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Research on the Development of Fibroin and Nano-Fiber from Silk Cocoons for Regenerated Tissue Engineering Applications by Electro-Spinning

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Advances in Nanoparticles 2024年第1期13卷 1-9页

作者： Md kamrul hasan Xinbo Ding School of Textile Science and Engineering International Silk Institute Zhejiang Sci-Tech University Hangzhou China

In this paper, the main goal is to prepare silk fibroin nano-fiber, which is used for regenerated tissue applications. Silk scaffold nano-fibers made by electro-spinning technology can be used in regenerated tissue applications. The purpose of the research is to prepare a silk-fibroin nano-fiber solution for potential applications in tissue engineering. Using a degumming process, pure silk fibroin protein is extracted from silk cocoons. The protein solution for fibroin is purified, and the protein content is determined. The precise chemical composition, exact temperature, time, voltage, distance, ratio, and humidity all have a huge impact on degumming, solubility, and electro-spinning nano-fibers. The SEM investigates the morphology of silk fibroin nano-fibres at different magnifications. It also reveals the surface condition, fiber orientation, and fiber thickness of the silk fibroin nano-fiber. The results show that regenerated silk fibroin and nano-fiber can be used in silk fibroin scaffolds for various tissue engineering applications.

关键词： Silk fibroin Scaffold electro-spinning nano-fiber Tissue Engineering

Towards a blockchain-SDN-based secure architecture for cloud computing in smart industrial IoT

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Digital Communications and Networks 2023年第2期9卷 411-421页

作者： Anichur Rahman Md Jahidul Islam Shahab S.Band Ghulam Muhammad kamrul hasan Prayag Tiwari Department of Computer Science and Engineering National Institute of Textile Engineering and Research(NITER)Constituent Institute of the University of DhakaSavarDhaka1350Bangladesh Department of Computer Science and Engineering Green University of BangladeshDhakaBangladesh Future Technology Research Center College of FutureNational Yunlin University of Science and TechnologyDouliouTaiwanChina Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadhSaudi Arabia Department of Information and Communication Engineering Hankuk University of Foreign StudiesSouth Korea Department of Computer Science Aalto UniversityFinland

Some of the significant new technologies researched in recent studies include BlockChain(BC),Software Defined Networking(SDN),and Smart Industrial Internet of Things(IIoT).All three technologies provide data integrity,confidentiality,and integrity in their respective use cases(especially in industrial fields).Additionally,cloud computing has been in use for several years now.Confidential information is exchanged with cloud infrastructure to provide clients with access to distant resources,such as computing and storage activities in the IIoT.There are also significant security risks,concerns,and difficulties associated with cloud computing.To address these challenges,we propose merging BC and SDN into a cloud computing platform for the IIoT.This paper introduces“DistB-SDCloud”,an architecture for enhanced cloud security for smart IIoT applications.The proposed architecture uses a distributed BC method to provide security,secrecy,privacy,and integrity while remaining flexible and scalable.Customers in the industrial sector benefit from the dispersed or decentralized,and efficient environment of BC.Additionally,we described an SDN method to improve the durability,stability,and load balancing of cloud infrastructure.The efficacy of our SDN and BC-based implementation was experimentally tested by using various parameters including throughput,packet analysis,response time,bandwidth,and latency analysis,as well as the monitoring of several attacks on the system itself.

关键词： Smart IIoT Blockchain SDN IoT Security Privacy OpenFlow SDN-Controller Data security Cloud computing Cloud management

Recent advancements in the diagnosis and treatment of acral melanoma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 106-122页

作者： Ahmad ALHASKAWI Sohaib hasan Abdullah EZZI Yanzhao DONG Haiying ZHOU Zewei WANG Jingtian LAI Chengjun YAO Vishnu Goutham KOTA Mohamed hasan Abdulla hasan ABDULLA Hui LU Department of Orthopedics the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310003China Department of Orthopaedics Third Xiangya HospitalCentral South UniversityChangsha410013China Zhejiang University School of Medicine Hangzhou310058China Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare Zhejiang UniversityHangzhou310058China

Acral melanoma(AM)is the most common histologic subtype of melanoma in dark-skinned patients and is associated with a worse prognosis and a high mortality rate,largely due to the inconspicuous nature of early-stage lesions,which can lead to late diagnosis.Because of the overlapping clinical and histopathological features of AM with other forms of cutaneous melanomas,early detection of AM requires a multidisciplinary approach that integrates various diagnostic modalities,including clinical examination,dermoscopy,histopathology,molecular testing,radiological imaging,and blood tests.While surgery is the preferred method of treatment for AM,other therapeutic options may be employed based on the stage and underlying etiology of the disease.Immune checkpoint inhibitors,molecular targeted therapy,radiotherapy,chemotherapy,and oncolytic virotherapy represent promising advanced treatment options for AM.In this review,we provide an overview of the latest advancements in diagnostic and therapeutic methods for AM,highlighting the importance of early detection and the prompt,individualized management of this challenging disease.

关键词： Acral melanoma Acral lentiginous melanoma Acral nevus Cutaneous malignant melanoma Dermoscopy Oncolytic virotherapy

Enhancing Ulcerative Colitis Diagnosis:A Multi-Level Classification Approach with Deep Learning

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 1129-1142页

作者： hasan J.Alyamani Department of Information Systems Faculty of Computing and Information Technology in RabighKing Abdulaziz UniversityJeddah21589Saudi Arabia

The evaluation of disease severity through endoscopy is pivotal in managing patients with ulcerative colitis,a condition with significant clinical implications.However,endoscopic assessment is susceptible to inherent variations,both within and between observers,compromising the reliability of individual evaluations.This study addresses this challenge by harnessing deep learning to develop a robust model capable of discerning discrete levels of endoscopic disease severity.To initiate this endeavor,a multi-faceted approach is embarked upon.The dataset is meticulously preprocessed,enhancing the quality and discriminative features of the images through contrast limited adaptive histogram equalization(CLAHE).A diverse array of data augmentation techniques,encompassing various geometric transformations,is leveraged to fortify the dataset’s diversity and facilitate effective feature extraction.A fundamental aspect of the approach involves the strategic incorporation of transfer learning principles,harnessing a modified ResNet-50 architecture.This augmentation,informed by domain expertise,contributed significantly to enhancing the model’s classification performance.The outcome of this research endeavor yielded a highly promising model,demonstrating an accuracy rate of 86.85%,coupled with a recall rate of 82.11%and a precision rate of 89.23%.

关键词： Ulcerative colitis deep learning CLAHE transfer learning geometric transformations

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 85-94页

作者： Iffat Ara Rita Turcio Tasmia Islam Md.Sabbir Hossain Md.kamrul hasan Department of Biochemistry and Molecular Biology Tejgaon CollegeNational UniversityGazipur-1700Bangladesh Department of Pharmacy University of Naples Federico IIvia Domenico Montesano49-80131 Napoli NAItaly Department of Genetic Engineering and Biotechnology Jashore University of Science and TechnologyJashore-7408Bangladesh Department of Public Health North South UniversityDhaka-1229Bangladesh

Background:Licochalcone A(LCA)is a flavonoid derived from the roots of Glycyrrhiza uralensis Fisch.ex DC and other related plants.Its natural source has been extensively used in complementary medicine,especially traditional Chinese medicine,to treat various ailments.Identified as a phenolic chalcone compound,LCA has gained significant attention in recent years due to its various pharmacological properties.Objective:The objective of this review article is to assess the anti-aging ralated pharmacological properties of LCA.Method:An exhaustive search of several scientific databases was conducted using various relevant keywords to write this review article on LCA,focusing on its therapeutic applications and anti-aging-related pharmacological activities.Some inclusion and exclusion criteria were strictly followed to retrieve updated relevant articles.Results:A collection of 292 papers were screened,and 131 were included in this review for an in-depth analysis of Licochalcone A,focusing on its anti-aging-related pharmacological activities and relevant mechanisms,and its toxicity and side effects.Moreover,the potential of LCA as a pharmacological product is discussed,emphasizing its health benefits and potential as a pharmaceutical product.Conclusion:These findings indicate that Licochalcone A is a promising natural therapeutic agent for anti-aging therapy and other ailments.

关键词： Licochalcone A Glycyrrhiza uralensis Chalcone Anti-aging Neuroprotective Antioxidant Skin protection Therapeutic agent

Theory for Charge Density Wave and Orbital-Flux State in Antiferromagnetic Kagome Metal FeGe

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Chinese Physics Letters 2024年第4期41卷 90-104页

作者：马海洋殷嘉鑫 M.Zahid hasan 刘健鹏 School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China Quantum Science Center of Guangdong-HongKong-Macao Greater Bay Area Shenzhen 518045China Laboratory for Topological Quantum Matter and Advanced Spectroscopy(B7) Department of PhysicsPrinceton UniversityPrincetonNew Jersey 08544USA Princeton Institute for Science and Technology of Materials Princeton UniversityPrincetonNew Jersey 08544USA Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720USA Liaoning Academy of Materials Shenyang 110167China

We theoretically study the charge order and orbital magnetic properties of a new type of antiferromagnetic kagome metal FeGe.Based on first-principles density functional theory calculations,we study the electronic structures,Fermi-surface quantum fluctuations,as well as phonon properties of the antiferromagnetic kagome metal FeGe.It is found that charge density wave emerges in such a system due to a subtle cooperation between electron-electron interactions and electron–phonon couplings,which gives rise to an unusual scenario of interaction-triggered phonon instabilities,and eventually yields a charge density wave(CDW)state.We further show that,in the CDW phase,the ground-state current density distribution exhibits an intriguing star-of-David pattern,leading to flux density modulation.The orbital fluxes(or current loops)in this system emerge as a result of the subtle interplay between magnetism,lattice geometries,charge order,and spin-orbit coupling(SOC),which can be described by a simple,yet universal,tight-binding theory including a Kane-Mele-type SOC term and a magnetic exchange interaction.We further study the origin of the peculiar step-edge states in FeGe,which sheds light on the topological properties and correlation effects in this new type of kagome antiferromagnetic material.

关键词： interaction phonon orbital

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聚乙烯醇/透明质酸复合导电水凝胶的制备及其传感和抗菌性能

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现代纺织技术 2024年

作者：王艳敏丁新波刘涛仇巧华 Md.kamrul hasan 朱灵奇周家宝浙江理工大学纺织科学与工程学院(国际丝绸学院)

为制备兼具传感和抗菌功能的导电水凝胶,以聚乙烯醇(PVA)和透明质酸(HA)为原料,通过原位聚合和冻融法制得氧化锌/聚(3, 4-乙烯二氧噻吩)/聚乙烯醇/透明质酸(Zn O/PEDOT/PVA/HA,简写ZP)导电水凝胶;并对其形貌、结构组成、力学性能、传感... 详细信息

为制备兼具传感和抗菌功能的导电水凝胶,以聚乙烯醇(PVA)和透明质酸(HA)为原料,通过原位聚合和冻融法制得氧化锌/聚(3, 4-乙烯二氧噻吩)/聚乙烯醇/透明质酸(Zn O/PEDOT/PVA/HA,简写ZP)导电水凝胶;并对其形貌、结构组成、力学性能、传感性能及其抗菌性能进行分析。结果表明:氧化锌的质量分数在0.3%时,ZP导电水凝胶的电导率最高可达2.91 S/m;ZP导电水凝胶具有良好的拉伸应变性能(≥100%)、灵敏的响应速度(1000次),能够对人体不同部位的运动信号进行监测识别;此外,ZP导电水凝胶对金黄色葡萄球菌(S.aureus)和大肠杆菌(E.coli)具有良好的抑制效果。该导电水凝胶在柔性可穿戴传感器及医疗健康监测方面具有良好的应用前景。

关键词：导电水凝胶传感性能柔性可穿戴传感器抗菌性能

聚乙烯醇/透明质酸复合导电水凝胶的制备及其传感和抗菌性能

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现代纺织技术 2024年

作者：王艳敏丁新波刘涛仇巧华 hasan MD kamrul 朱灵奇周家宝浙江理工大学纺织科学与工程学院(国际丝绸学院)

为制备兼具传感和抗菌功能的导电水凝胶，以聚乙烯醇(PVA)和透明质酸(HA)为原料，通过原位聚合和冻融法制得氧化锌/聚(3， 4-乙烯二氧噻吩)/聚乙烯醇/透明质酸（ZnO/PEDOT/PVA/HA，简写ZP）导电水凝胶；并对其形貌、结构组成、力学性能... 详细信息

为制备兼具传感和抗菌功能的导电水凝胶，以聚乙烯醇(PVA)和透明质酸(HA)为原料，通过原位聚合和冻融法制得氧化锌/聚(3， 4-乙烯二氧噻吩)/聚乙烯醇/透明质酸（ZnO/PEDOT/PVA/HA，简写ZP）导电水凝胶；并对其形貌、结构组成、力学性能、传感性能及其抗菌性能进行分析。结果表明：氧化锌的质量分数在0.3%时，ZP导电水凝胶的电导率最高可达2.91 S/m；ZP导电水凝胶具有良好的拉伸应变性能（≥100%）、灵敏的响应速度（<142 ms）和较好的稳定性（＞1000次），能够对人体不同部位的运动信号进行监测识别；此外，ZP导电水凝胶对金黄色葡萄球菌（S. aureus）和大肠杆菌（E. coli）具有良好的抑制效果。该导电水凝胶在柔性可穿戴传感器及医疗健康监测方面具有良好的应用前景。

关键词：导电水凝胶传感性能柔性可穿戴传感器抗菌性能

Robust design of sliding mode control for airship trajectory tracking with uncertainty and disturbance estimation

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Journal of Systems Engineering and Electronics 2024年第1期35卷 242-258页

作者： WASIM Muhammad ALI Ahsan CHOUDHRY Mohammad Ahmad SHAIKH Inam Ul hasan SALEEM Faisal Department of Aeronautics and Astronautics Engineering Institute of Space TechnologyIslamabad 44000Pakistan Department of Electrical Engineering University of Engineering and TechnologyTaxila 47080Pakistan Department of Measurements and Control Systems Silesian University of TechnologyGliwice 44-101Poland The Joint Doctoral School Silesian University of TechnologyGliwice 44-100Poland

The robotic airship can provide a promising aerostatic platform for many potential applications.These applications require a precise autonomous trajectory tracking control for airship.Airship has a nonlinear and uncertain dynamics.It is prone to wind disturbances that offer a challenge for a trajectory tracking control design.This paper addresses the airship trajectory tracking problem having time varying reference path.A lumped parameter estimation approach under model uncertainties and wind disturbances is opted against distributed parameters.It uses extended Kalman filter(EKF)for uncertainty and disturbance estimation.The estimated parameters are used by sliding mode controller(SMC)for ultimate control of airship trajectory tracking.This comprehensive algorithm,EKF based SMC(ESMC),is used as a robust solution to track airship trajectory.The proposed estimator provides the estimates of wind disturbances as well as model uncertainty due to the mass matrix variations and aerodynamic model inaccuracies.The stability and convergence of the proposed method are investigated using the Lyapunov stability analysis.The simulation results show that the proposed method efficiently tracks the desired trajectory.The method solves the stability,convergence,and chattering problem of SMC under model uncertainties and wind disturbances.

关键词： airship chattering extended Kalman filter(EKF) model uncertainties estimation sliding mode controller(SMC)

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