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Infectious Diseases of Poverty 2014年第1期3卷 397-413页

作者： kang yiu lai Wing yiu George Ng Fan Fanny Cheng Department of Intensive Care Queen Elizabeth HospitalHKSARB630 Gascoigne RdKowloonHong Kong SARChina Department of Medicine Queen Elizabeth HospitalHKSARKowloonHong Kong SAR China

The recent outbreak of the human Zaire ebolavirus(EBOV)epidemic is spiraling out of control in West *** EBOV hemorrhagic fever has a case fatality rate of up to 90%.The EBOV is classified as a biosafety level 4 pathogen and is considered a category A agent of bioterrorism by Centers for Disease Control and Prevention,with no approved therapies and vaccines available for its treatment apart from supportive *** several promising therapeutic agents and vaccines against EBOV are undergoing the Phase I human trial,the current epidemic might be outpacing the speed at which drugs and vaccines can be *** all viruses,the EBOV largely relies on host cell factors and physiological processes for its entry,replication,and *** have reviewed currently available therapeutic agents that have been shown to be effective in suppressing the proliferation of the EBOV in cell cultures or animal *** of the therapeutic agents in this review are directed against non-mutable targets of the host,which is independent of viral *** medications are approved by the Food and Drug Administration(FDA)for the treatment of other *** are available and stockpileable for immediate *** may also have a complementary role to those therapeutic agents under development that are directed against the mutable targets of the EBOV.

关键词： Ebola virus Non-mutable host cell therapeutic targets for Ebola virus Cocktail therapeutic intervention for RNA virus

Machine learning and neural network supported state of health simulation and forecasting model for lithium-ion battery

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Frontiers in Energy 2024年第2期18卷 223-240页

作者： Nan QI kang YAN Yajuan YU Rui LI Rong HUANG lai CHEN Yuefeng SU Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China Department of Energy and Environmental Materials School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Electric Vehicle Co. Ltd.Beijing 100176China

As the intersection of disciplines deepens,the field of battery modeling is increasingly employing various artificial intelligence(AI)approaches to improve the efficiency of battery management and enhance the stability and reliability of battery *** paper reviews the value of AI methods in lithium-ion battery health management and in particular analyses the application of machine learning(ML),one of the many branches of AI,to lithium-ion battery state of health(SOH),focusing on the advantages and strengths of neural network(NN)methods in ML for lithium-ion battery SOH simulation and *** is one of the important branches of ML,in which the application of NNs such as backpropagation NN,convolutional NN,and long short-term memory NN in SOH estimation of lithium-ion batteries has received wide *** so far have shown that the utilization of NN to model the SOH of lithium-ion batteries has the advantages of high efficiency,low energy consumption,high robustness,and scalable *** the future,NN can make a greater contribution to lithium-ion battery management by,first,utilizing more field data to play a more practical role in health feature screening and model building,and second,by enhancing the intelligent screening and combination of battery parameters to characterize the actual lithium-ion battery SOH to a greater *** in-depth application of NN in lithium-ion battery SOH will certainly further enhance the science,reliability,stability,and robustness of lithium-ion battery management.

关键词： machine learning lithium-ion battery state of health neural network artificial intelligence

Investigation of pore structure alteration and permeability enhancement of shale matrix by supercritical water treatment after hydraulic fracturing

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Petroleum 2024年第2期10卷 265-274页

作者： Yili kang Peisong Li Wangkun Cao Mingjun Chen Lijun You Jiang Liu Zhehan lai State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University Institute of Engineering Technology PetroChina Coalbed Methane Company Limited Chemical and Petroleum Engineering University of Calgary

Shale gas reservoirs are unconventional tight gas reservoirs, in which horizontal wells and hydraulic fracturing are required to achieve commercial development. The fracture networks created by hydraulic fracturing can increase the drainage area extensively to enhance shale gas recovery. However, large volumes of fracturing fluid that is difficult to flow back to the surface and remained in the shale formation, will inevitably lead to damages of the shale formations and limit the effectiveness of *** water(SCW) treatment after hydraulic fracturing is a new method to enhance shale gas recovery by using appropriate heat treatment methods to the specific formation to convert the retained fracturing fluid into a supercritical state(at temperatures in excess of 373.946°C and pressures in excess of 22.064 MPa). An experiment was conducted to simulate the reaction between shale and SCW, and the capacity of SCW treatment to enhance the permeability of the shale was evaluated by measuring the response of the shale porosity and permeability on SCW treatment. The experimental results show that the shale porosity and permeability increase by 213.43% and 2198.37%, respectively. The pore structure alteration and permeability enhancement of the shale matrix were determined by analyzing the changes in pore structure and mineral composition after SCW treatment. The mechanisms that affect pore structure and mineral composition include oxidative catalysis decomposition of organic matters and reducing minerals, acid-catalyzed decomposition of carbonate minerals and feldspar minerals, hydrothermal catalysis induced fracture extension and cementation weakening induced fracture *** treatment converts harm into a benefit by reducing the intrusion of harmful substances into the shale formation, which will broaden the scope and scale of shale formation stimulation.

关键词： Shale gas Formation damage control Formation heat treatment Supercritical water

Efficient piezo-catalytic dye degradation using piezoelectric 6H-SiC under harsh conditions

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Rare Metals 2024年第7期43卷 3173-3184页

作者： Lin-Lin Zhou Tao Yang kang Wang lai-Pan Zhu En-Hui Wang Kuo-Chih Chou Hai-Long Wang Xin-Mei Hou Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Institute of Steel Sustainable Technology Liaoning Academy of MaterialsShenyang 110000China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Materials Science Engineering Zhengzhou UniversityZhengzhou 450001China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing University of Science and TechnologyBeijing 100083China

The development of novel piezoelectric catalysts against harsh conditions is indeed crucial for improving the piezo-catalytic degradation efficiency of colored organic dyes in *** this work,6H-SiC nanoparticles(NPs)are utilized to piezo-catalytic degrade rhodamine B(RhB)and methylene blue(MB)under ultrasonic vibration for the first *** degradation efficiency of RhB and MB reaches 98.8%and 98.7%within 80 *** piezoelectricity of 6H-SiC is comprehensively analyzed by the piezoresponse force microscope(PFM)and finite element method(FEM).The strong oxidizing active free radicals generated by the continuous piezoelectric polarized electric field of 6H-SiC,i.e.,·O_(2)^(-)and·OH,induce the decomposition reactions of colored organic dyes in *** the dyes are proven to degrade to harmless or less-harmful products gradually during the piezo-catalysis process by high-performance liquid chromatography tandem mass spectrometry(HPLC-MS).Moreover,RhB is also decomposed efficiently by 6HSiC NPs under acidic and alkaline *** results prove the feasibility of 6H-SiC for decomposing common water pollutants under harsh conditions and provide a new perspective for water purification.

关键词： Piezo-catalytic degradation 6H-SiC Rhodamine B(RhB) Methylene blue(MB) Harsh conditions

Prostate health index can stratify patients with Prostate Imaging Reporting and Data System score 3 lesions on magnetic resonance imaging to reduce prostate biopsies

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Asian Journal of Andrology 2024年第1期26卷 20-24页

作者： John Shung-lai Leung Wai-Kit Ma Brian Sze-Ho Ho Stacia Tsun-Tsun Chun Rong Na Yongle Zhan Chi-Yuen Ng Chi-Ho Ip Ada Tsui-Lin Ng yiu-Chung Lam Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina Division of Urology Department of SurgeryPrincess Margaret HospitalHongKongChina

We aim to evaluate prostate health index as an additional risk-stratification tool in patients with Prostate Imaging Reporting and Data System score 3 lesions on multiparametric magnetic resonance *** with biochemical or clinical suspicion of having prostate cancer who underwent multiparametric magnetic resonance imaging in two tertiary centers(Queen Mary Hospital and Princess Margaret Hospital,Hong Kong,China)between January 2017 and June 2022 were ***-magnetic resonance imaging fusion biopsies were performed after prostate health index *** who only had Prostate Imaging Reporting and Data System score 3 lesions were further stratified into four prostate health index risk groups and the cancer detection rates were *** of the 747 patients,47.3%had Prostate Imaging Reporting and Data System score 3 lesions *** detection rate of clinically significant prostate cancer in this group was 15.0%.The cancer detection rates of clinically significant prostate cancer had statistically significant differences:5.3%in prostate health index<25.0,7.4%in prostate health index 25.0-34.9,17.9%in prostate health index 35.0-54.9,and 52.6%in prostate health index≥55.0(P<0.01).Among the patients,26.9%could have avoided a biopsy with a prostate health index<25.0,at the expense of a 5.3%risk of missing clinically significant prostate *** health index could be used as an additional risk stratification tool for patients with Prostate Imaging Reporting and Data System score 3 *** could be avoided in patients with low prostate health index,with a small risk of missing clinically significant prostate cancer.

关键词： biopsy fusion biopsy magnetic resonance imaging prostate cancer prostate health index

High mechanical strength Si anode synthesis with interlayer bonded expanded graphite structure for lithium-ion batteries

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Journal of Energy Chemistry 2024年第6期93卷 253-263,I0007页

作者： Wenhui lai Jong Hak Lee Lu Shi Yuqing Liu Yanhui Pu Yong kang Ong Carlos Limpo Ting Xiong Yifan Rao Chorng Haur Sow Barbaros Ozyilmaz Department of Material Science&Engineering National University of SingaporeSingapore 117575Singapore Center for Advanced 2D Materials National University of SingaporeSingapore 117546Singapore Department of Physics National University of SingaporeSingapore 117551Singapore Institute forFunctional Intelligent Materials National University of SingaporeSingapore 117544Singapore

Despite advancements in silicon-based anodes for high-capacity lithium-ion batteries,their widespread commercial adoption is still hindered by significant volume expansion during cycling,especially at high active mass loadings crucial for practical *** root of these challenges lies in the mechanical instability of the material,which subsequently leads to the structural failure of the ***,we present a novel synthesis of a composite combining expanded graphite and silicon *** composite features a unique interlayer-bonded graphite structure,achieved through the application of a modified spark plasma sintering ***,this innovative structure not only facilitates efficient ion and electron transport but also provides exceptional mechanical strength(Vickers hardness:up to658 MPa,Young's modulus:11.6 GPa).This strength effectively accommodates silicon expansion,resulting in an impressive areal capacity of 2.9 mA h cm^(-2)(736 mA h g^(-1)) and a steady cycle life(93% after 100cycles).Such outsta nding performance is paired with features appropriate for large-scale industrial production of silicon batteries,such as active mass loading of at least 3.9 mg cm^(-2),a high-tap density electrode material of 1.68 g cm^(-3)(secondary clusters:1.12 g cm^(-3)),and a production yield of up to 1 kg per day.

关键词： Lithium-ion battery Silicon anode Spark plasma sintering Interlayer bonding Mechanical strength Tap density

Sulfonated carbon dots modified IrO_(2)nanosheet as durable and high-efficient electrocatalyst for boosting acidic oxygen evolution reaction

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Nano Research 2024年第9期17卷 8017-8024页

作者： Mengjie Ma Wenxiang Zhu Fan Liao Kui Yin Hui Huang Kun Feng Dongdong Gao Jinxin Chen Zenan Li Jun Zhong lai Xu Yang Liu Mingwang Shao Zhenhui kang Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Macao Institute of Materials Science and Engineering(MIMSE) Macao University of Science and TechnologyTaipaMacao 999078China

Oxygen evolution reaction(OER)plays a crucial role in developing energy conversion and adjusting electronic structure of the electrocatalysts can effectively improve the catalytic activity and ***,it is a challenge to adjust the electronic structure on two-dimensional iridium dioxide nanosheets(IrO_(2)NS),which have the advantages of high atom ***,we regulate the surface properties of IrO_(2)NS through sulfonated carbon dots(SCDs)to promote the OER catalytic *** catalyst IrO_(2)NS/SCDs-2 exhibited excellent catalytic activity with a lower overpotential of 180 mV than IrO_(2)NS(230 mV)at the current density of 10 mA·cm^(-2)in a 0.5 M H2SO4 *** after 160 h of stability testing,the overpotential of IrO_(2)NS/SCDs-2 only decreased by 4 ***,transient potential scanning test can visually demonstrate that the addition of SCDs improves the conductivity of the catalyst and increases the electron transfer rate.

关键词： sulfonated carbon dots oxygen evolution reaction electrocatalysis transient potential scanning

Maillard reaction affecting immunobinding activity and digestibility of tropomyosin in Alectryonella plicatula food matrix

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Food Science and Human Wellness 2024年第5期13卷 2959-2969页

作者： Chenchen Yu Xinrong He Nairu Ji Shuai kang Dongxiao Li Huilin Zhang Yang Yang Dong lai Qingmei Liu Guangming Liu College of Ocean Food and Biological Engineering Xiamen Key Laboratory of Marine Functional FoodFujian Provincial Engineering Technology Research Center of Marine Functional FoodJimei UniversityXiamen 361021China The Second Affiliated Hospital of Xiamen Medical College Xiamen 361021China

In recent years,the allergy rate of oysters has surged,and daily food processing methods make it hard to reduce heat resistance and digestive allergy such as tropomyosin(TM).In this study,the Maillard reaction with xylose significantly reduced the IgE binding capacity of Alectryonella plicatula food matrix(AFM),that reduced by(77.81±2.68)%.The study found the Maillard reaction changes the structure of the AFM,in which the content ofα-helix decreased by(24.64±1.46)%.Structural transformation further explains why the Maillard reaction alters the immunobinding activity of *** addition,the Maillard reaction reduces the digestive stability of the AFM and makes TM in the *** food matrix Maillard reaction products(AFM-MRPs)more easily *** on the above research,10 amino acids on the 7 IgE epitopes of TM were *** result indicates that the Maillard reaction reduces the immunobinding activity of the AFM by changing the structure and modifying the amino acids on the epitope.

关键词： Alectryonella plicatula Food matrix Immunobinding activity Maillard reaction Tropomyosin

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Publication scope and priorities of FESE in an evolving world: An editorial update and perspective

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 169-171页

作者： Deng Shubo Jin Rencun Liang Sai Liu Fudong Liu, Jinyong Lyu lai Ning Daliang Pan Bingcai van Hullebusch Eric Wang, Bin Wen Xianghua kang, Xiao Xu, Elvis Genbo Yang, Hong Qi, Ying Zhan Xinmin Zhao Dongye

Frontiers of Environmental Science&Engineering(FESE)is one of the flagship journals of the Chinese Academy of *** is an international peer-reviewed journal that publishes cutting-edge scientific work in all aspects of environmental *** 2007,FESE has been an important platform for communicating the cutting-edge progress of theories,methods,technologies,and policies in environmental science and *** authors and readers involve scientists,engineers,and policymakers that are important stakeholders in dealing with environmental *** authors are encouraged to review recent issues of FESE to gain a deep understanding of the topics that are of great interest to the journal’s *** the cover letter,please clearly state the relevance to the journal’s publication scope and *** particular,prospective authors are directed to the following instructions for further details on the scope,novelty and quality expectations,and minimum requirements.

关键词： journal please dealing

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软黏土中吸力锚承载特性离心试验研究

岩土力学 2024年第5期45卷 1472-1480页

作者：熊根付栋康朱斌赖莹中国电建集团华东勘测设计研究院有限公司浙江杭州311122 浙江大学建筑工程学院浙江杭州310058

加载倾角和系泊点位置是吸力锚基础最重要的设计要素之一,能够改变锚体的破坏姿态以影响极限承载力。在饱和软黏土地基中选择不同的加载倾角及系泊点位置进行位移控制下的张紧式吸力锚离心模型试验,利用六自由度磁力计装置定量分析了加... 详细信息

加载倾角和系泊点位置是吸力锚基础最重要的设计要素之一,能够改变锚体的破坏姿态以影响极限承载力。在饱和软黏土地基中选择不同的加载倾角及系泊点位置进行位移控制下的张紧式吸力锚离心模型试验,利用六自由度磁力计装置定量分析了加载倾角和系泊点位置对吸力锚破坏姿态与极限承载力的影响。研究发现,系泊点位置在锚体约2/3高度时,吸力锚发生平动破坏,当加载倾角由35°变化至20°时,在相同的系泊点位置,吸力锚发生后仰破坏,归一化极限承载力稍增大,并且达到极限承载力后仍保持一定的承载力余量;系泊点位置在锚体2/3高度以上时,吸力锚发生前倾破坏,归一化极限承载力降低了25%左右,并且破坏后的承载力余量大大降低。无论破坏模式如何,均未发现锚内土塞与锚有明显分离。

关键词：离心模型试验吸力锚加载倾角系泊点位置破坏姿态极限承载力