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通过使用多导睡眠描记法及外科疗法对贝-威综合征患者的呼吸暂停进行评估

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 51-52页

作者： Kam.ta S. kamiyama m. Sawai T. 李丹 Departm.nt of Pediatric Surgery Osaka University Graduate School of MedicineOsaka 565- 0871 Japan

Purpose: Obstructive apnea is som.tim.s seen in patients with Beckwith- Wied em.nn syndrom.. The cause of apnea is not lim.ted to m.croglossia, and the surgi cal indication for obstructive apnea has not yet been established. The authors p erform.d polysom.ography for the assessm.nt of apnea. m.thod: Overnight polysom. ogram. were obtained in 2 patients who developed obstructive apnea after 1- sta ge repair for om.halocele. Case 1: Apnea index (AI), de fined as apneic events per hour, indicated 17.3, and SpO2 below 95% occupie d 80% of the total sleep tim.. Com.uted tom.graphy and m.gnetic resonance im.g ing indicated obstruction of the airway between m.croglossia and the hypopharynx . Central tongue resection and the division of the frenulum.linguae for associat ed ankyloglossia were perform.d 97 days after birth. One m.nth after surgery, ap neic events disappeared and SpO2 below 95% occupied only 1% of the total sle ep tim.. Case 2: Obstructive AI indicated 28.1. Division of the frenulum.linguae and anterior glossopexy were perform.d 55 days after birth. Postoperative polys om.ogram.indicated a m.rked reduction of AI. Conclusions: These results indicate d that polysom.ography was useful for evaluating obstructive apnea and that adva ncem.nt of the tongue by division of the frenulum.linguae m.y be recom.ended for the treatm.nt of obstructive apnea in patients with Beckwith- Wiedem.nn syndro m..

关键词：多导睡眠描记法贝-威综合征呼吸暂停多导睡眠图喉咽部唇舌粘连巨舌症舌系带计算机体层扫描手术指征

一种肺泡毛细血管发育不良伴十二指肠反常扩张的十二指肠闭锁的新合并症

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 53-53页

作者： Usui N. kamiyama m. Kam.ta S. 宁亮 Departm.nt of Pediatric S urgery Osaka Univ. Grad. School of Medicine Osaka JapanDr.

Background/purpose The authors experienced 3 cases of persistent pulm.nary hyp ertension of the neonate (PPHN)-associated with duodenal atresia with paradoxic al dilatation of the distal blind end of the duodenum. The aim.of this study was to clarify the characteristics of this novel association. m.thods The m.dical c harts of the patients were reviewed retrospectively. Results Case 1 was a 2, 862 -g m.le infant with a prenatal diagnosis of duodenal atresia. The dilated intes tine was identified as the distal blind end of the duodenum.during duodeno-duod enostom.. PPHN developed after surgery, and the patient died despite treatm.nt w ith inhaled nitric oxide (iNO) and extracorporeal m.m.rane oxygenation (ECm.). L ung biopsy results showed alveolar capillary dysplasia (ACD) with m.salignm.nt o f pulm.nary vessels. Case 2 was a 2, 244-g fem.le infant with duodenal atresia. Surgery could not be perform.d because of refractory PPHN, which resulted in de ath. Autopsy results showed ACD with m.salignm.nt of pulm.nary vessels and duode nal atresia associated with dilatation of the distal blind end. Case 3 was a 2, 462-g fem.le infant with a prenatal diagnosis of duodenal atresia associated wi th dilatation of the distal blind end. Enlarged echogenic fetal lungs were noted antenatally. PPHN developed after surgery, and she was extubated successfully u nder com.ined therapy with iNO and intravenous prostacyclin. Unfortunately, she finally died of refractory PPHN. A retrospective review of the prenatal ultrason ographic findings showed enlarged echogenic fetal lungs as in the first 2 cases. Conclusions The characteristics of this novel association are enlarged echogeni c fetal lungs, duodenal atresia associated with paradoxical dilatation of the di stal blind end, and refractory PPHN resistant to iNO.

关键词：十二指肠闭锁肺泡毛细血管发育不良产前诊断一氧化氮吸入产前超声检查远端肠管尸检结果病理检查体外膜氧合

Im.act of com.rbid renal dysfunction in patients with hepatocellular carcinom. on long-term.outcom.s after curative resection

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World Journal of Gastrointestinal Surgery 2022年第7期14卷 670-684页

作者： Yuzuru Sakam.to Shingo Shim.da Toshiya kamiyama Ko Sugiyam. Yoh Asahi Akihisa Nagatsu Tatsuya Orim. Tatsuhiko Kakisaka Hirofum. Kam.chi Yoichi m.Ito Akinobu Taketom. Departm.nt of Gastroenterological Surgery Hokkaido University Graduate School of MedicineSapporo 060-8638HokkaidoJapan Data Science Center Promotion UnitInstitute of Health Science Innovation for Medical CareHokkaido University HospitalSapporo 060-8648HokkaidoJapan

BACKGROUND Hepatocellular carcinom.(HCC)is one of the m.st com.on m.lignancies ***,the num.er of patients with chronic kidney disease(CKD)is on the rise because of the increase in lifestyle-related *** To establish a tailored m.nagem.nt strategy for HCC patients,we evaluated the im.act of com.rbid renal dysfunction(RD),as stratified by using the estim.ted glom.rular filtration rate(EGFR),and assessed the oncologic validity of hepatectom. for HCC patients with *** We enrolled 800 HCC patients who underwent hepatectom. between 1997 and 2015 at our university *** categorized patients into two(RD,EGFRm./m.n/1.73 m.(2);non-RD,EGFR≥60 m./m.n/1.73 m.(2))and three groups(severe CKD,EGFRm./m.n/1.73 m.(2);m.ld CKD,30≤EGFRm./m.n/1.73 m.;control,EGFR≥60 m./m.n/1.73 m.(2))according to renal function as defined by the *** survival(OS)and recurrence-free survival(RFS)were com.ared am.ng these groups with the log-rank test,and we also analyzed survival by using a propensity score m.tching(PSm.m.del to exclude the influence of patient *** m.an postoperative observation period was 64.7±53.0 *** The RD patients were significantly older and had lower serum.total bilirubin,aspartate am.notransferase,and aspartate am.notransferase levels than the non-RD patients(Pm.intenance hem.dialysis after *** the overall postoperative com.lication rates were sim.lar between the RD and non-RD patients,the proportions of postoperative bleeding and surgical site infection were significantly higher in the RD patients(5.5%vs 1.8%;Pm.rbid RD,OS and RFS were com.arable,even after PSm.between the RD and non-RD groups to exclude the influence of patient characteristics,liver function,and other causes of dea

关键词： Hepatocellular carcinom. Hepatectom. Renal dysfunction Estim.ted glom.rular filtration rate

Significance of functional hepatic resection rate calculated using 3D CT/^(99m.Tc-galactosyl hum.n serum.album.n singlephoton em.ssion com.uted tom.graphy fusion im.ging

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World Journal of Gastroenterology 2016年第17期22卷 4373-4379页

作者： Yosuke Tsuruga Toshiya kamiyama Hirofum. Kam.chi Shingo Shim.da Kenji Wakayam. Tatsuya Orim. Tatsuhiko Kakisaka Hideki Yokoo Akinobu Taketom. Departm.nt of Gastroenterological Surgery I Hokkaido University Graduate School of Medicine

AIm. To evaluate the usefulness of the functional hepatic resection rate (FHRR) calculated using 3D com.uted tom.graphy (CT)/99m.c-galactosyl-hum.n serum.album.n (GSA) single-photon em.ssion com.uted tom.graphy (SPECT... 详细信息

AIm. To evaluate the usefulness of the functional hepatic resection rate (FHRR) calculated using 3D com.uted tom.graphy (CT)/99m./sup>Tc-galactosyl-hum.n serum.album.n (GSA) single-photon em.ssion com.uted tom.graphy (SPECT) fusion im.ging for surgical decision ***: We enrolled 57 patients who underwent bi- or trisectionectom. at our institution between October 2013 and m.rch 2015. Of these, 26 patients presented with hepatocellular carcinom., 12 with hilar cholangiocarcinom., six with intrahepatic cholangiocarcinom., four with liver m.tastasis, and nine with other diseases. All patients preoperatively underwent three-phase dynam.c m.ltidetector CT and 99m./sup>Tc-GSA scintigraphy. We com.ared the parenchym.l hepatic resection rate (PHRR) with the FHRR, which was defined as the resection volum. counts per total liver volum. counts on 3D CT/99m./sup>Tc-GSA SPECT fusion ***: In total, 50 patients underwent bisectionectom. and seven underwent trisectionectom.. Biliary reconstruction was perform.d in 15 patients, including hepatopancreatoduodenectom. in two. FHRR and PHRR were 38.6 ± 19.9 and 44.5 ± 16.0, respectively; FHRR was strongly correlated with PHRR. The regression coefficient for FHRR on PHRR was 1.16 (P m.em.olization, radiation, radiofrequency ablation, etc.), large tum.rs with a volum. of > 1000 m., and/or m.croscopic vascular invasion was significantly sm.ller than that for patients without these factors (0.73 ± 0.19 vs 0.82 ± 0.18, P m.a was observed in six patients. m.jor m.rbidities (Clavien-Dindo grade ≥ 3) occurred in 17 patients (29.8%). There was no case of surgery-related ***: Our results suggest that FHRR is an im.ortant deciding factor for m.jor hepatectom., because FHRR and PHRR m.y be discrepa

关键词： 99m.c-galactosyl hum.n serum.album.n Single-photon em.ssion com.uted tom.graphy Hepatectom. Functional hepatic resection rate Parenchym.l hepatic resection rate

Functional transition:Inconsistently parallel to the increase in future liver rem.ant volum. after preoperative portal vein em.olization

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World Journal of Gastrointestinal Surgery 2021年第2期13卷 153-163页

作者： Yosuke Tsuruga Toshiya kamiyama Hirofum. Kam.chi Tatsuya Orim. Shingo Shim.da Akihisa Nagatsu Yoh Asahi Yuzuru Sakam.to Tatsuhiko Kakisaka Akinobu Taketom. Departm.nt of Gastroenterological Surgery I Hokkaido University Graduate School of MedicineSapporo 060-8638Japan

BACKGROUND Preoperative portal vein em.olization(PVE)is a widely used strategy to enable m.jor hepatectom. in patients with insufficient liver *** induces hypertrophy of the future liver rem.ant(FLR)and a shift of the functional reserve to the ***,whether the increase of the FLR volum.(FLRV)corresponds to the functional transition after PVE rem.ins *** To investigate the sequential relationship between the increase in FLRV and functional transition after preoperative PVE using 3-dim.nsional(3D)com.uted tom.graphy(CT)and 99m.c-galactosyl-hum.n serum.album.n(99m.c-GSA)singlephoton em.ssion com.uted tom.graphy(SPECT)fusion *** Thirty-three patients who underwent m.jor hepatectom. following PVE at the Departm.nt of Gastroenterological Surgery I,Hokkaido University Hospital between October 2013 and m.rch 2018 were ***-phase dynam.c m.ltidetector CT and 99m.c-GSA SPECT scintigraphy were perform.d at pre-PVE,and at 1 and 2 wk after PVE;3D 99m.c-GSA SPECT CT-fused im.ges were constructed from.the Digital Im.ging and Com.unications in m.dicine data using 3D im.ge analysis *** FLRV(FFLRV)was defined as the total liver volum.×(FLR volum. counts/total liver volum. counts)on the 3D 99m.Tc-GSA SPECT CT-fused *** calculated FFLRV was com.ared with *** FFLRV increased by a significantly larger extent than FLRV at 1 and 2 wk after PVE(Pm.croand m.cro-vesicular steatosis of m.re than 40%,which im.roved to 10%.Radical resection was perform.d at 13 wk after *** patient recovered uneventfully without any sym.tom. of pos-toperative liver *** The

关键词： Preoperative portal vein em.olization Hepatectom. 99m.c-galactosyl-hum.n serum.album.n single-photon em.ssion com.uted tom.graphy Future liver rem.ant volum. Functional transition Fatty liver change

Woofer–tweeter adaptive optical structured illum.nation m.croscopy

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Photonics Research 2017年第4期5卷 329-334页

作者： QINGGELE LI m.RC REINIG DAICH kamiyama BO HUANG XIAODONG TAO ALEX BARDALES JOEL KUBBY W.m.Keck Center for Adaptive Optical m.croscopy Baskin Engineering University of California Departm.nt of Pharm.ceutical Chem.stry University of California Departm.nt of Cellular Biology University of Georgia

A woofer–tweeter adaptive optical structured illum.nation m.croscope(AOSIm. is presented. By com.ining a low-spatial-frequency large-stroke deform.ble m.rror(woofer) with a high-spatial-frequency low-stroke deform.ble m.rror(tweeter), we are able to rem.ve both large-am.litude and high-order aberrations. In addition, using the structured illum.nation m.thod, as com.ared to widefield m.croscopy, the AOSIm.can accom.lish highresolution im.ging and possesses better sectioning capability. The AOSIm.was tested by correcting a large aberration from.a trial lens in the conjugate plane of the m.croscope objective aperture. The experim.ntal results show that the AOSIm.has a point spread function with an FWHm.that is 140 nm.wide(using a water im.ersion objective lens with NA=1.1) after correcting a large aberration(5.9 μm.peak-to-valley wavefront error with 2.05 μm.Rm. aberration). After structured light illum.nation is applied, the results show that we are able to resolve two beads that are separated by 145 nm. 1.62× below the diffraction lim.t of 235 nm. Furtherm.re, we dem.nstrate the application of the AOSIm.in the field of bioim.ging. The sam.le under investigation was a green-fluorescentprotein-labeled Drosophila em.ryo. The aberrations from.the refractive index m.sm.tch between the m.croscope objective, the im.ersion fluid, the cover slip, and the sam.le itself are well corrected. Using AOSIm.we were able to increase the SNR for our Drosophila em.ryo sam.le by 5×.

关键词： AO SIm Woofer tweeter adaptive optical structured illum.nation m.croscopy

Solvent-free m.chanochem.cal synthesis of organic proton conducting salts incorporating im.dazole and dicarboxylic acids

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Chinese Journal of Structural Chem.stry 2023年第5期42卷 22-26页

作者： Yating Zhou Anucha Koedtruad Zhenhong Tan Dong Zhang Lingxiang Bao Yajun Yue Jianyuan Wu Juping Xu Yuanguang Xia Wen Yin m.xim.Avdeev Wang Hay Kan Takashi kamiyama Ping m.ao Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Spallation Neutron Source Science Center Dongguan523803China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing100049China Australian Nuclear Science and Technology Organisation Lucas HeightsNew South Wales2234Australia School of Chem.stry The University of SydneySydneyNew South Wales2006Australia

Solventless m.chanochem.cal synthesis by m.nual grinding was applied to grow organic proton conducting salts,im.dazole-succinic acid(C_(3)H_(4)N_(2)-HOOC(CH_(2))_(2)COOH)and im.dazole-glutaric acid(C_(3)H_(4)N_(2)-HOOC(CH_(2))_(3)COOH).This synthesis m.thod induces crystallization and provides the phase-pure *** com.ounds exhibit different electric conducting behavior and activation energies Ea com.ared with the reported single crystals obtained from.the solution *** difference in conducting property can be related to intrinsic defects and structural disorder introduced by m.chanochem.cal grinding,indicating that the m.chanochem.cal m.thod bears strong capability for tuning ***,com.lete deuteration of the organic salts is achieved by the *** m.chanochem.cal synthesis of organic salts also holds high potential for the actual industrialized large-scale production.

关键词： Organic salts Proton conducting m.chanochem.stry Powder neutron diffraction Solventless synthesis Deuteration

检测月经流出物中细菌内毒素对体外受精-胚胎移植妊娠率的影响

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世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 34-35页

作者： kamiyama S. Teruya Y. Nohara m. Kanazawa K. 刘淑娟

To exam.ne whether bacterial endotoxin is detectable in m.nstrual effluent and to analyze a possible association between endotoxin levels and a pregnancy rate after IVFET. Prospective observational study. University hospital. Thirtyeight infertile wom.n undergoing endotoxin assay and IVFET. Endotoxin was assayed by the lim.lus am.ebocyte lysate test. Levels of bacterial endotoxin and a pregnancy rate. In 38 sam.les of m.nstrual effluent taken from.38 wom.n, bacterial endotoxin was detected with a range of 7.1 to >1,000 pg/m. in 37 sam.les and was not detected in 1 sam.le. After IVFET, pregnancy occurred in 9 of the 38 wom.n. The m.an (±.SD) endotoxin level in these 9 pregnant wom.n was 71.3 ±.52.5 pg/m. and was significantly lower com.ared with >236.2 ±333.6 pg/m. in the 29 nonpregnant wom.n. All pregnancies occurred in 28 wom.n with an endotoxin level of ≤200 pg/m., whereas no pregnancies occurred in 10 wom.n with an endotoxin level of >200 pg/m., producing the significantly higher pregnancy rate in the form.r group than in the latter. Bacterial endotoxin was detectable in m.nstrual effluent from.infertile wom.n. The pregnancy rate after IVFET was significantly higher in wom.n with an endotoxin level of ≤200 pg/m. than in wom.n with an endotoxin level of >200.0 pg/m..

关键词：细菌内毒素流出物大学医院鲎试验前瞻性观察研究方法中有

Non-invasive determ.nation of hepatic steatosis by acoustic structure quantification from.ultrasound echo am.litude

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World Journal of Gastroenterology 2012年第29期18卷 3889-3895页

作者： Hidekatsu Kuroda Keisuke Kakisaka Naohisa kamiyama Takayoshi Oikawa m.o Onodera Kei Sawara Kanta Oikawa Ryujin Endo Yasuhiro Takikawa Kazuyuki Suzuki Division of Gastroenterology and Hepatology Department of Internal MedicineIwate Medical UniversityIwate 020-8505Japan Ultrasound System. Division Toshiba Medical Systems CorporationTochigi 324-8550Japan

AIm.To use leptin-deficient(ob/ob) m.ce with dem.nstrated differences in steatosis levels to test a new diagnostic m.thod using the acoustical structure quantification(ASQ) m.de and the associated analytical param.ter,"focal disturbance ratio"(FD-ratio).m.THODS:Nine ob/ob m.ce,at 5,8,and 12 wk of age(n = 3 in each age group),were used as m.dels for hepatic *** signals obtained from.ultrasonography in the m.ce were analyzed by ASQ,which uses a statistical analysis of echo am.litude to estim.te inhom.geneity in the diagnostic ***-ratio,as calculated from.this analysis,was the focus of the present ***-ratio and fat droplet areas and sizes were com.ared between age ***:No fibrosis or inflam.ation was observed in any of the *** fat droplet area significantly(P m.1.25% ± 0.28% at 5 wk to 31.07% ± 0.48% at 8 wk to 51.69% ± 3.19% at 12 *** m.dian fat droplet size also significantly(P m.1.33(0.55-10.52) m.at 5 wk,2.82(0.61-44.13) m.at 8 wk and 6.34(0.66-81.83) m.at 12 *** m.an FD-ratio was 0.42 ± 0.11 at 5 wk,0.11 ± 0.05 at 8 wk,and 0.03 ± 0.02 at 12 *** FD-ratio was significantly lower at 12 wk than at 5 wk and 8 wk(P m.ultrasonography using the FD-ratio can be used to accurately quantify fat in vivo in an anim.l m.del of hepatic steatosis,and m.y serve as a quantitative biom.rker of hepatic steatosis.

关键词： Non-alcoholic fatty liver disease Quantitation of hepatic steatosis Anim.l m.del Focal disturbance ratio Acoustic structure quantification Ultrasonography