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Two-year delay in ulcerative colitis diagnosis is associated with anti-tumor necrosis factor alpha use

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World Journal of Gastroenterology 2019年第8期25卷 989-1001页

作者： Ho Suk kang Ja-Seol Koo kang Moon lee Dae-Bum Kim Ji Min lee Yoon Jae Kim Hyuk Yoon hyun Joo Jang Department of Internal Medicine Hallym Sacred Heart HospitalHallym University College of MedicineAnyang 14068South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Ansan HospitalDepartment of Internal MedicineKorea University College of MedicineAnsan 15355South Korea Department of Internal Medicine The Catholic University of KoreaSt.Vincent’s HospitalSuwon 16247South Korea Department of Gastroenterology Gachon Graduate School of Medicine Gil Medical CenterIncheon 21565South Korea Department of Internal Medicine Seoul National University Bundang HospitalSeongnam 13620South Korea Division of Gastroenterology Department of Internal MedicineDongtan Sacred Heart HospitalHallym University College of MedicineHwaseong 18450South Korea

BACKGROUND Ulcerative colitis(UC)is an uncommon inflammatory bowel disease(IBD).However,its incidence has recently increased in South ***,UC diagnoses are frequently delayed,and the relationship between diagnostic delay and UC prognosis has not been extensively studied in South Korean *** To identify meaningful diagnostic delay affecting UC prognosis and to evaluate risk factors associated with diagnostic delay in South Korean *** Medical records of 718 patients with UC who visited the outpatient clinic of six university hospitals in South Korea were reviewed;167 cases were excluded because the first symptom date was *** evaluated the relationship between the prognosis and a diagnostic delay of 3,6,12,18,and 24 mo by comparing the prognostic factors[anti-tumor necrosis factor(TNF)-αuse,admission history due to acute flare-ups,frequent admission due to flare-ups,surgery associated with UC,and the clinical remission state at the latest followup]at each diagnostic *** The mean diagnostic interval was 223.3±483.2 d(median,69 d;75th percentile,195 d).Among the prognostic factors,anti-TNFαuse was significantly increased after a diagnostic delay of 24 *** risk factors predictive of a 24-mo diagnostic delay were age24 mo was associated with increased anti-TNFα***<60 years at diagnosis,smoking history,and misdiagnosis of hemorrhoids were risk factors for delayed diagnosis.

关键词： Ulcerative colitis Diagnostic delay Anti-tumor necrosis factor alpha Smoking

Long-term outcomes of focal laser photocoagulation for the treatment of polypoidal choroidal vasculopathy

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1402-1407页

作者： Sooyeon Choe hyun Goo kang Kyu hyung Park Christopher Seungkyu lee Se Joon Woo Department of Ophthalmology Seoul National University College of MedicineSeoul National University HospitalSeoul 03080Republic of Korea Department of Ophthalmology Institute of Vision ResearchGangnam Severance HospitalYonsei University College of MedicineSeoul 06273Republic of Korea Department of Ophthalmology Seoul National University Bundang HospitalSeongnam 13620Republic of Korea Department of Ophthalmology Institute of Vision ResearchSeverance HospitalYonsei University College of MedicineSeoul 03722Republic of Korea

AIM:To evaluate the long-term effect and safety of focal laser photocoagulation treatment in eyes with polypoidal choroidal vasculopathy(PCV).METHODS:Medical records of 13 eyes of 13 patients with PCV were followed-up for more than 2 y after focal laser photocoagulation *** patients were diagnosed with PCV using indocyanine green angiography,and eyes with other comorbid ocular diseases were *** measurement outcomes of the study were the post-treatment regression and recurrence of polyps,complications,and changes in visual *** t-test was performed to compare visual outcome before and after the ***:The mean age of the 13 patients was 70.2±5.5 y,and the follow-up period was 72.3±31.0(range,25-118)*** eyes had juxtafoveal polyps and 10 eyes had extrafoveal *** the 13 eyes,9 eyes(69.2%)had regression of polyps 1.7±1.2(range,0.9-4)mo after focal laser *** eyes(55.6%)showed recurrence of polyps during the follow-up periods,and the recurrence period was 12.8±18.9(range,1.9-48)*** subretinal hemorrhage occurred in two eyes(15.4%)27 and 72 d after laser treatment,*** were no statistically significant differences in visual acuities at baseline;1,2,3 y post-treatment(all P>0.05);and last follow-up(0.63±0.5,0.73±0.70,0.67±0.57,0.75±0.7,and 0.95±0.8 log MAR,respectively).CONCLUSION:Focal laser photocoagulation is beneficial for early regression of polyps in eyes with PCV and does not result in significant submacular hemorrhage during the long-term ***,it can be primarily considered in eyes with PCV with extrafoveal or juxtafoveal polyps to regress risky polyps as well as to maintain visual acuity without serious hemorrhagic complications.

关键词： long-term efficacy polypoidal choroidal vasculopathy focal laser photocoagulation

Groundwater contamination and natural attenuation capacity at a petroleum spilled facility in Korea

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Journal of Environmental Sciences 2011年第10期23卷 1650-1659页

作者： hyun-Mi Choi Jin-Yong lee Department of Geology Kangwon National University

As a remedial option, the natural attenuation capacity of a petroleum contaminated groundwater at a military facility was examined. Hydrogeological conditions, such as high water level, permeable uppermost layer and frequent heavy rainfall, were favorable to natural attenuation at this site. The changes in the concentrations of electron acceptors and donors, as well as the relevant hydrochemical conditions, indicated the occurrence of aerobic respiration, denitrification, iron reduction, manganese reduction and sulfate reduction. The calculated BTEX expressed biodegradation capacity ranged between 20.52 and 33.67 mg/L, which appeared effective for the reduction of the contaminants levels. The contribution of each electron accepting process to the total biodegradation was in the order： denitrification 〉 iron reduction 〉 sulfate reduction 〉 aerobic respiration 〉 manganese reduction. The BTEX and benzene point attenuation rates were 0.0058-0.0064 and 0.0005-0.0032 day-1, respectively, and the remediation time was 0.7-1.2 and 2.5-30 years, respectively. The BTEX and benzene bulk attenuation rates were 8.69 × 10^-4 and 1.05 × 10^-3 day-l, respectively, and the remediation times for BTEX and benzene were 7.2 and 17.5 years, respectively. However, most of the natural attenuation occurring in this site can be attributed to dilution and dispersion. Consequently, the biodegradation and natural attenuation capacities were good enough to lower the contaminants levels, but their rates appeared to be insufficient to reach the remediation goal within a reasonable time frame. Therefore, some active remedial measures would be required.

关键词： petroleum contaminated site BTEX electron acceptor expressed biodegradation capacity natural attenuation

Removal of atmospheric methane by soil ecosystems and its controlling variables from microbial to global scales

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Pedosphere 2024年第1期34卷 15-18页

作者： Hojeong kang Jaehyun lee School of Civil and Environmental Engineering Yonsei UniversitySeoul 03722Korea

Methane (CH_(4)), a potent greenhouse gas, plays a pivotal role in the dynamics of climate change. While CH_(4) emissions have been widely investigated,biological removal of CH_(4) by upland soils has been less explored. Understanding the mechanisms and factors affecting CH_(4) oxidation in soils is of paramount importance for devising successful mitigation strategies. This perspective paper discusses different types of aerobic methanotrophs and their activities under varying environmental conditions, highlighting the significant contribution of soil ecosystems to global CH_(4) sinks. We emphasize the need for in-depth research on variables controlling CH_(4) sinks on different spatiotemporal scales and the exploration of previously unidentified CH_(4) sinks, such as deserts and areas of glacier retreat.

关键词： soil ecosystems controlling

Efficient Remote Identification for Drone Swarms

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Computers, Materials & Continua 2023年第9期76卷 2937-2958页

作者： kang-Moon Seo Jane Kim Soojin lee Jun-WooKwon Seung-hyun Seo The Department of Electronic&Electrical Engineering Graduate SchoolHanyang UniversityAnsanKorea School of Electrical Engineering Hanyang University ERICAAnsanKorea

With the advancement of unmanned aerial vehicle(UAV)technology,the market for drones and the cooperation of many drones are *** swarms move together in multiple regions to perform their tasks.A Ground Control Server(GCS)located in each region identifies drone swarmmembers to prevent unauthorized drones from *** on drone identification have been actively conducted,but existing studies did not consider multiple drone identification ***,developing a secure and effective identification mechanism for drone swarms is *** suggested a novel approach for the remote identification of drone *** an efficient identification process between the drone swarm and the GCS,each Reader drone in the region collects the identification information of the drone swarmand submits it to the GCS for *** proposed identification protocol reduces the verification time for a drone swarm by utilizing batch verification to verify numerous drones in a drone *** prove the security and correctness of the proposed protocol,we conducted a formal security verification using ProVerif,an automatic cryptographic protocol *** also implemented a non-flying drone swarmprototype usingmultiple Raspberry Pis to evaluate the proposed protocol’s computational overhead and *** showed simulation results regarding various drone simulation scenarios.

关键词： Drone remote identification drone swarms multi-drone authentication

Contrast in Fluid M etallogeny between the Tianmashan Au-S Deposit and the Datuanshan Cu Deposit in Tongling,Anhui Province

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Acta Geologica Sinica(English Edition) 2003年第1期77卷 116-124页

作者： lee hyun Koo Depatment of Geology Chungnam National University 220 Kungdong Yuseong Ku Taejon 305-764 Republic of Korea

A comprehensive contrast of ore-forming geological background and ore-forming fluid features, especially fluid ore-forming processes, has been performed between the Tianmashan and the Datuanshan ore deposits in Tongling, Anhui Province. The major reasons for the formation of the stratabound skarn Au-S ore deposit in Tianmashan and the stratabound skarn Cu ore deposit in Datuanshan are analyzed in accordance with this contrast. The magmatic pluton in Tianmashan is rich in Au and poor in Cu, but that in Datuanshan is rich in Cu and Au. The wallrock strata in Tianmashan contain Au-bearing pyrite layers with some organic substance but those in Datuanshan contain no such layers. Moreover, the ore-forming fluids in Tianmashan are dominantly magmatic ones at the oxide and sulfide stages, but those with high content of Cu in Datuanshan are mainly groundwater fluids. In addition, differences in compositional evolution and physicochemical condition variation of the ore-forming fluids result in gradual dispersion

关键词： fluid inclusion fluid ore-forming process contrast in fluid metallogeny Au-S ore deposit Cu ore deposit magmatic fluid groundwater fluid Tongling Anhui Province

Joint member angle limits of composite beams and CFT square columns

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Journal of Central South University 2013年第1期20卷 199-206页

作者： lee Seung-Jo lee kang-Guk Department of Architecture Chosun College of Science & Technology Research Center for Urban Affair Kyungil University

This work aims to understand the relationship between the member angle limit and the energy ratio for 24 test samples of composite beams and CFT square steel tube columns. This work also compares the formula applicability for member angle limit with the previous test result to provide the basic data for the design of composite beam-CFT column. The evaluation of the member angle limit was performed with concrete compressive strength (fC =22.16 MPa, 30.49 MPa), breadth-to-thickness ratio (B/t=25.0, 33.3, 43.5), and axial capacity ratio (N/N0=0, 0.3, 0.4, 0.5) as the main variables of the test samples. For the relationship between the member angle limit (Ru) and the energy ratio (ES/EC ), the test result shows that the energy ratio becomes lower as the axial capacity ratio and the breadth-to-thickness ratio increase. The energy ratio is lower for the Type B test sample compared with that of Types A and C. For the formula suggested by SATO, the test samples are distributed evenly for comparison between test values and the member angle limit; however, other formulas indicate a deviation. Specifically, for the comparison between R u,cal and R u (Test), Maeda's formula shows severe deviation.

关键词： square steel tube axial capacity ratio member angle limit breadth-to-thickness ratio

Simple technique for the rescue and refixation of a partially disenclavated retropupillary iris claw intraocular lens

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International Journal of Ophthalmology(English edition) 2020年第11期13卷 1833-1835页

作者： hyun Goo kang Jae Yong Han Sung Chul lee Min Kim Department of Ophthalmology Institute of Vision ResearchGangnam Severance HospitalYonsei University College of Medicine211 EonjuroGangnam-guSeoul 06273Republic of Korea Department of Ophthalmology Institute of Vision ResearchSeverance Eye HospitalYonsei University College of Medicine50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Dear Editor,We would like to introduce a simple technique for the efficient rescue and refixation of a subluxated retropupillary iris claw intraocular lens(RPICIOL;Artisan■Aphakia model 205,Ophtec BV,Groningen,the Netherlands).The RPICIOL is a suture-less,posterior iris-fixated,polyinethyl methacrylate intraocular lens(IOL)that has gained widespread recognition and expanding use because of its efficiency in management of aphakia,combined with long-term intraocular safety and excellent sustained visual outcomes11 Postoperative dislocation/disenclavation of the RPICIOL may occur spontaneously or following trauma,with a rate reportedly between 0 to 10%[4-6].

关键词： law gained sustained

Si nanomebranes: Material properties and applications

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Nano Research 2021年第9期14卷 3010-3032页

作者： Arijit Sarkar Yongjun lee Jong-hyun Ahn School of Electrical and Electronic Engineering Yonsei University50 Yonsei-roSeoul 03722Republic of Korea

Silicon(Si)has widely been used as an essential material in the modern semiconductor ***,new attempts have been actively made to apply Si to a variety of fields such as flexible electronic devices and biosensors by manufacturing Si nanomembranes(NMs)having nanometer *** particular,as the thickness of Si is reduced to a nanometer scale,its mechanical,electrical,and optical properties differ from that of its bulk form,which provides opportunities for the development of new conceptual *** this review,we present recent advances in Si NM technology that exhibit functional features different from the bulk *** addition,we discuss the opportunities and current challenges related to this field.

关键词： Si nanomebranes flexible electronics bio-integrated electronics Si optoelectronics strain engineering