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Local dose-dense chemotherapy for triple-negative breast cancer via minimally invasive implantation of 3D printed devices

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 69-85页

作者： Noehyun Myung hyun-Wook kang Department of Biomedical Engineering Ulsan National Institute of Science and Technology(UNIST)Ulju-gun 44919South Korea

Dose-dense chemotherapy is the preferred first-line therapy for triple-negative breast cancer(TNBC),a highly aggressive disease with a poor *** treatment uses the same drug doses as conventional chemotherapy but with shorter dosing intervals,allowing for promising clinical outcomes with intensive ***,the frequent systemic administration used for this treatment results in systemic toxicity and low patient compliance,limiting therapeutic efficacy and clinical ***,we report local dose-dense chemotherapy to treat TNBC by implanting 3D printed devices with timeprogrammed pulsatile release *** implantable device can control the time between drug releases based on its internal microstructure design,which can be used to control dose *** device is made of biodegradable materials for clinical convenience and designed for minimally invasive implantation via a *** density variation of local chemotherapy using programmable release enhances anti-cancer effects in vitro and in *** the same dose density conditions,device-based chemotherapy shows a higher anticancer effect and less toxic response than intratumoral *** demonstrate local chemotherapy utilizing the implantable device that simulates the drug dose,number of releases,and treatment duration of the dose-dense AC(doxorubicin and cyclophosphamide)regimen preferred for TNBC *** density modulation inhibits tumor growth,metastasis,and the expression of drug resistance-related proteins,including p-glycoprotein and breast cancer resistance *** the best of our knowledge,local dose-dense chemotherapy has not been reported,and our strategy can be expected to be utilized as a novel alternative to conventional therapies and improve anti-cancer efficiency.

关键词： Dose-dense chemotherapy Triple-negative breast cancer 3D printing Pulsatile release Local drug delivery systems

Frequency comb-to-comb stabilization over a 1.3-km free-space atmospheric optical link

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Light(Science & Applications) 2022年第9期11卷 2207-2216页

作者： JAEWON YANG DONG IL lee DONG-CHEL SHIN JAEhyun lee BYUNG SOO KIM hyun JAY kang YOUNG-JIN KIM SEUNG-WOO KIM Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Presently with Korea Research Institute of Standards and Science(KRISS) 267 Gajeong-roYuseong-guDaejeon 34113Republic of Korea

Stabilizing a frequency comb to an ultra-stable optical frequency reference requires a multitude of optoelectronic peripherals that have to operate under strict ambient ***,the frequency comb-to-comb stabilization aims to synchronize a slave comb to a well-established master comb with a substantial saving in required equipment and ***,we report an utmost case of frequency comb-to-comb stabilization made through a 1.3 km free-space optical(FSO)link by coherent transfer of two separate comb lines along with a feedback suppression control of atmospheric phase *** FSO link offers a transfer stability of 1.7×10-15 at 0.1 s averaging,while transporting the master comb,s stability of 1.2×10-15 at 1.0 s over the entire spectrum of the slave *** remote comb-to-comb stabilization is intended to expedite diverse long-distance ground-to-ground or ground-to-satellite applications;as demonstrated here for broadband molecular spectroscopy over a 6THz bandwidth as well as ultra-stable microwaves generation with phase noise of-80dBc Hz-1 at 1 Hz.

关键词： optical stabilization microwave

A Strategy of Signal Detection for Performance Improvement in Clipping Based OFDM System

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Computers, Materials & Continua 2020年第7期64卷 181-191页

作者： Jae-hyun Ro Won-Seok lee Min-Goo kang Dae-Ki Hong Hyoung-Kyu Song Department of Information and Communication Engineering Sejong UniversitySeoulKorea Department of IT Contents Hanshin UniversityOsan-siKorea Department of System Semiconductor Engineering SangMyung UniversityCheonan-si31066Korea

In this paper,the supervised Deep Neural Network(DNN)based signal detection is analyzed for combating with nonlinear distortions efficiently and improving error performances in clipping based Orthogonal Frequency Division Multiplexing(OFDM)*** of the main disadvantages for the OFDM is the high Peak to Average Power Ratio(PAPR).The clipping is a simple method for the PAPR ***,an effect of the clipping is nonlinear distortion,and estimations for transmitting symbols are difficult despite a Maximum Likelihood(ML)detection at the *** DNN based online signal detection uses the offline learning model where all weights and biases at fully-connected layers are set to overcome nonlinear distortions by using training data ***,this paper introduces the required processes for the online signal detection and offline learning,and compares error performances with the ML detection in the clipping-based OFDM *** simulation results,the DNN based signal detection has better error performance than the conventional ML detection in multi-path fading wireless *** performance improvement is large as the complexity of system is increased such as huge Multiple Input Multiple Output(MIMO)system and high clipping rate.

关键词： Clipping DNN ML nonlinear distortion OFDM

Three-dimensional spongy nanographene-functionalized silicon anodes for lithium ion batteries with superior cycling stability

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Nano Research 2018年第1期11卷 233-245页

作者： Chunfei Zhang Tong-hyun kang Jong-Sung Yu Department of Energy Systems Engineering DGIST Daegu 42988 Republic of Korea

An innovative spongy nanographene （SG） shell for a silicon substrate was prepared by low-temperature chemical vapor deposition on a hierarchical nickel nanotemplate. The SG-functionalized silicon （Si@SG） composite shows outstanding properties, which may be helpful to overcome issues affecting current silicon anodes used in lithium ion batteries such as poor conductivity, large volume expansion and high mass transfer resistance. The hierarchical nanographene shell exhibits elastic, sponge-like features that allow it to self-adaptively change its volume to accommodate the volume expansion of silicon. In addition, the porous, spongy framework containing randomly stacked graphene nanosheets presents low diffusion barriers and provides sufficiently free and short-haul channel segments to allow the fast migration of Li and electrolyte ions. The unique properties of the present silicon anode result in excellent electrochemical performances in terms of long-term cycling stability （95% capacity retention after 510 cycles）, rate performance, and cycling behavior for high mass loadings at different current densities.

关键词： spongy nanographene core-shell silicon lithium ion battery three-dimensionalstructure

A case with acute-on-chronic liver failure receiving liver transplantation during daclatasvir and asunaprevir therapy in chronic hepatitis C patient

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Gastroenterology Report 2019年第5期7卷 371-373,I0003页

作者： Wonhyeong Park Jihwan Jung Soo hyun Yang Danbi lee Hyo Jeong kang Department of Internal Medicine Veterans Health Service Medical CenterSeoulKorea Department of Internal Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

We report a case with hepatitis C virus genotype 1 b liver cirrhosis who received liver transplantation because of acute-onchronic liver failure during daclatasvir(DSV)and asunaprevir(ASV)combination *** our knowledge,this is the first case received liver transplantation during DSVtASV ***,clinicians should pay particular attention to the possibility of acute liver failure during DSV and ASV combination therapy.

关键词： Chronic hepatitis C liver failure:daclatasvir asunaprevir

MOF‑Derived CoSe2@N‑Doped Carbon Matrix Confined in Hollow Mesoporous Carbon Nanospheres as High‑Performance Anodes for Potassium‑Ion Batteries

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Nano-Micro Letters 2021年第1期13卷 123-137页

作者： Su hyun Yang Seung‑Keun Park Yun Chan kang Department of Materials Science and Engineering Korea UniversityAnam‑DongSeongbuk‑GuSeoul 136‑713Republic of Korea Department of Chemical Engineering Kongju National University1223‑24 Cheonan‑daeroSeobuk‑guCheonan 31080Republic of Korea

In this work,a novel vacuum-assisted strategy is proposed to homogenously form Metal-organic frameworks within hollow mesoporous carbon nanospheres(HMCSs)via a solid-state *** method is applied to synthesize an ultrafine CoSe2 nanocrystal@N-doped carbon matrix confined within HMCSs(denoted as CoSe2@NC/HMCS)for use as advanced anodes in highperformance potassium-ion batteries(KIBs).The approach involves a solvent-free thermal treatment to form a Co-based zeolitic imidazolate framework(ZIF-67)within the HMCS templates under vacuum conditions and the subsequent *** treatment under vacuum facilitates the infiltration of the cobalt precursor and organic linker into the HMCS and simultaneously transforms them into stable ZIF-67 particles without any *** the subsequent selenization process,the“dual confinement system”,composed of both the N-doped carbon matrix derived from the organic linker and the small-sized pores of HMCS,can effectively suppress the overgrowth of CoSe2 ***,the resulting uniquely structured composite exhibits a stable cycling performance(442 mAh g^−1 at 0.1 A g^−1 after 120 cycles)and excellent rate capability(263 mAh g^−1 at 2.0 A g^−1)as the anode material for KIBs.

关键词： Metal-organic frameworks Hollow mesoporous carbon nanospheres Potassium-ion batteries Cobalt selenides Electrode materials

Severe mediastinitis and pericarditis after endobronchial ultrasoundguided transbronchial needle aspiration:A case report

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World Journal of Clinical Cases 2021年第34期9卷 10723-10727页

作者： Jeong Suk Koh Yoon Joo Kim Da hyun kang Jeong Eun lee Song-I lee Department of Pulmonary and Critical Care Medicine Chungnam National University HospitalDaejeon 35015South Korea

BACKGROUND Endobronchial ultrasound-guided transbronchial needle aspiration(EBUS-TBNA)is a safe and minimally invasive diagnostic tool for mediastinal and hilum ***,infectious complications may occur after *** these,mediastinitis and pericarditis are *** SUMMARY A 67-year-old woman was referred to our hospital due to paratracheal lymph node enlargement on chest computed tomography(CT).EBUS-TBNA was performed on the lymph node lesions,and prophylactic oral antibiotics were *** days after EBUS-TBNA,the patient visited the emergency room with a high fever and chest *** test results revealed leukocytosis with a left shift and elevated C-reactive protein level(25.7 mg/dL).Chest CT revealed the formation of a mediastinal abscess in the right paratracheal lymph node and pericardial and bilateral pleural *** patient received intravenous antibiotic treatment,cardiac drainage through pericardiocentesis,and surgical *** patient recovered favorably and was discharged 31 d after the *** Mediastinitis and pericarditis after EBUS-TBNA are rare but should be considered even after the use of prophylactic antibiotics.

关键词： Endoscopic ultrasound-guided fine needle aspiration Complication Mediastinitis Pericarditis Antibiotics Case report

Synthesis,Properties,and Biological Application of Perfect Crystal Gold Nanowires:A Review

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Journal of Materials Science & Technology 2015年第6期31卷 573-580页

作者： Mijeong kang Hyoban lee Taejoon kang Bongsoo Kim Department of Chemistry KAISTDaejeon 305-701Korea BioNanotechnology Research Center and BioNano Health Guard Research Center

In the last decade,numerous kinds of nanoscale materials have been *** characteristics are critically influenced by their synthetic or fabrication *** this review article,we introduce perfect crystal gold nanowires(Au NWs) synthesized by vapor transport method and summarize their material properties and biological ***-crystalline Au NWs having no defects or twins show unique mechanical,electrical,and electrochemical ***,they are exceptionally competent in penetrating cells or tissues with minimum biological damage and in the electrical analysis and manipulation of biological activities in the cells and/or *** is expected that the Au NWs would give us technological breakthrough in diverse applications such as nanoscale functional components as well as new insights in fundamental material science.

关键词： Nanomaterials Nanostructured metallic materials Na

Fabrication of High-Density Out-of-Plane Microneedle Arrays with Various Heights and Diverse Cross-Sectional Shapes

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Nano-Micro Letters 2022年第2期14卷 60-78页

作者： Hyeonhee Roh Young Jun Yoon Jin Soo Park Dong-hyun kang Seung Min Kwak Byung Chul lee Maesoon Im Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792South Korea Division of Electrical Engineering College of EngineeringKorea UniversitySeoul 02841South Korea Micro/Nano Fabrication Center KISTSeoul 02792South Korea Division of Bio‑Medical Science&Technology KIST SchoolUniversity of Science&Technology(UST)Seoul 02792South Korea

Out-of-plane microneedle structures are widely used in various applications such as transcutaneous drug delivery and neural signal recording for brain machine *** work presents a novel but simple method to fabricate high-density silicon(Si)microneedle arrays with various heights and diverse cross-sectional shapes depending on photomask pattern *** proposed fabrication method is composed of a single photolithography and two subsequent deep reactive ion etching(DRIE)***,a photoresist layer was patterned on a Si substrate to define areas to be etched,which will eventually determine the final location and shape of each individual ***,the 1st DRIE step created deep trenches with a highly anisotropic etching of the Si ***,the photoresist was removed for more isotropic etching;the 2nd DRIE isolated and sharpened microneedles from the predefined trench *** on diverse photomask designs,the 2nd DRIE formed arrays of microneedles that have various height distributions,as well as diverse cross-sectional shapes across the *** these simple steps,high-aspect ratio microneedles were created in the high density of up to 625 microneedles mm^(-2)on a Si *** tests showed a small force as low as~172μN/microneedle is required for microneedle arrays to penetrate the dura mater of a mouse *** demonstrate a feasibility of drug delivery application,we also implemented silk microneedle arrays using molding *** fabrication method of the present study is expected to be broadly applicable to create microneedle structures for drug delivery,neuroprosthetic devices,and so on.

关键词： Microneedle Various heights Cross-sectional shapes Isotropic etch Deep reactive ion etching