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Oxidative stress:culprit or consequence in Alzheimer's amyloidopathy

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Neural Regeneration Research 2023年第9期18卷 1948-1949页

作者： Chanchal sharma Sang Ryong Kim School of Life Sciences Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National UniversityDaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

Oxidative stress in Alzheimer’s disease:Oxidative stress refers to an imbalance between the prooxidative and anti-oxidative states that are part of normal cell metabolism that results in the elevated production of reactive oxygen species(ROS) and free *** products oxidize lipids,proteins,and DNA,significantly threatening the integrity of neurons(Pratico,2008;Padurariu et al.,2013).

关键词： metabolism Alzheimer elevated

A transitioning universe with time varying G and decaying Λ

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Research in Astronomy and Astrophysics 2013年第5期13卷 501-508页

作者： Anil Kumar Yadav Amit sharma Department of Physics Anand Engineering College Department of Mathematics Anand Engineering College

We present a model of a universe that transitions from an early deceleration phase to the current acceleration phase under the framework of general relativity, in the presence of gravitational coupling G（t） and cosmological terms A（t）. Einstein＇s field equations have been solved by considering the time dependent deceleration parameter （DP） which renders the scale factor e = （thekt）1/m where m, n and k are positive con- stants. The cosmological term （A （t）） is found to be positive and a decreasing function of time, which supports the result obtained from observations of type Ia supernovae. The geometrical and kinematical features of the model are examined in detail.

关键词： early universe -- large scale structure of universe

Urban greenways： Operationalizing design syntax and integrating mathematics and science in design

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Frontiers of Architectural Research 2015年第1期4卷 24-34页

作者： Archana sharma Morgan State University School of Architecture and Planning CBEIS 1700 E. Cold Spring Lane BaltimoreMD 21251 USA

The ubiquitous sameness of urban greenways prompts questions on generative design grammar and syntax, whether creative, critical rethinking at that level might be lacking. However the design syntax of urban greenways is not explicitly discussed thus leaving a critical gap in knowledge. This paper begins tackling the larger question by acting on the fundamental subset of it, by operationatizing the design syntax of urban greenways. This is done through mathematics-based graph studies to analyze patterns and shapes, photography based thermal, material and morphology studies, and section analyses to make imagery-derived deductions on the design syntax. Recommendation on approaches to diversify and enrich the design syntax includes a more direct reference from ecosystem science theories such for siting and planning the urban greenways at macro- to meso-scale, a mixed-method approach, combining mathe- matics, photography and drawings based frames for analyses at meso- to micro-scale, and a turtle view scale for designing at meso- to micro-scale, with an emphasis on latter.

关键词： Design thinking Syntax Greenway Urban Ptanning Landscape STEM integrateddesgn Inter-discipLinary

Bioactive compounds and probiotics-a ray of hope in COVID-19 management

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Food Science and Human Wellness 2021年第2期10卷 131-140页

作者： Indu Bhushan Mahima sharma Malvika Mehta Shivi Badyal Varun sharma Indu sharma Hemender Singh Srinivas Sistla School of Biotechnology Shri Mata Vaishno Devi UniversityKatraJammu and KashmirIndia Birbal Sahni Institute of Palaeosciences LucknowUPIndia Institute for Structural Biology Drug Discovery and DevelopmentVirginia Commonwealth UniversityRichmondUSA

The use of bioactive compounds and probiotic bacteria against the viral diseases in human is known for a long ***-viral,anti-inflammatory and anti-allergic properties of bioactive compounds and bacteria with probiotic properties in respiratory viral diseases may have significance to enhance *** review highlights some of the important bioactive compounds and probiotic bacteria,suggesting them as a ray of hope in the milieu of the COVID-19 management.

关键词： Probiotics Bioactive compounds COVID Food Metabolites

Simultaneous imaging and measurement of tensile stress on cornea by using a common-path optical coherence tomography system with an external contact reference

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Chinese Optics Letters 2008年第12期6卷 910-912页

作者： Utkarsh sharma Jin U.Kang Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign405 North Mathews Avenue Urbana Department of Electrical and Computer Engineering Johns Hopkins University 3400 N.Charles StreetBaltimore

The objective of this study is to demonstrate that tensile stress resulting due to applied force on cornea can be accurately measured by using a time-domain common-path optical coherence tomography （OCT） system with an external contact reference. The unique design of the common-path OCT is utilized to set up an imaging system in which a chicken eye is placed adjacent to a glass plate serving as the external reference plane for the imaging system. As the force is applied to the chicken eye, it presses against the reference glass plate. The modified OCT image obtained is used to calculate the size of contact area, which is then used to derive the tensile stress on the cornea. The drop in signal levels upon contact of reference glass plate with the tissue are extremely sharp because of the sharp decline in reference power levels itself, thus providing us with an accurate measurement of contact area. The experimental results were in good agreement with the numerical predictions. The results of this study might be useful in providing new insights and ideas to improve the precision and safety of currently used ophthalmic surgical techniques. This research outlines a method which could be used to provide high resolution OCT images and a precise feedback of the forces applied to the cornea simultaneously.

关键词： Simultaneous imaging and measurement of tensile stress on cornea by using a common-path optical coherence tomography system with an external contact reference

Process engineering of demineralisation of moderate to high ash Indian coals through NaOH‑HCl leaching and HF leaching

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International Journal of Coal Science & Technology 2024年第2期11卷 111-122页

作者： Heena Dhawan D.K.sharma ANRF Ministry of ScienceNew DelhiIndia Department of Energy Science and Engineering Indian Institute of Technology DelhiNew Delhi 110016India

Chemical leaching of coals would be required to produce cleaner coals for some special applications where physical benefi-ciation may not be effective *** would also help in recovering Li and rare earth metals besides in the sequestration of CO_(2).About 20 Indian coals having complexly distributed moderate to high ash contents were sequentially treated with various alkali–acid such as NaOH-HCl,HF,HCl,HCl-HF,and NaOH-HCl-HF *** aimed to establish and design the best stepwise sequential process for the highest degree of demineralisation through a chemical leaching *** and process intensification studies were carried *** than 80%demineralisation of Madhaipur and Neemcha coals was observed using the best sequential treatment designed *** repeated stepwise treatment of the alkali and the acid was also studied,which was found to significantly enhance the degree of demineralisation of *** integrated process of alkali–acid leaching followed by solvent extraction(Organo-refining)and vice versa of the treated coal was also studied for producing cleaner coals.

关键词： Alkali–acid leaching Demineralisation Integrated process Rare earth elements

Probing the degradation of pharmaceuticals in urine using MFC and studying their removal efficiency by UPLC-MS/MS

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Journal of Pharmaceutical Analysis 2021年第3期11卷 320-329页

作者： Priya sharma Devendra Kumar Srikanth Mutnuri Applied Environmental Biotechnology Laboratory Birla Institute of Technology&Science(BITS)Pilani403726ZuarinagarIndia Central Sophisticated Instrumentation Facility Birla Institute of Technology&Science(BITS)Pilani403726ZuarinagarIndia Department of Pharmaceutical Sciences College of PharmacyUniversity of Nebraska Medical CenterOmahaNE68198-602USA

Nutrient recovery from source-separated human urine has attracted interest as it is rich in nitrogen and phosphorus that can be utilized as ***,urine also contains pharmaceuticals,steroid hormones,*** their removal is crucial as they have detrimental effects on the environment and human *** current study focuses on investigating the degradation of pharmaceuticals using a double-chamber microbial fuel cell(MFC).Urine was spiked with four pharmaceuticals(trimethoprim,lamivudine,levofloxacin,and estrone)at a concentration of 2 mg/*** MFC was operated for 7 months in batch mode with this spiked urine as *** degradation efficiency of the MFC was studied,for which a selective liquid chromatography-tandem mass-spectrometric method was developed for the quantitation of compounds used in the spiking experiments and was validated with a lower limit of quantification of 0.39 ng/*** maximum removal rate achieved was 96%±2%.The degradation mechanism involved processes like sorption and anoxic *** voltage curve obtained showed that the presence of pharmaceuticals had an initial negative impact on power generation along with increased organic content;however,after the reactor acclimatization,increased power output was achieved with maximum organics removal at 30 h of retention *** work opens a new perspective for the anoxic biodegradation of pharmaceuticals and can be useful in future bioremediation studies.

关键词： Pharmaceuticals Urine MFC Biodegradation Liquid chromatography mass spectroscopy

Bianchi Type-IX String Cosmological Models for Perfect Fluid Distribution in General Relativity

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Chinese Physics Letters 2010年第7期27卷 299-301页

作者： Atul Tyagi Keerti sharma Payal Jain Department of Mathematics and Statistics College of Science MLS University Udaipur-313001 India Department of Mathematics Techno India NJR Institute of Technology Udaipur-313004 India

The present study deals with Bianchi type-IX string cosmological models for perfect fluid distribution. We consider two cases：（i） ρ ＋ λ = 0, （ii） ρ - λ = 0, where ρ and λ are the rest energy density and the tension density of a string cloud, respectively. The physical and geometrical properties of the models are discussed.

关键词： Models Dormancy Density

Non Existence of Shear in Bianchi Type-ⅢString Cosmological Models with Bulk Viscosity and Time-Dependent A Term

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Chinese Physics Letters 2011年第2期28卷 55-57页

作者： R.K.Tiwari Sonia sharma Department of Mathematics Govt.Model Science CollegeRewa(MP)India Department of Mathematics Rayat Polytechnic CollegeRopar(Punjab)India

We study the non existence of shear in locally rotationally symmetric Bianchi type-Ⅲstring cosmological models with bulk viscosity and variable cosmological termΛ.Exact solutions of the field equations are obtained by assuming the conditions:the bulk viscosity is proportional to the expansion scalar,ξ∝θ,expansion scalar is proportional to shear scalar,θ∝σ,and A is proportional to the Hubble *** coefficient of bulk viscosity is assumed to be a power function of mass *** corresponding physical interpretations of the cosmological solutions are also discussed.

关键词： parameter density viscosity