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Optimization Studies in Simultaneous Saccharification and Fermentation of Wheat Bran Flour into Ethanol

Food and Nutrition Sciences 2022年第5期13卷 463-470页

作者： kanagasabai manikandan Selvanarayanan Rengadurai Elango Babu Shanmugam Sothivanan Department of Chemical Engineering Annamalai University Annamalai Nagar India

The effects of process variables in Simultaneous Saccharification and Fermentation (SSF) of wheat bran flour were studied in bulk fermentation using a coculture of Aspergillus niger - Kluveromyces marxianus. The effect of substrate density, pH, temperature, and enzyme concentration on wheat bran was predicted by designing experiments in which a single parameter is varied keeping other variables at a constant level. The above parameters were optimized for a batch culture in a fermentor. Optimal values for substrate concentration, pH, temperature, and enzyme concentration during processing were 200 g/l, 5.5, 65°C, and 7.5 IU, respectively. In pre-treatment experiments, the concentration of enzymes and the pre-treatment temperature are highly correlated. The influence of pH, temperature, and substrate density on ethanol production was investigated. Temperature pH was determined as optimal, 32°C and 5.5, respectively. After 48 hours of fermentation at optimum pH, a solution of wheat bran containing a maximum of 6% starch produces a maximum of 22.9 g/l ethanol.

关键词： Simultaneous Saccharification and Fermentation (SSF) Co-Culture Fermentation Single Factor Optimization Ethanol

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Synthesis,characterization and pharmacological evaluation of pyrazolyl urea derivatives as potential anti-inflammatory agents

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Acta Pharmaceutica Sinica B 2017年第2期7卷 230-240页

作者： kanagasabai Somakala Mohammad Amir Department of Pharmaceutical Chemistry Faculty of PharmacyHamdard UniversityNew Delhi 110062India

p38α mitogen activated protein kinase(MAPK) inhibitors provide a novel approach for the treatment of inflammatory disorders.A series of fifteen pyrazolyl urea derivatives(3a-o) were synthesized and evaluated for their p38α MAPK inhibition and antioxidant *** 3a-e,3g and 3h showed low micromolar range potency(IC_(50) values ranging from 0.037 ±1.56 to 0.069± 0.07μmol/L)compared to the standard inhibitor SB 203580(IC_(50) = 0.043 + 3.62μmol/L) when evaluated for p38αMAPK inhibition by an immunosorbent-based *** activity was measured by a 2,2'-diphenyl-1-picryl hydrazyl radical(DPPH) free radical scavenging method and one of the compounds,3c,showed better percentage antioxidant activity(75.06%) compared to butylated hydroxy anisole(71.53%)at 1 mmol/L *** 3a-e,3g and 3h showed promising in vivo anti-inflammatory activity(ranging from 62.25%to 80.93%) in comparison to diclofenac sodium(81.62%).The ulcerogenic liability and lipid peroxidation activity of these compounds were observed to be less in comparison to diclofenac *** compounds also potently inhibited the lipopolysaccharide(LPS)-induced TNF-αrelease in mice(ID_(50) of 3a-c = 19.98,11.32 and 9.67 mg/kg,respectively).Among the screened compounds,derivative 3c was found to be the most potent and its binding mode within the p38α MAPK is also reported.

关键词： Pyrazolyl urea p38 MAPK DPPH Anti-inflammatory Gastric toxicity Lipid peroxidation

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Optimal Energy Forecasting Using Hybrid Recurrent Neural Networks

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Intelligent Automation & Soft Computing 2023年第4期36卷 249-265页

作者： Elumalaivasan Poongavanam Padmanathan Kasinathan Kulothungan kanagasabai Department of Computer Science and Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai600062India Department of Electrical and Electronics Engineering Agni College of TechnologyChennai600130India Department of Information Science and Technology Anna UniversityChennai600025India

The nation deserves to learn what India’s future energy demand will be in order to plan and implement an energy *** energy demand will have to be fulﬁlled by an adequate mix of existing energy sources,considering the con-straints imposed by future economic and social changes in the direction of a more sustainable *** energy demand,on the other hand,is a tricky task because it is inﬂuenced by numerous *** a result,an macro model with only a few factors that may be predicted globally,rather than a detailed ana-lysis for each of these variables,is *** this work,a hybrid approach is proposed for identifying the optimal generation-based mix of electricity systems in *** approach is developed by combing Recalling-Enhanced Recurrent Neural Network(RERNN)and Giza Pyramids Construction(GPC).RERNN pos-sesses selective memory features whereas GPC is a meta-heuristic algorithm that deals with different sets of *** goal of this approach is to assess the present load requirements and production proﬁle to understand the current requirement and its production *** on regards to electricity load proﬁle involving the generation of all power plants,capacity factors and transmission limits were gathered from different sources including the Indian National Load Dispatch Centre,Central Electricity Authority database,annual reports of India and regional load dispatching *** proposal has introduced the RERNN technique to analyze the optimal time series whereas the GPC technique is involved in the optimization of RERNN *** present work is simu-lated in MATLAB and the performance assessed with different *** present technique gives an effective results in terms of accuracy,computational efﬁciency and feasibility.

关键词： Electricity generation demand RERNN GPC time series prediction

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The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts

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Bone Research 2014年第2期2卷 110-120页

作者： Thomas S Lisse kanagasabai Vadivel S Paul Bajaj Rui Zhou Rene F Chun Martin Hewison John S Adams Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center UCLA Los Angeles CA USA Department of Regenerative Biology and Medicine Mount Desert Island Biological Laboratory Bar Harbor ME USA

Heterogeneous nuclear ribonucleoprotein （hnRNP） C plays a key role in RNA processing but also exerts a dominant negative effect on responses to 1,25-dihydroxyvitamin D （1,25（OH）2D） by functioning as a vitamin D response element-binding protein （VDRE-BP）. hnRNPC acts a tetramer of hnRNPC1 （huC1） and hnRNPC2 （huC2）, and organization of these subunits is critical to in vivo nucleic acid-binding. Overexpression of either huC1 or huC2 in human osteoblasts is sufficient to confer VDRE-BP suppression of 1,25（OH）2D-mediated transcription. However, huC1 or huC2 alone did not suppress 1,25（OH）2D-induced transcription in mouse osteoblastic cells. By contrast, overexpression of huC1 and huC2 in combination or transfection with a bone-specific polycistronic vector using a ＂self-cleaving＂ 2A peptide to co-express huC1/C2 suppressed 1,25D-mediated induction of osteoblast target gene expression. Structural diversity of hnRNPC between human/NWPs and mouse/rat/rabbit/dog was investigated by analysis of sequence variations within the hnRNP CLZ domain. The predicted loss of distal helical function in hnRNPC from lower species provides an explanation for the altered interaction between huC1/C2 and their mouse counterparts. These data provide new evidence of a role for hnRNPC1/C2 in 1,25（OH）2D-driven gene expression, and further suggest that species-specific tetramerization is a crucial determinant of its actions as a regulator of VDR-directed transactivation.

关键词： gene The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts Figure EcoRI

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High prevalence of soil-transmitted helminth infections among primary school children,Uttar Pradesh,India,2015

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Infectious Diseases of Poverty 2017年第1期6卷 1235-1243页

作者： Sandipan Ganguly Sharad Barkataki Sumallya Karmakar Prerna Sanga K.Boopathi K.kanagasabai P.Kamaraj Punam Chowdhury Rituparna Sarkar Dibyendu Raj Leo James Shanta Dutta Rakesh Sehgal Priya Jha Manoj Murhekar National Institute of Cholera&Enteric Diseases Indian Council of Medical ResearchKolkataIndia Evidence Action-Deworm the World Initiative New DelhiIndia GFK Mode MumbaiIndia Department of Epidemiology National Institute of EpidemiologyIndian Council of Medical ResearchChennaiIndia Department of Medical Parasitology Postgraduate Institute of Medical Education and ResearchChandigarhIndia

Background:Soil-transmitted helminth(STH)infections often affect the poorest and most deprived *** order to generate reliable data for planning a school based deworming program,we conducted a survey among primary school children studying in government schools in the Indian state of Uttar *** objectives of our survey were to estimate the prevalence and intensity of STH ***:We conducted a cross-sectional survey among children studying in 130 primary schools from 9 agroclimatic zones,during May-August *** about socio-demographic details,defecation and handhygiene practices,and stool samples were collected from the school *** samples were examined using the Kato-Katz ***:Stool samples from 6421 school children were *** overall weighted prevalence of any STH in the State was 75.6%(95%CI:71.2-79.5).The prevalence was more than 50%in six of the nine agro-climatic *** was the most prevalent STH(prevalence:69.6%),followed by hookworm(prevalence:22.6%)and ***(4.6%).The majority of the STH infections were of low *** practice of open defecation and not washing hands with soap after defecation and residence in kutcha house were significant risk factors of STH ***:STH prevalence among primary school children in Uttar Pradesh was *** the WHO guidelines on deworming frequency according to STH prevalence,Govt of Uttar Pradesh needs to implement a school-based deworming program with bi-annual *** findings of our survey would also help monitor the performance of school based deworming programme.

关键词： Soil-transmitted helminths Uttar Pradesh India

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中美互换摘要

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中华高血压杂志 2022年第12期30卷 1260-1260页

作者： kanagasabai T Xie W Yan L Zhao L Carter E Guo D Daskalopoulou SS Chan Q Elliott P Ezzati M Yang X Xie G Kelly F Wu Y Baumgartner J 袁源郑武洪

中国老年人家庭空气污染与血压、血管损伤及心血管病亚临床指标的关系:资料表明,使用固体燃料(如煤和生物燃料)进行烹饪和取暖所造成的家庭空气污染可能导致高血压和血管损伤。2015年8月至2016年11月,本研究纳入中国3个不同省或直辖市(... 详细信息

中国老年人家庭空气污染与血压、血管损伤及心血管病亚临床指标的关系:资料表明,使用固体燃料(如煤和生物燃料)进行烹饪和取暖所造成的家庭空气污染可能导致高血压和血管损伤。2015年8月至2016年11月,本研究纳入中国3个不同省或直辖市(北京、山西、广西)的753名成年人(年龄40~79岁)作为研究对象,应用混合效应回归模型评估家庭空气污染与血压和血管功能的相关性。研究人员重复评估受试者家庭燃料使用情况,测量个人暴露于细颗粒物(particulate matter 2.5,PM2.5)空气污染、血压。

关键词：空气污染细颗粒物混合效应生物燃料心血管病血管损伤血管功能回归模型

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