学(北京)生态功能材料研究所北京100083

提出了一种用于荒漠化地区固沙植草的新材料技术。以OP-10、吐温20和吐温80为乳化剂对可完全降解的废弃植物油乳化,然后对取自荒漠化地区流沙下层的细土质憎水改性,最后配以草籽,混合均匀制成土质憎水改性固沙植草材料。通过对该材料进... 详细信息

提出了一种用于荒漠化地区固沙植草的新材料技术。以OP-10、吐温20和吐温80为乳化剂对可完全降解的废弃植物油乳化,然后对取自荒漠化地区流沙下层的细土质憎水改性,最后配以草籽,混合均匀制成土质憎水改性固沙植草材料。通过对该材料进行水分蒸发测试、模拟植草试验、显微分析、热分析和孔径-孔容分析,结果表明该材料具有透气保水功能,在人工气候箱中模拟植草试验效果明显,其最佳配方:乳化液与分散剂体积比为1:20,乳化液与土质颗粒比3:20(mL/g)。

关键词：植草喷膜荒漠化生态恢复憎水改性透气保水

Sufficient Optimality Conditions for Multiobjective Programming Involving (V, ρ)h,ψ-type Ⅰ Functions

在线全文

学校读者我要写书评

暂无评论

Chinese Quarterly Journal of Mathematics 2012年第3期27卷 409-416页

作者： zhang Qing-xiang JIANG Yan kang Rui-rui College of Mathematics and Computer Science Yanan University Yanan 716000 China ShenmuSeventh Middle School Shenmu 719300 China

New classes of functions namely (V, ρ)_(h,φ)-type I, quasi (V, ρ)_(h,φ)-type I and pseudo (V, ρ)_(h,φ)-type I functions are defined for multiobjective programming problem by using BenTal's generalized algebraic operation. The examples of (V, ρ)_(h,φ)-type I functions are given. The sufficient optimality conditions are obtained for multi-objective programming problem involving above new generalized convexity.

关键词： multiobjective programming (V,p)h,φ-type I functions Pareto efficient solu-tion sufficient optimality conditions

A novel silicone derivative of natural osalmid(DCZ0858)induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2020年第1期5卷 2118-2128页

作者： kang Lu Bo Li Hui zhang Zhijian Xu Dongliang Song Lu Gao Haiguo Sun Liping Li Yingcong Wang Qilin Feng Gege Chen Liangning Hu Rong Wei Yongsheng Xie dandan Yu Xiaosong Wu Weiliang Zhu Jumei Shi Department of Hematology Shanghai Tenth People’s HospitalTongji UniversitySchool of Medicine200072 ShanghaiChina Medical School of Nantong University 226001 NantongChina CAS Key Laboratory of Receptor Research Drug Discovery and Design CenterShanghai Institute of Materia MedicaChinese Academy of Sciences201203 ShanghaiChina

Diffuse large B-cell lymphoma(DLBCL)is a highly heterogeneous malignant tumor characterized by diffuse ***0858 is a novel small molecule with excellent antitumor effects in *** study explored in depth the inhibitory effect of DCZ0858 on DLBCL cell *** Counting Kit-8(CCK-8)and plate colony formation assays were used to evaluate cell proliferation *** cytometry was employed to analyze apoptosis and the cell cycle,and western blotting was used to quantify the expression of cell cycle *** results indicated that DCZ0858 inhibited cell growth in a concentration-dependent and time-dependent manner while inducing no significant toxicity in normal ***,DCZ0858 initiated cell apoptosis via both internal and external apoptotic ***0858 also induced cell cycle arrest in the G0/G1 phase,thereby controlling cell *** investigation of the molecular mechanism showed that the JAK2/STAT3 pathway was involved in the DCZ0858-mediated antitumor effects and that JAK2 was the key target for DCZ0858 *** of JAK2 partly weakened the DCZ0858-mediated antitumor effect in DLBCL cells,while JAK2 overexpression strengthened the effect of DCZ0858 in DLBCL ***,a similar antitumor effect was observed for DCZ0858 and the JAK2 inhibitor ruxolitinib,and combining the two could significantly enhance cancer-suppressive *** xenograft models showed that DCZ0858 inhibited tumor growth in vivo and had low toxicity in important organs,findings that were consistent with the in vitro *** summary,DCZ0858 is a promising drug for the treatment of DLBCL.

关键词： inhibited organs cycle

Fc fragment of immunoglobulin G receptor IIa(FCGR2A)as a new potential prognostic biomarker of esophageal squamous cell carcinoma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2022年第4期135卷 482-484页

作者： Sifen Lu Nan Li Zhiqiang Peng Zuhong Lu Xingyue Tu Wengeng zhang Yulin kang Precision Medicine Key Laboratory of Sichuan Province and Precision Medicine Center West China HospitalSichuan UniversityChengduSichuan 610041China Department of Information Center and National Clinical Research Center for Geriatrics West China HospitalSichuan UniversityChengduSichuan 610041China State Key Laboratory of Proteomics National Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 100850China State Key Lab of Bioelectronics National Demonstration Center for Experimental Biomedical Engineering EducationSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China Institute of Environmental Information Chinese Research Academy of Environmental SciencesBeijing 100012China

To the Editor: Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancer types and places a heavy burden on human health. The early diagnosis and prognosis monitoring of ESCC is important for therapy. Despite recent progress in treatment regimens for ESCC, the prognosis of ESCC remains poor.[1] Therefore, it is important to find new molecular therapeutic targets and prognostic monitoring biomarkers for ESCC patients. In this study, we aimed to explore new prognostic biomarkers for ESCC.

关键词： squamous prognosis esophageal

Deep Sequencing of Brachypodium Small RNAs at the Global Genome Level Identifies MicroRNAs involved in Cold Stress Response

在线全文

学校读者我要写书评

暂无评论

Deep Sequencing of Brachypodium Small RNAs at the Global Gen...

Phospho-Pon Binding-Mediated Fine-Tuning of Plk1 Activity

第十二届全国植物基因组学大会

作者： Jingyu zhang,Yunyuan Xu,Qing Huan,kang Chong~* 中科院植物所

High-throughput sequencing and whole-genome-wide data mining led to the identification of 27 conserved miRNAs,as well as 129 predicted miRNAs in *** expression of 3 conserved miRNAs and 25 predicted miRNAs showed significant changes in response to cold *** these miRNAs, some were cold-induced and some were cold-suppressed,but all the conserved miRNAs were up-regulated under cold stress *** results suggest that Brachypodium miRNAs are composed of a set of

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Phospho-Pon Binding-Mediated Fine-Tuning of Plk1 Activity

周期外力对频率涨落的过阻尼谐振子所作的功和能量随机共振

中国生物化学与分子生物学会2016年全国学术会议

作者： kang Zhu Zelin Shan Lu zhang Wenyu Wen Department of Neurosurgery Huashan Hospital Institutes of Biomedical SciencesFudan University Key Laboratory of Metabolism and Molecular Medicine Ministry of Education Department of Systems Biology for Medicine School of Basic Medical Sciences Shanghai Medical College of Fudan University

Asymmetric cell division(ACD)is a fundamental process in stem cell self-renewal and *** the ACD of Drosophila neuroblasts(NBs),the asymmetric localization of cell-fate determinants ensure the proper segregation of fate determinants between daughter cells,thereby endowing them with distinct cell *** polarized distribution of Numb is

关键词： Polo-like kinase 1 Partner of Numb PBD domain Cdk1 sequential phosphorylation Asymmetric cell division

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

物理学报 2013年第19期62卷 58-62页

作者：张良英曹力吴大进湖北文理学院物理与电子工程学院襄阳441053

研究了周期外力对频率涨落的过阻尼谐振子系统作功的特点.结果揭示了瞬时功率随时间的周期变化出现不对称性.研究结果还揭示周期外力一个周期对系统所做的功随乘法噪声强度的变化出现非单调行为,系统是否出现能量随机共振与抑制并存,由... 详细信息

研究了周期外力对频率涨落的过阻尼谐振子系统作功的特点.结果揭示了瞬时功率随时间的周期变化出现不对称性.研究结果还揭示周期外力一个周期对系统所做的功随乘法噪声强度的变化出现非单调行为,系统是否出现能量随机共振与抑制并存,由乘法噪声与加法噪声之间互关联的符号决定.

关键词：过阻尼谐振子频率涨落周期外力作功能量随机共振与抑制