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Construction Method of 3D Aorta Model

Journal of Mathematics and System Science 2012年第4期2卷 272-279页

作者： Nobuhiko mukai Yoshihiro Tatefuku Kiyomi Niki Shuichiro Takanashi Graduate School of Engineering Tokyo City University Tokyo 1588557 Japan Cardiovascular Surgery Sakakibara Heart Institute Tokyo 1830003 Japan

With the help of engineering technologies, there are varieties of medical supports such as surgical simulations, preoperative plans, intraoperative supports, and diagnostic explanations. In order to perform preoperative plans, the simulation model of the target organ is necessary, and is usually generated from some fine images obtained by imaging devices such as CT （computed tomography） or MRI （magnetic resonance imaging）. These devices, however, are very large and it is difficult to use them during the surgery although there is a kind of MRI that can be used during operations. On the other hand, there is a device called Ultrasonography （US Echo）. It is so handy and can be easily used during operations without radiation or magnetic effect. US images, however, are not usually used for the construction of 3D model for preoperative plans since there are so many noises in the image, and the quality of the image is not so good compared to the images obtained by CT or MRI. Therefore, the authors have tried to construct 3D volumetric shape model from just two 2D US （ultrasound） images, which are the horizontal and vertical cross-section images of the target organ. Their concrete target organ and surgery are the aorta and AAE （annuloaortic ectasia）, respectively. With some technologies of image processing, the boundary of the aorta is extracted for both cross-section images, and the thickness of the aorta is estimated. These processes are applied to not only the aorta wall but also the aorta valve. Finally, the aorta shape model can be constructed by inserting the estimated horizontal aorta images into the estimated vertical one. The constructed model has three dimensions so that it can be viewed from any point of view.

关键词： Image processing medical applications US image aorta.

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Gene Regulation through mRNA Expression

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Advances in Biological Chemistry 2015年第2期5卷 45-57页

作者： Haruko Inose Kotomi mukai Misa Ito Seiji Masuda Division of Integrated Life Science Graduate School of Biostudies Kyoto University Kyoto Japan

In eukaryotes, gene expression is achieved by four steps: transcription, processing, nuclear export, and translation. Each step requires multiple factors, and frequently two or more pathways are used by a single gene, enabling strictly regulated gene expression. Importantly, eukaryotes, taking advantage of the separated structures of the nucleus and the cytoplasm, have evolved complex and organized mRNA processing mechanisms that permit sophisticated biological activity. The processes are much more complicated than those found in prokaryotes, in which transcription and translation occur linearly in time and place. Here, we review gene expression, focusing on mRNA processing in the nucleus and the gene regulatory systems found at each step. Combination of gene regulation shows the typical phenotype in each cell. Further understanding of the uncertain mechanisms will uncover the gene regulation through mRNA expression.

关键词： Capping Splicing Polyadenylation Export Half Life

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Suppression of Sebum Production and Accumulation by <i>β</i>-Cryptoxanthin Due to the Inhibition of the Expression of Diacylglycerol Acyltransferase-1 and Perilipin in Hamster Sebocytes

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Journal of Cosmetics, Dermatological Sciences and Applications 2013年第1期3卷 99-106页

作者： Takashi Sato Yoshiyuki Shirakura Katsuyuki mukai Akira Ito Department of Biochemistry and Molecular Biology School of Pharmacy Tokyo University of Pharmacy and Life Sciences Hachioji Tokyo Japan R & D Center Unitika Ltd. Kyoto Japan

Background: Acne vulgaris is characterized by the enhancement of sebaceous lipogenesis and sebum secretion, and apart from retinoids and some natural products there are few effective antiacne agents that directly suppress sebum production and accumulation in sebaceous glands. Objective: We examined the effects of β-cryptoxanthin (β-CRX), which is a carotenoid pigment most abundant in Citrus unshiu Marcovich (Satsuma mandarin orange) and plays a role as a vitamin A precursor on sebum production and accumulation in hamster sebaceous gland cells (sebocytes). Materials and methods: The regulation of sebum production was examined by the measurement of triacylglycerols (TGs), the major sebum component, and oil red O staining in insulindifferentiated hamster sebocytes. The expression of diacylglycerol acyltransferase-1 (DGAT-1), a rate-limiting enzyme of TG biosynthesis, and perilipin 1 (PLIN1), a lipid storage droplet protein, was analyzed using real-time PCR and Western blotting. Results: Hamster sebocytes constitutively produced TGs during cultivation and the production of TGs was enhanced by insulin treatment. Both constitutive and insulin-enhanced TG productions were dose- and time-dependently inhibited by β-CRX as well as 13-cis retinoic acid. In addition, the gene expression of DGAT-1 was suppressed by β-CRX in the sebocytes. Furthermore, the insulin-en- hanced sebum accumulation as lipid droplets was reduced in the β-CRX-treated cells. Moreover, β-CRX was found to suppress the gene expression and production of PLIN1 in insulin-differentiated hamster sebocytes. Conclusions: These results provide novel evidence that β-CRX is an effective candidate for acne therapy by its ability to exert dual inhibitory actions against DGAT-1-dependent TG production and PLIN1-mediated lipiddroplet formation in hamster sebocytes.

关键词： β-Cryptoxanthin Sebocytes Triacylglycerol Biosynthesis Diacyglycerol Acyltransferase Perilipin Lipid-Droplet Formation Sebum

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Medical malpractice litigation related to gastrointestinal endoscopy in Japan:A two-decade review of civil court cases

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World Journal of Gastroenterology 2006年第42期12卷 6857-6860页

作者： Toru Hiyama Shinji Tanaka Masaharu Yoshihara Tatsuma Fukuhara Shinichi mukai Kazuaki Chayama Health Service Center Hiroshima University Higashihiroshima Department of Endoscopy Hiroshima University Hospital Hiroshima Department of Medicine and Molecular Science Division of Frontier Medical Science Programs for Biomedical Research Graduate School of Biomedical Sciences Hiroshima University Hiroshima Japan

AIM: To examine the allegations in malpractice litigations related to gastrointestinal endoscopy in Japan. METHODS: A retrospective review of cases tried in the civil court system during the 21-year period from 1985 to 2005, identified in a computerized legal database, was undertaken. RESULTS: Eighteen malpractice litigations and a total of 30 allegations were identified. Of the 18 (44%) malpractice litigations, 8 (44%) were related to eso- phagogastroduodenoscopy, 4 (22%) to colonoscopy, 4 (22%) to endoscopic sphincterotomy, and 2 (11%) to endoscopic retrograde cholangiopancreatography. Seventeen (94%) cases pertained to complications, and the remaining (6%) case pertained to misdiagnosis. In 10 cases, the patient died of the complications. Allegations were categorized as: (1) performance error during the endoscopic procedure (n = 12, 40%); (2) lack of informed consent (n = 9, 30%); (3) performance error during the treatment after the endoscopic procedure (n = 4, 13%); (4) premedication error (n = 3, 10%); (5) diagnostic error (n = 1, 3%); and (6) indication error for the endoscopic procedure (n = 1, 3%). CONCLUSION: These data may aid in the design of risk prevention strategies to be used by gastrointestinal endoscopists.

关键词： Gastrointestinal endoscopy Malpractice Litigation Risk management

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Proliferating Trichilemmal Tumor of the Gluteal Region of a Young Man with Spontaneous Regression

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Modern Plastic Surgery 2015年第3期5卷 19-22页

作者： Saori Nagasaki Shiro Niiyama Toshiaki Oharaseki Hideki mukai Department of Dermatology Toho University Ohashi Medical Center Tokyo Japan Department of Pathology Toho University Ohashi Medical Center Tokyo Japan

We describe a case of a proliferating trichilemmal tumor (PTT) on the gluteal region of a 24-year-old male, presenting as a solitary nodule with spontaneous regression. This is the first report of a case in PTT with s... 详细信息

关键词： Cyst Neoplasm Skin

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Clinically diagnosed late-onset fulminant Wilson's disease without cirrhosis: A case report

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World Journal of Gastroenterology 2018年第2期24卷 290-296页

作者： Takahiro Amano Tokuhiro Matsubara Tsutomu Nishida Hiromi Shimakoshi Akiyoshi Shimoda Aya Sugimoto Kei Takahashi Kaori mukai Masashi Yamamoto Shiro Hayashi Sachiko Nakajima Koji Fukui Masami Inada Department of Gastroenterology and Hepatology Toyonaka Municipal Hospital

A 64-year-old woman was referred to our hospital with jaundice of the bulbar conjunctiva and general fatigue. After admission, she developed hepatic encephalopathy and was diagnosed with fulminant hepatitis based on the American Association for the Study of Liver Disease(AASLD) position paper. Afterwards, additional laboratory findings revealed that serum ceruloplasmin levels were reduced, urinary copper levels were greatly elevated and Wilson's disease(WD)-specific routine tests were positive, but the Kayser-Fleischer ring was not clear. Based on the AASLD practice guidelines for the diagnosis and treatment of WD, the patient was ultimately diagnosed with fulminant WD. Then, administration of penicillamine and zinc acetate was initiated; however, the patient unfortunately died from acute pneumonia on the 28 th day of hospitalization. At autopsy, the liver did not show a bridging pattern of fibrosis suggestive of chronic liver injury. Here, we present the case of a patient with clinically diagnosed late-onset fulminant WD without cirrhosis, who had positive disease-specific routine tests.

关键词： Wilson’s disease Fulminant hepatitis Lateonset Liver cirrhosis Copper

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A Model Predictive Control Method for A High-speed Magnetic Actuator

A Model Predictive Control Method for A High-speed Magnetic ...

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第二十六届中国控制会议

作者： mukai Masakazu Seikoba Suguru Kawabe Taketoshi Graduate School of Information Science and Electrical Engineering Kyushu UniversityFukuokaJapan

This paper considers a novel model predictive control method for a high-speed magnetic *** actuator consists of two opposing electromagnets and an armature is suspended between *** armature reciprocates between the two *** armature is suspended by the springs with a large spring rate,enabling it to move at high speed.A difficulty is that push-pull control force for the armature is not available from the ***,magnetic force is effective only when the armature is very close to the pulling *** overcome those difficulties,we propose a controller using model predictive control method with a fixed *** on optimality,the model predictive controller generates a target trajectory with searching for the terminal time,and a fixed compensator is attached in order to improve robustness drastically.

关键词： Motion Control Model Predictive Control Robust Control Optimal Control

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Differences in clinicopathological characteristics between lipohypertrophy and localized insulin-derived amyloidosis:A scoping review

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Chronic Diseases and Translational Medicine 2024年第1期10卷 22-30页

作者： kanae mukai Hiromasa Tanno Junko Sugama Toshihiko Yanagita Emi Kanno Department of Clinical Nursing Faculty ofHealth SciencesInstitute of MedicalPharmaceutical and Health SciencesKanazawa UniversityKanazawaJapan Department of Translational Science forNursing Tohoku University Graduate School ofMedicineSendaiJapan Research Center for Implementation NursingScience Initiative School of Health SciencesFujita Health UniversityToyoakeJapan Department of Clinical Pharmacology Schoolof NursingUniversity of MiyazakiMiyazakiJapan

Insulin is used as a therapeutic agent in patients with diabetes,and cutaneous lipohypertrophy(LH)and localized insulin-derived amyloidosis(LIDA)are well-known adverse effects associated with insulin *** clinical implications,management,assessment methods,and pathological differentiation of LH and LIDA have been recently *** review was to update our knowledge of the pathological differentiation,effects of insulin absorption,hypoglycemic events,and recent assessment methods for LH and LIDA.A scoping review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta Analyses extension for Scoping Reviews *** studies and case reports in English were also *** and Scopus databases were searched for keywords to identify papers published up to January 2022.A total of 113 studies were identified through a database search,and 31 were eligible for inclusion in this scoping *** the 31 studies included in this review,patients with type 2 diabetes had high frequencies of LH and *** outcome parameters were assessed using pathological findings and *** is mainly determined by pathological methods,such as hematoxylin and eosin and Congo red *** in vitro and in vivo LIDA models of LIDA have been *** results suggest that pathological analysis is required to identify LH and *** is important to consider LIDA,as it likely influences insulin adsorption and glycemic *** several studies have evaluated the LIDA process,little is known about the mechanisms underlying the development of adverse effects associated with insulin injections.

关键词： diabetes mellitus insulin injection lipohypertrophy localized insulin-derived amyloidosis

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Congenital Epidermal Cyst of the Umbilicus: A Case Report

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Modern Plastic Surgery 2013年第4期3卷 128-129页

作者： Noriko Aramaki-Hattori Takara Tanaka Kiyoshi mukai Kazuo Kishi Department of Pathology Saiseikai Central Hospital Minato-ku Japan Department of Plastic and Reconstruc- tive Surgery Saiseikai Central Hospital Minato-ku Japan Department of Plastic and Reconstructive Surgery Keio University Hospital Tokyo Japan

Epidermal cysts are one of the most common benign skin tumors, although they are rarely found in the umbilicus of a child. Herein we report the case of a 13-year-old girl with a congenital umbilical mass. This mass had been misdiagnosed as a lipoma at birth. Awareness of this lesion can avoid its misdiagnosis and inappropriate treatment.

关键词： Congenital Epidermal Cyst Umbilicus

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Real-time virtual sonography visualization and its clinical application in biliopancreatic disease

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World Journal of Gastroenterology 2013年第42期19卷 7419-7425页

作者： Atsushi Sofuni Takao Itoi Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Reina Tanaka Junko Umeda Ryosuke Tonozuka Mitsuyoshi Honjo Shuntaro mukai Fuminori Moriyasu Department of Gastroenterology and Hepatology Tokyo Medical UniversityTokyo 160-0023Japan

AIM:To evaluate the usefulness of real-time virtual sonography(RVS)in biliary and pancreatic ***:This study included 15 patients with biliary and pancreatic *** can be used to observe an ultrasound image in real time by merging the ultrasound image with a multiplanar reconstruction computed tomography(CT)image,using pre-scanned CT volume *** ultrasound used was EUB-8500with a convex probe *** RVS images were evaluated based on 3 levels,namely,excellent,good and poor,by the displacement in ***:By combining the objectivity of CT with free scanning using RVS,it was possible to easily interpret the relationship between lesions and the surrounding organs as well as the position of vascular *** resulting evaluation levels of the RVS images were12 excellent(pancreatic cancer,bile duct cancer,cholecystolithiasis and cholangiocellular carcinoma)and 3 good(pancreatic cancer and gallbladder cancer).Compared with conventional B-mode ultrasonography and CT,RVS images achieved a rate of 80%superior visualization and 20%better ***:RVS has potential usefulness in objective visualization and diagnosis in the field of biliary and pancreatic diseases.

关键词： Biliary and pancreatic disease Computed tomography-multiplanar reconstruction image Navigation Real-time ultrasound image Real-time virtual sonography

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