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Virtual-reality-based digital twin of office spaces with social distance measurement feature

Virtual Reality & Intelligent Hardware 2022年第1期4卷 55-75页

作者： Abhishek MUKHOPADHYAY G S Rajshekar REDDY kamalpreet singh saluja Subhankar GHOSH Anasol PEÑA-RIOS Gokul GOPAL Pradipta BISWAS Indian Institute of Science BangaloreIndia BT Plc UK

Background Social distancing is an effective way to reduce the spread of the SARS-CoV-2 *** students and researchers have already attempted to use computer vision technology to automatically detect human beings in the field of view of a camera and help enforce social ***,because of the present lockdown measures in several countries,the validation of computer vision systems using large-scale datasets is a *** In this paper,a new method is proposed for generating customized datasets and validating deep-learning-based computer vision models using virtual reality(VR)*** VR,we modeled a digital twin(DT)of an existing office space and used it to create a dataset of individuals in different postures,dresses,and *** test the proposed solution,we implemented a convolutional neural network(CNN)model for detecting people in a limited-sized dataset of real humans and a simulated dataset of humanoid *** We detected the number of persons in both the real and synthetic datasets with more than 90%accuracy,and the actual and measured distances were significantly correlated(r=0.99).Finally,we used intermittent-layer-and heatmap-based data visualization techniques to explain the failure modes of a *** A new application of DTs is proposed to enhance workplace safety by measuring the social distance between *** use of our proposed pipeline along with a DT of the shared space for visualizing both environmental and human behavior aspects preserves the privacy of individuals and improves the latency of such monitoring systems because only the extracted information is streamed.

关键词： Virtual environment Digital twin 3D visualization Convolutional neural network Object detection Social distancing

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Management of splenic artery aneurysm associated with extrahepatic portal vein obstruction

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Hepatobiliary & Pancreatic Diseases International 2012年第3期11卷 330-333页

作者： Pramod Kumar Mishra Sundeep singh saluja Ashok K Sharma Premanand Pattnaik Department of Gastrointestinal Surgery Surgery GB Pant Hospital Department of Gastrointestinal Surgery and Department of Radiology Surgery GB Pant Hospital Department of Gastrointestinal Surgery GB Pant Hospital

BACKGROUND: Splenic artery aneurysms although rare are clinically significant in view of their propensity for spontaneous rupture and life-threatening bleeding. While portal hypertension is an important etiological factor, the majority of reported cases are secondary to cirrhosis of the liver. We report three cases of splenic artery aneurysms associated with extrahepatic portal vein obstruction and discuss their management. METHODS: The records of three patients of splenic artery aneurysm associated with extrahepatic portal vein obstruction managed from 2003 to 2010 were reviewed retrospectively. The clinical presentation, surgical treatment and outcome were analyzed. RESULTS: The aneurysm was >3 cm in all patients. The clinical symptoms were secondary to extrahepatic portal vein obstruction (hematemesis in two, portal biliopathy in two) while the aneurysm was asymptomatic. Doppler ultrasound demonstrated aneurysms in all patients. A proximal splenorenal shunt was performed in two patients with excision of the aneurysm in one patient and ligation of the aneurysm in another one. The third patient had the splenic vein replaced by collaterals and hence underwent splenectomy with aneurysmectomy. All patients had an uneventful post-operative course. CONCLUSIONS: Splenic artery aneurysms are associated with extrahepatic portal vein obstruction. Surgery is the mainstay of treatment. Although technically difficult, it can be safely performed in an experienced center with minimal morbidity and good outcome.

关键词： splenic artery aneurysm extrahepatic portal vein obstruction portal hypertension proximal splenorenal shunt

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Gastric conduit perforation

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World Journal of Clinical Cases 2014年第8期2卷 398-401页

作者： Nilesh Patil Arvind Kaushal Amit Jain Sundeep singh saluja Pramod Kumar Mishra Department of Gastrointestinal Surgery Academic BlockGB Pant Hospital and Maulana Azad Medical CollegeNew Delhi 110002India

As patients with carcinoma of the esophagus live longer, complications associated with the use of a gastric conduit are increasing. Ulcers form in the gastric conduit in 6.6% to 19.4% of patients. There are a few reports of perforation of a gastric conduit in the English literature. Almost all of these were associated with serious complications. We report a patient who developed a tension pneumothorax consequent to spontaneous perforation of an ulcer in the gastric conduit 7 years after the index surgery in a patient with carcinoma of the gastroesophageal junction. He responded well to conservative management. Complications related to a gastric conduit can be because of multiple factors. Periodic endoscopic surveillance of gastric conduits should be considered as these are at a higher risk of ulcer formation than a normal stomach. Long term treatment with proton pump inhibitors may decrease complications. There are no guidelines for the treatment of a perforated gastric conduit ulcer and the management should be individualized.

关键词： Gastric conduit Ulcer formation Perforation Carcinoma of the esophagus Proton pump inhibitors

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Composite pheochromocytoma masquerading as solidpseudopapillary neoplasm of pancreas

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World Journal of Clinical Cases 2015年第5期3卷 474-478页

作者： Geetanjali Gupta Ravindra Kumar Saran Satyajit Godhi Siddharth Srivastava Sundeep singh saluja Pramod Kumar Mishra Department of Pathology Academic Block GB Pant Hospital New Delhi 110002 India Department of Gastroenterology Academic Block GB Pant Hospital New Delhi 110002 India Department of Gastrointestinal Surgery Academic Block GB Pant Hospital New Delhi 110002 India

Pheochromocytoma and ganglioneuroma form rare composite tumours of the adrenal medulla comprising less than 3% of all sympathoadrenal tumours. We present a case of intraoperatively detected adrenal medullary tumour of composite pheochromocytoma and ganglioneuroma diagnosed on histopathology, in a normotensive patient. A 50-year-old male with a past history of chronic obstructive pulmonary disease presented with abdominal pain and significant weight loss since one month. Ultrasound and contrast-enhanced computed tomography abdomen revealed a large lobulated lesion in the distal body and tail of pancreas suggestive of solid and papillary neoplasm of body and tail of pancreas. Intra-operatively, a 15 cm × 10 cm solid lesion with cystic areas was seen arising from the left lower pole of the adrenal gland pushing the pancreas which appeared unremarkable. In our case, exploratory laparotomy with tumour excision was done. Extensive sectioning and microscopic examination of this adrenal tumour confirmed a diagnosis of composite Pheochromocytoma with Ganglioneuroma on histopathology. Immunophenotyping with S-100 further supported the diagnosis. The goal of this report is to increase the awareness of this rare disease and to further identify its variable presentation.

关键词： Ganglioneuroma Pheochromocytoma Adrenal

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Non-surgical management of dens invaginatus type IIIB in maxillary lateral incisor with three root canals and 6-year follow-up:A case report and review of literature

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World Journal of Clinical Cases 2022年第33期10卷 12240-12256页

作者： Suraj Arora Gurdeep singh Gill Shahabe Abullais Saquib Priyanka saluja Suheel M Baba Shafait Ullah Khateeb Anshad M Abdulla Shashit Shetty Bavabeedu Ahmed Babiker Mohamed Ali Mohamed Fadul A Elagib Department of Restorative Dental Sciences College of DentistryKing Khalid UniversityAbha 61421Saudi Arabia Department of Conservative Dentistry and Endodontics JCD Dental CollegeSirsa 125055India Department of Periodontics and Community Dental Sciences King Khalid UniversityAbha 61421Saudi Arabia Department of Pediatric Dentistry and Orthodontic Sciences King Khalid UniversityAbha 61421Saudi Arabia

BACKGROUND The presence of dens invaginatus(DI)complicates treatment of any tooth,from diagnosis to access cavity and biomechanical preparation and *** of successful non-surgical management of DI type IIIB in maxillary lateral incisor are ***,we report such a case,with three root canals and a long *** SUMMARY A 13-year-old female patient presented with mild pain in the maxillary right lateral incisor(#7)for 10-15 *** examination,the tooth was slightly rotated,with slight tenderness on percussion and grade I mobility but with no caries,pockets or restorations and non-vital pulp(via vitality tests).Radiographic examination revealed unusual configuration of the tooth’s root canals,with an enamel-lined invagination extending to the apex,suggesting the possibility of DI Oehler’s type IIIB and a periapical *** the access cavity lingually revealed one distinct buccal orifice and two distinct palatal orifices;under higher magnification of a dental operating microscope(DOM),the mesio palatal and disto-palatal orifices were observed as connected by a C-shaped *** root canals were prepared with hand K-files following a step-back technique,and obturated using a combination technique of lateral condensation and vertical *** the 6-year follow-up,the patient was asymptomatic,and the periapical radiography displayed significant healing around the apical end of the *** Proper knowledge of unusual root canal anatomy is required in treating *** methods of root canal treatment can successfully resolve such complex cases,facilitated by DOM and cone-beam computed tomography.

关键词： Dens invaginatus Maxillary lateral incisor Three root canals Root canal Anatomy Treatment Case report

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Ocular manifestations of central insulin resistance

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Neural Regeneration Research 2023年第5期18卷 1139-1146页

作者： Muneeb A.Faiq Trina Sengupta Madhu Nath Thirumurthy Velpandian Daman saluja Rima Dada Tanuj Dada Kevin C.Chan Dr.Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical SciencesNew DelhiIndia Neuroimaging and Visual Science Laboratory Department of OphthalmologyNYU Grossman School of MedicineNYU Langone HealthNew York UniversityNew YorkNYUSA Medical Biotechnology Laboratory Dr.B.R.Ambedkar Center for Biomedical ResearchUniversity of DelhiDelhiIndia Dr.Baldev singh Sleep Laboratory Department of PhysiologyAll India Institute of Medical SciencesNew DelhiIndia Department of Ocular Pharmacology Dr.Rajendra Prasad Center for Ophthalmic SciencesAll India Institute of Medical SciencesNew DelhiIndia Laboratory for Molecular Reproduction and Genetics Department of AnatomyAll India Institute of Medical SciencesNew DelhiIndia

Central insulin resistance, the diminished cellular sensitivity to insulin in the brain, has been implicated in diabetes mellitus, Alzheimer’s disease and other neurological disorders. However, whether and how central insulin resistance plays a role in the eye remains unclear. Here, we performed intracerebroventricular injection of S961, a potent and specific blocker of insulin receptor in adult Wistar rats to test if central insulin resistance leads to pathological changes in ocular structures. 80 mg of S961 was stereotaxically injected into the lateral ventricle of the experimental group twice at 7 days apart, whereas buffer solution was injected to the sham control group. Blood samples, intraocular pressure, trabecular meshwork morphology, ciliary body markers, retinal and optic nerve integrity, and whole genome expression patterns were then evaluated. While neither blood glucose nor serum insulin level was significantly altered in the experimental or control group, we found that injection of S961 but not buffer solution significantly increased intraocular pressure at 14 and 24 days after first injection, along with reduced porosity and aquaporin 4 expression in the trabecular meshwork, and increased tumor necrosis factor α and aquaporin 4 expression in the ciliary body. In the retina, cell density and insulin receptor expression decreased in the retinal ganglion cell layer upon S961 injection. Fundus photography revealed peripapillary atrophy with vascular dysregulation in the experimental group. These retinal changes were accompanied by upregulation of pro-inflammatory and pro-apoptotic genes, downregulation of anti-inflammatory, anti-apoptotic, and neurotrophic genes, as well as dysregulation of genes involved in insulin signaling. Optic nerve histology indicated microglial activation and changes in the expression of glial fibrillary acidic protein, tumor necrosis factor α, and aquaporin 4. Molecular pathway architecture of the retina revealed the three most s

关键词： brain ciliary bodies gene expression inflammation insulin receptor insulin resistance intraocular pressure neurodegeneration optic nerve retina retinal ganglion cells trabecular meshwork

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Chronic Dietary Administration of 2-Deoxy-D-Glucose Does Not Compromise Neurobehavioral Functions at Tumor Preventive Doses in Mice

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Journal of Behavioral and Brain Science 2015年第9期5卷 381-393页

作者： Saurabh singh Mayank Kumar Kailash Manda Seenu Haridas Anant Narayan Bhatt Daman saluja Bilikere S. Dwarakanath Division of Radiation Biosciences Institute of Nuclear Medicine and Allied Sciences Delhi India Medical Biotechnology Laboratory Dr. B.R. Ambedkar Center for Biomedical Research University of Delhi Delhi India

Beneficial effects of dietary energy restriction (DER), including extension of life-span, reduction in cancer risk, anti-cancer effects and decrease in age related neurodegenerative diseases have been well established. Given that DER is difficult to implement in humans due to practical constraints, development of energy restriction mimetics (ERMs) is considered as a suitable alternative. Our recent studies have established the anti-tumor effects of the dietary administration of the glycolytic inhibitor 2-deoxy-D-glucose, a potential ERM, an alternative to DER;without any adverse effects on general physiology. Since functioning of the brain is critically dependent on glucose, we investigated the effects of chronic dietary 2-DG administration on the behavioural outcome in mice. Our findings based on a battery of neuro-behavioural tests clearly suggest that the chronic dietary administration of 2-DG that appreciably impairs the process of tumorigenesis has no adverse effect on the cognitive, affective and sensory-motor functions. Together with the maintenance of normal physiology reported by us earlier, these observations strengthen the potential of dietary 2-DG as a safe cancer preventive strategy.

关键词： Glycolysis Energy Restriction Mimetics (ERMs) 2-Deoxy-D-Glucose (2-DG) Tumor Prevention Neuro-Behaviour

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