检索结果-南通市图书馆

Targeted delivery of factors and cells for improving cardiac tissue regeneration and heart function following myocardial infarction

引用

Engineered Regeneration 2024年第2期5卷 210-227页

作者： kamila raziyeva Zharylkasyn Zharkinbekov Yevgeniy Kim Arman Saparov School of Medicine Nazarbayev UniversityAstana 010000Kazakhstan

Following myocardial infarction(MI),cardiac tissue undergoes irreversible cellular alterations,with cardiomy-ocytes being replaced by fibrotic *** order to improve tissue regeneration,a previously characterized chitosan-based cryogel,which was designed by our group,was *** treatment regimen involved the sequen-tial delivery of the cryogel loaded with specific cytokines and growth factors,followed by a separate injection of pre-differentiated ***,the cryogel loaded with interleukin-10 and transforming growth factor-βwas injected into infarcted tissue immediately after MI induction,targeting the acute inflammatory *** day four post-MI,a second injection was administered,this time utilizing cryogel loaded with vascular endothelial growth factor and fibroblast growth factor-2,aimed at promoting tissue regeneration and ***-quently,on day six post-MI,the experimental group received cardiomyocyte-like cells,smooth muscle cells,and endothelial *** purpose of these cells,in synergy with cytokines and growth factors,was to repopulate the lost cellular populations,thereby enhancing myocardial *** treatment improved myocardial tissue regeneration,increased cardiac output,ejection fraction,and reduced fibrotic ***,the chitosan-based cryogel,enriched with anti-inflammatory and proangiogenic factors and supplemented with pre-differentiated cells,offers a promising platform for controlled release of therapeutics,promoting substantial tissue repair and regeneration following MI.

关键词： Myocardial infarction Tissue regeneration Cryogel Growth factors Stem cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：