检索结果-南通市图书馆

The impact of female sex hormones on cardiovascular disease:from mechanisms to hormone therapy

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2024年第6期21卷 669-681页

作者： Yi kan Yu-Lu PENG Ze-Hao zhao Shu-Tong DONG Yin-Xiao XU Xiao-Teng MA Xiao-Li LIU Yu-Yang LIU Yu-Jie ZHOU Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina

Cardiovascular disease remains the leading cause of mortality in women,yet it has not raised the awareness from the public.The pathogenesis of cardiovascular disease differs significantly between females and males concerning the effect of sex hormones.Estrogen and progestogen impact cardiovascular system through genomic and non-genomic effects.Before menopause,cardiovascular protective effects of estrogens have been well described.Progestogens were often used in combination with estrogens in hormone therapy.Fluctuations in sex hormone levels,particularly estrogen deficiency,were considered the specific risk factor in women’s cardiovascular disease.However,considerable heterogeneity in the impact of hormone therapy was observed in clinical trials.The heterogeneity is likely closely associated with factors such as the initial time,administration route,dosage,and formulation of hormone therapy.This review will delve into the pathogenesis and hormone therapy,summarizing the effect of female sex hormones on hypertension,pre-eclampsia,coronary heart disease,heart failure with preserved ejection fraction,and cardiovascular risk factors specific to women.

关键词： impact dosage protective

Relationship Between Climate Change and Marmot Plague of Marmota himalayana Plague Focus—the Altun Mountains of the Qinghai-Xizang Plateau,China,2000–2022

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2024年第4期6卷 69-74,I0006页

作者： Qun Duan Xiaojin Zheng Zhiqiang Gan Dongyue Lyu Hanyu Sha Xinmin Lu Xiaoling zhao Asaiti Bukai Ran Duan Shuai Qin Li Wang Jinxiao Xi Di Wu Peng Zhang Deming Tang zhaokai He Huaiqi Jing Biao kan Xin Wang National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Akesai Kazak Autonomous County Center for Disease Control and Prevention Jiuquan CityGansu ProvinceChina Jiuquan Center for Disease Control and Prevention Jiuquan CityGansu ProvinceChina Gansu Provincial Center for Disease Control and Prevention Lanzhou CityGansu ProvinceChina

Introduction:Plague is a zoonotic disease that occurs naturally in specific geographic areas.Climate change can influence the populations of the plague host or vector,leading to variations in the occurrence and epidemiology of plague in animals.Methods:In this study,we collected meteorological and plague epidemiological data from the Marmota himalayana plague focus in the Altun Mountains of the Qinghai-Xizang Plateau.The data spanned from 2000 to 2022.We describe the climatic factors and plague epidemic conditions and we describe their analysis by Pearson’s correlation.Results:During the period from 2000 to 2022,the isolation rates of Yersinia pestis(Y.pestis)from marmots and fleas were 9.27%(451/4,864)and 7.17%(118/1,646),respectively.Additionally,we observed a positive rate of F1 antibody of 11.25%(443/3,937)in marmots and 18.16%(142/782)in dogs.With regards to climate,there was little variation,and a decreasing trend in blowing-sand days was observed.The temperature in the previous year showed a negative correlation with the Y.pestis isolation rate in marmots(r=−0.555,P=0.011)and the positive rate of F1 antibody in marmots(r=−0.552,P=0.012)in the current year.The average annual precipitation in the previous two years showed a positive correlation with marmot density(r=0.514,P=0.024),while blowingsand days showed a negative correlation with marmot density(r=−0.701,P=0.001).Furthermore,the average annual precipitation in the previous three years showed a positive correlation with the isolation rate of Y.pestis from marmots(r=0.666,P=0.003),and blowing-sand days showed a negative correlation with marmot density(r=−0.597,P=0.009).Conclusions:The findings of this study indicate that there is a hysteresis effect of climate change on the prevalence of plague.Therefore,monitoring climate conditions can offer significant insights for implementing timely preventive and control measures to combat plague epidemics.

关键词： Plague epidemiology Plateau

Ice-volume and insolation influences on hydroclimate changes in central eastern China during the antepenultimate glacial period

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2023年第1期66卷 71-79页

作者： Quan WANG Shayue YUAN Yijia LIANG kan zhao Qingfeng SHAO Zhenqiu ZHANG Junji ZHU Xinggong KONG Yongjin WANG Jianghu LAN Hai CHENG Chengwei XIA Yi LI School of Geography and Tourism Chongqing Normal UniversityChongqing 401331China Chongqing Key Laboratory of Wetland Science Research of the Upper Reaches of the Yangtze River Chongqing 401331China School of Geographical Science Nantong UniversityNantong 226007China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application School of GeographyNanjing Normal UniversityNanjing 210023China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Institute of Global Environmental Change Xi’an Jiaotong UniversityXi’an 710054China

The rainfall changes in East Asian summer monsoon(EASM)regions on the orbital timescale remain controversial due to the lack of reliable rainfall records.Here,we present new multiproxy records(δ^(18)O,δ^(13)C,Sr/Ca and Mg/Ca)of a230Thdated stalagmite from Hulu Cave in central eastern China.Multiproxy records reconstruct a regional hydroclimate history from 340 to 261 kyr BP(thousand years before present),approximately covering the antepenultimate glacial period.Theδ^(18)O record is dominated by the precessional cycles,suggesting that EASM responds to changes in Northern Hemisphere summer insolation(NHSI)on the orbital timescale.Significant correlations amongst theδ^(13)C,Sr/Ca and Mg/Ca suggest that a common factor,i.e.,the local hydrological cycle,controlled their variability,and their leading principal component can be used as a proxy linked to regional rainfall.This composite record bears a good similarity to those from the Chinese Loess Plateau,showing a gradually decreasing rainfall during the antepenultimate glacial period,consistent with changes in global ice volume.Superimposed on the long-term trend,three relative wetter intervals were responding to the higher NHSI periods,suggesting that EASM rainfall variability was induced by integrated effects of global ice volume and NHSI.The increased ice sheets and lower NHSI resulted in an increased meridional temperature gradient and southward shift of the westerlies,which shortened the duration of Meiyu and midsummer rainfall.The differences between the rainfall record and the stalagmiteδ^(18)O record indicate that the latter represents the overall EASM intensity linked to monsoon circulation,but does not directly reflect the rainfall changes at the cave sites.

关键词： Hulu Cave Stalagmite records Antepenultimate glacial period East Asian summer monsoon rainfall

DDAH1 promotes neurogenesis and neural repair in cerebral ischemia

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第5期14卷 2097-2118页

作者： Qiming Gao Pinfei Ni Yilin Wang Peiyun Huo Xiaojie Zhang Sihan Wang Fuyao Xiao Yixuan Li Wei Feng Juntao Yuan Teng Zhang Qiang Li Boyu Fan Yuhao kan Zhirui Li Yimiao Qi Junfei Xing Zhenghong Yang Haixiao Cheng Xinran Gao Xiaoyan Feng Ming Xue Yang Liu Yumin Luo Zhongbing Lu Yuming zhao Department of Pharmacology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Cerebrovascular Diseases Research Institute and Department of Neurology Xuanwu Hospital of Capital Medical UniversityBeijing 100053China State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of ChemistryChinese Academy of SciencesBeijing 100190China College of Life Science University of Chinese Academy of SciencesBeijing 100049China Department of Laboratory Animal School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Department of Physiology and Pathophysiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

Choline acetyltransferase(ChAT)-positive neurons in neural stem cell(NSC)niches can evoke adult neurogenesis(AN)and restore impaired brain function after injury,such as acute ischemic stroke(AIS).However,the relevant mechanism by which ChAT+neurons develop in NSC niches is poorly understood.Our RNA-seq analysis revealed that dimethylarginine dimethylaminohydrolase 1(DDAH1),a hydrolase for asymmetric NG,NG-dimethylarginine(ADMA),regulated genes responsible for the synthesis and transportation of acetylcholine(ACh)(Chat,Slc5a7 and Slc18a3)after stroke insult.The dual-luciferase reporter assay further suggested that DDAH1 controlled the activity of ChAT,possibly through hypoxia-inducible factor 1α(HIF-1α).KC7F2,an inhibitor of HIF-1α,abolished DDAH1-induced ChAT expression and suppressed neurogenesis.As expected,DDAH1 was clinically elevated in the blood of AIS patients and was positively correlated with AIS severity.By comparing the results among Ddah1 general knockout(KO)mice,transgenic(TG)mice and wild-type(WT)mice,we discovered that DDAH1 upregulated the proliferation and neural differentiation of NSCs in the subgranular zone(SGZ)under ischemic insult.As a result,DDAH1 may promote cognitive and motor function recovery against stroke impairment,while these neuroprotective effects are dramatically suppressed by NSC conditional knockout of Ddah1 in mice.

关键词： DDAH1 Neurogenesis Neural repair ChAT HIF-1α ACh Stroke ADMA

ENSO-Like Pacing of the Asian Summer Monsoon during the Early Holocene

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2020年第2期34卷 325-335页

作者： Xiaohua SHAO Tao WANG Yongjin WANG Hai CHENG kan zhao Xinggong KONG School of Geography Nanjing University of Information Science & TechnologyNanjing 210044China Public Meteorological Service Center of Anhui Province Hefei 230031China Key Laboratory of Virtual Geographic Environment Ministry of EducationNanjing Normal UniversityNanjing 210023China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China Institute of Global Environmental Change Xi’an Jiaotong UniversityXi’an 710049China Department of Geology and Geophysics University of MinnesotaMN 55455USA

We present a230Th-dated stalagmite oxygen isotope(δ^18O)record from Loushanguan Cave in the Yangtze River valley,China.The^δ18O record,if viewed as a proxy of the Asian summer monsoon(ASM)intensity,provides an ASM history for the early Holocene with clear centennial-scale variability.A significant approximately 200-yr cycle between 10.2 and 9.1 ka BP(before present,where"present"is defined as the year AD 1950),as revealed by spectral power analyses,is of global significance and is probably forced by the Suess or de Vries cycle of solar activity.Here,we explore a physical mechanism to explain the relationship between the solar activity and the ASM.A strong coherence between the ASM and El Ni?o–Southern Oscillation(ENSO)has been observed by performing crosswavelet analyses on this cycle.Our study suggests that a strong(weak)ASM state corresponds to a warm(cold)ENSO,which is consistent with modern meteorological observations but contrasts with previous studies on regions far from the Meiyu rainbelt.We argue that the centennial fluctuations of the ASM are a fundamental characteristic forced by the solar activity,with the ENSO variability as a mediator.The relationship between ENSO and the ASM displayed spatial heterogeneity on the centennial scale during the early Holocene,which is a more direct analogue to the observed modern interannual variability of the ASM.

关键词： isotope records Asian summer monsoon El Nino-Southern Oscillation centennial scale solar activity Yangtze River valley early Holocene

首次经皮球囊压迫术与射频热凝术后再行经皮球囊压迫术治疗三叉神经痛的比较

在线全文

学校读者我要写书评

暂无评论

中南大学学报（医学版） 2024年第1期49卷 40-46页

作者：张鸿昊蒋宗滨吕旌赵鹏岳侃何睿林广西医科大学第二附属医院疼痛科南宁530007

目的:三叉神经痛有多种微创介入治疗方式,各种方法的疗效不同,对于首选治疗方案仍有争议。本研究旨在比较原发性三叉神经痛(primary trigeminal neuralgia,PTN)患者首次接受经皮球囊压迫术(percutaneous balloon compression,PBC)介入... 详细信息

目的:三叉神经痛有多种微创介入治疗方式,各种方法的疗效不同,对于首选治疗方案仍有争议。本研究旨在比较原发性三叉神经痛(primary trigeminal neuralgia,PTN)患者首次接受经皮球囊压迫术(percutaneous balloon compression,PBC)介入治疗和射频热凝术(radiofrequency thermocoagulation,RT)治疗后疼痛复发再接受PBC在治疗效果等方面的差异,以期为患者提供更科学、精准的治疗方案。方法:回顾性分析2020年1月至2021年12月广西医科大学第二附属医院疼痛科收治的103例PTN患者的临床资料,其中首次接受PBC治疗的患者49例(PBC组),RT术后疼痛复发接受PBC治疗的患者54例(RT+PBC组)。比较2组患者术前疼痛评分,术中卵圆孔形态、卵圆孔面积、球囊容积、压迫时长,术后第1天(T1)、第7天(T2)、第14天(T3)、1个月(T4)、3个月(T5)、1年(T6)各时间点的疼痛评分及疼痛复发情况等的差异,并分析术后复发情况与疼痛评分的相关性。结果:2组间一般资料、术前疼痛评分、卵圆孔形态、卵圆孔面积、T1~T3疼痛评分的差异均无统计学意义(均P>0.05)。与RT+PBC组比较,PBC组球囊充盈容积较小,T4~T6的疼痛评分较低,疼痛复发例数较少(均P<0.05),疼痛复发情况与T2~T6的疼痛评分均呈正相关(分别r=0.306、0.482、0.831、0.876、0.887,均P<0.01)。结论:PTN患者首次介入治疗建议选择PBC,在治疗效果和疼痛复发情况等方面均优于RT治疗后疼痛复发再选择PBC治疗。

关键词：经皮球囊压迫术射频热凝术原发性三叉神经痛治疗效果疼痛复发

煤与瓦斯突出过程颗粒煤碰撞诱发二次破碎理论研究

在线全文

学校读者我要写书评

暂无评论

中国矿业大学学报 2024年第3期53卷 524-533页

作者：涂庆毅袁亮薛生程远平金侃赵祖恒安徽理工大学深部煤矿采动响应与灾害防控国家重点实验室安徽理工大学煤炭安全精准开采国家地方联合工程研究中心中国矿业大学安全工程学院中国计量大学质量与安全工程学院

煤与瓦斯突出是一种威胁煤矿安全生产的典型动力灾害.本文在分析搬运过程突出煤颗粒间或与巷道(阻挡物)的碰撞导致的二次破碎的理论过程基础上，建立突出煤颗粒碰撞二次破碎理论模型，开展单次和多次碰撞极限破碎理论计算.结合突出煤颗... 详细信息

煤与瓦斯突出是一种威胁煤矿安全生产的典型动力灾害.本文在分析搬运过程突出煤颗粒间或与巷道(阻挡物)的碰撞导致的二次破碎的理论过程基础上，建立突出煤颗粒碰撞二次破碎理论模型，开展单次和多次碰撞极限破碎理论计算.结合突出煤颗粒二次破碎试验分析，讨论了煤的结构差异对二次破碎的影响及对突出的作用.结果表明：当抗压强度小于2 MPa时，突出煤颗粒单次碰撞后的极限粉碎率随着抗压强度的降低急剧升高；而抗压强度大于2 MPa时，突出煤碰撞后的粉碎率随着抗压强度的降低而增加的速度较为缓慢，粉碎率低于0.0415%.2次试验0.074 mm以下的破碎煤占突出煤的质量比均低于0.41%,证明了表观结构完整的颗粒煤破碎或粉化是极其困难的.突出煤在搬运过程中的二次破碎是必要的过程，这种二次破碎形成的小颗粒或粉化煤是突出过程中的瓦斯能快速释放的保障.煤的力学强度和表观结构决定了其能否在搬运过程中二次破碎，相对于表观结构完整、强度高的原生煤，由散体煤胶结而成的构造煤更容易由于颗粒碰撞而发生二次破碎或粉化，同样验证了构造煤极易满足突出的条件.研究成果对突出煤的高度破碎或粉化现象成因进行了解释，有助于揭示突出灾变过程与机理.

关键词：煤与瓦斯突出搬运过程颗粒碰撞二次破碎粉碎率

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

数字零工非体面工作感知与主动服务行为

经济与管理研究 2024年第4期45卷 76-92页

作者：阚卓凡陈嘉茜赵曙明南京大学商学院南京210093

本文基于认知评估理论,通过对460名数字零工的多期追踪调研,重点探讨数字零工非体面工作感知与主动服务行为的关系及内在机制。研究结果表明,非体面工作感知负向影响数字零工的主动服务行为,挑战性评估和工作重塑在非体面工作感知和主... 详细信息

本文基于认知评估理论,通过对460名数字零工的多期追踪调研,重点探讨数字零工非体面工作感知与主动服务行为的关系及内在机制。研究结果表明,非体面工作感知负向影响数字零工的主动服务行为,挑战性评估和工作重塑在非体面工作感知和主动服务行为之间起链式中介作用;雇佣关系氛围在非体面工作感知和挑战性评估关系中起调节作用,并且通过减弱非体面工作感知对挑战性评估的负向影响,调节挑战性评估和工作重塑在非体面工作感知与主动服务行为之间的链式中介作用。本文的研究结论不仅丰富了非体面工作感知和主动服务行为的相关研究,也可为平台管理者如何推动数字零工展现主动服务行为提供借鉴。

关键词：数字零工非体面工作感知认知评估工作重塑主动服务行为雇佣关系氛围

我国2000~2017年室内空气污染暴露造成的疾病负担

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

科学通报 2024年第1期69卷 7-9页

作者：刘宁睿刘炜邓芙蓉阚海东赵卓慧张寅平清华大学建筑技术科学系北京100084 北京市室内空气质量评价和控制重点实验室北京100084 重庆科技大学健康环境研究院重庆401331 北京大学公共卫生学院北京100191 复旦大学公共卫生学院上海200032

21世纪以来,我国经济与城镇化进程快速发展.与此同时,室外大气雾霾、室内装修引起的甲醛污染等一系列空气污染问题相继出现,严重威胁公众健康,引起学者和公众的广泛关注.由于人一生超过80%的时间在室内度过^([1,2]),室内空气污染的健康... 详细信息

21世纪以来,我国经济与城镇化进程快速发展.与此同时,室外大气雾霾、室内装修引起的甲醛污染等一系列空气污染问题相继出现,严重威胁公众健康,引起学者和公众的广泛关注.由于人一生超过80%的时间在室内度过^([1,2]),室内空气污染的健康影响不容忽视.室内空气污染物既可以来源于室外大气污染,也可以来源于室内各种污染源.

关键词：室内空气污染空气污染问题公众健康大气雾霾甲醛污染室内装修疾病负担污染源