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Human epidermal growth factor receptor 2 targeted therapy in endometrial cancer:Clinical and pathological perspectives

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World Journal of Clinical Oncology 2021年第10期12卷 868-881页

作者： Ayumi Saito Hiroshi Yoshida Tadaaki Nishikawa kan yonemori Department of Breast and Medical Oncology National Cancer Center HospitalTokyo 1040045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 1040045Japan

Endometrial cancer is the most common gynecological cancer in developed countries,and its incidence has *** majority of patients with endometrial cancer have an early disease and favorable prognosis;however,a significant proportion of endometrial cancer,which mainly comprises high-grade or type II endometrial cancer such as serous,clear cell,and carcinosarcoma,shows advanced/recurrent disease and dismal *** therapeutic development is required for patients with aggressive endometrial *** genomic and immunohistochemical analyses revealed human epidermal growth factor receptor 2(HER2)overexpression/gene amplification in 20%-40%of patients with type II endometrial ***,HER2 targeted therapy has been developed for various major cancers,including breast and gastric ***,recent advances in HER2 targeted therapy for patients with type II endometrial cancer are also expected to ***,an optimized HER2 test for endometrial cancer as companion diagnostics should be *** this review,we summarize the recent findings on endometrial cancer,current treatment,optimized HER2 testing,key clinical trials on HER2 targeted therapy,and future directions in aggressive endometrial cancer,including serous carcinoma and carcinosarcoma.

关键词： Endometrial cancer Serous carcinoma Carcinosarcoma Human epidermal growth factor receptor 2 Chemotherapy Antibody-drug conjugates

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