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Dependent Randomization in Parallel Binary Decision Fu.ion

IEEE/CAA Jou.nal of Au.omatica Sinica 2021年第2期8卷 361-376页

作者： Weiqiang Dong Moshe kam the Department of Electrical and Compu.er Engineering New Jersey Institute of TechnologyUniversity HeightsNJ 07102 USA

We consider a parallel decentralized detection system employing a bank of local detectors(LDs)to access a commonly-observed *** system makes a binary decision abou. the phenomenon,accepting one of two hypotheses(H_(0)("absent")or H_(1)("present")).The kth LD u.es a local decision ru.e to compress its local observations yk into a binary local decision u.;u.=0 if the kth LD accepts H_(0)and u.=1 if it accepts H_(1).The kth LD sends its decision u. over a noiseless dedicated channel to a Data Fu.ion Center(DFC).The DFC combines the local decisions it receives from n LDs(u.(1),u.(2),...,u.(n))into a single binary global decision u.(0)(u.(0)=0 for accepting H_(0)or u.(0)=1 for accepting H_(1)).If each LD u.es a single deterministic local decision ru.e(calcu.ating u. from the local observations yk)and the DFC u.es a single deterministic global decision ru.e(calcu.ating u.(0)from the n local decisions),the team receiver operating characteristic(ROC)cu.ve is in general *** system's performance u.der a neyman-Pearson criterion may then be su.optimal in the sense that a mixed strategy may yield a higher probability of detection when the probability of false alarm is constrained not to exceed a certain valu.,α>***,a"dependent randomization"detection scheme can be applied in certain circu.stances to improve the system's performance by making the ROC cu.ve *** scheme requ.res a coordinated and synchronized action between the DFC and the *** this stu.y,we specify when dependent randomization is needed,and discu.s the proper response of the detection system if synchronization between the LDs and the DFC is temporarily lost.

关键词： Data fu.ion decision fu.ion dependent randomization parallel decentralized detection synchronization

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Targeting LIF/LIFR signaling in cancer

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Genes & Diseases 2022年第4期9卷 973-980页

作者： Su.yavathi Viswanadhapalli Kalarickal V.Dileep kam Y.J.Zhang Hareesh B.nair Ratna K.Vadlamu.i Department of Obstetrics and Gynecology University of Texas Health San AntonioSan AntonioTX 78229USA Laboratory for Stru.tu.al Bioinformatics Center for Biosystems Dynamics ResearchRIKENYokohamaKanagawa 230-0045Japan Evestra Inc.San AntonioTX 78245USA Mays Cancer Center University of Texas Health San AntonioSan AntonioTX 78229USA

Leu.emia inhibitory factor (LIF), and its receptor (LIFR), are commonly over-expressed in many solid cancers and recent stu.ies have implicated LIF/LIFR axis as a promising clinical target for cancer therapy. LIF/LIFR activate oncogenic signaling pathways inclu.ing JAK/STAT3 as immediate effectors and MAPK, AKT, mTOR fu.ther downstream. LIF/LIFR signaling plays a key role in tu.or growth, progression, metastasis, stemness and therapy resistance. Many solid cancers show overexpression of LIF and au.ocrine stimu.ation of the LIF/LIFR axis;these are associated with a poorer relapse-free su.vival. LIF/LIFR signaling also plays a role in modu.ating mu.tiple immu.e cell types present in tu.or micro environment (TME). Recently, two targeted agents that target LIF (hu.anized anti-LIF antibody, MSC-1) and LIFR inhibitor (EC359) were u.der development. Both agents showed effectivity in preclinical models and clinical trials u.ing MSC-1 antibody are in progress. This article reviews the significance of LIF/LIFR pathways and inhibitors that disru.t this process for the treatment of cancer.

关键词： LIF LIFR LIFR inhibitor STAT3 Targeted therapy

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