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BIOCELL 2013年第3期37卷 71-76页

作者： Tamilselvan SUBRAMANI Suresh RAO kamatchiammal senthilkumar Soundararajan PERIASAMY Noorjahan Banu ALITHEEN Department of Cell and Molecular Biology Faculty of Biotechnology and Biomolecular SciencesUniversiti Putra MalaysiaSerdangMalaysia. Department of Periodontics Faculty of Dental ScienceSri Ramachandra UniversityChennaiIndia. Virology Division National Environmental Engineering Research InstituteChennaiIndia. Department of Nephrology Faculty of MedicineSri Ramachandra UniversityChennaiIndia.

The present study demonstrates that the expression of c-Jun and c-Fos are elevated in gingival fibroblast cells treated with angiotensin Ⅱ and *** healthy human gingival tissues were collected and gingival fibroblasts were isolated and *** used RT-PCR and Western blot analysis to identify the expression of c-Jun and c-Fos in cyclosporine and angiotensin II treated human gingival fibroblast *** found that angiotensin Ⅱ in combination with cyclosporine induces c-Jun and c-Fos expressions significantly;however,the angiotensin Ⅱ antagonist losartan inhibits the expression of c-Jun and c-Fos(p<0.01).The data suggest that angiotensin Ⅱ in combination with cyclosporine modulates the expression of c-Jun and c-Fos in human gingival fibroblast cells.

关键词： angiotensin c-Jun c-Fos transcription factor cyclosporine gingival overgrowth.

Application of Taguchi Method for the Optimization of System Parameters of Centrifugal Evaporative Air Cooler

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Journal of Thermal Science 2010年第5期19卷 473-479页

作者： K.senthilkumar PSS.Srinivasan Department of Mechanical Engineering SNS College of Technology Department of Mechanical Engineering Knowledge Institute of TechnologyKaka PalayamSalemTamilnaduINDIA

A new evaporative cooling system based on the action of centrifugal forces is *** systems are suitable for cooling large air volumes in tropical *** of geometrical and operational parameters on system performance are optimized using Taguchi *** is observed that disc speed,air flow rate and water flow rate are found to have major influence on system performance and other parameter,viz.,disc diameter,pin geometry,evaporation chamber length and orientation of pin have less influence.

关键词： Humidifier Evaporative air cooler Centrifugal force Taguchi method

Influence of Shallow and Deep Cryogenic Treatment on Tribological Behavior of En 19 Steel

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Journal of Iron and Steel Research International 2011年第9期18卷 53-59页

作者： D senthilkumar I Rajendran Department of Mechanical Engineering Dr Mahalingam College of Engineering and Technology

The influence of cryogenic treatment on the wear resistance of En 19 steel was studied. Furthermore, a comparative analysis on the effect of Deep Cryogenic Treatment （DCT, 196℃× 24 h）, Shallow Cryogenic Treatment （SCT -80℃ × 5 h） and Conventional Heat Treatment （CHT） was done through dry sliding wear testing. The microstructures of CHT, SCT and DCT samples were also examined through scanning electron microscopy. The results indicated that the wear resistance of shallow and deep cryogenically treated samples is higher when compared to that of conventionally treated samples. X-ray diffraction pattern revealed that the transformation of retained austenite into martensite is responsible for the wear resistance improvement.

关键词： steel wear cryogenic treatment automotive

An Efficient Approach for Simulation of Water Levels due to the Nonlinear Interaction of Tide and Surge Along the Coast of Bangladesh

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China Ocean Engineering 2020年第4期34卷 537-546页

作者： Gour Chandra Paul Sukumar senthilkumar Rana Pria Department of Mathematics University of RajshahiRajshahi-6205Bangladesh School of Mathematical Sciences Universiti Sains MalaysiaPulau Pinang-11800Malaysia Mathematics Discipline ScienceEngineering&Technology SchoolKhulna UniversityKhulna-9208.Bangladesh

The ultimate goal and highlight of this paper are to explore water levels along the coast of Bangladesh efficiently due to the nonlinear interaction of tide and surge by employing the method of lines(MOLs)with the aid of newly proposed RKAHeM(4,4)*** this regard,the spatial derivatives of shallow water equations(SWEs)were discretized by means of a finite difference method to obtain a system of ordinary differential equations(ODEs)of initial valued with time as an independent *** obtained system of ODEs was solved by the RKAHeM(4,4)***-way nested grid technique was exercised to incorporate coastal complexities closely with minimum computational cost.A stable tidal oscillation was produced over the region of interest by applying the most influential tidal constituent M2 along the southern open boundary of the outer *** newly developed model was applied to estimate water levels due to the non-linear interaction of tide and surge associated with the catastrophic cyclone April 1991 along the coast of *** approach employed in the study was found to perform well and ensure conformity with real-time observations.

关键词： method of lines RKAHeM(4 4)technique error estimation storm surge nested grid

Throughput Analysis of IEEE 802.11 Multirate WLANs with Collision Aware Rate Adaptation Algorithm

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International Journal of Automation and computing 2010年第4期7卷 571-577页

作者： Dhanasekaran senthilkumar A.Krishnan Department of Electronics and Communication Engineering K.S.Rangasamy College of Technology

This paper presents a mathematical model that analyzes the throughput of the IEEE 802.11b distributed coordination function （DCF） with the collision aware rate adaptation （CARA） algorithm. IEEE 802.11 WLANs provide multiple transmission rates to improve system throughput by adapting the transmission rate to the current channel conditions. The system throughput is determined by some stations using low transmission rates due to bad channel conditions. CARA algorithm does not disturb the existing IEEE 802.11b formats and it can be easily incorporated into the commercial wireless local area networks （WLAN） devices. Finally, we verify our findings with simulation.

关键词： Distributed coordination function (DCF) IEEE 802.11 collision aware rate adaptation (CARA) multirate medium access control (MAC).

Nonsaturation Throughput Enhancement of IEEE 802.11b Distributed Coordination Function for Heterogeneous Traffic under Noisy Environment

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International Journal of Automation and computing 2010年第1期7卷 95-104页

作者： Dhanasekaran senthilkumar A. Krishnan Department of Electronics and Communication Engineering K.S.Rangasamy College of Technology

In this paper, we propose a mechanism named modified backoff （MB） mechanism to decrease the channel idle time in IEEE 802.11 distributed coordination function （DCF）. In the noisy channel, when signal-to-noise ratio （SNR） is low, applying this mechanism in DCF greatly improves the throughput and lowers the channel idle time. This paper presents an analytical model for the performance study of IEEE 802.11 MB-DCF for nonsaturated heterogeneous traffic in the presence of transmission errors. First, we introduce the MB-DCF and compare its performance to IEEE 802.11 DCF with binary exponential backoff （BEB）. The IEEE 802.11 DCF with BEB mechanism suffers from more channel idle time under low SNR. The MB-DCF ensures high throughput and low packet delay by reducing the channel idle time under the low traffic in the network. However, to the best of the authors＇ knowledge, there are no previous works that enhance the performance of the DCF under imperfect wireless channel. We show through analysis that the proposed mechanism greatly outperforms the original IEEE 802.11 DCF in the imperfect channel condition. The effectiveness of physical and link layer parameters on throughput performance is explored. We also present a throughput investigation of the heterogeneous traffic for different radio conditions.

关键词： IEEE 802.11 medium access control (MAC) distributed coordination function (DCF) nonsaturated traffic heteroge- neous traffic signal-to-noise ratio (SNR) binary exponential backoff (BEB).

A Novel Approach for Network Vulnerability Analysis in IIoT

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Computer Systems Science & Engineering 2023年第4期45卷 263-277页

作者： K.Sudhakar S.senthilkumar Department of Computer Science and Engineering University College of EngineeringPattukkottaiRajamadam614701India

Industrial Internet of Things(IIoT)offers efficient communication among business partners and *** an enlargement of IoT tools connected through the internet,the ability of web traffic gets *** to the raise in the size of network traffic,discovery of attacks in IIoT and malicious traffic in the early stages is a very demanding issues.A novel technique called Maximum Posterior Dichotomous Quadratic Discriminant Jaccardized Rocchio Emphasis Boost Classification(MPDQDJREBC)is introduced for accurate attack detection wi th minimum time consumption in *** proposed MPDQDJREBC technique includes feature selection and ***,the network traffic features are collected from the *** applying the Maximum Posterior Dichotomous Quadratic Discriminant analysis to find the significant features for accurate classification and minimize the time *** the significant features selection,classification is performed using the Jaccardized Rocchio Emphasis Boost *** Rocchio Emphasis Boost Classification technique combines the weak learner result into strong *** Rocchio classification technique is considered as the weak learners to identify the normal and ***,proposed MPDQDJREBC technique gives strong classification results through lessening the quadratic *** assists for proposed MPDQDJREBC technique to get better the accuracy for attack detection with reduced time *** assessment is carried out with UNSW_NB15 Dataset using different factors such as accuracy,precision,recall,F-measure and attack detection *** observed results exhibit the MPDQDJREBC technique provides higher accuracy and lesser time consumption than the conventional techniques.

关键词： Industrial internet of things(iiot) attack detection features selection maximum posterior dichotomous quadratic discriminant analysis jaccardized rocchio emphasis boost classification

Delay-dependent Robust Stabilization and H_∞ Control for Uncertain Stochastic T-S Fuzzy Systems with Discrete Interval and Distributed Time-varying Delays

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International Journal of Automation and computing 2013年第1期10卷 18-31页

作者： P.Balasubramaniam T.senthilkumar Department of Mathematics Gandhigram Rural University

In this paper, delay-dependent robust stabilization and H∞ control for uncertain stochastic Takagi-Sugeno （T-S） fuzzy systems with discrete interval and distributed time-varying delays are discussed. The purpose of the robust stochastic stabilization problem is to design a memoryless state feedback controller such that the closed-loop system is mean-square asymptotically stable for all admissible uncertainties. In the robust H∞ control problem, in addition to the mean-square asymptotic stability requirement, a prescribed H∞ performance is required to be achieved. Sufficient conditions for the solvability of these problems are proposed in terms of a set of linear matrix inequalities （LMIs） and solving these LMIs, a desired controller can be obtained. Finally, two numerical examples are given to illustrate the effectiveness and less conservativeness of our results over the existing ones.

关键词： Robust stability robust H∞ control stochastic fuzzy systems distributed delay linear matrix inequality (LMI)

Chaotic Whale Optimized Fractional Order PID Controller Design for Desalination Process

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Computers, Materials & Continua 2022年第5期71卷 2789-2806页

作者： F.Kavin R.senthilkumar Department of Electronics and Instrumentation Engineering Saveetha Engineering CollegeThandalamChennai602105India Department of Electrical and Electronics Engineering Saveetha Engineering CollegeThandalamChennai602105India

The main aim of this work is to design a suitable Fractional Order Proportionl Integral Derivative(FOPID)controller with Chaotic Whale Optimization Algorithm(CWOA)for a RO desalination *** research on Reverse Osmosis(RO)desalination plants is a promising technique for satisfaction with sustainable and efficient RO *** work implements CWOA based FOPID for the simulation of reverse osmosis(RO)desalination process for both servo and regulatory *** modeling is a vital constituent of designing advanced and developed engineering processes,which helps to gain a deep study of processes to predict the performance,more *** approaches have been employed for mathematical models based on mass and heat transfer and concentration of permeable flow *** of FOPID controllers is broadly used to improve the dynamic response of the system,at the same time,to reduce undershoot or overshoot,steady state error and hence improve the *** performances of the FOPID controller with optimization is compared in terms of measures such as Integral Time Absolute Error(ITAE)and Integral Square Error(ISE).Simulation results with FOPID on desalination process achieved rise time of 0.0311 s,settling time of 0.0489 s and 0.7358%overshoot,better than the existing techniques available in the literatures.

关键词： Desalination FOPID integral of absolute error reverse osmosis water treatment

Mapping allosteric pathway in NIa-Pro using computational approach

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Quantitative Biology 2023年第1期11卷 82-93页

作者： Rashmi Panigrahi senthilkumar Kailasam Department of Biochemistry University of AlbertaEdmontonT6G 2H7Canada Canadian Centre for Computational Genomics McGill UniversityMontréalH3A 0G1Canada

Background:Computer simulation studies complement in vitro experiments and provide avenue to understand allosteric regulation in the absence of other molecular viewing *** dynamics captures internal motion within the protein and enables tracing the communication path between a catalytic site and a distal allosteric *** this article,we have identified the communication pathway between the viral protein genome linked(VPg)binding region and catalytic active site in nuclear inclusion protein-a protease(NIa-Pro).Methods:Molecular dynamics followed by in silico analyses have been used to map the allosteric ***:This study delineates the residue interaction network involved in allosteric regulation of NIa-Pro activity by *** studies indicate that point mutations in the VPg interaction interface of NIa-Pro lead to disruption in these networks and change the orientation of catalytic ***142Ala and His167Ala mutations do not show a substantial change in the overall protease structure,but rather in the residue interaction network and catalytic site ***:Our mutagenic study delineates the allosteric pathway and facilitates the understanding of the modulation of NIa-Pro activity on a molecular level in the absence of the structure of its complex with the known regulator ***,our in silico analysis explains the molecular concepts and highlights the dynamics behind the previously reported wet lab study findings.

关键词： NIa-Pro VPg simulation residue interaction network allostery