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Journal of Materials Science & Technology 2005年第6期21卷 851-855页

作者： B.Eghbali A.Abdollah-zadeh Department of Materials Engineering Tarbiat Modarres University P.O. Box 14115-143 Tehran Iran

Grain refinement is one of the effective methods to develop new generation low carbon microalloyed steels possessing excellent combination of mechanical properties. The microstructural evolution and ferrite grain refinement at the deformation temperature of 865℃, above ar3, with different strain rates were investigated using single pass isothermal hot compression experiments for a low carbon Nb-Ti microalloyed steel. The physical processes that occurred during deformation were discussed by observing the optical microstructure and analyzing the true stress-true strain responses. At strain rates of 0.001 and 0.01s^-1, there is no evidence of work hardening behavior during hot deformation and strain-induced transformation （SIT） leads to dynamic flow softening in flow curves. Optical microscopy observation shows that ultrafine and equiaxed ferrite with grain sizes of 2μm can be obtained by applying deformation with strain rate of 0.1 s^-1 due to SIT just after deformation. Furthermore, increasing the strain rate from 0.001 to 0.1 s^-1 reduces both the grain size of the equiaxed ferrite and the amount of deformed ferrite.

关键词： Low carbon microalloyed steel Hot compression Grain refinement Strain induced transformation

让肾脏健康人人可享,处处可及——从预防到诊治

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肾脏病与透析肾移植杂志 2020年第1期29卷 1-7页

作者： Philip kam Tao Guillermo Garcia Garcia Siu Fai Lui Sharon Andreoli Winston Wing Shing Fung Anne Hradsky Latha Kumaraswami Vassilios Liakopoulos Ziyoda Rakhimova Gamal Saadi Luisa Strani Ifeoma Ulasi kam.ar kalantar zadeh 无 Department of Medicine and Therapeutics Carol&Richard Yu PD Research CentrePrince of Wales HospitalChinese University of Hong KongHong Kong Nephrology Service Hospital Civil de Guadalajara Fray Antonio AlcaldeUniversity of Guadalajara Health Sciences CenterGuadalajaraJaliscoMexico Division of Health System Policy and ManagementJockey Club School of Public Health and Primary CareThe Chinese University of Hong KongHong Kong James Whitcomb Riley Hospital for Children Indiana University School of MedicineIndianapolisIndianaUSA World Kidney Day Office BrusselsBelgium Tanker Foundation ChennaiIndia Division of Nephrology and Hypertension 1st Department of Internal MedicineAHEPA HospitalAristotle University of ThessalonikiThessalonikiGreece Nephrology Unit Department of Internal MedicineFaculty of MedicineCairo UniversityGizaEgypt Renal Unit Department of MedicineCollege of MedicineUniversity of NigeriaItuku OzallaEnuguNigeria Division of Nephrology and Hypertension and Kidney Transplantation University of California Irvine School of MedicineOrangeCaliforniaUSA the World Kidney Day Steering Committee

around 850 million people currently are affected by different types of kidney *** to 1 in 10 adults worldwide has chronic kidney disease(CKD),which is invariably irreversible and mostly *** global burden of CKD is increasing,and CKD is projected to become the fifth most common cause of years of life lost globally by *** CKD remains uncontrolled and if the affected person survives the ravages of cardiovascular and other complications of the disease,CKD progresses to endstage kidney disease,where life cannot be sustained without dialysis therapy or kidney ***,CKD is a major cause of catastrophic health expenditure.

关键词： awareness detection kidney diseases prevention

A physics informed bayesian optimization approach for material design: application to NiTi shape memory alloys

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npj Computational Materials 2023年第1期9卷 85-95页

作者： Danial Khatamsaz Raymond Neuberger arunabha M.Roy Sina Hossein zadeh Richard Otis Raymundo arróyave Materials Science and Engineering Department Texas A&M UniversityCollege StationTX 77843USA Engineering and Science Directorate Jet Propulsion LaboratoryCalifornia Institute of TechnologyPasadenaCA 91109USA Mechanical Engineering Department Texas A&M UniversityCollege StationTX 77843USA Department of Industrial&Systems Engineering Texas A&M UniversityCollege StationTX 77843USA

The design of materials and identification of optimal processing parameters constitute a complex and challenging task,necessitating efficient utilization of available *** Optimization(BO)has gained popularity in materials design due to its ability to work with minimal ***,many BO-based frameworks predominantly rely on statistical information,in the form of input-output data,and assume black-box objective *** practice,designers often possess knowledge of the underlying physical laws governing a material system,rendering the objective function not entirely black-box,as some information is partially *** this study,we propose a physics-informed BO approach that integrates physics-infused kernels to effectively leverage both statistical and physical information in the decision-making *** demonstrate that this method significantly improves decision-making efficiency and enables more data-efficient *** applicability of this approach is showcased through the design of NiTi shape memory alloys,where the optimal processing parameters are identified to maximize the transformation temperature.

关键词： alloys shape approach

Development of a dual targeting scaffold of SET7/MLL inhibitor for castration-resistant prostate cancer treatment

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Genes & Diseases 2023年第6期10卷 2260-2262页

作者： Guodong Li Qi Huang Vincent kam Wai Wong Wanhe Wang Chung-Hang Leung Institute of Chinese Medical Sciences and State Key Laboratory of Quality Research in Chinese Medicine University of MacaoMacao SAR 999078China Dr.Neher's Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao SAR 999078China Institute of Medical Research Northwestern Polytechnical UniversityXi'anShaanxi 710072China Macao Centre for Research and Development in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China Department of Biomedical Sciences Faculty of Health SciencesUniversity of MacaoMacao SAR 999078China Zhuhai UM Science and Technology Research Institute ZhuhaiGuangdong 519000China

Histone methyltransferase enzyme SET7 and mixed-lineage leukemia protein(MLL)complex are crucial co-activators of androgen receptor(ar)and have recently emerged as potential therapeutic targets for advanced castration-resistant prostate cancer(CRPC).In this study,we described the identification of a rhodium-based hybrid complex(SM_1)as a potent blocker of ar activity via simultaneously inhibiting SET7 and MLL complex activity,which makes it a potential lead scaffold for CPRC drug development.

关键词： cancer inhibiting treatment

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2018世界肾脏日：关注女性和肾脏疾病

肾脏病与透析肾移植杂志 2018年第1期27卷 1-6页

作者： Giorgina B.Piccoli Mona Alrukhaimi Zhi-Hong Liu Elena Zakharova Adeera Levin Philip kam Tao Li Guillermo Garcia-Garcia Mohammed Benghanem-Gharbi kam.ar kalantar-zadeh Charles Kernahan Latha Kumaraswami Giorgina Barbara Piccoli Gamal Saadi Louise Fox Sharon Andreoli 陈樱花 Department of Clinical and Biological Sciences University of Torino Nephrology Centre Hospitalier Le Mans Department of Medicine Dubai Medical College National Clinical Research Center of Kidney Diseases Jinling Hospital Nanjing University School of Medicine Nephrology Moscow City Hospital n.a. S.P. Botkin Nephrology Moscow State University of Medicine and Dentistry Nephrology Russian Medical Academy of Continuous Professional Education the World Kidney Day Steering Committee Department of Medicine Division of NephrologyUniversity of British Columbia 国家肾脏疾病临床医学研究中心南京总医院

女性是现代家庭和社会的重要贡献者。但目前在世界范围内,男性和女性在受教育程度、医疗保健等方面仍存在显著差异。2018年第13个世界肾脏日恰逢国际妇女节,其主题是"肾脏和女性健康",给我们提供了一个关注女性健康,尤其是女性肾脏健康... 详细信息

女性是现代家庭和社会的重要贡献者。但目前在世界范围内,男性和女性在受教育程度、医疗保健等方面仍存在显著差异。2018年第13个世界肾脏日恰逢国际妇女节,其主题是"肾脏和女性健康",给我们提供了一个关注女性健康,尤其是女性肾脏健康的重要契机。为此,世界肾脏日指导委员会(World Kidney Day Steering Committee)特别组织了全球具有代表性的5位女性肾脏病学家,撰写了述评文章,借机呼吁肾脏病学术领域和全社会更加重视女性健康,让更多女性从肾脏病学术研究中获益。关注女性肾脏健康,利在当代功在千秋!

关键词：女性健康肾脏疾病世界范围肾脏病学学术研究国际妇女节现代家庭医疗保健

Systematic investigation of millimeter-wave optic modulation performance in thin-film lithium niobate

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Photonics Research 2022年第10期10卷 2380-2387页

作者： YIWEN ZHANG LINBO SHAO JINGWEI YANG ZHAOXI CHEN KE ZHANG kam-MAN SHUM DI ZHU CHI HOU CHAN MarKO LONČar CHENG WANG Department of Electrical Engineering City University of Hong KongKowloonHong KongChina John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMassachusetts 02138USA Bradley Department of Electrical and Computer Engineering Virginia TechBlacksburgVirginia 24061USA State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongKowloonHong KongChina Institute of Materials Research and Engineering Agency for ScienceTechnology and Research(A^(*)STAR)Singapore 138634Singapore

Millimeter-wave(mmWave)band(30–300 GHz)is an emerging spectrum range for wireless communication,short-range radar,and sensor ***-optic modulators that could efficiently convert mmWave signals into the optical domain are crucial components for long-haul transmission of mmWave signals through optical *** these ultrahigh frequencies,however,the modulation performances are highly sensitive to the transmission line loss as well as the velocity-and impedance-matching conditions,while precise measurements and modeling of these parameters are often *** we present a systematic investigation of the mmWave-optic modulation performances of thin-film lithium niobate modulators through theoretical modeling,electrical verifications,and electro-optic measurements at frequencies up to 325 *** on our experimentally verified model,we demonstrate thin-film lithium niobate mmWave-optic modulators with a measured 3-dB electro-optic bandwidth of 170 GHz and a 6-dB bandwidth of 295 *** device also shows a low RF half-wave voltage of 7.3 V measured at an ultrahigh modulation frequency of 250 *** work provides a comprehensive guideline for the design and characterization of mmWave-optic modulators and paves the way toward future integrated mmWave photonic systems for beyond-5G communication and radar applications.

关键词： millimeter lithium film

Material Engineering in Gut Microbiome and Human Health

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Research 2022年第3期2022卷 145-176页

作者： Letao Yang Lin Y.Hung Yuefei Zhu Suwan Ding Kara G.Margolis kam W.Leong Department of Biomedical Engineering Columbia UniversityNew YorkNYUSA Department of Pediatrics Columbia UniversityNew YorkNew YorkUSA Department of Systems Biology Columbia UniversityNew YorkNYUSA

Tremendous progress has been made in the past decade regarding our understanding of the gut microbiome’s role in human ***,however,a comprehensive and focused review marrying the two distinct fields of gut microbiome and material research is *** bridge the gap,the current paper discusses critical aspects of the rapidly emerging research topic of“material engineering in the gut microbiome and human health.”By engaging scientists with diverse backgrounds in biomaterials,gut-microbiome axis,neuroscience,synthetic biology,tissue engineering,and biosensing in a dialogue,our goal is to accelerate the development of research tools for gut microbiome research and the development of therapeutics that target the gut *** this purpose,state-of-the-art knowledge is presented here on biomaterial technologies that facilitate the study,analysis,and manipulation of the gut microbiome,including intestinal organoids,gut-on-chip models,hydrogels for spatial mapping of gut microbiome compositions,microbiome biosensors,and oral bacteria delivery *** addition,a discussion is provided regarding the microbiome-gut-brain axis and the critical roles that biomaterials can play to investigate and regulate the ***,perspectives are provided regarding future directions on how to develop and use novel biomaterials in gut microbiome research,as well as essential regulatory rules in clinical *** this way,we hope to inspire research into future biomaterial technologies to advance gut microbiome research and gut microbiome-based theragnostics.

关键词： biomaterials directions biome

Large-scale, adhesive-free and omnidirectional 3D nanocone anti-reflection films for high performance photovoltaics

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Journal of Semiconductors 2019年第4期40卷 35-41页

作者： Lei Tang Kwong-Hoi Tsui Siu-Fung Leung Qianpeng Zhang Matthew kam Hsin-Ping Wang Jr-Hau He Zhiyong Fan HKUST-Shenzhen Research Institute Department of Electronic and Computer Engineering Hong Kong University of Science and Technology (HKUST) Computer Electrical and Mathematical Sciences and Engineering King Abdullah University of Science and Technology

An effective and low-cost front-side anti-reflection(ar) technique has long been sought to enhance the performance of highly efficient photovoltaic devices due to its capability of maximizing the light absorption in photovoltaic devices. In order to achieve high throughput fabrication of nanostructured flexible and anti-reflection films, large-scale, nano-engineered wafer molds were fabricated in this work. Additionally, to gain in-depth understanding of the optical and electrical performance enhancement with ar films on polycrystalline Si solar cells, both theoretical and experimental studies were performed. Intriguingly,the nanocone structures demonstrated an efficient light trapping effect which reduced the surface reflection of a solar cell by17.7% and therefore enhanced the overall electric output power of photovoltaic devices by 6% at normal light incidence. Notably, the output power improvement is even more significant at a larger light incident angle which is practically meaningful for daily operation of solar panels. The application of the developed ar films is not only limited to crystalline Si solar cells explored here, but also compatible with any types of photovoltaic technology for performance enhancement.

关键词： antireflection crystalline Si solar cells flexible film

Mechanically induced Ca^(2+) oscillations in osteocytes release extracellular vesicles and enhance bone formation

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Bone Research 2018年第1期6卷 72-82页

作者： Andrea E.Morrell Genevieve N.Brown Samuel T.Robinson Rachel L.Sattler Andrew D.Baik Gehua Zhen Xu Cao Lynda F.Bonewald Weiyang Jin Lance C.kam X.Edward Guo Bone Bioengineering Laboratory Department of Biomedical Engineering Columbia University Center for Musculoskeletal Research Department of Orthopaedic Surgery Johns Hopkins University Indiana Center for Musculoskeletal Health Indiana University School of Medicine Microscale Biocomplexity Laboratory Department of Biomedical Engineering Columbia University

The vast osteocytic network is believed to orchestrate bone metabolic activity in response to mechanical stimuli through production of sclerostin, RANKL, and osteoprotegerin(OPG). However, the mechanisms of osteocyte mechanotransduction remain poorly understood. We've previously shown that osteocyte mechanosensitivity is encoded through unique intracellular calcium (Ca^(2+) ) dynamics. Here, by simultaneously monitoring Ca^(2+) and actin dynamics in single cells exposed to fluid shear flow, we detected actin network contractions immediately upon onset of flow-induced Ca^(2+) transients, which were facilitated by smooth muscle myosin and further confirmed in native osteocytes ex vivo. Actomyosin contractions have been linked to the secretion of extracellular vesicles(EVs), and our studies demonstrate that mechanical stimulation upregulates EV production in osteocytes through immunostaining for the secretory vesicle marker Lysosomal-associated membrane protein 1(LAMP1) and quantifying EV release in conditioned medium, both of which are blunted when Ca^(2+) signaling was inhibited by neomycin. Axial tibia compression was used to induce anabolic bone formation responses in mice, revealing upregulated LAMP1 and expected downregulation of sclerostin in vivo. This load-related increase in LAMP1 expression was inhibited in neomycin-injected mice compared to ***-computed tomography revealed significant load-related increases in both trabecular bone volume fraction and cortical thickness after two weeks of loading, which were blunted by neomycin treatment. In summary, we found mechanical stimulation of osteocytes activates Ca^(2+) -dependent contractions and enhances the production and release of EVs containing bone regulatory proteins. Further, blocking Ca^(2+) signaling significantly attenuates adaptation to mechanical loading in vivo, suggesting a critical role for Ca^(2+) -mediated signaling in bone adaptation.

关键词： OPG conditioned medium Ca2+-dependent

Determinants for asthma control, quality of life and use of complementary and alternative medicine in asthmatic pediatric patients in four cities

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World Journal of Pediatrics 2018年第5期14卷 482-491页

作者： kam Lun Hon Yan Min Bao Kate C.Chan Kin Wai Chau Rong-Shan Chen Kun Tat Gary Cheok Wa Keung Chiu Li Deng Chun-Hui He Kin Mui Ieong Jeng Sum C.Kung Ping Lam Shu Yan David Lam Qun Ui Lee So Lun Lee Ting Fan Leung Theresa N.H.Leung Lei Shi Ka Ka Siu Wei-Ping Tan Maggie Haitian Wang Tak Wai Wong Bao-Jing Wu Ada Y.F.Yip Yue-Jie Zheng Daniel K.Ng Department of Pediatrics The Chinese University of Hong Kong 6/F Prince of Wales HospitalRoom 84042ShatinN.THong Kong SARChina Department ofR espiratory Diseases Shenzhen Children’s HospitalShenzhen 518026China Hong Kong Society of P ediatric Respirology and Aller gy Hong K ong S ARChina Pediatric Respiratory andSleep Disorders Center Room 1315DArgyle Centre Phase 1688 Nathan RoadMongkokKowloonHong K ong S ARChina Department of R espiration Guangzhou Women and Children’s Medical CenterGuangzhou 510623China Department of P ediatrics Kiang Wu HospitalMacaoChina Department of P ediatrics and A dolescent Medicine United Christian Hospital130Hip Wo StreetKwun TongHong K ong S ARChina Department of P ediatrics Central Hospital Conde S.JanuarioMacaoChina Department of P ediatrics and A dolescent Medicine Caritas Medical Center111Wing Hong StreetSham Shui PoHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Tuen Mun Hospital23 Tsing Chung Koon RoadTuen MunNewT erritoriesHongK ongS ARChina Department of P ediatrics and A dolescent Medicine Princess Margaret Hospital2-10 Princess Margaret Hospital RoadLai Chi KokKowloonHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Queen Mary Hospital102Pokfulam RoadHong K ong S ARChina Department of P ediatrics and A dolescent Medicine The University of Hong KongHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Pamela Youde Nethersole Eastern Hospital3Lok Man RoadChaiwanHong K ong S ARChina Department of P ediatrics The University of Hong Kong-Shenzhen Hospital1Haiyuan 1st RoadFutianShenzhenChina Department of P ediatrics and A dolescent Medicine Kwong Wah Hospital25 Waterloo RoadKLN Hong K ong S ARChina Department of P ediatrics Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China JC School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong K ong S ARChina Department of P ediatrics and A dolescen

Background Asthma is a significant chronic health problem worldwide. Management aims at disease control by reducing functional impairment and exacerbations and improving quality of life (QoL). We report a multi-center study to survey asthma control and QoL in four cities in the Pearl River Delta. Methods The conjoint survey involved ten Hong Kong pediatric hospitals/units, two Shenzhen hospitals, two Macao hos-pitals, and two Guangzhou hospitals on asthma control (using Asthma Control Test) and QoL (Pediatric Allergic Disease Quality of Life Questionnaire, PADQLQ). Acceptability of a treatment is graded as very good/good/fair/poor. Results Good asthma control was only reported in 80% subjects in Hong Kong, but higher in sister cities (85–94%, Parious PADQLQ domains. Conversely, worse PADQLQ was associated with allergic rhinitis severity (B=4.77, P are some clinical and cultural differences among the four southern Chinese cities within the Guangdong province. This study identifies potentially modifiable environmental and treatment factors associated with poor asthma control and QoL for health-care interventions. Having a smoker in the family is independently associated with poor asthma control and QoL.

关键词： Asthma Complementary and alternative medicine Control Inhaled bronchodilator Inhaled corticosteroid Pediatric Allergic Disease Quality of Life Questionnaire Smoking Traditional Chinese medicine