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THREE ASPECTS ON SOLVING QUEUING SERVICE SYSTEM IN SHANGHAI WORLD EXPO

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Journal of Systems Science and Systems Engineering 2013年第3期22卷 340-361页

作者： Jifa GU Shanying XU Yong FANG kan shi Benfu LV Geng PENG Bo WANG Li SONG Rong XIE Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Management University of Chinese Academy of Sciences School of Management Shanghai University of Science and Technology Institute of Image Communication and Information Processing Shanghai Jiaotong University

This paper analyzes the queuing problem that was experienced during the Shanghai World Expo of 2010. The queuing problem will be discussed at three levels. The three levels include the physical, psychological, and social aspects of the queuing problem. The collective behavior of visitors is studied through analyzing the information from the different sources, such as, the network of electronic eyes, the evaluation platform based on mobile phone system and the Internet. A hybrid information network technology is implemented. Based on the Wuli-shili-Renli （WSR） system methodology, a new theoretical analysis framework for the queuing problem is proposed.

关键词： Shanghai world expo queuing system psychology satisfactory

Organizational Behavior Research in Transition Time of China

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Journal of Electronic Science and Technology of China 2004年第3期2卷 110-115页

作者： shi kan Research Center for Contemporary Management Tsinghua University Beijing 100084 China Center for Social & Economic BehaviorInstitute of PsychologyChinese Academy of Sciences Beijing 100864 China

The article is to introduce author's research results in recent years in the field of leadership behavior. The main researches conducted in this field include competency model of senior executives in communication industry and family firms; transformational leadership and its relationship with leadership effectiveness, the impact of supervisor's feedback on employees' behavior and the cross-culture study of supervisor's feedback. Theoretical and practical contributions of these researches are explained. Directions for future research are discussed.

关键词： competency model transformational leadership leadership effectiveness feedback

Role of savolitinib in advanced gastric adenocarcinoma with meningeal carcinomatosis and cerebellar metastasis:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2636-2641页

作者： Zhi-Yun Weng Wen-Ye Huang Bin-kan shi Jian-Jia Pan Department of Hematology The Affiliated Yueqing Hospital of Wenzhou Medical UniversityYueqing 325600Zhejiang ProvinceChina

BACKGROUND Brain metastases(BM)are very rare in gastric adenocarcinoma(GaC),and patients with BMs have a higher mortality rate due to stronger tumor ***,its pathogenesis remains *** testing revealed cellular-mesenchymal epithelial transition factor receptor(MET)***,treatment with savolitinib,a small molecule inhibitor of c-Met,was *** SUMMARY A 66-year-old woman was diagnosed with advanced GaC 6 months prior to presentation due to back *** and meningeal metastases were observed during candonilimab combined with oxaliplatin and capecitabine *** patient experienced frequent generalized seizures and persistent drowsiness in the emergency *** testing of cerebrospinal fluid and peripheral blood revealed increased MET *** discussing treatment options with the patient,savolitinib tablets were *** a month of treatment,the intracranial lesions shrank *** BM is very rare in advanced GaC,especially in meningeal cancer,that is characterized by rapid disease *** are very few effective treatment options available;however,technological breakthroughs in genomics have provided a basis for personalized ***,MET amplification may be a key driver of BM in gastric cancer;however,this conclusion requires further investigation.

关键词： Cellular-mesenchymal epithelial transition factor receptor Savolitinib Meningeal carcinomatosis Gastric adenocarcinoma Case report

Methionine addition improves the acid tolerance of Lactiplantibacillus plantarum by altering cellular metabolic flux,energy distribution,lipids composition

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Stress Biology 2022年第1期2卷 109-119页

作者： Qiang Meng Yueyao Li Yuxin Yuan Shaowen Wu kan shi Shuwen Liu College of Enology Northwest A&F UniversityYangling 712100ShaanxiChina Shaanxi Engineering Research Center for Viti-Viniculture Yangling 712100ShaanxiChina Viti-viniculture Engineering Technology Center of State Forestry and Grassland Administration Yangling 712100ShaanxiChina Heyang Experimental and Demonstrational Stations for Grape Northwest A&F UniversityHeyang 715300ShaanxiChina Ningxia Helan Mountain’s East Foothill Wine Experiment and Demonstration Station Northwest A&F UniversityYongning 750104NingxiaChina

This paper reported a wine-derived lactic acid bacterium,Lactiplantibacillus plantarum XJ25,which exhibited higher cell viability under acid stress upon methionine *** morphology and the composition of the cytomembrane phospholipids revealed a more solid membrane architecture presented in the acid-stressed cells treated with methionine *** analysis showed *** XJ25 reduced methionine transport and homocysteine biosynthesis under acid *** overexpression assays proved that methio-nine supplementation could alleviate the cell toxicity from homocysteine accumulation under acid ***,*** XJ25 employed energy allocation strategy to response environmental changes by balancing the uptake methionine and adjusting saturated fatty acids(SFAs)in *** data support a novel mechanism of acid resistance involving methionine utilization and cellular energy distribution in LAB and provide crucial theoretical clues for the mechanisms of acid resistance in other bacteria.

关键词： Acid stress Lactiplantibacillus plantarum Methionine Cell viability Transcription level Membrane lipids

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基于胜任特征模型的人力资源开发

心理科学进展 2006年第4期14卷 586-595页

作者：时勘中国科学院心理研究所北京100101

基于胜任特征模型(CompetencyModel)的探索,建立新型的人力资源开发与管理体系,是上世纪70年代以来,组织行为学和人力资源管理理论研究的前沿课题之一。文章主要介绍作者及其领导的课题组自80年代以来,基于我国社会经济转型时期和文化... 详细信息

基于胜任特征模型(CompetencyModel)的探索,建立新型的人力资源开发与管理体系,是上世纪70年代以来,组织行为学和人力资源管理理论研究的前沿课题之一。文章主要介绍作者及其领导的课题组自80年代以来,基于我国社会经济转型时期和文化背景的差异,在不同行业的胜任特征模型的建构、及其相关的领导行为研究方面的探索和发现。由于胜任特征模型也是人力资源开发和应用方面的热点问题,文章还介绍了胜任特征模型在国内人力资源开发、管理体系建设实践应用方面的进展。并对于未来开展本领域的理论研究和实践应用提出了建议。

关键词：胜任特征胜任特征模型 BEI行为事件访谈变革型领导人力资源开发

Quantitative effect of kerogen type on the hydrocarbon generation potential of Paleogene lacustrine source rocks,Liaohe Western Depression,China

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Petroleum Science 2024年第1期21卷 14-30页

作者： Sha-Sha Hui Xiong-Qi Pang Fu-Jie Jiang Chen-Xi Wang Shu-Xing Mei Tao Hu Hong Pang Min Li Xiao-Long Zhou kan-Yuan shi State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Exploration and Development Research Institute PetroChina Liaohe Oilfield CompanyPanjin 124010LiaoningChina

Kerogen types exert a decisive effect on the onset and capacity of hydrocarbon generation of source *** source rocks in the Liaohe Western Depression are characterized by thick deposition,high total organic carbon(TOC)content,various kerogen types,and a wide range of thermal ***,their hydrocarbon generation potential and resource estimation can be *** this study,geochemical tests,numerical analysis,hydrocarbon generation kinetics,and basin modeling were integrated to investigate the differential effects of kerogen types on the hydrocarbon generation potential of lacustrine source *** hydrocarbon generation and expulsion(HGE)models of different kerogen types were established quantitatively upon abundant Rock-Eval/TOC/vitrinite reflectance(R_(o))*** sets of good-excellent source rocks deposited in the fourth(Es4),third(Es3),and first(Es1)members of Paleogene Shahejie Formation,are predominantly types I-II_(1),II_(1)-II_(2),and II-III,*** activation energy of types I-II_(2)kerogen is concentrated(180-230 kcal/mol),whereas that of type III kerogen is widely distributed(150-280 kcal/mol).The original hydrocarbon generation potentials of types I,II_(1),II_(2),and III kerogens are 790,510,270,and 85 mg/g TOC,*** Ro values of the hydrocarbon generation threshold for type I-III source rocks gradually increase from 0.42%to 0.74%,and Ro values of the hydrocarbon expulsion threshold increase from 0.49%to 0.87%.Types I and II_(1)source rocks are characterized by earlier hydrocarbon generation,more rapid hydrocarbon expulsion,and narrower hydrocarbon generation windows than types II_(2)and III source *** kerogen types also affect the HGE history and resource *** types(conventional,tight,and shale oil/gas)and three levels(realistic,expected,and prospective)of hydrocarbon resources of different members in the Liaohe Western Depression are *** suggest that t

关键词： Kerogen type Hydrocarbon generation potential Lacustrine source rocks Liaohe western depression

Integrated flotation therapy for emotional regulation during the viral recovery period: Applying “form and spirit co-nourishing” in Chinese medicine

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Journal of Integrative Nursing 2024年第4期6卷 196-200页

作者： Hongmei DUAN Hongxin LIU Tao ZHONG kan shi Qingbin WU Xiaobai BAI Jihong XU Clinical Teaching and Research Department Nursing SchoolBeijing University of Chinese MedicineBeijingChina Outpatient Department of Traditional Chinese Medicine(TCM) Fangshan Hospital Beijing University of Chinese MedicineBeijingChina College of Education Academy of Wenzhou Model DevelopmentWenzhou UniversityWenzhouZhejiangChina Department of Mental Health Second Hospital of Shanxi Medical UniversityTaiyuanShanxiChina Taiyuan Shenghe Hospital TaiyuanShanxiChina

Objective:The objective of this study was to evaluate the effectiveness of flotation therapy combined with psychological resilience training in improving emotional regulation and sleep quality in patients recovering from viral infections and to assess the application of the traditional Chinese medicine(TCM)theory of“form and spirit co-nourishing”in modern healthcare ***:A total of 20 patients recovering from viral infections with anxiety and sleep disturbances were randomly assigned to the experimental group(n=10)and the control group(n=10).The experimental group received a combination of resilience training,targeting five key areas:physiological regulation,cognitive restructuring,emotional management,self-efficacy,and social support,alongside flotation therapy,with 45-min weekly *** control group received conventional medical *** levels were measured using the Hamilton Anxiety Scale,while sleep quality was assessed using the Pittsburgh Sleep Quality Index,both before and after the ***:Compared with intervention before,the resilience level of the experimental group significantly increased after the intervention(P0.05);the experimental group demonstrated significantly lower anxiety level and sleep disorder level and higher resilience level compared to the control group after the intervention(all Pshing,”significantly improves emotional regulation and sleep quality in patients recovering from viral *** integrative approach supports both physical and psychological healing,aligning with the TCM holistic treatment model,and offers a promising avenue for modern mental health interventions.

关键词： Emotional regulation flotation therapy form and spirit co-nourishing resilience training traditional Chinese medicine culture

Expression and Characterization of a Recombinant Truncated Capsid Protein of Hepatitis E Virus in Pichia pastoris

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Chemical Research in Chinese Universities 2010年第2期26卷 235-239页

作者： YANG En-cheng CHI Bao-rong LI Xiao LIU Yan GAO Peng JIA Peng kan shi-fu WEN Zhong-mei WANG Wan JIN Ning-yi The First Hospital of Jilin University Changchun 130021 P R. China Genetic Engineering Laboratory of PLA Academy of Military Medical Sciences Changchun 130062 P. R. China The Hospital of Digestive Diseases People＇s Hospital of Heilongjiang Province Harbin 150001 P. R. China Department of Pharmacy the First Hospital of Harbin Medical University Harbin 150001 P. R. China

Hepatitis E is an enterically transmitted viral disease caused by infection with hepatitis E virus（HEV）. HEV is a nonenveloped virus that bas been classified in the family of Caliciviridae. The virus appears to be a polya-denylated, positive-stranded RNA virus with three major open reading frames（ORFs）. The capsid protein of HEV is encoded by the open reading frame 2（ORF2）. We attempted to produce a truncated capsid protein, designed p293, in Pichia pastoris. The p293 gene encoding amino acids（aa） 382-674 of HEV ORF2 was designed based on the full length of HEV ORF2, cloned into the yeast vector pPIC9K, and expressed in P. pastoris strain GS 115. SDS-PAGE and Western blotting demonstrated that the recombinant protein p293 could well be expressed in P pastoris. Under optimized conditions （culture medium pH, 6.0-6.5; methanol concentration added daily, 3.0%; inoculum density, OD600=60; induction time point, 72-96 h）, the yield of soluble p293 was approximately 80 mg/L. We also observed p293 secretory expressed in P. pastoris to be 30 nm viral like particles by using electron microscopy. These results show that the p293 may has utility in the analysis of cell specific factors in the protein processing and assembly of HEV, and serve as a useful antigen for both diagnostic and vaccine purposes.

关键词： Hepatitis E virus Capsid protein Pichiapastoris Protein purification

Expression and Activities Experiment of DNA Transduction Motif Based on GAL4 in Pichia Pastoris

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Chemical Research in Chinese Universities 2010年第2期26卷 221-224页

作者： XU Xiao-hong CHI Bao-rong LI Xiao YANG En-cheng GAO Peng LIU Yan JIA Peng kan shi-fu WEN Zong-mei JIN Ning-yi The First Hospital Bethune Faculty of Medical Sciences of Jilin University Changchun 130021 R. P. China Key Laboratory of Genetic Engineering of PLA Academy of Military Medical Sciences Changchun 130062 R. P. China Department of Pharmacy the First Hospital of Harbin Medical University Harbin 150001 P. R. China

The genes encoding DNA-binding domain（BD） designed based on the yeast transcriptional activator GAL4 and protein transduction domain of HIV-1 Tat protein were fused via soft linker peptide sequence, and cloned into yeast expression vector pPIC9k. The resulted plasmid pTG was linearized and transfected into Pichia pastoris strains GS 115 by electroporation. High copies of transformants were obtained with Muts and HIS＋ phenotype identi- fication, PCR amplification and screening of G418. After flask culture and expression induced by methanol, the target protein named TG was well expressed and analyzed by SDS-PAGE and Western blot. Under optimized conditions, the yield of soluble recombinant protein was approximately 39.7 mg/L. DNA binding activity and cell transduction property of TG were analyzed by gel eleetrophoresis and fluorescent microscopy. The results show that the recombinant protein could bind strongly to the plasmid containing upstream activating sequence（UAS）. The cell experiments revealed that TG could deliver the binding plasmid into HEK-293 cells effectively. In summary, the work presented here suggests that TG is specific toward UAS containing plasmid and has the potential for use as nonviral DNA delivery agent.

关键词： Nonviral DNA delivery Yeast transcription activator(GAL4) Cell-penetrating peptide Upstream activating sequence(UAS) Secrete expression Pichia pastoris