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RBC aggregation,deformation and adhesion to endothelium:Role of nitric oxide derived from L-Arginine and sodium nitroprusside

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Journal of Innovative Optical Health Scien.es 2024年第5期17卷 53-65页

作者： M.K.Maksimov P.B.ermolinskiy O.n.Scheglovitova n.n.Sklyankina A.V.Muravyov A.e.Lugovtsov A.V.Priezzhev Faculty of Physics M.V.Lomonosov Moscow State University bld.1subbuilding.2Leninskie goryMoscow 11991Russia n.F.Gamaleya national Research Cen.er for epidemiology and Microbiology 18 Gamaleya StreetMoscow 123098Russia K.D.Ushinsky Yaroslavl State Pedagogical University 108/1 Respublikanskaya StreetYaroslavl 150000Russia

Red blood cells(RBCs)are the most abundant human blood *** aggregation and deformation strongly determine blood viscosity which impacts hemorheology and *** turn,RBC properties depend on di®erent endogenous and exogenous *** such factor is nitric oxide(nO),which is mainly produced by endothelial cells(eC)from L-arginine amino acid in the circulatory *** the mechanisms of the RBC-endothelium in.erplay are not clear up to date and considering its possible clinical importan.e,the aims of this study are to in.estigate in vitro:(1)The e®ect of L-arginine induced nO on RBC aggregation and adhesion to endothelium;(2)the nO e®ect on RBC aggregation and deformation induced by L-arginine and sodium nitroprusside without the presen.e of endothelium in the *** RBC aggregation and adhesion to a monolayer of eC were studied using optical tweezers(OT).The RBC deformability and aggregation without endothelium in the samples were studied using the°ow chamber method and Myren.e *** con¯rmed that nO increases deformability and decreases aggregation of *** showed that the soluble guanylate cyclase pathway appears to be the only nO signaling pathway *** the samples with the endothelium,the\bell-shaped"depen.en.e of RBC aggregation force on L-arginine con.entration was observed,which improves our knowledge about the process of nO production by ***,data related to L-arginine accumulation by endothelium were obtained:necessity of the presen.e of extracellular L-arginine stated by other authors was put un.er *** our study,nO decreased the RBC-endothelium adhesion,however,the ten.ency appeared to be weak and was not con¯rmed in another set of *** our knowledge,this is the¯rst attempt to measure the forces of RBC adhesion to endothelium monolayer with OT.

关键词： Red blood cells aggregation L-arginine endothelium optical tweezers Myren.e flow chamber

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Tailored heterostructured ni_(3)n-niO nano-frameworks for boosting electrocatalytic oxygen.evolution via surface-modulated plasma strategy

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nano Research 2024年第9期17卷 7909-7917页

作者： Bo Ouyang Haonan Qin Chao Sun Yilin Deng Ang Li Jipeng Zhu erjun kan Rajdeep Singh Rawat MIIT Key Laboratory of Semiconductor Microstructure and Quantum Sensing School of ScienceNanjing University of Science&TechnologyNanjing 210094China The Laboratory of Road and Bridge Civil EngineeringSchool of ScienceNanjing University of Science&TechnologyNanjing 210094China Institute for energy Research Jiangsu UniversityZhenjiang 212013China natural Scien.es and Scien.e education National Institute of EducationNanyang Technological University637616Singapore

The facile reconfiguration of phases plays a pivotal role in.enhancing the electrocatalytic production of H2 through heterostructure *** chemical methods have been.explored extensively for this purpose,plasma-based techniques offer a promising aven.e for achieving heterostructured ***,the con.entional plasma approach introduces complexities,leading to a multi-step fabrication process and challen.es in precisely controlling partial surface structure modulation due to the intricate in.eraction *** our pursuit of heterostructures with optimized oxygen.evolution reaction(OeR)behavior,we have designed a facile auxiliary insulator-confined plasma system to directly attain a ni_(3)n-niO heterostructure(hninO).By meticulously controlling the surface heating process during plasma processing,such approach allows for the streamlined fabrication of hninO *** resulting nano-framework exhibits outstanding catalytic performan.e,as eviden.ed by its overpotential of 320 mV at a current density of 10 mA·cm^(-2),in an alkaline *** stands in stark contrast to the performan.e of niO-covered ni_(3)n fabricated using the con.entional plasma method(sninO).Operando plasma diagnostics,coupled with numerical simulations,further substantiates the influen.e of surface heating due to auxiliary insulator confinement of the substrate on typical plasma parameters and the formation of the ni_(3)n-niO nanostructure,highlighting the pivotal role of controlled surface temperature in creating a high-performan.e heterostructured electrocatalyst.

关键词： structural modulation auxiliary insulator-confined plasma surface heating control heterostructure electrocatalytic O_(2) evolution

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Management of obstructed colorectal carcinoma in an.emergency setting:An update

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World Journal of Gastroin.estinal Oncology 2024年第3期16卷 598-613页

作者： efstathios T Pavlidis Ioannis n Galanis Theodoros e Pavlidis 2nd Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Colorectal carcinoma is common,particularly on the left *** 20%of patients,obstruction and ileus may be the first clinical manifestations of a carcinoma that has advan.ed(stage II,III or even IV).Diagnosis is based on clinical presentation,plain abdominal radiogram,computed tomography(CT),CT colonography and positron.emission tomography/*** best management strategy in terms of short-term operative or in.erventional and long-term oncological outcomes re-mains *** the most common left-sided obstruction,the first choice should be either emergency surgery or endoscopic decompression by self-expen-dable metal stents or *** operative plan should be either one-stage or two-stage ***-stage resection with on-table bowel decompression and irrigation can be accompan.ed or not accompan.ed by proximal defunctioning stoma(colostomy or ileostomy).Primary anastomosis is more con.en.ent but has increased risks of anastomotic leakage and ***-stage resection(Hart-mann’s procedure)is safer and the most widely used despite temporally affecting quality of *** control surgery in high-risk frail patients is less frequently performed sin.e it can be successfully substituted with endoscopic stenting or *** the less common right-sided obstruction,one-stage surgical resection is more beneficial than.endoscopic *** role of minimally invasive surgery(laparoscopic or robotic)is a subject of *** laparoscopic-assisted management is advantageous to some extent but requires much expertise due to in.erent difficulties in dissecting the disten.ed colon and the risk of rup-ture and subsequent septic *** decompressing stent as a bridge to elective surgery more substantially decreases the risks of morbidity and mortality than.emergency surgery for decompression and has equivalent medium-term overall survival and disease-free survival *** combination with neoadjuvant chemotherapy or radiation may have a p

关键词： Acute abdomen Obstructive ileus Colorectal carcinoma emergency surgery Colectomy Intraluminal metal stents

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Quantitative un.erstanding of phase segregation behaviors by precisely building discrete oligo-ester-b-oligo-olefin block copolymers

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Scien.e China Chemistry 2024年第3期67卷 1008-1016页

作者： Yuxin Liu rui Tan Haibing Wu Xue-Hui Dong Zhengbiao Zhang College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China State Key Laboratory of Radiation Medicine and Protection Soochow UniversitySuzhou 215123China South China Advan.ed Institute for Soft Matter Scien.e and Technology School of Molecular Science and EngineeringSouth China University of TechnologyGuangzhou 510640China

Block copolymers(BCPs) with high Flory-Huggins parameter(χ) and balan.ed surface energy have aroused tremendous in.erest for ultra-small nanopatterns ***,high χ and balan.ed surface energy are generally *** fine tune of chain structure might be a useful way to achieve high χ and balan.ed surface *** realize this,the block copolymer with exactly uniform chain structure,i.e.,defined molecular structure,is highly desirable for accurately evaluating the phase ***,two kinds of discrete oligo ester-b-oligo olefin block copolymers with different chemical structures(oligo lactic acid-boligo olefin BCP,oLA_(n)-b-C_(m);oligo phenyl lactic acid-b-oligo olefin BCP,oPL_(n)-b-C_(m)) were modularly synthesized through iterative growth *** effect of chain structure on segregation strength and surface properties was quantitatively in.estigated using the discrete BCPs as precise *** the one hand,introducing rigid and nonpolar phenyl groups into oligo ester block has a negligible effect on the chemical incompatibility,as confirmed by the identical high χ values of oLA_(n)-b-C_(m) and oPL_(n)-b-C_(m)(χ_(oLA/C)=0.21 and χ_(oPL/C)=0.19).On the other hand,the incorporation of nonpolar phenyl groups creates balan.ed surface energy,that is,the high χ and balan.ed surface energy were simultaneously achieved by oPL_(n)-b-C_(m).Therefore,sub-10 nm perpendicular nanopatterns can be easily produced upon brief thermal treatment,demonstrating its potential application in semiconductor manufacturing with ultra-small feature *** discrete BCP can serve as a quantitative and exquisite model to study the critical contribution of chain structures on phase separation behavior,providing insightful un.erstanding to facilitate the potential application in the chip process.

关键词： discrete polymer iterative growth self-assembly highχ balan.ed surface

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First results of turbulen.e in.estigation on Globus-M2 using radial correlation Doppler reflectometry

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Plasma Scien.e and Technology 2024年第10期26卷 49-55页

作者： A.POnOMARenKO A.YASHIn V.GUSeV e.KISeLeV G.KURSKIeV V.MIn.eV Y.PeTROV n.SAKHAROV P.SHCHeGOLeV e.TKACHenKO n.ZHILTSOV Peter the Great St.Petersburg Polytechnic University St.Petersburg 195251Russia Ioffe Institute St.Petersburg 194064Russia

The first results of in.estigation of the turbulen.e structure using Doppler backscattering(DBS)on the Globus-M2 tokamak are presen.ed.A one-chan.el DBS system with a variable probing frequency within the 18–26 GHz ran.e was installed to in.estigate the edge plasma at normalized minor radiiρ=0.9–*** correlation Doppler reflectometry was used to study the chan.es in turbulen.e eddies after the LH *** analysis was applied to the phase derivative of complex in-phase and quadrature(IQ)signals of the DBS diagnostic as it contains information about the poloidal plasma rotation *** L-mode,the radial correlation length L_(r)is estimated to be 3 cm and after transition to H-mode reduces to approximately 2 *** modelling in a linear local approximation using code Gene indicates that the instability with positive growth rate at the normalized minor radiusρ=0.75 in L-mode and H-mode on Globus-M2 was the ion temperature gradient(ITG)mode.

关键词： tokamak turbulen.e Doppler backscattering correlation reflectometry

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Current considerations on intraductal papillary neoplasms of the bile duct and pancreatic duct

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World Journal of Gastroen.erology 2024年第10期30卷 1461-1465页

作者： efstathios T Pavlidis Ioannis n Galanis Theodoros e Pavlidis 2^(nd) Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Pancreatobiliary intraductal papillary neoplasms(IPns)represent precursors of pancreatic can.er or bile duct cholangiocarcinoma that can be detected and *** advan.es in diagnostic methods,identifying these premalignant lesions is still challenging for treatment *** imaging,biomarkers and molecular tests for genomic alterations can be used for diagnosis and *** in.ervention in combination with new chemotherapeutic agents is considered the optimal treatment for malignant *** balan.e between the risk of malignancy and any risk of resection guides management policy;therefore,treatment should be individualized based on a meticulous preoperative assessment of high-risk *** of the bile duct is more aggressive;thus,early diagnosis and surgery are *** con.ervative management of low-risk pancreatic branch-duct lesions is safe and effective.

关键词： Biliary tree diseases Pancreatic cystic neoplasms Biliary tract neoplasms extrahepatic cholangiocarcinoma Pancreatic adenocarcinoma

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Fuel cell stack design and modelling with a double-stage boost con.erter coupled to a single-phase in.erter

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Clean.energy 2024年第1期8卷 188-196页

作者： Basem e.elnagi Ahmed M.Ismaiel Hany S.e.Mansour M.n.Abd-Alwahab electrical engin.ering Department Faculty of EngineeringSuez Canal UniversityIsmailia 41522Egypt

A comprehensive proton.exchan.e membrane fuel cell stack model was developed and in.egrated with a two-stage DC/DC boost *** was directly coupled to a single-phase(two levels-four pulses)in.erter without a *** pulse-width modu-lation signal was used to in.epen.ently regulate every con.erter *** con.erter was modelled using a MATLAB®/Simulink®environ.ent and an appropriate voltage control *** analysis features of the suggested circuit were created and,through established experiments,the simulation results were verified.A single-phase(two levels-four pulses)in.erter control circuit was tested and it produced a pure sinusoidal waveform with voltage *** matches the voltage of the network in terms of amplitude and frequency.A sinusoidal pulse-width modulation approach was performed using a single-phase(two levels-four pulses)pulse-width modulation *** results demonstrated an.enhan.ement in the standard of the output wave and tuned the dead time with a reduction of 63μs compared with 180μs in con.entional techniques.

关键词： PeM fuel cell pulse-width modulation single-phase in.erter and double-stage DC/DC boost con.erter

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enhancing efficiency and stability of organic solar cells through a simplified four-step synthesis of fully non-fused ring electron acceptor

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Journal of energy Chemistry 2024年第6期93卷 601-608,I0015页

作者： Chenyang Han Huanhuan Gao Yanna Sun Yuanyuan kan Zhaozhao Bi Wei Ma Yani Zhang Juan Antonio Zapien Yingguo Yang Ke Gao College of new energy Xi’an Shiyou UniversityXi’an 710065ShaanxiChina Shandong Provincial Key Laboratory for Scien.e of Material Creation and energy Con.ersion Institute of Frontier ChemistrySchool of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237ShandongChina State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina Department of Materials Scien.e and engin.ering City University of Hong KongKowloonHong Kong 99907China School of Microelectronics Fudan UniversityShanghai 200433China

Design and synthesis of superior cost-effective non-fullerene acceptors(nFAs)are still big challen.es for facilitating the commercialization of organic solar cells(OSCs),yet to be ***,two medium bandgap fully non-fused ring electron acceptors(nFReAs,medium bandgap,i,e.,1,3-1,8 eV),namely PTR-2Cl and PTR-4Cl are synthesized with only four steps by using intramolecular noncovalent in.eraction central core,structured alkyl side chain orientation linking units and flanking with different electron-withdrawing end *** them,PTR-4C1 exhibits increased average electrostatic potential(eSP)differen.e with polymer donor,enhan.ed crystallinity and compactπ-πstacking compared with the control molecule *** a result,the PTR-4Cl-based OSC achieved an impressive power con.ersion.efficiency(PCe)of 14.72%,with a much higher open-circuit voltage(V_(OC))of 0.953 V and significantly improved fill factor(FF)of 0.758,demonstrating one of the best acceptor material in the top-performing fully nFReA-based OSCs with both high PCe and V_(OC).notably,PTR-4Cl-based cells maintain a good T_80lifetime of its initial PCe after over 936 h un.er a continuous thermal an.ealing treatment and over1300 h T_(80)lifetime without *** work provides a cost-effective design strategy for nFReAs on obtaining high V_(OC),efficient exciton dissociation,and ordered molecular packing and thus high-efficiency and stable OSCs.

关键词： Organic solar cells Fully non-fused ring acceptors end group engin.ering Morphology regulation High efficiency

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Why ecosystem characteristics predicted from remotely sen.ed data are unbiased and biased at the same time-and how this affects applications

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Forest ecosystems 2024年第1期11卷 24-31页

作者： Goran Ståhl Terje Gobakken Svetlana Saarela Henrik J.Persson Magnus ekstrom Sean P.Healey Zhiqiang Yang Johan Holmgren.eva Lindberg Ken.eth nystrom eman.ele Papucci Patrik Ulvdal Hans OleØrka erik næsset Zhengyang Hou Håkan Olsson Ronald e.McRoberts Department of Forest Resource Management Swedish University of Agricultural Sciences90183UmeåSweden Faculty of environ.ental Scien.es and natural Resource Management Norwegian University of Life SciencesÅsNorway USDA Forest Service Rocky Mountain Research StationOgdenUTUSA The Key Laboratory for Silviculture and Con.ervation of Ministry of education Beijing Forestry UniversityBeijing100083China Department of Forest Resources University of MinnesotaSt.PaulMNUSA

Remotely sen.ed data are frequently used for predicting and mapping ecosystem characteristics,and spatially explicit wall-to-wall information is sometimes proposed as the best possible source of information for ***,wall-to-wall information typically relies on model-based prediction,and several features of model-based prediction should be un.erstood before extensively relying on this type of *** such feature is that model-based predictors can be considered both unbiased and biased at the same time,which has important implications in several areas of *** this discussion paper,we first describe the con.entional model-unbiasedness paradigm that un.erpins most prediction techniques using remotely sen.ed(or other)auxiliary *** this point of view,model-based predictors are typically ***,we show that for specific domains,identified based on their true values,the same model-based predictors can be considered biased,and sometimes severely *** suggest distinguishing between con.entional model-bias,defined in the statistical literature as the differen.e between the expected value of a predictor and the expected value of the quantity being predicted,and design-bias of model-based estimators,defined as the differen.e between the expected value of a model-based estimator and the true value of the quantity being *** show that model-based estimators(or predictors)are typically design-biased,and that there is a trend in the design-bias from overestimating small true values to un.erestimating large true ***,we give examples of applications where this is important to acknowledge and to potentially make adjustments to correct for the design-bias *** argue that relying entirely on con.entional model-unbiasedness may lead to mistakes in several areas of application that use predictions from remotely sen.ed data.

关键词： Bias Model-based in.eren.e Design-based in.eren.e

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Phanerozoic co-evolution of O2-CO2 and ocean habitability

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national Scien.e Review 2024年第6期11卷 18-21页

作者： Zunli Lu Rosalind e.M.Rickaby Jonathan L.Payne Ashley n.Prow Department of earth & environ.ental Scien.es Syracuse University Department of earth Scien.es University of Oxford Department of earth and Planetary Scien.es Stanford University

Atmospheric carbon dioxide and oxygen con.entrations are partially lin.ed via the geological cycle of organic carbon （Fig. 1A–C; e.g. CO2+H2O■CH2O+O2）. The history of these two biologically active components, controls on their con.entrations, and implications for the complexity of the biosphere and habitability of earth have been hotly debated, but are generally considered in.epen.ently.

关键词： CO2-COn.enTRATInG MeCHAnISM OXYGen eVOLUTIOn AnOXIA

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