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Mucinous neoplasm of the appendix:A case report and review of literature

World Journal of Gastrointestinal Surgery 2024年第3期16卷 944-954页

作者： Hao-cheng Chang Jung-cheng kang Ta-Wei Pu Ruei-Yu Su Chao-Yang Chen Je-Ming Hu Department of Surgery Tri-Service General HospitalTaipei 114TaiwanChina Division of Colon and Rectal Surgery Department of SurgeryTaiwanChina Adventist HospitalTaipei 105TaiwanChina Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105TaiwanChina Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105TaiwanChina Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 325TaiwanChina

BACKGROUND Appendiceal mucinous neoplasms(AMNs),although not classified as rare,are relatively uncommon tumors most often discovered incidentally during colorectal *** identification of AMNs is difficult due to non-specific sym-ptoms,overlapping tumor markers with other conditions,and the potential for *** underscores the urgent need for precision in diagnosis to pre-vent severe *** SUMMARY This case report describes the unexpected discovery and treatment of a low-grade AMN(LAMN)in a 74-year-old man undergoing laparoscopic hemicolectomy for transverse colon adenocarcinoma(AC).Preoperatively,non-specific gastroin-testinal symptoms and elevated tumor markers masked the presence of *** tumor,presumed to be an AMN peritoneal cyst intraoperatively,was con-firmed as LAMN through histopathological *** neoplasm exhibited mucin accumulation and a distinct immunohistochemical profile:Positive for Ho-meobox protein CDX-2,Cytokeratin 20,special AT-rich sequence-binding protein 2,and Mucin 2 but negative for cytokeratin 7 and Paired box gene *** profile aids in distinguishing appendiceal and ovarian mucinous *** recovery was uncomplicated,and the patient initiated adjuvant chemotherapy for the colon *** This case highlights the diagnostic complexity of AMNs,emphasizing the need for vigilant identification to avert potential complications,such as pseudomyxoma peritonei.

关键词： Adenocarcinoma Appendiceal neoplasms Low-grade appendiceal mucinous neoplasm Peritoneal neoplasms Pseudomyxoma peritonei Case report

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Epimedin B exhibits pigmentation by increasing tyrosinase family proteins expression,activity,and stability

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Journal of Pharmaceutical Analysis 2024年第1期14卷 69-85页

作者： Chen Hong Yifan Zhang Lili Yang Haoyang Xu kang cheng Zhi Lv Kaixian Chen Yiming Li Huali Wu Department of TCM Chemistry School of PharmacyShanghai University of Traditional Chinese MedicineShanghai200000China Department of Dermatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200000China International Education College Shanghai University of Traditional Chinese MedicineShanghai200000China Shanghai Inoherb Cosmetics Co. Ltd.Shanghai200000China

Epimedin B(EB)is one of the main flavonoid ingredients present in Epimedium brevicornum Maxim.,a traditional herb widely used in *** previous study showed that EB was a stronger inducer of melanogenesis and an activator of tyrosinase(TYR).However,the role of EB in melanogenesis and the mechanism underlying the regulation remain ***,as an extension to our previous investigation,we provide comprehensive evidence of EB-induced pigmentation in vivo and in vitro and elucidate the melanogenesis mechanism by assessing its effects on the TYR family of proteins(TYRs)in terms of expression,activity,and *** results showed that EB increased TYRs expression through microphthalmia-associated transcription factor-mediated p-Akt(referred to as protein kinase B(PKB))/glycogen synthase kinase 3β(GSK3β)/β-catenin,p-p70 S6 kinase cascades,and protein 38(p38)/mitogen-activated protein(MAP)kinase(MAPK)and extracellular regulated protein kinases(ERK)/MAPK pathways,after which EB increased the number of melanosomes and promoted their maturation for melanogenesis in melanoma cells and human primary melanocytes/skin ***,EB exerted repigmentation by stimulating TYR activity in hydroquinone-and N-phenylthiourea-induced TYR inhibitive models,including melanoma cells,zebrafish,and ***,EB ameliorated monobenzone-induced depigmentation in vitro and in vivo through the enhancement of TYRs stability by inhibiting TYR misfolding,TYR-related protein 1 formation,and retention in the endoplasmic reticulum and then by downregulating the ubiquitination and proteolysis *** data conclude that EB can target TYRs and alter their expression,activity,and stability,thus stimulating their pigmentation function,which might provide a novel rational strategy for hypopigmentation treatment in the pharmaceutical and cosmetic industries.

关键词： Epimedin B Melanosome Tyrosinase Melanogenesis

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Stercoral perforation of the cecum:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1189-1194页

作者： Hung-Chun Yu Ta-Wei Pu Jung-cheng kang Chao-Yang Chen Je-Ming Hu Ruei-Yu Su Department of Surgery Taichung Armed Forces General HospitalTaichung 411228Taiwan Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 325Taiwan

BACKGROUND With less than 90 reported cases to date,stercoral perforation of the colon is a rare *** ulceration is thought to occur due to ischemic pressure necrosis of the bowel wall,which is caused by the presence of a stercoraceous *** underscore this urgent surgical situation concerning clinical presentation,surgical treatment,and results,we present the case of a 66-year-old man with a stercoral *** SUMMARY A 66-year-old man with a history of hypertension,hyperlipidemia,and gout presented at the emergency department with lower abdominal pain and a low-grade fever lasting for a few *** computed tomography indicated a suspected bezoar(approximately 7.6 cm)in the dilated cecum,accompanied by pericolic fat stranding,mild proximal dilatation of the ileum,pneumoperitoneum,and minimal ***,feculent peritonitis with isolated cecal perforation were ***,a right hemicolectomy with peritoneal lavage was performed.A histopathological examination supported the intraoperative *** In stercoral perforations,a diagnosis should be diligently pursued,especially in older adults,and prompt surgical intervention should be implemented.

关键词： Acute abdomen Colectomy Peritoneal lavage Pneumoperitoneum Bezoars Case report

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文化爆炸

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外国文学 2024年第5期 89-99页

作者：康澄华南师范大学外国语言文化学院广东广州510631

“文化爆炸”是洛特曼后期文化符号学的重要概念。围绕这一学术关键词形成的文化爆炸论是他学术生涯最后十年的思想结晶,是他文化符号学理论的重要组成部分。《文化与爆炸》和《文化的不可预见机制》是洛特曼有关文化爆炸论的代表作,由... 详细信息

“文化爆炸”是洛特曼后期文化符号学的重要概念。围绕这一学术关键词形成的文化爆炸论是他学术生涯最后十年的思想结晶,是他文化符号学理论的重要组成部分。《文化与爆炸》和《文化的不可预见机制》是洛特曼有关文化爆炸论的代表作,由它们引发的相关讨论已成为国际洛特曼学和文化学的新热点,也是我国洛特曼学亟待填补的研究空白。文化爆炸论含纳诸多重要的文化议题,其中包括文化爆炸与历史进程的关系、渐进与爆炸的关系、文化爆炸的不可预见机制等,这些问题极富学术和思想价值,对处于文化巨变中的当下社会具有重要的启示意义。

关键词：洛特曼文化符号学文化爆炸渐进不可预见机制

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Cellular angiofibroma arising from the rectocutaneous fistula in an adult: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1778-1784页

作者： Hao-En Chen Yu-Yang Lu Ruei-Yu Su Hong-Hau Wang Chao-Yang Chen Je-Ming Hu Jung-cheng kang Kuan-Hsun Lin Ta-Wei Pu Department of Surgery Taichung Armed Forces General HospitalTaichung 411Taiwan Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pediatrics Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 32551Taiwan Department of Radiology Tri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan

BACKGROUND Rectocutaneous fistulae are *** infection originates within the anal glands and subsequently extends into adjacent regions,ultimately resulting in fistula *** angiofibroma(CAF),also known as an angiomy ofibroblastoma-like tumor,is a rare benign soft tissue neoplasm predominantly observed in the scrotum,perineum,and inguinal area in males and in the vulva in *** describe the first documented case CAF that developed within a rectocutaneous fistula and manifested as a perineal *** SUMMARY In the outpatient setting,a 52-year-old male patient presented with a 2-year history of a growing perineal mass,accompanied by throbbing pain and minor scrotal *** examination revealed a soft,well-defined,non-tender mass at the left buttock that extended towards the perineum,without a visible *** initial assessment identified a soft tissue tumor,and the laboratory data were within normal *** and pelvic computed tomography(CT)revealed swelling of the abscess cavity that was linked to a rectal cutaneous fistula,with a track-like lesion measuring 6 cm×0.7 cm in the left perineal region and attached to the left *** examination found no significant inner orifices.A left medial gluteal incision revealed a thick-walled mass,which was excised along with the extending tract,and curettage was *** examination confirmed CAF *** patient achieved total resolution during follow-up assessments and did not require additional *** CT imaging supports perineal lesion diagnosis and *** angiofibromas,even with a cutaneous fistula,can be excised transperineally.

关键词： Angiofibroma Perineal mass Rectocutaneous fistula Anorectal fistula Anal fistula Case report

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发展中大国“先富带后富”效应的计量评价——基于中国省级面板数据的非线性最小二乘法估计

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湖南师范大学社会科学学报 2024年第4期53卷 39-50页

作者：罗富政程抗湖南师范大学商学院湖南长沙410081

中国是代表性发展中大国,具有典型区域二元结构特征,强化“先富带后富”效应对于推动二元区域共同富裕具有重要意义。利用我国省级面板数据,基于引入空间地理权重矩阵的非线性最小二乘法,计量评价省际“先富带后富”效应并检验地理距离... 详细信息

中国是代表性发展中大国,具有典型区域二元结构特征,强化“先富带后富”效应对于推动二元区域共同富裕具有重要意义。利用我国省级面板数据,基于引入空间地理权重矩阵的非线性最小二乘法,计量评价省际“先富带后富”效应并检验地理距离衰减规律。研究发现:我国存在显著的省际“先富带后富”效应,先富省份人均实际GDP每提升1个单位能带动后富省份人均GDP提高0.1899个单位,稳健性检验和反事实检验后依然成立。“先富带后富”效应符合地理距离衰减规律,形成平滑式和跳跃式两种类型且存在地理阈值差异。先富省份之间存在正外部性的发展带动效应;我国东部和中部地区的区域性增长极具备“先富带后富”效应,且中部地区强于东部地区。

关键词： “先富带后富”效应发展中大国地理距离衰减规律

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空间“界限”与人物塑造——以洛特曼对果戈理小说中艺术空间的认识为例

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学术研究 2024年第4期 171-176页

作者：伍廖圆康澄华南师范大学外国语言文化学院广东广州510631

在洛特曼文化空间理论中,“界限”是决定空间特征的主导性因素,它从整体上确定了空间模型的样貌和结构布局,也不可避免地影响着文本空间中人物的建构。界限的不可渗透性确立了人物类型特征,在果戈理作品中主要有两种确立形式:对戏剧和... 详细信息

在洛特曼文化空间理论中,“界限”是决定空间特征的主导性因素,它从整体上确定了空间模型的样貌和结构布局,也不可避免地影响着文本空间中人物的建构。界限的不可渗透性确立了人物类型特征,在果戈理作品中主要有两种确立形式:对戏剧和造型艺术的重视以及对系统化的追求。而界限的双面性及其过滤功能则让人物类型特征的演变成为可能,“越界”也成为了人物形象发生根本性改变的重要标志。洛特曼的界限研究并未局限于具体文学作品,它还被投射到更广阔的文化中,以寻求一种理解文本人物形象的普遍范式,来描述和研究各民族文学、文化最普遍、最一般的特征。

关键词：空间界限人物洛特曼果戈理

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Treatment of benign rectal stricture caused by repeated anal insertion by endoscopy and balloon dilation:A case report

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World Journal of Gastrointestinal Endoscopy 2024年第2期16卷 91-97页

作者： Shih-Hung Liu Jung-cheng kang Je-Ming Hu Chao-Yang Chen Kuan-Hsun Lin Ta-Wei Pu Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgerySongshan BranchTri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan

BACKGROUND Benign rectal strictures can be categorized as primary(disease-related)and secondary(surgical anastomosis-related).Secondary strictures arise from surgical complications,whereas primary strictures have diverse etiologies,including various inflammatory *** strictures are usually managed by surgery and *** present an unusual etiology of benign rectal stricture caused by the repeated insertion of foreign objects into the rectum for sexual purposes,resulting in rectal injury and subsequent chronic *** SUMMARY A 53-year-old man presented to the outpatient clinic of the Colorectal Surgery Department with symptoms of chronic constipation and bloody *** patient previously experienced rectal injury due to foreign object insertion for sexual *** revealed benign circumferential narrowing of the *** underwent treatment by endoscopic argon plasma coagulation and balloon dilation and follow-up as an outpatient for 4 months.A colonoscopy at the end of the follow-up period revealed no evidence of rectal stricture *** A history of rectal injury,followed by chronic inflammation,should be considered in patients with benign rectal *** with endoscopic argon plasma coagulation and balloon dilation can prevent the need for surgical resection of benign rectal strictures.

关键词： Chronic rectal inflammation Colonoscopy Benign rectal stricture Foreign body insertion Rectal injury Case report

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“物”的符号身份及其意义的生成与阐释

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广东外语外贸大学学报 2024年第5期35卷 40-50页

作者：康澄华南师范大学外国语言文化学院

物与文字、仪式等其他的符号形态一样,行使着保存、传递和创造文化意义的职能。多层次、多类别和多样式的物构成一个文化复合体,维系并促进着群体和民族的文化认同和传承。物既属于现实世界又属于意义世界,具有物性和符号性并拥有实用... 详细信息

物与文字、仪式等其他的符号形态一样,行使着保存、传递和创造文化意义的职能。多层次、多类别和多样式的物构成一个文化复合体,维系并促进着群体和民族的文化认同和传承。物既属于现实世界又属于意义世界,具有物性和符号性并拥有实用功能和象征功能。俄罗斯民俗学家阿·巴伊布林用物在符号标尺上的位置来确定其符号身份,符号身份的量值和符号性成正比,和物性成反比,其变化受到诸多因素的影响。物性与符号性之间的关系决定着物的意义建构。从物的实体与象征之间是理据的,还是约定俗成的来看物的意义建构是逻辑思维的产物。事实上,神话思维下建构起来的物的意义并未完全丢失,它们是物的文化记忆的重要组成部分。对物的意义阐释既可来自于证据确凿的考据,也可来自于符合逻辑的推测和判断,还可依靠联想获得超越物的制造者本意的含义。物的意义阐释也包含着想象、推测、曲解甚至破坏。

关键词：物符号身份意义生成意义阐释

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氢燃料双模态冲压发动机火焰结构及其稳定机制的LES研究

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推进技术 2024年第1期45卷 153-164页

作者：袁梦铖王平张洋田野陈爽程康江苏大学能源研究院江苏镇江212013 中国空气动力研究与发展中心空天技术研究所四川绵阳621000

为深入理解双模态冲压发动机内流场结构和燃烧特性,本文采用精细的有限速率化学反应模型,对凹腔内氢气直喷式超声速燃烧室火焰进行了大涡模拟研究。发动机隔离段入口马赫数为2.0,滞止温度和压力分别为950 K和0.82 MPa。定性和定量的验... 详细信息

为深入理解双模态冲压发动机内流场结构和燃烧特性,本文采用精细的有限速率化学反应模型,对凹腔内氢气直喷式超声速燃烧室火焰进行了大涡模拟研究。发动机隔离段入口马赫数为2.0,滞止温度和压力分别为950 K和0.82 MPa。定性和定量的验证分析表明,计算结果良好符合试验所反映的物理规律,再现了两种典型的工作模态及其稳焰模式。当量比为0.1时,发动机处于超燃模态,为凹腔剪切层稳焰模式;当量比为0.3时,发动机处于亚燃模态,为凹腔辅助射流尾迹稳焰模式,分离涡的大尺度脉动及凹腔回流区的缺失致使火焰剧烈振荡。同时采用改进的火焰因子和过滤函数详细分析了局部火焰特征和流动模式,观察到了不同规律的局部熄火现象,并且剧烈的流动振荡对于局部火焰结构的稳定性有着不利影响。

关键词：双模态冲压发动机超声速燃烧火焰结构火焰稳定机制大涡模拟

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