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SCN1A错义突变位置对癫痫不同表型严重程度的影响

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世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 39-40页

作者： kanai k. Hirose S. Oguni H. 李一明 Department of Neuropsychiatry Hirosaki Univ. School of Medicine 5 Zaifu-cho Hirosaki Aomori 036-8562 Japan Dr.

Back.round and Methods: Many missense mutations in the voltage gated sodium channel subunit gene SCN1A were identified in patients with generalized epilepsy with febrile seizures plus (GEFS+ ) and severe myoclonic epilepsy of infancy (SMEI), although GEFS+ is distinct from SMEI in terms of clinical symptoms, severity, prognosis, and responses to antiepileptic drugs. The authors analyzed the localization of missense mutations in SCN1A identified in patients with GEFS+ and SMEI to clarify the phenotype genotype relationships. Results: Mutations in SMEI occurred more frequently in the “ Pore” regions of SCN A than did those in GEFS+ . These SMEI mutations in the “ pore” regions were more strongly associated than mutations in other regions with the presence of ataxia and tendency to early onset of disease. The possibility of participation of ion selectivity dysfunction of the channel in the pathogenesis of SMEI was suggested by a mutation in the pore region (R946C) identified in a SMEI patient. Conclusions: There was a significant phenotype genotype relationship in generalized epilepsy with febrile seizures plus and severe myoclonic epilepsy of infancy with SCN1A missense mutations. More severe sodium channel dysfunctions including abnormal ion selectivity that are caused by mutations in the pore regions may be involved in the pathogenesis of SMEI.

关键词：错义突变 SCN1A 肌阵挛型癫痫全身性癫痫抗癫痫药物离子通道亚单位孔区发病机制热性癫痫发作

维普期刊数据库

醛糖还原酶抑制改变了糖尿病患者神经结点处的Na+电流和神经传导

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 5-5页

作者： Misawa S. k.wabara S. kanai k. 郭俊牛亚利 Dr.Department of Neurology Chiba University School of Medicine1-8-1 InohanaChuo-kuChiba260-8670Japan

BACk.ROUND:In diabetic nerves,activation of the polyol pathway via an aldose reductase and the resulting impairment of the Na+-k.pump would lead to a decreased transaxonal Na+gradient and thereby reduced nodal Na+***:To investigate whether the aldose reductase inhibitor(ARI)epalrestat improves nodal Na+currents and nerve conduction in human diabetic ***:The authors conducted a 6-month,open clinical trial with an ARI,epalrestat,in 30 patients with mild-to-moderate diabetic *** latent addition technique and measurements of the strength duration time constant were used to estimate nodal persistent Na+currents in median motor *** testing and extensive nerve conduction studies including F-wave analyses were performed before and 1 and 6 months after the initiation of treatment with oral ***:Within a month of the start of treatment,there was a significant improvement in nerve conduction,particularly in conduction times across the carpal tunnel and F-wave *** results of latent addition(p < 0.05)and strength-duration time constant(p = 0.06)suggested increased nodal persistent Na+*** 6 months,nerve conduction continued to ***:Aldose reductase pathway inhibition could rapidly increase nodal Na+currents and thereby improve the slowing of nerve conduction,presumably because of a restoration of the membranous Na+gradient.

关键词：神经传导醛糖还原酶糖尿病性神经病结点奇点 Na 电流

A GAN-based temporally stable shading model for fast animation of photorealistic hair

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Computational Visual Media 2021年第1期7卷 127-138页

作者： Zhi Qiao Tak.shi kanai Department of General Systems Studies Graduate School of Arts and SciencesThe University of TokyoTokyoJapan

We introduce an unsupervised GANbased model for shading photorealistic hair *** model is much faster than previous rendering algorithms and produces fewer artifacts than other neural image translation *** main idea is to extend the Cycle-GAN structure to avoid semitransparent hair appearance and to exactly reproduce the interaction of the lights with the *** use two constraints to ensure temporal coherence and highlight *** approach outperforms and is computationally more efficient than previous methods.

关键词： hair animation fast shading neural network.

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Therapeutic applications of curcumin for patients with pancreatic cancer

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World Journal of Gastroenterology 2014年第28期20卷 9384-9391页

作者： Masashi kanai Department of Clinical Oncology and Pharmacogenomics Graduate School of MedicineKyoto University KyotoJapan Kyoto University Hospital

A number of preclinical studies have demonstrated anticancer effects for curcumin in various types of tumors, including pancreatic cancer. Curcumin has anticancer effects both alone and in combination with other anticancer drugs (e.g., gemcitabine, 5-fluorouracil, and oxaliplatin), and it has been shown to modulate a variety of molecular targets in preclinical models, with more than 30 molecular targets identified to date. Of these various molecules, NF-κB is thought to be one of the primary targets of curcumin activity. Based on these promising preclinical results, several research groups, including our own, have progressed to testing the anticancer effects of curcumin in clinical trials; however, the poor bioavailability of this agent has been the major challenge for its clinical application. Despite the ingestion of gram-level doses of curcumin, plasma curcumin levels remain at low (ng/mL) levels in patients, which is insufficient to yield the anticancer benefits of curcumin. This problem has been solved by the development of highly bioavailable forms of curcumin (THERACURMIN®), and higher plasma curcumin levels can now be achieved without increased toxicity in patients with pancreatic cancer. In this article, we review possible therapeutic applications of curcumin in patients with pancreatic cancer.

关键词： Curcumin Pancreatic cancer Nuclear factor-k.ppa B Bioavailability THERACURMIN

Chronic atrophic gastritis detection with a convolutional neural network.considering stomach regions

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World Journal of Gastroenterology 2020年第25期26卷 3650-3659页

作者： Misak. kanai Ren Togo Tak.hiro Ogawa Mik. Haseyama Graduate School of Information Science and Technology Hokkaido UniversitySapporo 0600814HokkaidoJapan Education and Research Center for Mathematical and Data Science Hokkaido UniversitySapporo 0600812HokkaidoJapan Faculty of Information Science and Technology Hokkaido UniversitySapporo 0600814HokkaidoJapan

BACk.ROUND The risk.of gastric cancer increases in patients with Helicobacter pylori-associated chronic atrophic gastritis(CAG).X-ray examination can evaluate the condition of the stomach,and it can be used for gastric cancer mass ***,sk.lled doctors for interpretation of X-ray examination are decreasing due to the diverse of *** To evaluate the effectiveness of stomach regions that are automatically estimated by a deep learning-based model for CAG *** We used 815 gastric X-ray images(GXIs)obtained from 815 *** ground truth of this study was the diagnostic results in X-ray and endoscopic *** a part of GXIs for training,the stomach regions are manually annotated.A model for automatic estimation of the stomach regions is trained with the *** the rest of them,the stomach regions are automatically ***,a model for automatic CAG detection is trained with all GXIs for *** In the case that the stomach regions were manually annotated for only 10 GXIs and 30 GXIs,the harmonic mean of sensitivity and specificity of CAG detection were 0.955±0.002 and 0.963±0.004,*** By estimating stomach regions automatically,our method contributes to the reduction of the work.oad of manual annotation and the accurate detection of the CAG.

关键词： Gastric cancer risk Chronic atrophic gastritis Helicobacter pylori Gastric Xray images Deep learning Convolutional neural network Computer-aided diagnosis

Transporter-Mediated Organ Toxicity

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毒理学杂志 2005年第S1期 173-174页

作者： Hitoshi Endou,Yoshik.tsu kanai Department of Pharmacology and Toxicology k.orin University School of Medicine 6-20-2 Shink.wa Mitak. Tok.o 181-8611 Japan Department of Pharmacology and Toxicology k.orin University School of Medicine 6-20-2 Shink.wa Mitak. Tok.o 181-8611 Japan

Hypoxia and fatty liver

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World Journal of Gastroenterology 2014年第41期20卷 15087-15097页

作者： Tomohiro Suzuk. Satok. Shinjo Tak.tomo Arai Mai kanai Nobuhito Goda Department of Life Science and Medical BioScience Waseda University School of Advanced Science and Engineering

The liver is a central organ that metabolizes excessive nutrients for storage in the form of glycogen and lipids and supplies energy-producing substrates to the peripheral tissues to maintain their function,even under starved *** processes require a considerable amount of oxygen,which causes a steep oxygen gradient throughout the hepatic *** consumption and/or excessive food intak. can alter the hepatic metabolic balance drastically,which can precipitate fatty liver disease,a major cause of chronic liver diseases worldwide,ranging from simple steatosis,through steatohepatitis and hepatic fibrosis,to liver *** hepatic metabolism and tissue remodeling in fatty liver disease further disrupt hepatic oxygen homeostasis,resulting in severe liver *** master regulators of adaptive responses to hypoxic stress,hypoxia-inducible factors(HIFs) modulate various cellular and organ functions,including erythropoiesis,angiogenesis,metabolic demand,and cell survival,by activating their target genes during fetal development and also in many disease conditions such as cancer,heart failure,and *** the past decade,it has become clear that HIFs serve as k.y factors in the regulation of lipid metabolism and fatty liver *** review discusses the molecular mechanisms by which hypoxia and HIFs regulate lipid metabolism in the development and progression of fatty liver disease.

关键词： Hypoxia Fatty liver disease Hypoxia-inducible factor Lipid metabolism Obstructive sleep apnea

Transporter-Mediated Organ Toxicity

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毒理学杂志 2005年第A3期19卷 173-174页

作者： Hitoshi Endou Yoshik.tsu kanai Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan

The absorption, distribution and excretion of most of xenobiotics, drugs, environmental toxins and their metabolites are mediated by membrane transporters.

关键词：环境毒素调节机构输送机构分子水平

Automatic registration of MLS point clouds and SfM meshes of urban area

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Geo-Spatial Information Science 2016年第3期19卷 171-181页

作者： Reiji Yoshimura Hiroak. Date Satoshi kanai Ryohei Honma k.zuo Oda Tatsuya Ik.da Graduate School of Information Science and Technology Hokkaido UniversitySapporoJapan Asia Air Survey Co. LtdKawasakiJapan

Recent advances in 3D scanning technologies allow us to acquire accurate and dense 3D scan data of large-scale environments ***,there are various methods for acquiring largescale 3D scan data,such as Mobile Laser Scanning(MLS),Airborne Laser Scanning,Terrestrial Laser Scanning,photogrammetry and Structure from Motion(SfM).Especially,MLS is useful to acquire dense point clouds of road and road-side objects,and SfM is a powerful technique to reconstruct meshes with textures from a set of digital *** this research,a registration method of point clouds from vehicle-based MLS(MLS point cloud),and textured meshes from the SfM of aerial photographs(SfM mesh),is proposed for creating high-quality surface models of urban areas by combining *** general,SfM mesh has non-scale information;therefore,scale,position,and orientation of the SfM mesh are adjusted in the registration *** our method,first,2D feature points are extracted from both SfM mesh and MLS point *** process consists of ground-and building-plane extraction by region growing,random sample consensus and least square method,vertical edge extraction by detecting intersections between the planes,and feature point extraction by intersection tests between the ground plane and the ***,the corresponding feature points between the MLS point cloud and the SfM mesh are searched efficiently,using similarity invariant features and ***,the coordinate transformation is applied to the SfM mesh so that the ground planes and corresponding feature points are ***,scaling Iterative Closest Point algorithm is applied for accurate *** results for three data-sets show that our method is effective for the registration of SfM mesh and MLS point cloud of urban areas including buildings.

关键词： Registration MLS point clouds SfM mesh urban area hash similarity invariant feature