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项目驱动:建筑物理实验教学改革的方向

林区教学 2024年第8期 76-79页

作者：成侃湖北工程学院建筑学院湖北孝感432100

项目式实验教学有助于重构学生对客观世界的认识方式、提升学生的合作探究能力和自主探究能力。当前一些高校的建筑物理实验教学面临着实验基础设施不足、实验教学手段传统等问题。将项目式实验教学纳入建筑物理实验教学中,能够克服传... 详细信息

项目式实验教学有助于重构学生对客观世界的认识方式、提升学生的合作探究能力和自主探究能力。当前一些高校的建筑物理实验教学面临着实验基础设施不足、实验教学手段传统等问题。将项目式实验教学纳入建筑物理实验教学中,能够克服传统建筑物理实验教学的不足,调动学生参与建筑物理实验教学积极性,促进教师在实施建筑物理实验教学中不断提升自我,并通过实验准备、实验组织、实验实施、实验结果展示与评价推动建筑物理项目式实验教学的具体实践。

关键词：项目式教学建筑物理实验教学改革

A global analysis searching for neutrinos associated with black hole merger gravitational wave events

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Research in Astronomy and Astrophysics 2018年第11期18卷 11-16页

作者： Yu-Zi Yang Jia-Jie Ling Wei Wang Zhao-kan cheng School of Physics Sun Yat-sen University School of Science Harbin Institute of Technology

Several neutrino observatories have searched for coincident neutrino signals associated with gravitational waves induced by the merging of two black holes. No statistically significant neutrino signal in excess of the background level was observed. These experiments use different neutrino detection technologies and are sensitive to various neutrino types. A combined analysis was performed on the KamLAND, Super-Kamiokande and Borexino experimental data with a frequentist statistical approach to achieve a global picture of the associated neutrino fluence. Both monochromatic and Fermi-Dirac neutrino spectra were assumed in the calculation. The final results are consistent with null neutrino signals associated with the process of a binary black hole merger. The derived 90% confidence level upper limits on the fluence and luminosity of various neutrino types are presented for neutrino energy less than110 MeV.

关键词： gravitational wave black hole merger neutrino fluence global analysis

Interspecific hybridization between Bursaphelenchus xylophilus and Bursaphelenchus mucronatus

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Journal of Forestry Research 2019年第2期30卷 699-707页

作者： kan-cheng Liu Ailing Ben Zhengmin Han Ye Guo Dongxia Cao College of Forestry Nanjing Forestry University Nanjing Xiaozhuang University

Bursaphelenchus xylophilus is the pathogen that causes pine wilt disease, which has greatly damaged forests and ecosystems in countries of East Asia and *** mucronatus is closely related to B. xylophilus in morphology and host plant specificity. A longrunning debate has existed regarding whether these two species can successfully produce hybrid offspring. In the present study, we performed in the laboratory, hybridization of two B. xylophilus nematode isolates from China and Japan and three B. mucronatus isolates from China, Japan and France. Nematode isolates of B. xylophilus were successfully crossed with B. mucronatus isolates, and the rate of hybridization was relatively high; however, some hybrid offspring died. Successful hybridization occurred between B. xylophilus and B. mucronatus isolates from China, and 22 generations of hybrids were produced. All F1 hybrids could be backcrossed with their parents and produce offspring. Variation in mucro length among the hybrid offspring and their parents was observed. The hybrid offspring and their parents were inoculated into 3-months-old black pine(Pinus tunbergii) seedlings. Weaker pathogenicity of hybrid offspring was observed compared with that of their parents, and significantly fewer offspring nematodes than parents were reisolated from pines. Therefore, the offspring of B. xylophilus and B. mucronatus may exist in the forest and could influence disease epidemics.

关键词： Bursaphelenchus xylophilus Bursaphelenchus mucronatus Interspecific hybridization Variation

Specific effects of c-Jun NH2-terminal kinaseinteracting protein 1 in neuronal axons

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Neural Regeneration Research 2016年第1期11卷 114-118页

作者： Shu Tang Qiang Wen Xiao-jian Zhang Quan-cheng kan Department of Pharmacy the First Affiliated Hospital of Zhengzhou University Department of Clinical Pharmacology Basic Medical College Zhengzhou University

c-Jun NH2-terminal kinase（JNK）-interacting protein 3 plays an important role in brain-derived neurotrophic factor/tropomyosin-related kinase B（Trk B） anterograde axonal transport. It remains unclear whether JNK-interacting protein 1 mediates similar effects, or whether JNK-interacting protein 1 affects the regulation of Trk B anterograde axonal transport. In this study, we isolated rat embryonic hippocampus and cultured hippocampal neurons in vitro. Coimmunoprecipitation results demonstrated that JNK-interacting protein 1 formed Trk B complexes in vitro and in vivo. Immunocytochemistry results showed that when JNK-interacting protein 1 was highly expressed, the distribution of Trk B gradually increased in axon terminals. However, the distribution of Trk B reduced in axon terminals after knocking out JNK-interacting protein 1. In addition, there were differences in distribution of Trk B after JNK-interacting protein 1 was knocked out compared with not. However, knockout of JNK-interacting protein 1 did not affect the distribution of Trk B in dendrites. These findings confirm that JNK-interacting protein 1 can interact with Trk B in neuronal cells, and can regulate the transport of Trk B in axons, but not in dendrites.

关键词： nerve regeneration c-Jun NH2-terminal kinase-interacting protein neurons brain-derived neurotrophic factor tropomyosin-related kinase B axons hippocampus dendrites regulation neural regeneration

Preparation of polymeric microspheres with high content of sulphonate groups

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Chinese Chemical Letters 2010年第2期21卷 234-236页

作者： Chen, Yun Shen Wang, Ji Shuai Hou, Zhao Sheng kan, cheng You Tsinghua Univ Dept Chem Engn Beijing 100084 Peoples R China Tsinghua Univ Key Lab Adv Mat Minist Educ Beijing 100084 Peoples R China

Poly(styrene-co-sodium styrene sulphonate)(P(St-NaSS)) latex particles were prepared using the mixture of ethanol and water as continuous phase in the presence of surfactant by dispersion--emulsion combined *** influence of recipes on polymerization process as well as the content of sulphonate group in the purified products was *** showed that the copolymerization could be performed *** the mole ratio of NaSS/St/divinyl benzene(DVB) was 25/75/2 and the weight ratio ...

关键词： Styrene Sodium styrene sulphonate Microspheres Polymerization

Effect of FK506 nanospheres on regeneration of allogeneic nerve after transplant

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Asian Pacific Journal of Tropical Medicine 2014年第6期7卷 478-482页

作者： Ting Li Xiao-Jian Zhang Jun Li Quan-cheng kan Department of Pharmacy the First Affiliated Hospital of Zhengzhou University

Objective:To discuss effect of FK506 nanospheres used at different time on the regcneration of allogeneic nerve after ***:Single emulsion-solvent evaporation method(0/W) was adopted to prepare the FK506 nanospheres and the tibial nerve of rats after allogeneic ***506 nanospheres were used in group A after operation immediately,in group B in 24 h after operation,and in group C in 3 d after operation while FK506 nanospheres were not used in group D:in the 4th,8th and 12th week after operation respectively,general observation of transplanted nerves,histological examination,image analysis of myelinated fibers,wetweight determination of musculi triceps surae,retrogradely labeling of neurons by the fluorescein and electrophysiological comparison of bilateral tibial nerve were carried ***:FK506nanospheres can be degraded and absorbed *** neural regenerations in group A and B were similar,which were both much belter than those in group C and *** difference was statistically significant and so was the difference between group C and ***:Drug release rate of FK506 nanospheres is accordant with the regeneration law of damaged nerves and the local application can promote the regenerations of *** effect would be better if the drug is used in earlier period(within 24 h).

关键词： Allogeneic transplantation Nanospheres FK506

Matrine ameliorates experimental autoimmune encephalomyelitis by regulating the differentiation of encephalitogenic Th1/Th17 and Th2/regulatory T cells

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中国药理学与毒理学杂志 2016年第10期30卷 1037-1038页

作者： ZHANG Ming-liang kan Quan-cheng ZHANG Hui-jun ZHU Lin Department of Pharmacy The First Affiliated Hospital of Zhengzhou University The First Affiliated Hospital of Zhengzhou University

OBJECTIVE Experimental autoimmune encephalomyelitis(EAE),the classical animal model for multiple sclerosis(MS)is triggered by an impaired balance of T helper(Th)cells and regulatory T(Tregs)***(MAT),a quinolizidine alkaloid derived from the herb Radix Sophorae Flave,has been shown to ameliorate the clinical signs,inflammatory infiltration,demyelination in acute EAE ***,whether MAT protect from EAE by adjusting Th and Treg cells response in specific-cellular and molecular level is *** Herein,MAT was tested for its effects on Th1,Th2,Th17 and Treg cells in the spinal cord of EAE mice and splenocyte-extracted from EAE mice with MOG35-55-restimulated,*** Our findings revealed that MAT significantly inhibit the proliferation of splenocyte,and remarkably down-regulate the differentiation of Th1/Th17 cells with decreased expressions of CD4+IFN-γ+cells and CD4+IL-17+cells in vivo and IL-17,IFN-γ,ROR-γt,T-bet in vitro,meanwhile it dramatically up-regulate the Th2/Treg cells response associated with increased levels of CD4+TGF-β+1cells and CD4+IL-10+cells in vivo and IL-4,IL-10,TGF-β1,Foxp3 and GATA3in *** Considering the effective therapeutic effects of MAT on EAE,it′s worth to find its new values on other autoimmune diseases.

关键词： matrine experimental autoimmune encephalomyelitis T helper cells regulatory T cells

ANALYSIS OF WARRANTY POLICIES

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Systems Science and Mathematical Sciences 1997年第1期10卷 50-60页

作者： cheng kan (Institute of Applied Mathematics Academia Sinica, Beijing 100080, China) 中科院应用数学所北京

There are some warranty policies commonly used: (1) Free-replacement warranty policy (FRW). (2) Pro-rata warranty policy (PRW). (3) Combination policies. In this paper) a brief review of policies 1 and 2 as well as some new distribution properties of successive purchase times under the combination policies are given. In addition, a new warranty policy is suggested. Under this policy the failed item within free replacement period [0,W] is subjected to minimal repair. Under certain cost structure, the long run average cost of customers and the profit of producers are analyzed. Finally, some examples are given.

关键词： Warranty policy free-replacement warranty policy pro-rata warranty policy minimal repair life classes

RELIABILITY BOUNDS IN NWUE CLASS WITH KNOWN MEAN AND VARIANCE

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Systems Science and Mathematical Sciences 1993年第2期6卷 145-149页

作者： cheng kan HE Zongfu Institute of Applied of Mathematics,Academia Sinica,Beijing 100080,China Air Force Engineering College,Xi’an 710038, China

Let. F∈NWUE with known mean and variance. In this note a simple sharplower bound of F=1-F(t) is given.

关键词： NWUE class reliability bounds