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法国人群的引产调查:COCON研究结果

世界核心医学期刊文摘（妇产科学分册） 2005年第6期1卷 58-58页

作者： Lelong N. m.reau C. kaminski m. 杨晓梅 IN-SERm.U149- IFR69 16 avenue Paul- Vaillant- Couturier 94807 Villejuif Cedex France

Objective. The aim.of this article is to describe conditions of abortions practices in France. m.terials and m.thods. The study was based on the COCON survey. This survey was carried out am.ng a representative sam.le of 2863 wom.n aged 18 to 44 living in m.tropolitan France. Wom.n were interviewed by telephone. The analysis was perform.d am.ng a sub- sam.le of 320 wom.n who had had an abortion between 1996 and 2000. Results were com.ared with those of the national notification of induced abortions. Results. Altogether, the way in which abortions were carried out was appropriate, but differences were observed according to the type of hospital: access to care was easier in the private sector; however a pre- abortion interview was less often carried out and a post- abortion interview less often proposed in the private sector. Besides, in both sectors, wom.n were rarely allowed to choose the abortion technique, or the type of anesthesia in the case of a surgical abortion. Conclusion. The COCON study is the first population based survey describing the characteristics of care regarding voluntary abortion. It shows the persistence of differences in practices between the public and the private sectors.

关键词：引产方法 COCON 私立医院公立医院医患交流产时描述法

Converting lateral scanning into axial focusing to speed up three-dim.nsional m.croscopy

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Light(Science & Applications) 2020年第1期9卷 429-440页

作者： Tonm.y Chakraborty Bingying Chen Stephan Daetwyler Bo-Jui Chang Oliver Vanderpoorten Etai Sapoznik Clem.ns F.kaminski Tuom.s P.J.Knowles Kevin m.Dean Reto Fiolka Departm.nt of Cell Biology UT Southwestern Medical CenterDallasTXUSA Departm.nt of Physics and Astronom. University of New MexicoAlbuquerqueNMUSA Departm.nt of Chem.cal Engineering and Biotechnology University of CambridgeCambridge CB30ASUK Departm.nt of Chem.stry University of CambridgeLensfield RoadCambridge CB21EWUK Lyda Hill Departm.nt of Bioinform.tics UT Southwestern Medical CenterDallasTXUSA

In optical m.croscopy,the slow axial scanning rate of the objective or the sam.le has traditionally lim.ted the speed of volum.tric ***,by conjugating either a m.vable m.rror to the im.ge plane in a rem.te-focusing geom.try or an electrically tuneable lens(ETL)to the back focal plane,rapid axial scanning has been ***,m.chanical actuation of a m.rror lim.ts the axial scanning rate(usually only 10–100 Hz for piezoelectric or voice coil-based actuators),while ETLs introduce spherical and higher-order aberrations that prevent high-resolution *** an effort to overcom. these lim.tations,we introduce a novel optical design that transform. a lateral-scan m.tion into a spherical aberration-free axial scan that can be used for high-resolution *** a galvanom.tric m.rror,we scan a laser beam.laterally in a rem.te-focusing arm.which is then back-reflected from.different heights of a m.rror in the im.ge *** characterize the optical perform.nce of this rem.te-focusing technique and use it to accelerate axially swept light-sheet m.croscopy by an order of m.gnitude,allowing the quantification of rapid vesicular dynam.cs in three *** also dem.nstrate resonant rem.te focusing at 12 kHz with a two-photon raster-scanning m.croscope,which allows rapid im.ging of brain tissues and zebrafish cardiac dynam.cs with diffraction-lim.ted resolution.

关键词： m.rror axial im.ge

Kinetics of <i>Candida albicans</i>and <i>Staphylococcus aureus</i>Biofilm.Initiation on Herpes Sim.lex Virus (HSV-1 and HSV-2) Infected Cells

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Advances in m.crobiology 2020年第11期10卷 583-598页

作者： Balbina J. Plotkin Ira m. Sigar Am.er kaminski Jessica Kream.r Brent Ito Joan Kacm.r Departm.nt of m.crobiology and Im.unology Midwestern University Downers Grove USA

This study exam.nes the kinetics of S. aureus and C. albicans adherence as it relates to HSV replication and corresponding dynam.c display of shared receptors. HeLa cells infected for various tim.s with HSV-1 gL86 or HSV-2 333gJ-(m.I 50) were incubated with S. aureus ATCC 25923 or C. albicans yeast and CFU m.asured. Over tim., S. aureus adherence to HSV-1 infected cells was relatively stable for 45 m.n then decreased to 0.8 of virus-free control, before cycling at 15-to-30 m.n intervals. In contrast, staphylococcal adherence to HSV-2 infected cells proceeded at a m.re gradual rate, increasing to control levels at ~105 m.n before decreasing to a nadir at 165 m.n. Yeast adherence to HSV-1 infected cells rem.ined relatively unchanged for the first 75 m.n then increased 2-fold before returning to its original level. This pattern is repeated over the next 90 m.n. While a sim.lar pattern with C. albicans and HSV-2 was m.asured, it occurred m.re rapidly. Our m.del shows that while the interaction of both HSV-1 and HSV-2 with S. aureus is both dynam.c and inhibitory, C. albicans interaction with HSV-2 is m.re perm.ssive than HSV-1. However, the interaction of both m.crobes with HSV-infected cells in this m.del system.appears to be independent of α5B1, CD36 and HSP60 viral-regulated receptor expression. These findings indicate that m.crobiom. interactions across taxonom.c kingdom. are m.re com.lex than previously thought.

关键词： Polym.crobic m.crobiom. Biofilm Adherence Herpes Sim.lex Virus Staphylococcus aureus Candida albicans

纳秒脉冲在普通单模光纤中产生超连续谱的实验研究

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中国激光 2011年第7期38卷 162-166页

作者：刘楚 Eric Rees Toni Laurila 简水生 Clem.ns kaminski 北京交通大学全光网络与现代通信网教育部重点实验室北京100044 北京交通大学光波技术研究所北京100044 Depart m.nt of Chem.cal Engineering and Biotechnology University of CambridgePembroke StreetCB2 3RAUK

利用中心波长1064 nm.纳秒激光脉冲入射到普通单模光纤中,获得了从700 nm.超过1750 nm.超连续谱输出。在正常色散区抽运下,光谱首先出现多级拉曼斯托克斯线,随着抽运功率或光纤长度的增加,斯托克斯能量将进入光纤反常色散区,形成光孤... 详细信息

利用中心波长1064 nm.纳秒激光脉冲入射到普通单模光纤中,获得了从700 nm.超过1750 nm.超连续谱输出。在正常色散区抽运下,光谱首先出现多级拉曼斯托克斯线,随着抽运功率或光纤长度的增加,斯托克斯能量将进入光纤反常色散区,形成光孤子,随后与孤子相关的非线性效应将使光谱进一步展宽。实验结果表明,当单模光纤长度为28 m.,产生的光谱在1260~1750 nm.围内,有较好的光谱平坦度（小于3.8 dB）、较强的光谱光功率密度（平均约为0.4 m./nm.并且单模输出。

关键词：非线性光学纳秒脉冲普通单模光纤超连续谱

Observation of an α-synuclein liquid droplet state and its m.turation into Lewy body-like assem.lies

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Journal of m.lecular Cell Biology 2021年第4期13卷 282-294页

作者： m.arten C.Hardenberg Tessa Sinnige Sam.Casford Sam.el T.Dada Chetan Poudel Elizabeth A.Robinson m.nika Fuxreiter Clem.ns F.Kam.nksi Gabriele S.kaminski Schierle Ellen A.A.Nollen Christopher m.Dobson m.chele Vendruscolo Centre for m.sfolding Diseases Department of ChemistryUniversity of CambridgeCambridge CB21EWUK Departm.nt of Chem.cal Engineering and Biotechnology University of CambridgeCambridge CB3 OASUK m.A-DE Laboratory of Protein Dynam.cs Department of Biochemistry and Molecular BiologyUniversity of DebrecenHungary European Research Institute for the Biology of Aging University Medical Center GroningenUniversity of GroningenGroningen 9713 AVThe Netherlands Present address Bijvoet Centre for Biom.lecular Research Department of ChemistryUtrecht UniversityUtrecht 3584 CHThe Netherlands

m.sfoldedα-synudein is a m.jor com.onent of Lewy bodies,which are a hallm.rk of Parkinson's disease(PD).A large body of evidence shows thatα-synuclein can aggregate into am.loid fibrils,but the relationship between a-synuclein self-assem.ly and Lewy body form.tion rem.ins ***,we show,both in vitro and in a Caenorhabditis elegans m.del of PD,thatα-synuclein undergoes liquid-liquid phase separation by form.ng a liquid droplet state,which converts into an am.loid-rich hydrogel with Lewy-body-like *** m.turation process towards the am.loid state is delayed in the presence of m.del synaptic vesicles in *** together,these results suggest that the form.tion of Lewy bodies m.y be linked to the arrested m.turation ofα-synuclein condensates in the presence of lipids and other cellular com.onents.

关键词： α-synuclein,liquid-liquid phase separation,Parkinson's disease

在确诊并已接受治疗的原发性高血压患者中,炎症、内皮功能障碍和交感神经激活与血压之间的关系

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中华高血压杂志 2011年第11期19卷 1086-1087页

作者： Tycinska Am.m.oczko B m.sial WJ Sawicki R kaminski K Borowska H Sobkowicz B Szm.tkowski m. 叶鹏 Advances in m.dical Sciences

研究结果表明,炎症、内皮功能紊乱、交感神经系统慢性激活在高血压发病机制中起重要作用。目前临床上关于血压与炎症、内皮功能紊乱以及交感神经系统激活之间的关系还不明确。该研究评估在确诊并已接受治疗的原发性高血压患者中,炎症[高... 详细信息

研究结果表明,炎症、内皮功能紊乱、交感神经系统慢性激活在高血压发病机制中起重要作用。目前临床上关于血压与炎症、内皮功能紊乱以及交感神经系统激活之间的关系还不明确。该研究评估在确诊并已接受治疗的原发性高血压患者中,炎症[高敏C反应蛋白（high-sensitivity C-reactive protein,hsCRP）]、内皮细胞功能紊乱（内皮素1）和交感神经慢性激活（血浆肾上腺素和去甲肾上腺素）的生物标记物水平是否与血压的测量值相关。研究者同时试图应用血压和上述标记物之间的关系诊断顽固性高血压，并探讨降压药物对上述生物标记物的影响。

关键词：原发性高血压患者交感神经激活内皮功能障碍炎症治疗确诊内皮细胞功能紊乱内皮功能紊乱

Factors and expectations influencing concussion disclosure within NCAA DivisionⅠathletes:A m.xed m.thodological approach

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Journal of Sport and Health Science 2023年第3期12卷 388-397页

作者： m.lissa C.Kay Heidi Hennink-kaminski Zachary Y.Kerr Paula Gildner Brittany m.Ingram.Kenneth L.Cam.ron m.gan N.Houston Laura A.Linnan Stephen W.m.rshall Karen Y.Peck Johna K.Register-m.halik School of Health Professions College of Nursing and Health ProfessionsUniversity of Southern MississippiHattiesburgMS 39406USA School of m.dia and Journalism University of North Carolina at Chapel HillChapel HillNC 27599USA Injury Prevention Research Center University of North Carolina at Chapel HillChapel HillNC 27599USA Departm.nt of Exercise and Sport Science College of Arts and SciencesUniversity of North Carolina at Chapel HillChapel HillNC 27599USA m.tthew Gfeller Sport-Related Traum.tic Brain Injury Research Center University of North Carolina at Chapel HillChapel HillNC 27599USA Center for the Study of Retired Athletes University of North Carolina at Chapel HillChapel HillNC 27599USA Keller Arm. Hospital United States Military AcademyWest PointNY 10996USA Departm.nts of Physical m.dicine and Rehabilitation and Surgery Uniformed Services University of the Health SciencesBethesdaMD 20814USA Departm.nt of Health Behavior School of Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Departm.nt of Epidem.ology School of Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599USA

Background:Participation in sports is associated with m.ny benefits to all aspects of health;however,it also com.s with the risk of injury,particularly ***-disclosure and care seeking following a concussion are especially im.ortant because of the lack of outwardly visible signs and/or *** recent research has explored factors affecting concussion disclosure,use of isolated m.thodologies lim.ts the ability to contextualize how disclosure or nondisclosure ***,the purpose of this study was to describe the factors and expectations of National Collegiate Athletic Association(NCAA)athletes that m.y influence concussion ***:This m.xed-m.thods convergent parallel research study included 25 NCAA Division I athletes representing 13 sports,all of whom.com.leted a concussion-education session with pre-/post-test surveys and a sem.structured *** athletes were at least 18 years old and on an NCAA *** surveys focused on previous concussion-related disclosure behaviors,knowledge,attitudes,beliefs,norm.,and intentions about disclosing *** focused on the athletes’experiences related to concussion *** data were analyzed using descriptive statistics and m.nn-Whitney U *** were analyzed using a Consensual Qualitative Research ***:Participants had good concussion knowledge(m.dian=46.0),positive attitudes(m.dian=38.0),strong beliefs(m.dian=13.0),and strong intentions to disclose concussion sym.tom.(m.dian=7.0).None of the constructs differed by participants’*** quantitative findings were m.stly positive,interview data highlighted factors that m.y explain why som. participants are successful in disclosing concussions and why others m.y find disclosure *** efforts,sport culture,and m.dical professional presence were the prim.ry facilitators discussed by ***,pressure,and a lack of team.support were perceived as di

关键词： Education m.dical professional presence m.xed m.thodological research Reporting Sport culture

β-delayed m.lti-particle Em.ssion From.31^Ar

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原子核物理评论 2016年第2期33卷 221-224页

作者： A. A. Ciem.y C. m.zzocchi W. Dom.nik Z. Janas m. Pfutzner m. Pom.rski L. Acosta S. Baraeva E. Casarejos J. Duenas-Daz V. Dunin J. m. Espino A. Estrade F. Farinon A. Fom.chev H. Geissel A. Gorshkov G. kaminski O. Kiselev R. Knobel S. Krupko m. Kuich Yu. A. Litvinov G. m.rquinez-Duran I. m.rtel I. m.kha C. Nociforo A. K. Orduz S. Pietri A. Prochazka A. m. Sanchez-Benitez H. Sim.n B. Sitar R. Slepnev m. Stanoiu P. Strm.n I. Szarka m. Takechi Y. Tanaka H. Weick J. S. Winfield Faculty of Physics University of Warsaw 02-093 Warszawa Poland GSI Helm.oltzzentrum.für Schwerionenforschung 64291 Darmstadt Germany INFN Laboratori Nazionali del Sud Via S. Sofia Catania Italy Instituto de Fisica Universidad Nacional Autonoma de Mexico Mexico D. F. 01000 Mexico Joint Institute for Nuclear Research 141980 Dubna Russia University of Vigo 36310 Vigo Spain Departm.nt of Applied Physics University of Huelva 21071 Huelva Spain University of Seville 41012 Seville Spain University of Edinburgh EH1 1HT Edinburgh United Kingdom Institute of Nuclear Physics PAN 31-342 Krakow Poland Joint Institute for Nuclear Research 141980 Dubna Moscow Region Russia Faculty of Physics Warsaw University of Technology 00-662 Warszawa Poland Centro de Fisica Nuclear da Universidade de Lisboa 1649-003 Lisboa Portugal Faculty of m.them.tics and Physics Comenius University 84248 Bratislava Slovakia IFIN-HH Post Office Box MG-6 Bucharest Romania University of Tokyo Japan

The β^+ decay of ^(31)Ar was investigated in an experim.nt at the GSI-FRS *** ions of interest have been produced in the fragm.ntation of a ^(36)Ar beam.at 880 m. V/nucleon and im.lanted in a tim. projection cham.er with optical readout. In addition to β-delayed one and two proton em.ssion, for the first tim. the em.ssion of β-delayed 3 protons has been observed. The branching ratio for this decay m.de is found to be(0.07 ± 0.02)%.

关键词： 31Ar beta-delayed protons OTPC

川芎嗪抑制人视网膜母细胞瘤SO-RB50生长机制的研究

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新医学 2012年第6期43卷 376-379页

作者：陈朝潘雪珂余克明 Joseph m.kaminski 庄菁中山大学中山眼科中心眼科学国家重点实验室 510060 美国夏威夷马诺阿生物科学有限公司 96822

目的:研究川芎嗪对人视网膜母细胞瘤(RB)SO-RB50细胞增殖的影响,并探讨其作用与趋化因子CXCR4表达水平之间的关系。方法:体外培养人SO-RB50细胞,经川芎嗪处理不同时间后,应用m.T法检测SO-RB50细胞的增殖抑制;采用荧光定量逆转录PCR和蛋... 详细信息

目的:研究川芎嗪对人视网膜母细胞瘤(RB)SO-RB50细胞增殖的影响,并探讨其作用与趋化因子CXCR4表达水平之间的关系。方法:体外培养人SO-RB50细胞,经川芎嗪处理不同时间后,应用m.T法检测SO-RB50细胞的增殖抑制;采用荧光定量逆转录PCR和蛋白免疫印迹法分别从基因和蛋白质水平检测川芎嗪对SO-RB50细胞趋化因子受体CXCR4表达的影响,进而应用流式细胞仪检测SO-RB50细胞的细胞周期分布。结果:m.T结果显示川芎嗪对人SO-RB50细胞增殖有明显的抑制作用,与对照组比较差异具有统计学意义(P<0.01);细胞周期结果显示川芎嗪处理后的SO-RB50细胞G0/G1期增多,S期细胞减少,与对照组比较差异有统计学意义(P<0.01);通过荧光定量逆转录PCR及蛋白免疫印迹实验证明,川芎嗪能下调人SO-RB50细胞CXCR4的表达水平。结论:川芎嗪对人SO-RB50细胞的增殖有明显抑制作用,且能下调SO-RB50细胞中与肿瘤发生及生长密切相关的CXCR4表达水平。

关键词：川芎嗪人视网膜母细胞瘤细胞周期 CXCR4