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DNA-guided hepatitis b treatment,viral load is essential,but not sufficient

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World Journal of Gastroenterology 2009年第4期15卷 423-430页

作者： Rafael bárcena Marugán Silvia García Garzón Services of Liver-Gastroenterology Hospital Ramón y CajalUniversity of Alcalá Department of Gastroenterology Hospital Universitario de GuadalajaraUniversity of Alcalá

Hepatitis b virus （HbV） infection is a global public health problem that concerns 350 million people worldwide. Individuals with chronic hepatitis b （Crib） are at increased risk of developing liver cirrhosis, hepatic de-compensation and hepatocellular carcinoma. To maintain undetectable viral load reduces chronic infection complications. There is no treatment that eradicates HbV infection. Current drugs are expensive, are associated with adverse events, and are of limited efficacy. Current guidelines try to standardize the clinical practice. Nevertheless, controversy remains about management of asymptomatic patients with Crib who are hepatitis b e antigen （HbeAg）-positive with normal alanine aminotransferase, and what is the cut-off value of viral load to distinguish HbeAg- negative Crib patients and inactive carriers. We discuss in detail why DNA level alone is not sufficient to begin treatment of Crib.

关键词： Hepatitis b virus Viral DNA Alaninetransaminase Antiviral drug Hepatitis b e antigen Antiviral drug resistance

Nonsmooth Semi-Infinite Minmax Programming Involving Generalized(Φ, ρ)-Invexity

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Journal of Systems Science & Complexity 2015年第4期28卷 857-875页

作者： UPADHYAY b b MISHRA S K Department of basic Sciences & Humanities National Institute of Technology

This paper introduces some new generalizations of the concept of （~, p）-invexity for non- differentiable locally Lipschitz functions using the tools of Clarke subdifferential. These functions are used to derive the necessary and sufficient optimality conditions for a class of nonsmooth semi-infinite minmax programming problems, where set of restrictions are indexed in a compact set. Utilizing the sufficient optimality conditions, the authors formulate three types of dual models and establish weak and strong duality results. The results of the paper extend and unify naturally some earlier results from the literature.

关键词： Duality, generalized invexity locally Lipschitz functions, minmax programming, semi-infinite programming.

Investigation of nanocrystalline structure in selected carbonaceous materials

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International Journal of Minerals,Metallurgy and Materials 2014年第9期21卷 940-946页

作者： Manoj b Department of Physics Christ University

The structural parameters of nine Indian coals were determined by X-ray diffraction （XRD） and Kaman spectroscopy. The study revealed that the coals contain crystalline carbon of turbostratic structure with amorphous carbon. The stacking height （Lc） and interlayer spacing （rico2） of the crystallite structure of the coals ranged from 1.986 to 2.373 nm and from 0.334 to 0.340 nm, respectively. The degree of graphitization was calculated to range from 42% to 99%, thereby confirming the ordering of the carbon layers with the increase in coal rank. An exponential correlation was observed among the aromaticity （fa）, the lateral size （La）, and the rank （I20/I26）, suggesting that the coal crystallites are nanocrystalline in nature. A very strong correlation was observed between the structural parameters （fa, d002, Lc, the H/C ratio, and I20/I26）, the volatile matter content, and the elemental carbon content, indicating the structures of coals are controlled by the degree of contact metamorphism. The Raman spectra exhibited two prominent bands： the graphitic band （G） and the fn＇st-order characteristic defect band （D）. The deconvolufion resulted in five peaks： G, D1, D2, D3, and D4. The intense D1 band, which appeared at -1350 cm^-1, corresponds to a lattice vibration mode with Alg symmetry. The D2 mode, which appeared at -1610 cm^-1, arises from the structural disorder as a shoulder on the G band.

关键词： nanocrystals graphitization aromaticity carbonaceous materials

Rethinking the solar flare paradigm

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Plasma Science and Technology 2018年第7期20卷 15-21页

作者： d b melrose SIfA School of PhysicsThe University of SydneyNSW 2006Australi

It is widely accepted that solar flares involve release of magnetic energy stored in the solar corona above an active region, but existing models do not include the explicitly time-dependent electrodynamics needed to describe such energy release. A flare paradigm is discussed that includes the electromotive force （EMF） as the driver of the flare, and the flare-associated current that links different regions where magnetic reconnection, electron acceleration, the acceleration of mass motions and current closure occur. The EMF becomes localized across regions where energy conversion occurs, and is involved in energy propagation between these regions.

关键词： solar flares electrodynamics time-dependence

Optimization of the Synthesis Conditions of a Cesium Confinement Matrice, a Pollucite Analogue, Simulated with Potassium

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材料科学与工程（中英文A版） 2013年第10期3卷 704-709页

作者： Nour-el-hayet kamel Dalila Moudir Hadda belabes Hamid Ait Amar Ziane kamel Fairouz Aouchiche Soumia Kamariz Yasmina Mouheb Algiers Nuclear Research Centre Department of Spectrometry B.P 399 Alger-RP Algiers Algeria Houari boumediene University of Sciences and Technology P.O.Box: 111 El-Alia Bab Ezzouar Algiers Algeria

Influence of the Crystal Growth Temperature on the Formation of Zr Reach Crystalline Phases in a Nuclear Waste Confinement Glass Ceramic

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材料科学与工程（中英文b版） 2014年第8期4卷 220-225页

作者： Dalila Moudir Nour-el-hayet kamel Abdelbaki benmounah Yasmina Mouheb Rafika Souag boudjmaa bezzazi Fairouz Aouchiche Ziane kamel Soumia Kamariz Algiers Nuclear Research Centre Division of Nuclear Techniques P.O.Box: 399 Alger-RP Algiers Algeria Research Unit on Materials Processes and Environment (URMPE) University M'hamed Bouguerra Avenue de l 'ind~pendance35000 Boumerdks Algeria

Oil spill model development and application for emergency response system

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Journal of Environmental Sciences 2001年第2期13卷 252-256页

作者： b Qiao Environmental Science Center Peking University Beijing 100871 China.

The paper introduces systematically the developing principle of CWCM 1.0 oil spill model based on Lagrange system and oil spill fate processes in environment, reviews two oil spill incidents of "East Ambassador" in Jiaozhou bay and "Min Fuel 2" in the mouth of Pearl River, and designs the predictable system simulating oil spill applied in contingency plans. It is indicated that CWCM 1.0 has met preliminarily the demands for functions of precision simulating and predicting oil spill, and can plan an important role to support oil spill response.

关键词： Oil spill model development and application for emergency response system

Analysis of non-symmetrical flapping airfoils

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Acta Mechanica Sinica 2009年第4期25卷 433-450页

作者： W.b.Tay K.b.Lim Department of Mechanical Engineering National University of Singapore

Simulations have been done to assess the lift, thrust and propulsive efficiency of different types of non-symmetrical airfoils under different flapping configurations. The variables involved are reduced frequency, Strouhal number, pitch amplitude and phase angle. In order to analyze the variables more efficiently, the design of experiments using the response surface methodology is applied. Results show that both the variables and shape of the airfoil have a profound effect on the lift, thrust, and efficiency. by using non- symmetrical airfoils, average lift coefficient as high as 2.23 can be obtained. The average thrust coefficient and efficiency also reach high values of 2.53 and 0.61, respectively. The lift production is highly dependent on the airfoil＇s shape while thrust production is influenced more heavily by the variables. Efficiency falls somewhere in between. Two-factor interac- tions are found to exist among the variables. This shows that it is not sufficient to analyze each variable individually. Vorticity diagrams are analyzed to explain the results obtained. Overall, the S1020 airfoil is able to provide relatively good efficiency and at the same time generate high thrust and lift force. These results aid in the design of a better ornithopter＇s wing.

关键词： Flapping Non-symmetrical Design ofexperiments Ornithopter Airfoil

Microstructure and Mechanical Properties of Mg–7.4% Al Alloy Matrix Composites Reinforced by Nanocrystalline Al–Ca Intermetallic Particles

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Acta Metallurgica Sinica(English Letters) 2015年第4期28卷 444-448页

作者： A.K.Chaubey b.b.Jha b.K.Mishra Institute of Minerals and Materials Technology (IMMT)

Mg-7.6% Al （in mass fraction） alloy matrix composites reinforced with different volume fractions of nano- crystalline Al3Cas particles were synthesized by powder metallurgy, and the effect of the volume fraction of reinforcement on the mechanical properties was studied. Room temperature compression test reveals considerable improvement on mechanical properties as compared to unreinforced matrix. The compressive strength increases from 683 MPa for unre- inforced alloy matrix to about 767 and 823 MPa for the samples having 20 and 40 vol% of reinforcement, respectively, while retaining appreciable plastic deformation ranging between 12 and 24%. The specific strength of the composites increased significantly, demonstrating the effectiveness of the low-density AlaCas reinforcement.

关键词： Intermetallics Consolidation Dispersion strengthening Powder metallurgy Mechanicalproperty Electron microscopy