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Systemic lupus erythematosus in a 15-year-old female with multiple splenic nodules:A case report

World Journal of Clinical Cases 2024年第12期12卷 2128-2133页

作者： mi Il kang Hyeok Chan Kwon Division of Rheumatology Department of Internal MedicineDankook University College of MedicineCheonan-si 31116South Korea Division of Rheumatology Department of Internal MedicineDankook University HospitalDankook University College of MedicineCheonan-si 31116South Korea

BACKGROUND Systemic lupus erythematosus(SLE)is a chronic inflammatory disease primarily affecting young females.SLE can invade any organ,and various forms of splenic invasion have been reported.Manifestations include splenomegaly and splenic infarction,rupture,and calcification.The study encountered a rare case of splenic involvement,with nodules of various sizes without calcifications or ruptures.CASE SUMMARY A 15-year-old girl presented with arthralgia,weight loss,fever,increased levels of inflammatory markers,and positive antinuclear antibody test results.The patient was diagnosed with SLE.She was asymptomatic while taking steroids and hydroxychloroquine.Ten months after discharge,the patient developed a fever and abdominal pain.Lupus enteritis was suspected,and abdominopelvic computed tomography(AP-CT)was performed.There were no specific findings in the gastrointestinal tract,but multiple splenic nodules were observed.Infection or hemangioma was considered;however,no specific radiological findings were observed.A biopsy of the spleen was performed to determine the possibility of malignancy.The histological findings of the spleen included extensive periarteriolar necrosis with hematoxylin bodies and numerous karyorrhectic debris.Based on the biopsy results,the patient was diagnosed with an SLE flare-up and was maintained on high-dose steroids and immunosuppressants.CONCLUSION As disease activity increased,multiple nodules in the spleen that were previously unseen were observed using AP-CT and histologically confirmed.Spleen invasion by SLE can appear in multiple nodular forms and patterns.Therefore,physicians should consider these findings when differentiating these nodules from infections and malignancies.

关键词： Multiple nodules Spleen Splenectomy Systemic lupus erythematosus Differential diagnosis Case report

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The SARS-CoV-2 spike protein induces lung cancer migration and invasion in a TLR2-dependent manner

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Cancer Communications 2024年第2期44卷 273-277页

作者： mi-Jeong Kim Ji Young Kim Ji Hye Shin Juhee Son Yeeun kang Soo-Kyung Jeong Duk-Hwan Kim Kyun-Hwan Kim Eunyoung Chun Ki-Young Lee Department of Immunology Samsung Biomedical Research InstituteSungkyunkwan University School of MedicineSuwonRepublic of Korea Research and Development Center CHA Vaccine InstituteSeongnam-siRepublic of Korea Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonRepublic of Korea Department of Precision Medicine Sungkyunkwan University School of MedicineSuwonRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences&TechnologySamsung Medical CenterSungkyunkwan UniversitySeoulRepublic of Korea

Dear editor,Severe acute respiratory syndrome coronavirus2(SARS-CoV-2)infection can lead to severe outcomes in patients with cancer[1].It has been reported that patients with lung cancers disproportionately manifest severe COVID-19 with a high rate of hospitalization and death[2].Notably,the SARS-CoV-2 Spike(S)protein can induce hyper-inflammation in both epithelial cells and macrophages through toll-like receptor(TLR)1/TLR2 or TLR2/6-dependent nuclear factor-kappaB(NF-κB)path-way[3].However,molecular and cellular evidence on whether the SARS-CoV-2 virus affects the severity of lung cancer patients through TLR1/2 or TLR2/6 signaling remains unclear.

关键词： lung TLR2 invasion

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Knockout of miR396 genes increases seed size and yield in soybean

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Journal of Integrative Plant Biology 2024年第6期66卷 1148-1157页

作者： Hongtao Xie Fei Su Qingfeng Niu Leping Geng Xuesong Cao minglei Song Jinsong Dong Zai Zheng Rui Guo Yang Zhang Yuanwei Deng Zhanbo Ji kang Pang Jian-kang Zhu Jianhua Zhu School of Life Sciences Anhui Agricultural University Research Center for Biological Breeding Technology Research Institute of Frontier Science Anhui Agricultural University Bellagen Biotechnology Co.Ltd Institute of Crop Sciences/National Nanfan Research Institute Chinese Academy of Agricultural Sciences Key Laboratory of Gene Editing Technologies (Hainan) Ministry of Agriculture and Rural Affairs Southern University of Science and Technology Hainan Yazhou Bay Seed Laboratory

Yield improvement has long been an important task for soybean breeding in the world in order to meet the increasing demand for food and animal feed. mi R396 genes have been shown to negatively regulate grain size in rice,but whether mi R396 family members may function in a similar manner in soybean is unknown. Here, we generated eight soybean mutants harboring different combinations of homozygous mutations in the six soybean mi R396genes through genome editing with clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated nuclease(Cas)12SF01 in the elite soybean cultivar Zhonghuang 302(ZH302). Four triple mutants (mir396aci, mir396acd, mir396adf, and mir396cdf), two quadruple mutants(mir396-abcd and mir396acfi), and two quintuple mutants(mir396abcdf and mir396bcdfi) were characterized. We found that plants of all the mir396 mutants produced larger seeds compared to ZH302 plants. Field tests showed that mir396adf and mir396cdf plants have significantly increased yield in growth zones with relatively high latitude which are suited for ZH302 and moderately increased yield in lower latitude. In contrast, mir396abcdf and mir396bcdfiplants have increased plant height and decreased yield in growth zones with relatively high latitude due to lodging issues, but they are suited for low latitude growth zones with increased yield without lodging problems.Taken together, our study demonstrated that loss-of-function of mi R396 genes leads to significantly enlarged seed size and increased yield in soybean, providing valuable germplasms for breeding high-yield soybean.

关键词： Cas12SF01 CRISPR/Cas miR396 seed size soybean yield

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能耗双控转向碳双控的政策影响评估——基于安徽省动态CGE模型

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中国环境科学 2024年第4期44卷 1795-1804页

作者：安康欣刘米可范淑婷王灿清华大学环境学院北京100084

通过以安徽省为案例构建混合动态可计算一般均衡模型,分析能耗双控优化以及转向碳双控的能源经济影响.研究发现,扣除新增可再生能源显著促进能耗双控政策支持可再生能源的作用并改善经济有效性,2035年可再生能源发电占比达到27.9%,而GD... 详细信息

通过以安徽省为案例构建混合动态可计算一般均衡模型,分析能耗双控优化以及转向碳双控的能源经济影响.研究发现,扣除新增可再生能源显著促进能耗双控政策支持可再生能源的作用并改善经济有效性,2035年可再生能源发电占比达到27.9%,而GDP损失降低0.2个百分点;转向碳双控政策会进一步促进可再生能源发展、腾挪能源消费空间并提高经济效率,GDP损失率进一步下降0.05个百分点;控制政策会产生赢家和输家行业,转向碳双控政策将会降低输家行业产出损失,2035年行业产出的变化率在-20.6%至10.3%之间.建议坚持实施能耗双控制度优化措施并在“十五五”时期向碳双控政策过渡,匹配以前瞻性的产业布局和必要的公正转型措施来降低产业调整的不利影响,在降低短期政策调整波动的同时促进中长期“双碳”目标实现.

关键词：能耗双控碳双控安徽省可计算一般均衡模型

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All-optical attosecond time domain interferometry

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National Science Review 2021年第10期8卷 15-22页

作者： Zhen Yang Wei Cao Yunlong Mo Huiyao Xu kang mi Pengfei Lan Qingbin Zhang Peixiang Lu Wuhan National Laboratory for Optoelectronics and School of Physics Huazhong University of Science and Technology Hubei Key Laboratory of Optical Information and Pattern Recognition Wuhan Institute of Technology CAS Center for Excellence in Ultra-intense Laser Science

Interferometry, a key technique in modern precision measurements, has been used for length measurement in engineering metrology and astronomy. An analogous time-domain interferometric technique would represent a significant complement to spatial domain applications and require the manipulation of interference on extreme time and energy scales. Here, we report an all-optical interferometer using laser-driven high order harmonics as attosecond temporal slits. By controlling the phase of the temporal slits with an external field, a time domain interferometer that preserves both attosecond temporal resolution and hundreds of me V energy resolution is implemented. We apply this exceptional temporal resolution to reconstruct the waveform of an arbitrarily polarized optical pulse, and utilize the provided energy resolution to interrogate the abnormal character of the transition dipole near the Cooper minimum in argon. This novel attosecond interferometry paves the way for high precision measurements in the time-energy domain using all-optical approaches.

关键词： interferometry attosecond all-optical precision measurement

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Changes in structural plasticity of hippocampal neurons in an animal model of multiple sclerosis

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Zoological Research 2024年第2期45卷 398-414页

作者： Poornima D.E.Weerasinghe-Mudiyanselage Sohi kang Joong-Sun Kim Sung-Ho Kim Hongbing Wang Taekyun Shin Changjong Moon Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 FOUR ProgramChonnam National UniversityGwangju 61186Republic of Korea Department of Anatomy and Convergence Medical Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinju 52727Republic of Korea Department of Physiology and Neuroscience Program Michigan State UniversityEast LansingMI 48824USA Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJeju 63243Republic of Korea

Structural plasticity is critical for the functional diversity of neurons in the brain.Experimental autoimmune encephalomyelitis(EAE)is the most commonly used model for multiple sclerosis(MS),successfully mimicking its key pathological features(inflammation,demyelination,axonal loss,and gliosis)and clinical symptoms(motor and non-motordysfunctions).Recentstudieshave demonstrated the importance of synaptic plasticity in EAE pathogenesis.In the present study,we investigated the features of behavioral alteration and hippocampal structural plasticity in EAE-affected mice in the early phase(11 days post-immunization,DPI)and chronic phase(28DPI).EAE-affected mice exhibited hippocampus-related behavioral dysfunction in the open field test during both early and chronic phases.Dendritic complexity was largely affected in the cornu ammonis 1(CA1)and CA3 apical and dentate gyrus(DG)subregions of the hippocampus during the chronic phase,while this effect was only noted in the CA1 apical subregion in the early phase.Moreover,dendritic spine density was reduced in the hippocampal CA1 and CA3 apical/basal and DG subregions in the early phase of EAE,but only reduced in the DG subregion during the chronic phase.Furthermore,mRNA levels of proinflammatory cytokines(Il1β,Tnfα,and Ifnγ)and glial cell markers(Gfap and Cd68)were significantly increased,whereas the expression of activity-regulated cytoskeletonassociated protein(ARC)was reduced during the chronic phase.Similarly,exposure to the aforementioned cytokines in primary cultures of hippocampal neurons reduced dendritic complexity and ARC expression.Primary cultures of hippocampal neurons also showed significantly reduced extracellular signal-regulated kinase(ERK)phosphorylation upon treatment with proinflammatory cytokines.Collectively,these results suggest that autoimmune neuroinflammation alters structural plasticity in the hippocampus,possibly through the ERK-ARC pathway,indicating that this alteration may be associated with hippocampal dysfunctions in EAE.

关键词： Activity-regulated cytoskeleton-associated protein Anxiety-like behavior Experimental autoimmune encephalomyelitis Hippocampal dysfunction Neuroinflammation

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Streamflow abrupt change and the driving factors in glacierized basins of Tarim Basin,Northwest China

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Advances in Climate Change Research 2024年第1期15卷 75-89页

作者： Cheng-De YANG min XU Shi-Chang kang Cong-Sheng FU Wei ZHANG Di-Di HU State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Watershed Geographic Sciences Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210000China

A climate transition towards warm-wet conditions in Northwest China has drawn much attention.With continuous climate change and universal glacier degradation,increasing water-related hazards and vulnerability have become one of the important problems facing the Tarim Basin.However,the impacts of the climate transition on streamflow abrupt change and extreme hydrological events were less discussed,especially in glacial basins.In the present study,the discharge datasets in four glacial basins of Tarim Basin from 1979 to 2018 were constructed using the GRU-GSWAT+model first.The differences in streamflow characteristics,the shift of hydrological extreme pattern,and potential changes of the controlling factors before and after the abrupt changes were investigated.The results indicated that the abrupt change point(ACP)in streamflow occurred in 2000 in the Qarqan River Basin,2002 in the Weigan River Basin,and 1994 in the Aksu River Basin and the Yarkant River Basin.A general decrease in streamflow before the ACP has shifted to a notable upward trend in the Qarqan River Basin and the Aksu River Basin,while minor upward fluctuations were observed in other basins.Moreover,the hydrological characteristics in extreme events vary dramatically before and after the ACPs,characterized by a pronouncing shift from drought-dominant pattern to wet events dominated pattern.The driven climate factors have been altered after the ACPs with notable spatial heterogeneity,in which temperature remained as the dominant role in meltwater-dominated basins while the influence of precipitation has increased after the ACPs,whereas the sensitivity of temperature on streamflow change has been enhanced in basins dominated by precipitation such as the Qarqan River Basin.Owing to the evident warming-wetting trend and glacier compensation effect,both the inter-annual and intra-annual streamflow fluctuations can be efficiently smoothed in basins with a high glacier area ratio(GAR).These findings provide a further understanding of the abrupt change in st

关键词： Abrupt change Streamflow Hybrid model Tarim Basin Glacier

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教育数字化转型背景下西北地区高职院校劳动教育的内涵特质、逻辑理路与发展路向

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西北成人教育学院学报 2024年第1期 64-69页

作者：米鑫李康邯郸幼儿师范高等专科学校学前教育系河北邯郸056000

教育数字化转型深刻改变了劳动的既有形态与方式,同时加剧了西北地区高职劳动教育变革的复杂性。在教育数字化转型背景下,西北地区高职劳动教育展示出劳动+职业、劳动+数字、劳动+创造的内涵特质。深刻探寻其发展的逻辑理路在于通过数... 详细信息

教育数字化转型深刻改变了劳动的既有形态与方式,同时加剧了西北地区高职劳动教育变革的复杂性。在教育数字化转型背景下,西北地区高职劳动教育展示出劳动+职业、劳动+数字、劳动+创造的内涵特质。深刻探寻其发展的逻辑理路在于通过数字技术贯通创生劳动教育新生态、采用数字劳动牵动引领劳动教育新形式、强化数字素养涵育提高劳动教育新成效。为进一步顺应数字化背景下开展劳动教育的新要求,西北地区高职劳动教育应树高职院校劳动之观,彰显以劳育人的价值导向;育高职院校劳动之容,统整劳动教育的理念内容;促高职院校劳动之行,跨越时空开展具身化实践。

关键词：教育数字化西北地区高职院校劳动教育

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A Novel Deep Learning-Based Model for Classification of Wheat Gene Expression

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Computer Systems Science & Engineering 2024年第2期48卷 273-285页

作者： Amr Ismail WalidHamdy Aya MAl-Zoghby Wael AAwad Ahmed Ismail Ebada Yunyoung Nam Byeong-Gwon kang Mohamed Abouhawwash Faculty of Science Port Said UniversityPort SaidEgypt Modern Academy for Computer Science and Management Technology Cairo11742Egypt Faculty of Computers and Artificial Intelligence Damietta UniversityNew DamiettaEgypt Department of ICT Convergence Soonchunhyang UniversityAsan31538South Korea Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA

Deep learning(DL)plays a critical role in processing and converting data into knowledge and decisions.DL technologies have been applied in a variety of applications,including image,video,and genome sequence analysis.In deep learning the most widely utilized architecture is Convolutional Neural Networks(CNN)are taught discriminatory traits in a supervised environment.In comparison to other classic neural networks,CNN makes use of a limited number of artificial neurons,therefore it is ideal for the recognition and processing of wheat gene sequences.Wheat is an essential crop of cereals for people around the world.Wheat Genotypes identification has an impact on the possible development of many countries in the agricultural sector.In quantitative genetics prediction of genetic values is a central issue.Wheat is an allohexaploid(AABBDD)with three distinct genomes.The sizes of the wheat genome are quite large compared to many other kinds and the availability of a diversity of genetic knowledge and normal structure at breeding lines of wheat,Therefore,genome sequence approaches based on techniques of Artificial Intelligence(AI)are necessary.This paper focuses on using the Wheat genome sequence will assist wheat producers in making better use of their genetic resources and managing genetic variation in their breeding program,as well as propose a novel model based on deep learning for offering a fundamental overview of genomic prediction theory and current constraints.In this paper,the hyperparameters of the network are optimized in the CNN to decrease the requirement for manual search and enhance network performance using a new proposed model built on an optimization algorithm and Convolutional Neural Networks(CNN).

关键词： Gene expression convolutional neural network optimization algorithm genomic prediction wheat

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新疆玛纳斯河流域地下水砷氟碘分布及共富集成因

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中国环境科学 2024年第7期44卷 3832-3842页

作者：康文辉周殷竹雷米韩双宝周金龙新疆农业大学水利与土木工程学院新疆乌鲁木齐830052 新疆水文水资源工程技术研究中心新疆乌鲁木齐830052 新疆水利工程安全与水灾害防治重点实验室新疆乌鲁木齐830052 中国地质调查局水文地质环境地质调查中心天津300304

为了更好地掌握新疆玛纳斯河流域地下水中As、F、I的分布及富集成因,通过相关性分析和地球化学模拟,分析了高As、高F、高I地下水的水化学特征及空间分布状况;结合地质条件和地下水赋存环境进一步阐明地下水As、F和I的来源、迁移与富集... 详细信息

为了更好地掌握新疆玛纳斯河流域地下水中As、F、I的分布及富集成因,通过相关性分析和地球化学模拟,分析了高As、高F、高I地下水的水化学特征及空间分布状况;结合地质条件和地下水赋存环境进一步阐明地下水As、F和I的来源、迁移与富集的水文地球化学过程.结果表明:地下水砷、氟、碘含量变化范围分别为1.13~41.35µg/L、0.06~8.02mg/L、<0.025~0.249mg/L,地下水As、F、I超标分别为62.9%、45.7%、45.7%,有31.4%的地下水砷氟碘均超标.砷氟碘共富集的地下水主要分布在玛纳斯河流域东部靠近沙漠边缘的平原区,水化学类型主要为HCO_(3)·SO_(4)·Cl-Na型.自山前单一结构潜水区至平原承压水区,地下水As含量沿流向先增大后在沙漠边缘区减小,水平方向上,地下水的淋滤作用导致南部富As岩层中的As向平原承压水区富集,且碱性条件下SO_(4)2-的还原有助于As的解吸附;地下水F含量沿地下水流向逐渐增大,在古尔班通古特沙漠边缘达到2.5mg/L.高HCO_(3)^(-)、高Na^(+)、高pH值的地下水还原环境是F从含水层基质向地下水释放的重要原因;地下水I含量沿地下水流向整体呈上升趋势,在承压水区潜水中主要受蒸发浓缩作用的影响,在承压水中主要受岩石风化作用的影响.砷氟碘共富集地下水主要分布于100~310m的承压水中.在封闭的承压含水层,碱性还原环境下矿物溶解与沉淀和水岩相互作用是地下水砷氟碘共富集的主要机制.

关键词：砷氟碘共富集成因水化学玛纳斯河流域

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