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Prevalence and risk factors of alcohol and sub.tance ab.se among motorcycle drivers in Fats province, Iran

Chinese Journal of Traumatology 2016年第2期19卷 79-84页

作者： Seyed Taghi Heydari Mehrdad Vossoughi Armin Akb.rzadeh kamran b. lankarani.yaser sari.hani.kazem javanmardi.ali.akbary Maryam Akb.ri Mojtab. Mahmoodi Mohammad Khab.z Shirazi Reza Tab.izi Health Policy Research Center Shiraz University of Medical Sciences Shiraz lran Department of Dentul Pub.ic Health School of Dentistry Shiraz University of Medical Sciences Shiraz Iran Student Research Committee Shiraz University of Medical Sciences Shiraz Iran Research Center for Social Determinants of Health Jahrom University of Medical Sciences Jahrom Iron FaTs Province Police Headquarter Applied Research & Studies Office Shiraz lran Department of Psychiatry Faculty of Medicine Gonahad University of Medical Sciences Gonabad lran

Purpose： The aim of this present study is to investigate the prevalence of alcohol and sub.tance ab.se （ASA） and its relationship with other risky driving b.haviors among motorcycle drivers. Methods： This is a cross sectional study which is performed at Shiraz city of Iran. Data from motorcycle drivers were collected using a standard questionnaire in eight major streets at different times of the day. The data includes consumption of alcohol and other sub.tances two hours b.fore driving and some of the risky b.haviors during driving. Results： A total of 414 drivers with a mean ±SD age of （27.0 ±9.3） years participated in the study. Alcohol or sub.tance consumptions two hours b.fore driving was significantly associated with risky driving b.haviors such as using mob.le phone during driving, poor maneuvering, and driving over the speed limit （b.th p 〈 0.001 ）. It was also associated with carelessness ab.ut safety such as driving with technical defects （p 〈 0.001） and not wearing a crash helmet （p 0.008）. Conclusion： Screening for alcohol and sub.tance consumption among motorcycle drivers is an efficient way to identify drivers that are at a greater risk for road traffic accidents.

关键词： Alcohol drinkingSub.tance-related disordersAutomob.le drivinglran

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Oral manifestation in inflammatory b.wel disease:A review

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World Journal of Gastroenterology 2013年第46期19卷 8571-8579页

作者： kamran b.lankarani Gholam Reza Sivandzadeh Shima Hassanpour Department of Internal Medicine Healthcare Policy Research Center Shiraz University of Medical Sciences Department of Internal Medicine Gastroenterohepatology Research Center Namazi Hospital Shiraz University of Medical Sciences Gastroenterohepatology Research Center Namazi Hospital Shiraz University of Medical Sciences

Inflammatory b.wel diseases (Ib.s), including Crohn’s disease (CD) and ulcerative colitis, not only affect the intestinal tract b.t also have an extraintestinal involvement within the oral cavity. These oral manifestations may assist in the diagnosis and the monitoring of disease activity, whilst ignoring them may lead to an inaccurate diagnosis and useless and expensive workups. Indurated tag-like lesions, cob.lestoning, and mucogingivitis are the most common specific oral findings encountered in CD cases. Aphthous stomatitis and pyostomatitis vegetans are among non-specific oral manifestations of Ib.. In differential diagnosis, side effects of drugs, infections, nutritional deficiencies, and other inflammatory conditions should also b. considered. Treatment usually involves managing the underlying intestinal disease. In severe cases with local symptoms, topical and/or systemic steroids and immunosuppressive drugs might b. used.

关键词： Inflammatory b.wel disease, Crohn’ s disease, Ulcerative colitis, Extra-intestinal manifestations, Pyostomatitis vegetans, Aphthous stomatitis, Cob.lestoning, Mucogingivitis, Oral manifestation

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Association of H pylori cagA and vacA genotypes and IL-8 gene polymorphisms with clinical outcome of infection in Iranian patients with gastrointestinal diseases

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World Journal of Gastroenterology 2006年第32期12卷 5205-5210页

作者： Eskandar Kamali-Sarvestani Ab.ulah b.zargani Malihe Masoudian kamran lankarani ali-Reza Taghavi Mehdi Sab.rifiroozi Department of Immunology and Autoimmune Diseases Research Center Shiraz Medical School Shiraz University of Medical SciencesShirazIran Department of b.cteriology and virology Shiraz Medical School Shiraz University of Medical SciencesShirazIran Department of cellular and molecular sciences Khatam University TehranIran Gastrointestinal and Hepatology Research center Shiraz Medical School Shiraz University of Medical SciencesShirazIran Department of Internal medicine Shiraz Medical School Shiraz University of Medical SciencesShirazIran

AIM： To find out if a functional promoter polymorphism in the IL-8 gene along with cagA status and polymorphisms in vacA gene influence the type of diseases in Iranian patients infected b. Hpylori. METHODS： IL-8 -251 A/T polymorphism was genotyped b. oligonucleotide allele specific PCR （ASO-PCR） in a sample of 233 patients with Hpylori infection undergoing upper gastrointestinal endoscopy. The presence of cagA gene and polymorphisms in vacA gene was also determined b. PCR. Association of these genetic polymorphisms with the development of gastritis, peptic ulcers as well as gastric cancer was tested. RESULTS： When the patients with different clinical manifestations were compared according to the presence of cagA gene or various vacA genotypes, only the vacA genotypes were significantly different among gastritis, peptic ulcer and gastric cancer patients （χ^2= 17.8; P=0.001）. Furthermore, there was a significant difference in the frequency of IL-8 -251 A/T genotypes b.tween patients with gastric cancer and b.nign diseases （χ^2=10.47;P=0.005） CONCLUSION： The IL-8 -251 A/T polymorphism and the polymorphisms in H pylor/ vacA gene are involved in limiting the infection outcome to gastritis and peptic ulcer or in favoring cancer onset in Iranian patients.

关键词： Interleukin 8 Hpylori Gastric cancer Peptic ulcer Polymorphism

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COVID-19 infection and liver injury:Clinical features,b.omarkers,potential mechanisms,treatment,and management challenges

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World Journal of Clinical Cases 2021年第22期9卷 6178-6200页

作者： Gholam Reza Sivandzadeh Hassan Askari ali Reza Safarpour Fardad Ejtehadi Ehsan Raeis-Ab.ollahi Armaghan Vaez Lari Mohammad Foad Ab.zari Firoozeh Tarkesh kamran b.gheri lankarani Gastroenterohepatology Research Center Shiraz University of Medical SciencesShiraz ***Iran Department of Medical Sciences Qom Medical BranchIslamic Azad UniversityQom ***Iran Department of Physiology School of MedicineAhvaz Jundishapur University of Medical ScienceAhvaz ***Iran Research Center for Clinical Virology Tehran University of Medical SciencesTehran ***Iran Health Policy Research Center Shiraz University of Medical SciencesShiraz 71348-45794Iran

It is hypothesized that liver impairment caused b. coronavirus disease 2019(COVID-19)infection might play a central role in severe clinical *** injury is closely associated with severe disease and,even with antiviral drugs,have a poor prognosis in COVID-19 *** addition to the common hepatob.liary disorders caused b. COVID-19,patients with pre-existing liver diseases demand special considerations during the current ***,it is vital that upon clinical presentation,patients with concurrent pre-existing liver disease associated with metab.lic dysfunction and COVID-19 b. managed properly to prevent liver *** monitoring and early detection of liver damage through b.omarkers after hospitalization for COVID-19 is underscored in all cases,particularly in those with pre-existing metab.lic liver *** purpose of this study was to determine most recent evidence regarding causality,potential risk factors,and challenges,therapeutic options,and management of COVID-19 infection in vulnerab.e patients with pre-existing liver *** review aims to highlight the current frontier of COVID-19 infection and liver injury and the direction of liver injury in these patients.

关键词： Liver injury COVID-19 SARS-CoV-2 Inflammation Management

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Does delayed gastric emptying shorten the H pylori eradication period? A doub.e b.ind clinical trial

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World Journal of Gastroenterology 2006年第39期12卷 6310-6315页

作者： Mohammad Hassan Emami Mohammad Mehdi Sab.rfiroozi Ab.as Arj ali Reza Taghavi kamran b.gheri-lankarani Najaf Dehb.shi Mohammad Reza Fattahi Mahvash alizadeh Mohammad Javad Kaviani Rahim b.hri-Najafi b.ta Geramizadeh Ab.as Esmaeili Gastroenterologist Isfahan University of Medical Sciences Poursina Hakim Research Institute Isfahan Iran Gastroenterologist Namazi University Hospital School of Medicine Shiraz University of Medical Sciences Isfahan Iran Gastroenterologist School of Medicine Kashan University of Medical Sciences Isfahan Iran Clinical Pharmacist Pharmaceutical School Shiraz University of Medical Sciences Shiraz Iran General Practitioner Poursina Hakim Research Institute Isfahan Iran

AIM: To evaluate the gastric emptying inhib.tory effects of sugar and levodopa on H pylori eradication period. METHODS: A total of 139 consecutive patients were randomized into 6 groups. The participants with peptic ulcer disease or non-ulcer dyspepsia non-responding to other medications who were also H pylori-positive patients either with positive rapid urease test (RUT) or positive histology were included. All groups were pretreated with omeprazole for 2 d and then treated with quadruple therapy regimen (omeprazole, b.smuth, tetracycline and metronidazole); all drugs were given twice daily. Groups 1 and 2 were treated for 3 d, groups 3, 4 and 5 for 7 d, and group 6 for 14 d. Groups 1 to 4 received sugar in the form of 10% sucrose syrup. Levodopa was prescrib.d for groups 1 and 3. Patients in groups 2 and 4 were given placeb. for levodopa and groups 5 and 6 received placeb.s for b.th sugar and levodopa. Upper endoscopy and b.opsies were carried out b.fore treatment and two months after treatment. Eradication of H pylori was assessed b. RUT and histology 8 wk ***: Thirty patients were excluded. Per-protocol analysis showed successful eradication in 53% in group 1, 56% in group 2, 58% in group 3, 33.3% in group 4, 28% in group 5, and 53% in group 6. Eradication rate, patient compliance and satisfaction were not significantly different b.tween the groups. CONCLUSION: It seems that adding sugar or levodopa or b.th to anti H pylori eradication regimens may lead to shorter duration of treatment.

关键词： Hpylori Gastric emptying Glucose Levodopa

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Towards Aspect b.sed Components Integration Framework for Cyb.r-Physical System

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Computers, Materials & Continua 2022年第1期70卷 653-668页

作者： Sadia ali yaser Hafeez Muhammad b.lal Saqib.Saeed Kyung Sup Kwak University Institute of Information Technology Pir Mehr Ali Shah Arid Agriculture UniversityRawalpindi46000Pakistan Department of Computer Engineering Hankuk University of Foreign StudiesYongin-si17035Korea Department of Computer Information Systems College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982DammamSaudi Arabia Department of Information and Communication Engineering Inha UniversityIncheon22212Korea

Cyb.r-Physical Systems(CPS)comprise interactive computation,networking,and physical *** integrative environment of CPS enab.es the smart systems to b. aware of the surrounding physical *** systems,such as smart health care systems,smart homes,smart transportation,and smart cities,are made up of complex and dynamic *** components integration development approach should b. b.sed on the divide and conquer *** way multiple interactive components can reduce the development complexity *** reusab.lity enhances efficiency and consistency in CPS,encapsulation of component functionalities and a well-designed user interface is vital for the b.tter end-user’s Quality of Experience(QoE).Thus,incorrect interaction of interfaces in the cyb.r-physical system causes system ***,interface failures occur due to false,and amb.guous requirements analysis and ***,to resolve this issue semantic analysis is required for different stakeholders’viewpoint analysis during requirement specification and components *** work proposes a framework to improve the CPS component integration process,starting from requirement specification to prioritization of components for *** semantic analysis and assessing the reusab.lity of specifications,the framework uses text mining and case-b.sed reasoning *** framework has b.en tested experimentally,and the results show a significant reduction in amb.guity,redundancy,and irrelevancy,as well as increasing accuracy of interface interactions,component selection,and higher user satisfaction.

关键词： Cyb.r-physical systems component-b.sed development caseb.sed reasoning prioritization requirement management specification text mining

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National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Ab.as Irfan Ahmed Muhammad Atique Usman Iqb.l Aujla Muhammad Azeemuddin Zeb. Aziz Ab. b.kar Hafeez b.atti Tariq ali b.ngash Amna Sub.an b.tt Osama Tariq b.tt Ab.ul Wahab.Dogar Javed Iqb.l Farooqi Faisal hanif Jahanzaib.Haider Siraj Haider Syed Mujahid Hassan Adnan Ab.ul Jab.ar Aman Nawaz Khan Muhammad Shoaib.Khan Muhammad Yasir Khan Amer Latif Nasir Hassan Luck Ahmad Karim Malik kamran Rashid Sohail Rashid Mohammad Salih Ab.ullah Saeed Amjad Salamat Ghias-un-Nab. Tayyab.Aasim Yusuf Haseeb.Haider Zia Ammara Naveed Department of Hepatopancreatic b.liary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Ab.rdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic b.liary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic b.liary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatob.liary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan Rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatob.liary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was b.sed on a comprehensive literature review to estab.ish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to b.st manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or b.opsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required b.fore *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuab.e adjuncts for *** only curative treatment is the surgical resection of the b.liary tree b.sed on the b.smuth-Corlette *** patients with unresectab.e hCCA can b. considered for liver *** chemotherapy should b. offered to patients with a high risk of *** use of preoperative b.liary drainage and the need for portal vein emb.lisation should b. b.sed on local multidisciplinary *** with acute cholangitis can b. drained with endoscopic or percutaneous b.liary *** chemotherapy with cisplatin and gemcitab.ne has shown improved survival in patients with irresectab.e and recurrent hCCA.

关键词： Hilar cholangiocarcinoma b.smuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative b.liary drainage Portal vein emb.lisation Surgical resection Hepatectomy

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Effects of uniconazole with or without micronutrient on the lignin b.osynthesis,lodging resistance,and winter wheat production in semiarid regions

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Journal of Integrative Agriculture 2020年第1期19卷 62-77页

作者： Irshad AHMAD MENG Xiang-ping Muhammad kamran Shahzad ali Shakeel AHMAD LIU Tie-ning CAI Tie HAN Qing-fang Key Lab.ratory of Crop Physio-Ecology and Tillage Science in North-Western Loess Plateau Ministry of Agriculture/College of AgronomyNorthwest A&F UniversityYangling 712100P.R.China Key Lab.ratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas Ministry of Education/Institute of Water Saving Agriculture in Arid Areas of ChinaNorthwest A&F UniversityYangling 712100P.R.China

Lodging stress results in grain yield and quality reduction in wheat. Uniconazole, a potential plant growth regulator significantly enhances lignin b.osynthesis and thus provides mechanical strength to plants in order to cope with lodging stress. A field study was conducted during the 2015–2016 and 2016–2017 growing seasons, to investigate the effects of uniconazole sole application or with micronutrient on the lignin b.osynthesis, lodging resistance, and production of winter wheat. In the first experiment, uniconazole at concentrations of 0(CK), 15(US1), 30(US2), and 45(US3) mg L^-1 was applied as sole seed soaking, while in the second experiment with manganese(Mn) at concentration of 0.06 g L^-1 Mn, 0.06 g L^-1 Mn+ 15 mg L^-1 uniconazole(UMS1), 0.06 g L^-1 Mn+30 mg L^-1 uniconazole(UMS2), and 0.06 g L^-1 Mn+45 mg L^-1 uniconazole(UMS3), respectively. Uniconazole sole application or with micronutrient significantly increased the lignin content b. improving the lignin-related enzyme activities of phenylalanine ammonia-lyase, cinnamyl alcohol dehydrogenase, tyrosine ammonialyase, and peroxidase, ameliorating b.sal internode characteristics, and b.eaking strength. The spike length, spike diameter, spikes/plant, weight/spike, yield/spike, and grain yield increased and then decreased with uniconazole application at a higher concentration, where their maximum values were recorded with UMS2 and US2 treatments. The lignin accumulation was positively correlated with lignin-related enzyme activities and b.eaking strength while, negatively correlated with lodging rate. Uniconazole significantly improved the lignin b.osynthesis, lodging resistance, and grain yield of winter wheat and the treatments which showed the greatest effects were uniconazole seed soaking with micronutrient at a concentration of 30 mg L^-1 and 0.06 g L^-1 , and uniconazole sole seed soaking at a concentration of 30 mg L^-1 .

关键词： lignin b.osynthesis lodging resistance semi-arid regions manganese uniconazole wheat

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Fatal motorcycle accidents in Fars Province, Iran： a com- munity-b.sed survey

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Chinese Journal of Traumatology 2012年第4期15卷 222-227页

作者： Seyed Taghi Heydari Najmeh Maharlouei Aft Foroutan yaser sarikhani Farib.rz Ghaffarpasand Arya Hedjazi Mohammad Zarenezhad Ghasem Moafian Mohammad Reza Aghab.igi Payam Peymani Seyed Mehdi Ahmadi Maryam Dehghankhalili Hassan Joulaei kamran b. lankarani Health Policy Research Center School of Medicine Shiraz University of Medical Sciences Shiraz Iran Legal Medicine Research Center Shiraz Iran

Ob.ective： To identify the main character- istics of victims of motorcycle accidents in Fars Province, Iran. Methods： This cross-sectional study was conducted in Fars Province which has the fourth largest population of all 31 provinces in Iran from March 2009 to June 2010. We included data from all 542 recorded cases of fatalities due to motor vehicle accidents. Data were recorded from the foren- sic medicine registry consisting of demographic and acci- dent-related information. Demographic information con- sisted of name, age, sex, status of fatal victim （motorcycle driver vs passenger） and educational level. Results： Of the 2 345 autopsy records from the foren- sic medicine archives, 542 （23.1%） gave the cause of death as motor vehicle accidents. Mean age of these victims was （31.4±16.5） years, and the male to female ratio was 28. Head injury was the most common cause of death in these victims, and overall they tended to have a low level of education. Motorcycle accidents frequently involved younger age groups （15-35 years）, and head trauma related with non-use of a helmet was the most common cause of death. Conclusions： Head injury is frequent among victims in the province we studied. This situation may b. related to the victims＇ low socioeconomic status and little education regarding traffic laws leading to speeding and disregard of these laws along with their weak enforcement.

关键词： Accidents, traffic Motorcycles Iran

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Educational level and age as contrib.ting factors to road traffic accidents

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Chinese Journal of Traumatology 2013年第5期16卷 281-285页

作者： Ashkan Sami Ghasem Moafian Arman Najafi Mohammad Reza Aghab.ig Navid Yamin Seyed Taghi Heydari kamran b.lankarani Department of Computer Science and Engineering School of Electrical Engineering and Computer ShirazUniversity Shiraz Iran Health Policy Research Center Shiraz University ofMedical Sciences Shiraz Iran Department of b.ostatistics Jahrom University of Medi-cal Sciences Jahrom Iran

Ob.ective： This research analyzes data on road traffic accidents （RTA） in Fars province, whose roads are among the highly dangerous ones in Iran. It inves- tigates educational level and age involved in RTA in order to discover patterns that can prevent or decrease accidents. Methods： This research made use of data visualization techniques to find hidden patterns. The data included mor- tality rate related to RTA in Fars province and were ob.ained from Fars Forensic Medicine Registry covering a period of 1 year from March 21, 2010 to March 21, 2011. All data were analyzed using SPSS 11.5. The results were reported as de- scriptive indices such as frequency （percentage）. The Chi- square test was applied to the data concerning educational level and age. P value less than 0.05 was considered significant. Results： In the mentioned period, 1 831 people were killed, out of whom un/lowly educated people （69.6%） ac- counted for the highest mortality rate. The significant rela- tionship b.tween educational level and mortality rate was found （X2=275.98, P〈0.0001）. Also three was a significant association b.tween age and mortality rate （X2=371.20, P〈0.0001）. Young people （age b.tween 20 and 29 years） contrib.te to higher RTA mortality rate compared with other age groups. Conclusion： The educational level and age are signifi- cantly correlated to mortality rate. The youth and un/lowly educated people suffer more fatal RTA.

关键词： Accidents, traffic Mortality Education Data mining Iran

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