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Beneficial Effect of Berberis amurensis Rupr. on Penile Erection

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Chinese Journal of Integrative Medicine 2018年第6期24卷 448-454页

作者： Rui Tan Yun Jung Lee Kyung Woo Cho dae gill kang Ho Sub Lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University Hanbang CardioRenal Syndrome Research Center Wonkwang University Brain Korea 21 Plus Team Professional Graduate School of Oriental MedicineWonkwang University

Objective： To investigate whether the methanol extract of Berberis amurensis Rupr. （BAR） augments penile erection using in vitro and in vivo experiments. Methods： The ex vivo study used corpus cavemosum strips prepared from adult male New Zealand White rabbits. In in vivo studies for intracavernous pressure （ICP）, blood pressure, mean arterial pressure （MAP）, and increase of peak ICP were continuously monitored during electrical stimulation of Sprague-Dawley rats. Results： Preconstricted with phenylephrine （PE） in isolated endothelium- intact rabbit corus cavernosum, BAR relaxed penile smooth muscle in a dose-dependent manner, which was inhibited by pretreatment with NG-nitro-L-arginine methyl ester （L-NAME）, a nitric oxide synthase inhibitor, and 1H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin-l-one, a soluble guanylyl cclase inhibitor. BAR significantly relaxed penile smooth muscles dose-dependently in ex vivo, and this was inhibited by pretreatment with L-NAME 1H-[1,2,4]- oxadiazole-[4,3-α ]-quinoxalin-l-one. BAR-induced relaxation was significantly attenuated by pretreatment with tetraethylammonium （TEA, P〈0.01）, a nonselective K＋ channel blocker, 4-aminopyridine （4-AP, P〈0.01）, a voltage-dependent K＋ channel blocker, and charybdotoxin （P〈0.01）, a large and intermediate conductance Ca2. sensitive-K＋ channel blocker, respectively. BAR induced an increase in peak ICP, ICP/MAP ratio and area under the curve dose dependently. Conclusion： BAR augments penile erection via the nitric oxide/cyclic guanosine monophosphate system and Ca2. sensitive-K＋（BK＋ and IK＋） channels in the corpus cavemosum.

关键词： penile erection Berberis amurensis Rupr. nitric oxide cyclic guanosine monophosphate K+ channel

Photophysical,optical,and photocatalytic hydrogen production properties of layered-type BaNb_(2-x)Ta_(x)P_(2)O_(11)(x=0,0.5,1.0,1.5,and 2.0)compounds

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Journal of Materials Science & Technology 2022年第3期98卷 26-32页

作者： Min Je kang gill Sang Han In Sun Cho Department of Materials Science and Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Energy Systems Research Ajou UniversitySuwon 16499Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea

Layered-type metal phosphates of BaNb_(2-x)Ta_(x)P_(2)O_(11)(x=0,0.5,1.0,1.5,and 2.0)were synthesized using a solid-state reaction *** photophysical,optical,and photocatalytic hydrogen production properties of the resulting powders were investigated for the first ***-pure and homogeneous powders with irregular morphologies were obtained at a calcination temperature of 1200℃.As the Ta content increased,the interlayer distance along the c-axis increased by up to 0.14%.Additionally,the optical bandgap values increased from 3.32 to 3.59 *** energy band positions were estimated from the Mott–Schottky ***_(2)P_(2)O_(11)(x=0)exhibited the lowest conduction band edge position(-0.14 V *** normal hydrogen electrode,NHE),which is located above the water reduction potential(0.0 V ***).In comparison,BaTa_(2)P_(2)O_(11)(x=2.0)exhibited the highest conduction band edge position(-0.29 V ***),comparable to that of TiO_(2).The photocatalytic activity for hydrogen produced from splitting water was measured under ultraviolet light ***,BaTa_(2)P_(2)O_(11)exhibited the highest activity(7.3μmol/h),which was 15 and 10 times larger than BaNb_(2)P_(2)O_(11)(0.5μmol/h)and nano-TiO_(2)(0.7μmol/h),*** activity of BaTa_(2)P_(2)O_(11)increased to 24.4μmol/h after deposition of the NiO_(x)co-catalyst(1 wt.%),which remained stable during continuous operation(~35 h).

关键词： BaNb_(2)P_(2)O_(11) BaTa_(2)P_(2)O_(11) Layered crystal structure Bandgap Band edge positions Photocatalytic hydrogen production

Hwangryunhaedoktang exerts anti-inflammation on LPS-induced NO production by suppressing MAPK and NF-κB activation in RAW264.7 macrophages

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Journal of Integrative Medicine 2017年第4期15卷 326-336页

作者： Byung Hyuk Han Yun Jung Lee Jung Joo Yoon Eun Sik Choi Seung Namgung Xian Jun Jin Da Hye Jeong dae gill kang Ho Sub Lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University Hanbang Body-fluid Research Center Wonkwang University

OBJECTIVE： This study aimed to evaluate whether Hwangryunhaedoktang （HHT）, a herbal compound, has an inhibitory effect on lipopolysaccharide （LPS）-induced inflammation in RAW264.7 macrophages. METHODS： The effects of HHT were evaluated by confirming nitric oxide （NO） production and expression of inducible NO synthase （iNOS） and mitogen-activated protein kinases （MAPKs） in LPS-stimulated RAW264.7 macrophages via the Griess assay, Western blotting, and real-time reverse transcription quantitative polymerase chain reaction. Western blot analyses and luciferase assays were used to evaluate whether HHT has an effect on the phosphorylation and translocation of nuclear factor-κB （NF-κB）. The secretion and expression of tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） were determined via enzyme-linked immunosorbent assay and Western blot analyses. RESULTS： HHT suppressed LPS-induced NO production and expression of iNOS in a dose-dependent manner. Additionally, MAPKs activation was also attenuated via inhibition of phosphorylation of extracellular signal-regulated kinases 1/2, c-Jun N-terminal kinase and p38 which were related to inflammatory pathway. Furthermore, HHT also effectively attenuated NF-κB activation and its translocation to the nucleus, a process that is closely linked to inflammation. LPS normally induced the expression of inflammatory cytokines such as TNF-α and IL-6, but the secretion and expression of TNF-α and IL-6 were significantly attenuated by pretreating the cells with HHT. CONCLUSION： HHT suppressed LPS-induced NO production by blocking the activation of NF-κB and MAPK signaling pathways in RAW264.7 macrophages. Furthermore, HHT may have an anti-inflammatory effect by suppressing the LPS-induced secretion of TNF-α and IL-6. Therefore, the traditional herbal formula HHT might be a useful potential therapeutic agent for inflammation.

关键词： medicine, Chinese traditional lipopolysaccharide nitric oxide nuclear factor-κB mitogen-activatedprotein kinases tumor necrosis factor-a inflammation

Involvement of heme oxygenase-1 induction in anti-vascular inflammation effects of Xanthoceras sorbifolia in human umbilical vein endothelial cells

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Journal of Traditional Chinese Medicine 2018年第6期38卷 803-814页

作者： Jung Joo Yoon Byung Hyuk Han Eun Sik Choi Seung Namgung Da Hye Jeong Song Nan Jin Yun Jung Lee dae gill kang Ho Sub Lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University Hanbang Cardio-Renal Syndrome Research Center Wonkwang University Institute of Materia Medica Taishan Medical University

OBJECTIVE: To define the effects of Xanthoceras sorbifolia(EXS) on vascular inflammation and the mechanisms in endothelial ***: Vascular protective effects of an ethanol extract of seeds from EXS(1-50 μg/mL) against tumor necrosis factor-α(TNF-α)-induced vascularinflammation were examined in human umbilical vein endothelial cells(HUVECs).RESULTS: EXS significantly decreased TNF-α-induced expression of cell adhesion molecules, such as intracellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial cell selectin,in a dose-dependent manner. Pre-treatment with EXS significantly inhibited translocation and transcriptional activity of nuclear factor-κB(NF-κB) increased by TNF-α. EXS also significantly inhibited formation of intracellular reactive oxygen species(ROS). Moreover, the vascular protective effects of EXS were linked to up-regulation of heme oxygenase-1(HO-1) and nuclear factor E2-related factor-2(Nrf-2) expression. EXS-induced HO-1 expression was significantly decreased in SnPP(HO-1 inhibitor)-and HO-1 siRNA-treated cells, whereas an increase was found in cobalt protoporphyrin IX(CoPP)(HO-1 inducer)-treated cells. In addition, pretreatment with EXS increased HO-1 and Nrf-2 expression under TNF-α stimulation with or without N-acetyl-L-cysteine. Furthermore, the inhibitory effects of EXS on TNF-α-induced vascular inflammation were partially reversed in SnPP-and of HO-1siRNA-treated cells but increased by ***: These results suggest that EXS may have important implications for prevention of vascular complications associated with vascular inflammation by inhibition of the NF-κB/ROS pathway and activation of the Nrf-2/HO-1 pathway.

关键词： Sapindaceae Vascular disease inflammation Human umbilical vein endothelial cells Cell adhesion molecules NF-kappa B Heme oxy-genase-1

High-Throughput Pb Recycling for Perovskite Solar Cells Using Biomimetic Whitlockite

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Energy & Environmental Materials 2023年第3期6卷 170-176页

作者： Jung Sug Hong Hee Jung Kim Chang Hwun Sohn Oh Yeong Gong Jin Hyuk Choi kang Hee Cho gill Sang Han Ki Tae Nam Hyun Suk Jung Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Korea

Pb contamination in aquatic environments causes severe pollution;therefore,harmless absorbents are *** this study,we report a novel synthesis of whitlockite(WH,Ca_(18)Mg_(2)(HPO_(4))_(2)(PO_(4))_(12)),which is the second most abundant biomineral in human bone,and its application as a high-performing Pb^(2+)***(HAP)and WH are prepared via a simple precipitation *** Pb2+absorption performance and mechanism of the synthesized biominerals are investigated in aqueous solutions at neutral *** results demonstrate that WH exhibits an excellent Pb2+absorption capacity of 2339 mg g^(−1),which is 1.68 times higher than the recorded value for ***,the absorbed Pb^(2+) ions are recycled into high-purity PbI_(2).This is employed as a precursor for the fabrication of perovskite solar cells(PSCs),resulting in a conversion efficiency of 19.00%comparable to that of commercial PbI2 powder(99.99%purity).Our approach provides an efficient way to remove Pb^(2+)ions from water and reuse them in the recycling of PSCs.

关键词： Pb absorption Pb recycling perovskite solar cells water purification whitlockite

Preparation of silver nanoparticle using organophosphoric acid

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Preparation of silver nanoparticle using organophosphoric ac...

Evaluation of Reference Genes for Quantitative Real-Time PCR Analysis in Manila Clam Ruditapes philippinarum Under Hypoxic Stress

13th Asian Chemical Congress

作者： SHIN,Jung Sik OH,Sung-Il kang,Jun-gill Department of Chemistry Chungnam National University

Silver nanoparticles were synthesized by reduction of AgNO via adjusting concentration of ***(2-ethylhexyl)phosphite,Bis(2-ethyIhexyl)-phosphate and Mono(2-ethylhexyl) 2-ethylhexylphosphonate were used as *** particle... 详细信息

关键词： Silver nanoparticle phosphoric acid dye

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Journal of Ocean University of China 2023年第4期22卷 1059-1067页

作者： JING Hao ZHOU Liqing GONG Miao TU kang LIU Zhihong WU Biao SUN Xiujun College of Fisheries and Life Science Shanghai Ocean UniversityShanghai 201306China State Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdao 266071China Laboratory for Marine Fisheries Science and Food Production Processes Laoshan LaboratoryQingdao 266237China School of Marine Science and Fisheries Jiangsu Ocean UniversityLianyungang 222005China Putian Institute of Aquaculture Science of Fujian Province Putian 351100China

Quantitative real-time PCR(qRT-PCR)has been widely used for gene expression analysis,and selection of reference genes is a key point to obtain accurate *** find out optimal reference genes for qRT-PCR in Manila clam Ruditapes philippinarum in response to hypoxia,different tissues were used and compared to evaluate the stability of candidate reference genes under low oxygen stress(DO 0.5mgL^(−1) and DO 2.0mgL^(−1))and normal condition(DO 7.5mgL^(−1)).Seven candidate reference genes were selected to evaluate the stability of their expression *** reference genes were evaluated by Delta Ct,BestKeeper,NormFinder and geNorm,and then screened by RefFinder *** hypoxic stress of 0.5mgL^(−1),the most suitable reference gene for gill and hepatopancreas was RPL31,and the optimal reference genes for axe foot and adductor muscle were TUB and HIS,*** hypoxic stress of 2.0mgL^(−1),the most stable reference gene for gill and hepatopancreas was RPL31,and the optimal reference genes for axe foot and adductor muscle were RPS23 and EF1A,*** the normal condition,HIS and EF1A were identified as the optimal internal reference genes in gill and hepatopancreas respectively,and GFRP2 was the best internal reference gene for axe foot and adductor *** present findings will provide important basis for the selection of reference genes for qRT-PCR analysis of gene expression level in bivalves under hypoxic stress,which might be helpful for the analysis of other molluscs too.

关键词： clam reference gene hypoxia quantitative real-time PCR

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Modified green dragon swaying its tail needling manipulation for treatment of knee osteoarthritis

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World Journal of Acupuncture-Moxibustion 2017年第3期27卷 15-20页

作者： HUANG Wei[[ JIAO Yang WAN Bi-jiang WU Chang-zheng LI Jia-kang[[ Hubei University of Chinese Medicine/The Co-innovation Center for Preventive Treatment of Disease of Acupuncture-moxibustion in Hubei Province Department of Acupuncture-Moxibustion Hubei Provincial Hospital of TCMInstitute of Hubei Provincial Hospital of TCM

Objective To compare the difference in the effect of modified green dragon swaying its tail needling manipulation and common needling manipulations on the overall rating of pain of patients with knee osteoarthritis, and to evaluate the advantages of modified green dragon swaying its tail needling manipulation for. Methods Ninety-five patients with knee osteoarthritis were divided into 2 groups according to the random number table method with 48 patients in the modified green dragon swaying its tail group（group special manipulation, SM group for short） and 47 patients in the common acupuncture group（group convention needling, CN group for short）, and different acupuncture manipulations were applied in the two groups. Internationally recognized Simplified Mc gill Pain Questionnaire（SF-MPQ） scale used for description and measurement of pain was applied to evaluate the pain degree, including pain rating index（PRI）, visnal analogue scale（VAS）and present pain intensity（PPI）. The index of severity for osteoarthritis（ISOA） was adopted for evaluation of clinical efficacy. Results（1） In SM group, the scores of PRI, VAS and PPI were 6.63±4.67, 2.23±1.45 and 0.65±1.32, respectively, after treatment, and in CN group, the scores of PRI, VAS and PPI were 13.32±7.96, 4.34±1.79 and 2.28±1.21, respectively, the scores decreased in the two groups after treatment（all P〈0.05）, and the improvement in SM group was superior to that in CN group（all P〈0.01）.（2） The clinical cure rate in SM group was 52.08%, and the total effective rate was 97.92%, the clinical cure rate in CN group was 25.53%, and the total effective rate was 85.10%. The comparison of clinical cure rate in the two groups showed that P〈0.01. Conclusion The SM group is obviously superior to CN group in the improvement of overall rating of pain of patients. It is indicated that modified green dragon swaying its tail acupuncture therapy can effectively relieve the pain of patients with knee osteoarthritis, which was worthy of po

关键词： knee osteoarthritis green dragon swaying its tail of needlingmanipulation MPQ pain scale Index of severity for osteoarthritis (ISOA)

急性盐度胁迫对摄食不同镁水平饲料鲈血清渗透压和离子水平以及鳃丝ATP酶活力的影响

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水产学报 2012年第9期36卷 1425-1434页

作者：张春晓周磊叶继丹王玲皇康康翟秋玲集美大学农业部东海海水健康养殖重点实验室集美大学厦门市饲料检测与安全评价重点实验室

为研究饲喂不同镁水平饲料后,鲈血清渗透压、离子水平和鳃丝ATP酶活力对急性盐度胁迫的反应,实验用镁水平为0.413 g/kg(D1,对照组)、1.042 g/kg(D2)、1.577 g/kg(D3)、1.991 g/kg(D4)的4种实验饲料,分别投喂初始平均体质量为(30±0.5)g... 详细信息

为研究饲喂不同镁水平饲料后,鲈血清渗透压、离子水平和鳃丝ATP酶活力对急性盐度胁迫的反应,实验用镁水平为0.413 g/kg(D1,对照组)、1.042 g/kg(D2)、1.577 g/kg(D3)、1.991 g/kg(D4)的4种实验饲料,分别投喂初始平均体质量为(30±0.5)g的鲈。实验鱼在淡水循环养殖系统中饲养50 d后立即转入海水循环养殖系统,并在转入前(0 h)和转入后1、3、6、12、24 h分别采集鲈鳃丝和血液样本。结果显示:盐度胁迫前饲料镁水平对鲈血清渗透压、Na+、K+、Cl-、Mg2+含量和鳃丝中Na+/K+-ATP(NKA)与Ca2+/Mg2+-ATP(CMA)酶的活力有显著影响(P<0.05),其中血清渗透压、Mg2+含量和NKA酶活力随饲料镁水平的增加而升高。D4组的血清渗透压、Mg2+含量、NKA和CMA酶活力显著高于其他组(P<0.05),表明该组鲈处于高强度的渗透压调节的生理状态。急性盐度胁迫中,血清Na+和Cl-含量随胁迫时间的延长呈逐渐上升趋势,血清渗透压、K+、Ca2+、Mg2+和鳃丝ATP酶活力在0～24 h内呈波动性变化。D1组的NKA和CMA酶活力在胁迫1 h时显著低于其他组(P<0.05),表明长期摄食低镁水平的饲料会降低鲈鳃丝NKA和CMA酶对环境盐度刺激的敏感度。研究表明,淡水养殖鲈的饲料中镁水平应低于1.991 g/kg,以减少维持鳃丝NKA与CMA酶高活力而导致的能量损失,而在环境由低盐向高盐的快速转变过程中,较高的饲料镁水平可通过快速提高的鳃丝NKA与CMA酶活力而有利于鲈快速适应高盐环境。

关键词：鲈镁渗透压 ATP酶血清离子