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Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice

World Journal of Hepatology 2019年第8期11卷 619-637页

作者： kandy t velázquez Reilly t Enos Jackie E Bader Alexander t Sougiannis Meredith S Carson Ioulia Chatzistamou James A Carson Prakash S Nagarkatti Mitzi Nagarkatti E Angela Murphy Department of Pathology Microbiology and Immunology School of Medicine University of South Carolina Columbia SC 29209 United States College of Health Professions University of Tennessee Health Sciences Center Memphis TN 38163 United States

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) has become an epidemic largely due to the worldwide increase in obesity. While lifestyle modifications and pharmacotherapies have been used to alleviate NAFLD, successful treatment options are limited. One of the main barriers to finding safe and effective drugs for long-term use in NAFLD is the fast initiation and progression of disease in the available preclinical models. therefore, we are in need of preclinical models that (1) mimic the human manifestation of NAFLD and (2) have a longer progression time to allow for the design of superior treatments. AIM to characterize a model of prolonged high-fat diet (HFD) feeding for investigation of the long-term progression of NAFLD. MEtHODS In this study, we utilized prolonged HFD feeding to examine NAFLD features in C57BL/6 male mice. We fed mice with a HFD (60% fat, 20% protein, and 20% carbohydrate) for 80 wk to promote obesity (Old-HFD group, n = 18). A low-fat diet (LFD)(14% fat, 32% protein, and 54% carbohydrate) was administered for the same duration to age-matched mice (Old-LFD group, n = 15). An additional group of mice was maintained on the LFD (Young-LFD, n = 20) for a shorter duration (6 wk) to distinguish between age-dependent and age-independent effects. Liver, colon, adipose tissue, and feces were collected for histological and molecular *** Prolonged HFD feeding led to obesity and insulin resistance. Histological analysis in the liver of HFD mice demonstrated steatosis, cell injury, portal and lobular inflammation and fibrosis. In addition, molecular analysis for markers of endoplasmic reticulum stress established that the liver tissue of HFD mice have increased phosphorylated Jnk and CHOP. Lastly, we evaluated the gut microbial composition of Old-LFD and Old-HFD. We observed that prolonged HFD feeding in mice increased the relative abundance of the Firmicutes phylum. At the genus level, we observed a significant increase in the abundance

关键词： High-fat diet Obesity Non-alcoholic fatty liver disease Gut microbiome Endoplasmic reticulum stress Inflammation Fibrosis

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Acetaminophen and zinc phosphide for lethal management of invasive lizards Ctenosaura similis

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Current Zoology 2011年第5期57卷 625-629页

作者： Michael L. AVERY John D. EISEMANN kandy L. KEACHER Peter J. SAVARIE United States Department of Agriculture Wildlife Services National Wildlife Research Center Florida Field Station 2820 East University Avenue Gainesville FL 32641 USA United States Department of Agriculture Wildlife Services National Wildlife Research Center Ft. Collins CO 80225 USA

Reducing populations of invasive lizards through trapping and shooting is feasible in many cases but effective inte-grated management relies on a variety of tools, including toxicants. In Florida, using wild-caught non-native black spiny-tailed iguanas Ctenosaura similis, we screened acetaminophen and zinc phosphide to determine their suitability for effective population management of this prolific invasive species. Of the animals that received acetaminophen, none died except at the highest test dose, 240 mg per lizard, which is not practical for field use. Zinc phosphide produced 100% mortality at dose levels as little as 25 mg per lizard, equivalent to about 0.5% in bait which is lower than currently used in commercial baits for commensal rodent con-trol. We conclude that zinc phosphide has potential as a useful tool for reducing populations of invasive lizards such as the black spiny-tailed iguana provided target-selective delivery methods are developed [Current Zoology 57 （5）： 625~529, 2011].

关键词： Acetaminophen Black spiny-tailed iguana Ctenosaura similis Florida Invasive Zinc phosphide

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Femtosecond laser deposition of tiO_2 nanoparticleassembled films with embedded CdS nanoparticles

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Optoelectronics Letters 2014年第1期10卷 43-46页

作者：倪晓昌桑丽霞张洪杰 Anoop Kiliyanam-kandy Salvatore Amoruso 王宣 Rosalba Fittipaldi 李彤胡明列徐丽娟 School of Electronic Engineering Tianjin University of Technology and Education CNR-SPIN and Dipartimento di Fisica Università degli Studi di Napoli Federico IIComplesso Universitario Monte S.AngeloVia Cintia Key Laboratory of Enhanced Heat transfer and Energy Conservation Ministry of Educationand Key Laboratory of Heat Transfer and Energy ConversionBeijing MunicipalityCollege of Environmental and Energy EngineeringBeijing University of Technology CNR-SPIN UOS Salerno Via Ponte don Melillo Ultrafast Laser Laboratory and Key Laboratory of Opto-electronic Information TechnologyMinistry of EducationTianjin University

Based on the normal pulsed laser ablation method,femtosecond pulsed laser deposition(fs-PLD)is adopted in vacuum for the production of tiO2nanoparticle-assembled *** study the morphology and electronic characteristics of tiO2nanoparticle-assembled films deposited at different oxygen background gas pressures from high vacuum(~10-4Pa)to 100 Pa and different deposition *** results show that tiO2nanoparticle-assembled films obtained in high vacuum present both a mixture with rutile phase and anatase phase and a pure rutile *** the same time,there are more mesoporous structures in the film after annealing,which is beneficial for the enhancement of photocatalytic *** water splitting experiment,part of the tiO2nanoparticle-assembled films embedded with a small mass fraction of CdS nanoparticles(~5%)present an interesting photocurrent enhancement with a maximum value of^0.2mA/cm2under a solar simulator.

关键词：脉冲激光沉积 CdS纳米粒子纳米粒子薄膜二氧化钛纳米颗粒嵌入式飞秒沉积时间金红石相

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First Italian outbreak of VIM-producing Serratia marcescens in an adult polyvalent intensive care unit, August-October 2018: A case report and literature review

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World Journal of Clinical Cases 2019年第21期7卷 3535-3548页

作者： Maria Rosaria Iovene Vincenzo Pota Massimiliano Galdiero Giusy Corvino Federica Maria Di Lella Debora Stelitano Maria Beatrice Passavanti Maria Caterina Pace Aniello Alfieri Sveva Di Franco Caterina Aurilio Pasquale Sansone Vettakkara kandy Muhammed Niyas Marco Fiore Department of Experimental Medicine University of Campania"Luigi Vanvitelli"Naples 80138Italy Department of Women Child and General and Specialized SurgeryUniversity of Campania"Luigi Vanvitelli"Naples 80138Italy Department of Medicine All India Institute of Medical SciencesNew Delhi 110029India

BACKGROUND Carbapenem-resistant Enterobacteriaceae has become a significant public health concern as hospital outbreaks are now being frequently reported and these organisms are becoming difficult to treat with the available *** SUMMARY An outbreak of VIM-producing Serratia marcescens occurred over a period of 11 wk(August,1 to October,18)in patients admitted to the adult polyvalent intensive care unit of the University of Campania“Luigi Vanvitelli”located in *** episodes occurred in three patients(two patients infected,and one patient colonized).All the strains revealed the production of *** After three decades of carbapenem antibiotics use,the emergence of carbapenemresistance in Enterobacteriaceae has become a significant concern and a stricter control to preserve its clinical application is *** is,to our knowledge,the first outbreak of VIM-producing Serratia marcescens in *** policies must be implemented to avoid future outbreaks.

关键词： Serratia marcescens Carbapenamase VIM Intensive care unit Outbreak Case report

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Clinical profile of mechanically ventilated COVID-19 patients:A retrospective observational study from Dubai

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Discussion of Clinical Cases 2021年第1期8卷 15-23页

作者： Prashant Nasa Aanchal Singh Habib talal Syed Saroj Patidar Vishal Sapakale kandy Koul Rajesh Kumar Critical Care Medicine NMC Speciality Hospital DubaiUnited Arab Emirates

Background:We did a retrospective analysis of critical coronavirus disease 2019(COVID-19)patients admitted to our intensive care unit(ICU).the objective was to evaluate the outcome,risk factors and effect of prone position in critically ill patients requiring invasive mechanical ventilation(IMV).Patients and methods:the data were collected regarding demographics,comorbidities,laboratory parameters and *** regression was used for analysis of the association of risk factors to the ***:From 15 March to 30 May 2020,35(59.3%)out of 59 critical COVID-19 requiring IMV were admitted to a tertiary care hospital in *** day-28 ICU mortality was 28.8% and 48.6% in patients requiring *** position(PP)was used in 17(48.6%)patients for median duration of 19(5-20)hours with significant PaO_(2)/FiO_(2) *** kidney injury was common(30.5%),and half of the patients required renal replacement therapy(RRt)with higher mortality(77.8%).Lactate dehydrogenase(LDH)odd ratio(OR)-1.006[95%CI-1.00-1.01],D-dimer(OR-1.003[1.000-1.000]),low total leucocyte count(OR-1.135[1.01-1.28]),and lymphopenia(OR-0.909[0.84-0.98])were independently associated with increased risk of ***:IMV requirement in patients with COVID-19 is associated with higher *** markers like LDH,D-dimer,and lymphopenia can be used to predict the *** patients with COVID-19 on IMV respond significantly with prone position,and it should be considered early with a longer duration.

关键词： Coronavirus disease 2019 COVID-19 related respiratory failure Acute respiratory distress syndrome Invasive mechanical ventilation

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Geo-Spatial Information System for Developing tourism Industry in kandy District, Sri Lanka

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Chinese Business Review 2017年第9期16卷 436-446页

作者： t. M. S. P. K. thennakoon H. M. G. D. Welagedara University of Sri Jayewardenepura Gangodawila Nugegoda Sri Lanka Strategic Enterprise Management Agency Colombo Sri Lanka

tourism is a rapidly growing investment point in Sri Lanka, where huge investment is takeing place. Even though the investment is very massive, the planning, development, and marketing are key components of success in tourism zone enhancement. the main objective of this study was to implement a geo-spatial information system for development of tourism in kandy district. Primary data collection methods i.e. questionnaire survey, interviews, focus group interviews, and observations were employed for data collection. Google maps with Google API standards which are specially designed for developers and computer programmers were used for implementation of the system. System requirements were identified by interviewing tourists and observations made on tourist sites. Proximity analysis, spatial joint, and network analysis with Google direction application program interface （API） and Google place API were used to analyze data. the study highlights the potential tourist attractions and the accessibility and other required details through a web output. Issues and challenges faced by travelers are mainly lack of specific location information, public transport schedules, and reliable tourist attraction information. Online geo-spatial information system created in this study provides a guide for tourists to fred the destination routes, the service areas, and all necessary details on particular destinations.

关键词： tourism geo-database API GIS geo-spatial kandy

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