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chinese Journal of chemistry 2011年第4期29卷 745-750页

作者： kamboj, ramesh c.kumar, dinesh sharma, geeta arora, rita Department of chemistry Kurukshetra University Kurukshetra 136119 India

Photo-irradiation of 2-（5-methylthiophen-2-yl）-3-[（naphthalen-2-yl）methoxy]-4H-chromen-4-ones yielded the fascinating angular tetracyclic products via cyclization involving both 2-thienyl ring and naphthylmethoxy group via 1,4-biradical generated in the Norrish type-II process. The stereochemical dispositions of the products were determined by MM2 energy minimized programme and spectroscopic analysis.

关键词： type-II reaction radicals thienylchromone sigmatropic rearrangement substituent effects

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： chanchal sharma Sehwan Kim Hyemi Eo Sang Ryong Kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

Rare earth(La)and metal ion(Pb)substitution induced structural and multiferroic properties of bismuth ferrite

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Journal of Advanced ceramics 2015年第4期4卷 292-299页

作者： Poorva sharma Ashwini kumar dinesh VARSHNEY Materials Science Laboratory School of PhysicsVigyan BhawanDevi Ahilya UniversityKhandwa Road CampusIndore 452001India Department of Physics Southeast UniversityJiangning DistrictNanjing 211189China

In this study,bulk samples of multiferroic with compositional formula,BiFeO3 and Bi_(0.825)A_(0.175)FeO_(3)(A=La,Pb),were synthesized by solid state reaction route.X-ray diffraction(XRD)along with the Rietveld refinement revealed the distorted rhombohedral(R3c)structure for pristine BiFeO3 and Bi0.825La0.175FeO3 and tetragonal(P4/mmm)for Bi_(0.825)Pb_(0.175)FeO_(3)*** support the structural results,bond length between atoms for both of the compounds was calculated.A change in Raman mode position in BiFeO3(BFO)has been observed with La and Pb substitution from Raman scattering measurements and also recommended a structural change with rare earth and metal ion substitution at Bi *** the frequency dependent dielectric constant and dielectric loss plots,a decrease in dielectric values with increase in frequency was observed for both of the *** microelectronic devices,porous ceramics with lower value of dielectric constant are most ***,further studies are also needed to carefully tune the magnetoelectric properties and structural distortion after La/Pb substitution in BFO.

关键词： ceramics X-ray diffraction(XRD) Raman spectroscopy dielectric properties

Translocator protein and neurodegeneration: insights from Alzheimer’s disease

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Neural Regeneration Research 2025年第4期20卷 1090-1091页

作者： Arpit kumar Pradhan Rainer Rupprecht Gerhard Rammes Klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Graduate School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany Department of Psychiatry and Psychotherapy University RegensburgRegensburgGermany

The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce *** main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic c terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关键词： cholesterol organs

Association of Overt Diabetes Mellitus with the Non-cc but not the cc Genotype of Interleukin-28B in Hepatitis c Virus Infected Patients

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Journal of clinical and Translational Hepatology 2016年第1期4卷 26-31页

作者： Ashish kumar Varun Gupta Praveen sharma Naresh Bansal Vikas Singla Anil arora Institute of Liver Gastroenterology & Panceatico-Biliary Sciences Sir Ganga Ram Hospital New Delhi India

Background:Interleukin-28B (IL-28B) polymorphism is an important predictor for hepatitis c virus (HcV) treatment *** IL-28b genotypes also influence other nontreatment related clinical parameters is ***:Patients with HcV-related chronic liver diseases who attended our department during 2012-2014 were retrospectively *** single nucleotide polymorphisms (SNPs) of rs12979860 (IL-28B) were correlated with various clinical *** also compared these parameters in patients with and without overt diabetes to identify possible ***:A total of 115 patients were included (median age 48,range 15-76 years;70% males).Overall,43/115(37%) patients had chronic hepatitis,while the remaining 72/115 (63%) had *** most common IL-28B genotype was cc,which was found in 53% of patients (61/115),while the remaining 47% were noncc [cT 42% (48/115) and T-r 5% (6/115)].clinical and laboratory parameters like Hb,white blood cell (WBc),platelets,bilirubin,transaminases,and albumin were similar in the cc and noncc *** diabetes mellitus was present in 22% (25/115) of *** with noncc genotype had significantly higher prevalence of overt diabetes mellitus than patients with cc genotype (31% [17/54] versus 13% [8/61];p compared in patients with and without overt diabetes mellitus,only IL-28B and age were significantly associated with overt diabetes mellitus (p conclusion:In HcV patients,overt diabetes mellitus was more commonly associated with the noncc genotype of IL-28B than the cc *** of the T-allele of SNP rs12979860 were more likely to have insulin resistance than cc homozygotes,and this finding may explain the higher prevalence of diabetes in non-cc ***,an IL-28B test may be useful in patients of HcV in order to determine their likelihood of developing diabetes mellitus.

关键词： chronic hepatitis c Diabetes mellitus cirrhosis IL-28B chronic liver disease Insulin resistance

Why is graphene an extraordinary material? A review based on a decade of research

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Frontiers of Materials Science 2022年第2期16卷 1-39页

作者： Sachin sharma Ashok kumar Shahid BASHIR Kasi ramesh Subramaniam ramesh centre for Ionics University of Malaya Department of PhysicsFaculty of ScienceUniversiti MalayaKuala Lumpur 50603Malaysia Higher Institution centre of Excellence(HIcoE) UM Power Energy Dedicated Advanced Centre(UMPEDAC)Level 4Wisma R&DUniversiti MalayaJalan Pantai BaharuKuala Lumpur 59990Malaysia

During this decade,graphene which is a thin layer of carbon material along at ease with synthesis and functionalization has become a hot topic of research owing to excellent mechanical strength,very good current density,high thermal conductivity,superior electrical conductivity,large surface area,and good electron *** research on graphene has exponentially accelerated specially when Geim and Novoselov developed and analyzed *** this basis,for industrial application,researchers are exploring different techniques to produce high-quality ***,reviewed in this article is a brief introduction to graphene and its derivatives along with some of the methods developed to synthesize graphene and its prospective applications in both research and *** this work,recent advances on applications of graphene in various fields such as sensors,energy storage,energy harvesting,high-speed optoelectronics,supercapacitors,touch-based flexible screens,and organic light emitting diode displays have been summarized.

关键词： graphene graphene oxide electrochemical sensor fuel cell supercapacitor dye-sensitized fuel cell lithium battery energy storage

Feature selection for face recognition:a memetic algorithmic approach

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第8期10卷 1140-1152页

作者： dinesh kumar Shakti kumar c.S.RAI Department of computer Science & Engineering Guru Jambheshwar University of Science & Technology Institute of Science and Technology University School of Information Technology GGS Indraprastha University

The eigenface method that uses principal component analysis(PcA) has been the standard and popular method used in face *** paper presents a PcA-memetic algorithm(PcA-MA) approach for feature *** has been extended by MAs where the former was used for feature extraction/dimensionality reduction and the latter exploited for feature *** were performed over ORL and YaleB face databases using Euclidean norm as the *** was found that as far as the recognition rate is concerned,PcA-MA completely outperforms the eigenface *** compared the performance of PcA extended with genetic algorithm(PcA-GA) with our proposed PcA-MA *** results also clearly established the supremacy of the PcA-MA method over the PcA-GA *** further extended linear discriminant analysis(LDA) and kernel principal component analysis(KPcA) approaches with the MA and observed significant improvement in recognition rate with fewer *** paper also compares the performance of PcA-MA,LDA-MA and KPcA-MA approaches.

关键词： Face recognition Memetic algorithm (MA) Principal component analysis (PcA) Linear discriminant analysis (LDA) Kernel principal component analysis (KPcA) Feature selection

An overview of deep eutectic solvents:Alternative for organic electrolytes,aqueous systems&ionic liquids for electrochemical energy storage

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Journal of Energy chemistry 2023年第7期82卷 592-626,I0013页

作者： Akshay sharma Renuka sharma ramesh c.Thakur Lakhveer Singh Department of chemistry Himachal Pradesh UniversitySummer HillShimla171005Himachal PradeshIndia Department of chemistry Sardar Patel UniversityMandi175001Himachal PradeshIndia

As the demand for sustainable energy sources continues to rise,the need for efficient and reliable energy storage systems becomes *** order to effectively store and distribute renewable energy,new and innovative solutions must be *** review examines the deep eutectic solvents(DESs)as a green,safe,and affordable solution for the electrochemical energy storage and conversion field,offering tremendous opportunities and a promising *** are a class of environment-friendly solvents known for their low toxicity and unique properties,such as their good conductivity,high thermal stability,and *** review explores the fundamentals,preparations,and various interactions that often predominate in the formation of DESs,the properties of DESs,and how DESs are better than traditional solvents involving cost-ineffective and unsafe organic electrolytes and ionic liquids as well as inefficient aqueous systems due to low energy density for electrochemical energy storage ***,a particular focus is placed on the various electrochemical applications of DESs,including their role in the electrolytes in batteries/supercapacitors,electropolishing and electrodeposition of metals,synthesis of electrode materials,recycling of electrodes,and their potential for use in cO_(2)*** review concludes by exploring the challenges,research gaps,and future potential of DESs in electrochemical applications,providing a comprehensive overview,and highlighting key considerations for their design and use.

关键词： Deep eutectic solvent Green solventHole theory Energy storage devices Aqueous electrolyte

Vigna radiata var. GM4 Plant Growth Enhancement and Root colonization by a Multi-Metal-Resistant Plant Growth-Promoting Bacterium Enterobacter sp. c1D in cr(VI)-Amended Soils

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Pedosphere 2018年第1期28卷 144-156页

作者： Gangavarapu SUBRAHMANYAM Rakesh kumar sharma Gattupalli Naresh kumar Gattupalli ARcHANA Department of Microbiology and Biotechnology centre The Maharaja Sayajirao University of Baroda Department of Biomedical Science Nitte University Center for Science Education and Research (NUCSER) Nitte University central Muga Eri Research and Training Institute Central Silk Board Department of Biochemistry Faculty of Science The Maharaja Sayajirao University of Baroda

contamination of agricultural soils by heavy metals has become a major concern due to their toxic effects on plant growth,symbiosis and consequently the yields of crops. In the present study, to enhance plant growth in cr（VI）-amended soils, novel metalresistant plant growth-promoting bacteria（PGPB） were isolated from a soil contaminated with industrial waste effluent. One of the bacterial isolates, identified as Enterobacter sp. c1 D by 16 S r RNA gene sequencing, was found to be multi-metal resistant in nature with excellent plant growth-promoting（PGP） traits. Mung bean（Vigna radiata var. GM4） inoculation with Enterobacter sp.c1 D significantly（P ＆lt; 0.01） increased root and shoot length, shoot and root weight, and chlorophyll content in a range of cr（VI）treatments. Plant tolerance towards cr（VI） measured as effective concentration showed higher values with Enterobacter sp. c1 Dtreated plants compared to un-inoculated plants. Root colonization study was also carried out using green fluorescence protein-labeled Enterobacter sp. c1 D under a hydroponic system. confocal laser scanning microscopy of the plant roots showed heavy bacterial loads on the surface of the plant root specifically at the root tip and the point of root hair/lateral root formation. The results of PGP traits showed that elevated indole acetic acid levels and 1-aminocyclopropane-1-carboxylate deaminase activity enabled Enterobacter sp. c1 D to enhance V. radiata growth in cr（VI）-amended soils, whereby it significantly increased plant tolerance towards elevated cr（VI） concentrations.

关键词： chromium(VI) Enterobacter sp c1D heavy metal metal toxicity plant tolerance

Novel generation of 9H-furo[3,2-b]chromen-9-ones from (E)-3-hydroxy-2-styrylchromones by excited state intramolecular proton transfer

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chinese chemical Letters 2008年第7期19卷 780-782页

作者： Surinder Berar Urmila Berar Satish c.Gupta ramesh c.kamboj Department of chemistry Kurukshetra UniversityKurukshetra 136119India

Photocyclisation of substituted （E）-3-hydroxy-2-（V-methyl-2＇-phenylvinyl）-4-oxo-4H-1-benzopyrans to yield linear novel tricyclic 9H-furo[3,2-b]chromen-9-ones and angular fused tetracyclic xanthenones is described.

关键词： 9H-Furo(3,2-b)chromen-9-one Photocyclisation Xanthenones