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Optical coherence tomography findings in chronic progressive external ophthalmoplegia

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Chinese Medical Journal 2019年第10期132卷 1202-1207页

作者： Yuan Wu lei kang Hai-Long Wu Yue Hou Zhao-Xia Wang Department of Ophthalmology Peking University First Hospital Beijing 100034 China Department of Neurology Peking University First Hospital Beijing 100034 China

Background: Chronic progressive external ophthalmoplegia (CPEO) is a mitochondrial encephalomyopathy caused by multiple mtDNA abnormalities. There is little information about the changes of ocular fundus with CPEO. The aim of this work was to measure and evaluate changes in the macular retinal thickness and optic nerve head in patients with CPEO using spectral-domain optical coherence tomography and to compare the findings with those of healthy individuals. Methods: Totally, 18 CPEO patients were enrolled in this study. Healthy volunteers matched for gender, age, and diopter settings were included as a control group. The retinal thickness of macular central fovea, inner and outer retinal layer thickness of perifoveal macular, optic nerve head parameters, and peripapillay retinal nerve fiber layer thickness (pRNFLT) for all included cases were measured using spectral-domain optical coherence tomography. A paired t test was used to compare the differences in the studied parameters between the two groups. The correlations between macular retinal thickness, pRNFLT, disease duration, and age of onset were also analyzed. Results: Among the macular parameters, retinal thickness of macular central fovea (t=—2.135, P < 0.05) and outer retinal layer thickness (t =—1.994, P < 0.05) of patients in the CPEO group were statistically significant lower than those of patients in the normal control group. For the optic nerve head parameters, the patients in the CPEO group showed a larger rim volume (t =—2.499, P < 0.05) and nerve head volume (t =—2.103, P < 0.05). The overall pRNFLT of patients in the CPEO group was statistically significant lower than that of patients in the control group (t =—4.125, P < 0.05). The comparison of pRNFLT in eight sectors showed that the pRNFLT of patients in the CPEO group was statistically significant lower than that of the control group mainly in the inferior and temporal sectors. The degree of pRNFL defect negatively correlated with the disease dur

关键词： Optical coherence tomography Chronic progressive external ophthalmoplegia Retina Nerve fiber layer

Solution-processed all-inorganic lead halide perovskite/layered double hydroxides superlattices

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Science China Chemistry 2024年第9期67卷 2904-2910页

作者： Deyu Li Mingming Zhang Lulu Wei Shubing Tian Mingze Sun kang Liu Jixiang Xu lei Wang Jun Xing Key Laboratory of Eco-chemical Engineering Ministry of EducationCollege of Chemistry and Molecular EngineeringQingdao University of Science&TechnologyQingdao 266042China College of Sino-German Science and Technology Qingdao University of Science&TechnologyQingdao 266042China

Quantum wells and superlattices are key building blocks in the semiconductor industry,normally fabricated using epitaxial growth techniques,such as vapor phase epitaxy,metalorganic chemical vapor deposition and molecular beam ***,these complicated preparation processes,as well as their high cost,limit their extensive *** is essential to develop a simple solution process for building ***,we demonstrate an ion exchange strategy for synthesizing an allinorganic superlattice cesium lead bromide/layered double hydroxides(CsPbBr_3/LDH)in *** room temperature,the perovskite ions diffuse into the interlayer of LDH and assemble into layered perovskite with various *** with traditional organic-inorganic hybrid perovskite superlattice,the all-inorganic perovskite superlattice CsPbBr_(3)/LDH has weak quantum confinement,which exhibits narrow emission line-widths of 20 nm,high quantum yields of 55%,and radiative lifetimes of several *** findings offer a new route to synthesize novel perovskite superlattices and enrich the perovskite supercrystal platform for electronics,photonics and optoelectronics devices.

关键词： halide perovskite superlattice layered double hydroxides 2D

Fabrication and characteristics of ZnO MOS capacitors with high-K HfO_2 gate dielectrics

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Science China(Technological Sciences) 2010年第9期53卷 2333-2336页

作者： HAN DeDong,WANG Yi,ZHANG ShengDong,SUN lei,kang JinFeng,LIU XiaoYan,DU Gang,LIU LiFeng & HAN RuQi Institute of Microelectronics,Peking University,Beijing 100871,China Institute of Microelectronics Peking University Beijing China

ZnO thin films are first deposited on n-type silicon by radio frequency (rf) magnetron sputtering at room *** high-K HfO2 gate dielectrics thin films are deposited on ZnO films to form metal-oxide semiconductor (MOS) *** temperature to fabricate ZnO MOS capacitors is 400°C,and the low temperature process is applicable for thin film transistors,flat-panel display (FPD),flexible display,*** electronic availability of ZnO thin films,which serve as a semiconductor material for MOS capacitors with HfO2 gate dielectric is *** frequency (1 MHz) capacitance-voltage (C-V) and current-voltage (I-V) characteristics of ZnO-based MOS capacitors are *** thermal stability and electronic stability of the ZnO capacitors are investigated,*** results indicate that good electrical characteristics can be obtained on ZnO substrates with high-K HfO2 gate ***,the ZnO capacitors can exhibit high thermal and electronic stabilities.

关键词： ZnO high-K HfO2 low temperature process

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浓香型白酒“增己降乙”工艺研究进展

酿酒科技 2024年第1期 107-111页

作者：赵宏朋雷康吴华星李浩熊峰陈勇邱毅廖俊羊朱亮四川水井坊股份有限公司四川成都610036

在浓香型白酒中,己酸乙酯、乙酸乙酯等酯类物质比例关系到酒体风格和酒质,它们是生产技术人员非常看重的关键性指标。本文归纳了影响浓香型白酒己酸乙酯与乙酸乙酯含量的因素,综述了浓香型白酒酿造工艺及微生物对“增己降乙”的影响,对... 详细信息

在浓香型白酒中,己酸乙酯、乙酸乙酯等酯类物质比例关系到酒体风格和酒质,它们是生产技术人员非常看重的关键性指标。本文归纳了影响浓香型白酒己酸乙酯与乙酸乙酯含量的因素,综述了浓香型白酒酿造工艺及微生物对“增己降乙”的影响,对贮存中影响己酸乙酯、乙酸乙酯的条件及相关物理技术研究应用进行探讨,为浓香型白酒企业改善酒质提供参考,助力浓香型白酒进一步健康发展。

关键词：增己降乙己酸乙酯乙酸乙酯浓香型白酒乙己比

脑脊液乳酸联合血肌钙蛋白I、N末端脑钠肽前体水平对动脉瘤性蛛网膜下腔出血预后有预测价值

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内科急危重症杂志 2024年第1期30卷 51-54,74页

作者：康寿磊李金秀荣风燕李亚霖王文涛山东第一医科大学附属聊城第二人民医院重症医学科山东临清252600

目的:探讨脑脊液中乳酸联合血肌钙蛋白I (cTnI)、N末端脑钠肽前体(NT-proBNP)水平对动脉瘤性蛛网膜下腔出血(aSAH)患者预后的评估价值。方法:选择80例aSAH患者,检测并记录患者发病后第1、3、7天脑脊液乳酸浓度,收集患者血常规、肝肾功... 详细信息

目的:探讨脑脊液中乳酸联合血肌钙蛋白I (cTnI)、N末端脑钠肽前体(NT-proBNP)水平对动脉瘤性蛛网膜下腔出血(aSAH)患者预后的评估价值。方法:选择80例aSAH患者,检测并记录患者发病后第1、3、7天脑脊液乳酸浓度,收集患者血常规、肝肾功能、心肌酶、血气分析等指标。3个月后对患者进行随访,根据格拉斯哥预后评分将其分为预后良好组和预后不良组,比较2组患者以上指标,绘制受试者工作特征(ROC)曲线,分析脑脊液乳酸联合血cTnI、NT-proBNP对预后的评估价值。结果:80例患者中预后良好45例,预后不良35例。预后良好组第1、3天脑脊液乳酸浓度明显低于预后不良组(P<0.05),ROC曲线分析显示第1天脑脊液乳酸浓度对aSAH预后的评估效能优于第3天、第7天,曲线下面积(AUC)分别为0.842、0.657、0.533。预后良好组患者血尿素氮、血糖、pH、cTnI、NT-proBNP明显低于预后不良组(P均<0.05),ROC曲线分析显示第1天脑脊液乳酸浓度联合血cTnI、NT-proBNP对预后的评估效能最高,AUC为0.94,灵敏度88.6%,特异性88.9%,优于尿素氮、血糖、pH及单项cTnI和NT-proBNP。结论:脑脊液中乳酸浓度联合血cTnI、NT-proBNP水平对aSAH预后有较高的预测价值。

关键词：动脉瘤性蛛网膜下腔出血脑脊液乳酸肌钙蛋白Ⅰ N末端脑钠肽前体

Chemoselective and Living/Controlled Polymerization of Alkenyl Methacrylates by the Phosphonium Ylide/Organoaluminum Lewis Pairs

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Chinese Journal of Polymer Science 2024年第2期42卷 159-167,I0005页

作者： Zhi-kang Chen Wu-Chao Zhao Yi-Ling Zhao Cong-lei Liu Liu-Yin Jiang Yue-Tao Zhang Hong-Ping Zhu State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012China

Chemoselective,living/controlled polymerizations of allyl methacrylate(AMA) and vinyl methacrylate(VMA) with/without methyl methacrylate(MMA) by using the phosphonium ylide/organoaluminum based Lewis pairs(LPs) have been *** P-ylide-2/AIMe(BHT)_(2)(Pylide-2=Ph_(3)P=CHMe and BHT=2,6-iBu_(2)-4-MeC_(6)H_(2)O) was demonstrated to be superior by which homopolymers PAMAs(M_(n)=27.6-111.5kg/mol and ■=1.14-1.25) and PVMAs(M_(n)=28.4-78.4 kg/mol and ■=1.12-1.18) and block copolymers PMMA-b-PAMA,PAMA-b-PVMA,PAMA-bPMMA,PMMA-b-PAMA-b-PMMA,PAMA-b-PMMA-b-PAMA,and PAMA-b-PVMA-b-PAMA were *** the polymerizations,all of the monomers were reacted by the conjugated ester vinyl groups leaving intactly the nonconjugated acryloxy *** pendant acryloxy groups attached to the main chain enable further to post-functionalization by the AIBN-induced radical "thiol-ene" reaction using PhCH_(2)*** thiolether side group-containing polymers PAMA-SCH_(2)Ph and PAMA-SCH_(2)Ph-b-PMMA-b-PAMA-SCH_(2)Ph were thus prepared.

关键词： Phosphonium ylide Alkenyl methacrylate Chemoselectivity Living/controlled polymerization Post-functionalization

Effects of radiation-induced suicide gene therapy under radiation of radionuclide 125I on human hepatocarcinoma cells in vitro

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Chinese Medical Journal 2014年第7期127卷 1385-1387页

作者： Li Ling Zhang Chunli Yan Ping Yin lei kang lei Zhao Qian Wang Rongfu Key Laboratory of Nuclear Medicine Ministry of Health Jiangsu Key Laboratory of Molecular Nuclear Medicine Jiangsu Institute of Nuclear Medicine Wuxi Jiangsu 214063 China Department of Nuclear Medicine Peking University First HospitalBeijing 100034 China

There are few efficient therapeutic approaches to *** et al1 developed iodine （131I） metuximab injection （Licartin）,a novel 131I-labeled HAb18G/CD147-specific monoclonal antibody Fab＇2 ***18G/CD147 is a hepatocellular carcinoma-associated *** their results have no obvious improvements in survival rate of patients with ***：radiation effects; promoter regions, genetic lentivirus; cytosine deaminase; fluorocytosine; HepG2 cells

关键词： radiation effects promoter regions, genetic lentivirus cytosine deaminase fluorocytosine HepG2 cells

Fast prototype and rapid construction of three-dimensional and multi-scaled pitcher for controlled drainage by systematic biomimicry

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International Journal of Extreme Manufacturing 2024年第3期6卷 489-503页

作者： Tao Shen Ning Li Shijie Liu Cunlong Yu Chengqi Zhang kang Yang Xingfei Li Ruochen Fang lei Jiang Zhichao Dong Research Institute for Frontier Science Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education BeijingSchool of ChemistryBeihang UniversityBeijing 100191People’s Republic of China CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083People’s Republic of China School of Future Technology&School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 101407People’s Republic of China School of Chemistry and Materials Science University of Science and Technology of China230026 HefeiAnhuiPeople’s Republic of China Suzhou Institute for Advanced Research University of Science and Technology of China215123 SuzhouJiangsuPeople’s Republic of China State Key Laboratory of Precision Measuring Technology and Instruments Tianjin University300072 TianjinPeople’s Republic of China

Biomimetic materials that use natural wisdom to solve practical problems are developing *** trend for systematic biomimicry is towards in-situ characterization of naturalcreatures with high spatial ***,rapid reconstruction of digital twin models with the same complex features as the prototype is ***,it faces bottlenecks and limits in fast characterization and fabrication,precise parameter optimization,geometricdeviations control,and quality *** solve these challenges,here,we demonstrate astate-of-the-art method taking advantage of micro-computed tomography and three-dimensional printing for the fast characterization of the pitcher plant Nepenthes x ventrata and fabrication of its biomimetic model to obtain a superior drainage controller with multiscale structures withprecise surface morphology optimization and geometric deviation ***-rupture-based drainage dynamic and mechanisms are characterized by x-ray and high-speed videography,which determines the crucial structures for unique *** the optimized artificial pitchers are further developed into sustained drainage devices with novel applications,such as detection,reaction,and smoke control.

关键词： systematic biomimicry biomimetic materials Micro-CT drainage digital twin

Effect of different quenching processes following solid-solution treatment on properties and precipitation behaviors of 7050 alloy

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Transactions of Nonferrous Metals Society of China 2018年第11期28卷 2163-2173页

作者： lei kang Gang ZHAO Guang-dong WANG Kun LIU Ni TIAN Key Laboratory for Anisotropy and Texture of Materials Ministry of EducationSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Department of Applied Science University of Quebec at ChicoutimiQuebecG7H 2B1Canada

The effects of quenching in different ways following solid-solution treatment on properties and precipitation behaviors of7050 alloy were investigated by transmission electron microscopy （TEM）, scanning electron microscopy （SEM）, selected areaelectron diffraction （SAED）, hardness and electrical conductivity tests. Results show that after quenching in different ways, electricalconductivity of the alloy decreases rapidly in the first 48 h of natural aging. The electrical conductivity of 7050 alloy in natural agingstate is determined by the size and density of GP zones, and the size of GP zones is the main factor. After natural aging for 70 d, thesize of GP zones is 1.8-2.6 nm in matrix of the immersion quenched sample and it is 1.4-1.8 nm in matrix of both water mist andforced air quenched samples. After natural and artificial peak aging, the hardness of the water mist quenched sample is HV 193.6 andits electrical conductivity is 30.5% （IACS） which are both higher than those of the immersion quenched sample. Therefore, watermist quenching is an ideal quenching method for 7050 alloy sheets after solid-solution treatment.

关键词： 7050 aluminum alloy quenching method precipitation behavior electrical conductivity nucleation site