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Iron dysregulation in beta-thalassemia

Asian Pacific Journal of Tropical Medicine 2016年第11期9卷 1013-1021页

作者： kamonlak leecharoenkiat Pathrapol Lithanatudom Wannapa Sornjai Duncan R.Smith Department of Clinical Microscopy Faculty of Allied Health SciencesChulalongkorn University Department of Biology Faculty of ScienceChiang Mai University Molecular Pathology Laboratory.Institute of Molecular Biosciences Mahidol University

Iron deficiency anemia and iron overload conditions affect more than one billion people *** homeostasis involves the regulation of cells that export iron into the plasma and cells that utilize or store *** cellular iron balance in humans is primarily mediated by the hepcidin-ferroportin *** is the sole cellular iron export protein,and its expression is regulated transcriptionally,post-transcriptionally and ***,a hormone produced by liver cells,post-translationally regulates ferroportin expression on iron exporting cells by binding with ferroportin and promoting its internalization by endocytosis and subsequent degradation by *** of iron homeostasis leading to iron deposition in vital organs is the main cause of death in betathalassemia ***-thalassemia patients show marked hepcidin suppression,ineffective eiythropoiesis,anemia and iron ***-thalassemia is common in the Mediterranean region,Southeast Asia and the Indian subcontinent,and the focus of this review is to provide an update on the factors mediating hepcidin related iron dysregulation in beta-thalassemia *** this process may pave the way for new treatments to ameliorate iron overloading and improve the long term prognosis of these patients.

关键词： Beta-thalassemia Hepcidin Iron overload Ferroportin

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Sedimentology and Stratigraphy of Phu Sung Fossil Site of the Lower Cretaceous Sao Khua Formation, Sakon Nakhon Province, Northeastern Thailand

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Open Journal of Geology 2019年第10期9卷 684-687页

作者： Pitaksit Ditbanjong Phornphen Chanthasit kamonlak Wongko Department of Geological Sciences Faculty of Science Chiang Mai University Chiang Mai Thailand Sirindhorn Museum Department of Mineral Resources Sahatsakhan Kalasin Thailand Phu Wiang Fossil Research Center and Dinosaur Museum Department of Mineral Resources Khon Kaen Thailand

“Phu Sung”, a new fossil site in Sakon Nakhon Province was recently reported. Phu Sung fossils are very complete and in very well-preserved condition. They were found in reddish micaceous silty mudstone. The stratigraphy and sedimentology show that Phu Sung succession is a continental deposit in the fluvial system and it is in the Early Cretaceous Sao Khua Formation of the Khorat Group. According to lithology, fossils were deposited in a quiet environment, such as overbank deposit, small pond or oxbow lake margin. Sedimentary structures such as desiccation crack and calcrete indicate semi-arid to arid paleoclimate condition which probably corresponds to the taphonomy or preservation of the fossils.

关键词： Fluvial Deposits Sao Khua Formation Lower Cretaceous Northeastern Thailand

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New Vertebrate Fossil Site from the Early Cretaceous Sao Khua Formation, Sakon Nakhon Province, Northeastern Thailand

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Open Journal of Geology 2019年第10期9卷 619-622页

作者： Phornphen Chanthasit Suravech Suteethorn Wilailak Naksri Haiyan Tong kamonlak Wongko Teppei Sonoda Sirindhorn Museum Department of Mineral Resources Sahatsakhan Kalasin Thailand Palaeontological Research and Education Centre Mahasarakham University Kantarawichai Mahasarakham Thailand Department of Biology Faculty of Science Mahasarakham University Mahasarakham Thailand Northeastern Research Institute of Petrified Wood and Mineral Resources Nakhon Ratchasima Rajabhat University Nakhon Ratchasima Thailand Phu Wiang Fossil Research Center and Dinosaur Museum Department of Mineral Resources Khon Kaen Thailand Fukui Prefectural Dinosaur Museum Fukui Japan

A new vertebrate fossil site, “Phu Sung” in Sakon Nakhon Province was discovered. Various vertebrate fossils belonging to fresh water shark, bony fish, turtle, crocodile and dinosaur were found in reddish silty mudstone of the Early Cretaceous Sao Khua Formation of the Khorat Group. Crocodilian remains including a complete skull and partial articulated skeleton are very well preserved associated with turtle remains. Moreover, well preserved 19 turtle shells were found accumulated together. These discoveries will certainly fulfill our knowledge about these aquatic taxa from the Early Cretaceous Sao Khua Formation. The exceptional preservation of Phu Sung fossils could probably relate to the paleoenvironment in the Early Cretaceous of Thailand.

关键词： Vertebrate Sao Khua Formation Early Cretaceous Northeastern Thailand

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