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Mortality Pattern in Intensive Care Unit: Experience at Abakaliki Southeastern Nigeria

World Journal of Cardiovascular Diseases 2020年第7期10卷 473-482页

作者： Chukwuemeka O. Eze Francis C. Okoro Thomas Nnaji Monday Nwobodo Uma kalu Richard Ewah Internal Medicine Department Alex Ekwueme Federal University Teaching Hospital Abakaliki (AEFUTHA) Ebonyi State Nigeria Anaesthesia Department Alex Ekwueme Federal University Teaching Hospital Abakaliki (AEFUTHA) Ebonyi State Nigeria

Background: An intensive care unit (ICU) is a special unit of a hospital that provides intensive treatment for patients with severe or life-threatening illnesses and injuries, which require constant care and close mon... 详细信息

g>Background: g>An intensive care unit (ICU) is a special unit of a hospital that provides intensive treatment for patients with severe or life-threatening illnesses and injuries, which require constant care and close monitoring with life support equipment. The mortality rate is still very high in most ICUs especially in the developing countries due to late presentation of patients, unavailability of well trained staff and lack of life support equipment. There has not been any previous study on the mortality pattern in ICU of Alex Ekwueme Federal University Teaching Hospital Abakaliki (AEFUTHA). It is against this background that we embarked on this retrospective descriptive hospital based study of the mortality pattern in ICU of a Tertiary Hospital in Abakaliki, South-eastern Nigeria. Method: This is a retrospective descriptive hospital based study. The admission and discharge registers of the ICU ward were used to extract information on biodata, diagnosis, duration and outcome of all admissions from January to December 2019 (12 months). Results: A total of 174 (male 113, female 71) patients were admitted over the 12 months period with mean age of 46.31 ± 12.28 years. Seventy-

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污秽地区高压架空线路绝缘子运行条件的模拟计算方法

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电瓷避雷器译丛 1997年第44期 51-54页

作者： kalu.,AJ 陈闽

现有的选择和计算污秽地区运行的高压绝缘子表面性能的方法，远不足以计算绝级子在电压和环境共同的作用的运行条件下的闪络时间。

关键词：模拟计算污秽高压架空线路绝缘子运行条件

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Reducing Side Effects of Chloroquine with Medicinal Synthetic Aluminum-Magnesium Silicate®[Msams: Al4(SiO4)3+ 3Mg2SiO4→2Al2Mg3(SiO4)3] before Assessing Its Anti-Covid-19 Efficacy

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Health 2020年第4期12卷 368-377页

作者： Maduike Ezeibe Favour Onyeachonam Ijeoma Ogbonna Clara Akpan Mary Sanda Ekenma kalu Njoku Njoku Munachi Udobi Ugochukwu Agu College of Veterinary Medicine M’ichael Okpara University of Agriculture Umudike Nigeria Directorate of Information Computer Technology Michael Okpara University of Agriculture Umudike Nigeria

To reduce Chloroquine’s (CQ) side effects, so that increasing its duration for anti-Covid-19 trials could be safe, the drug was potentiated by stabilizing it with Medicinal synthetic Aluminum-magnesium silicate (MSAMS). CQ-treatment for five Plasmodium berghie-infected mice-groups were: 7 mg/kg (normal dose);7 mg/kg (CQ-MSAMS);7 mg/kg (CQ-MSAMS + B-vitamins), 5.25 mg/kg (CQ-MSAMS + B-vitamins) and the control. Means of parasitaemia, 42.00 ± 15.74 of the normal-dose group, 37.22 ± 11.88 of the 7 mg/kg (CQ-MSAMS) group and 33.57 ± 12.62 of the 7 mg/kg (CQ-MSAMS + B-vitamins) group showed no significant (P ≥ 0.05) reduction from 52.50 ± 11.99 of the control, but the 5.25 mg/kg (CQ-MSAMS + B-vitamins) dose, cleared (P ≤ 0.01) the parasiteamia (00.00 ± 00.00), showing that MSAMS-potentiated Chloroquine, has best efficacy at 75% of the recommended dose. Fever and anemia were absent at that 5.25 mg/kg, suggesting that lower doses of CQ have reduced side effects.

关键词： Antiviral Treatment with Chloroquine Lower Doses Reduction of Side Effects MSAMS

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多底井剖面

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国外钻井技术 2000年第1期15卷 12-16页

作者： kalu.,AT 宋玉玲

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环境温度对热继电器和热脱扣器性能的影响

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电器与能效管理技术 1973年第4期 63-67页

作者： kalu Moschekoff 胡明忠

关于环境温度对使用于-10℃至+40℃范围内的热继电器和热脱扣器的脱扣特性曲线的影响,长期以来就一直在讨论着,然而至今还不是所有问题都已搞得一清二楚,并都在技术条件和技术标准中得到反映。为了使热继电器和热脱扣器能适用于不同的... 详细信息

关于环境温度对使用于-10℃至+40℃范围内的热继电器和热脱扣器的脱扣特性曲线的影响,长期以来就一直在讨论着,然而至今还不是所有问题都已搞得一清二楚,并都在技术条件和技术标准中得到反映。为了使热继电器和热脱扣器能适用于不同的气候地区,愈来愈要求扩大其适用温度范围,这也就使得论述这个问题更有意义。随着直接检测温度的保护元件的不断发展,研究这个问题的重要性有所下降,因为对于这种保护元件,并不存在扩大温度保护范围的问题。但仍可断言,由耗电设备电流加热的双

关键词：环境温度热脱扣器脱扣特性电器特性控制继电器热继电器极限电流

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An Evaluation of Cotinine as an Index of Exposure to Tabacco Smoke in Children with Recurrent Respiratory Tract Infections Using HPLC Method

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American Journal of Analytical Chemistry 2013年第7期4卷 54-62页

作者： Barbara Kamer Renata Pasowska Anna Matczak-Rynkowska Anna Socha-Banasiak Joanna kalużna-Czaplińska Wioletta grys Jacek Rynkowski 2nd Department of Pediatrics and Allergology Polish Mother’s Memorial Hospital Research InstituteLodzPoland Institute of general and Ecological Chemistry Lodz University of TechnologyLodzPoland

The authors evaluated the frequency of exposure to tobacco smoke among children suffering from respiratory tract infections. The investigations comprised 141 children aged from 2 months to 6 years that were treated in the 2nd Department of Pediatric and Allergology of Polish Mother’s Memorial Hospital Research Institute in ?ód? (Poland). 69 of them were exposed to tobacco smoke in their home environment. The remaining 72 children came from non-smoking families. 26 (37.7%) individuals among the passive smokers and 15 (20.83%) among the children from non-smoking families suffered from recurrent respiratory tract infections. Cotinine concentrations were evaluated in the group of 69 children using the HPLC-UV method. The determined average cotinine/creatinine index expressed as median was higher in passive smokers with recurrent respiratory infections than among passive smokers with non-recurrent respiratory infections. Moreover, it was stated that the exposure to cigarette smoke was more often among children of younger and less well educated parents as well as living in poor housing conditions. These studies clearly indicate that there is a need for extensive education on the harmful effects of passive smoking and the recurrence of infections.

关键词： HPLC Cotinine Urine Passive Smoking Respiratory Infections

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Assessment of Antiretroviral Efficacy of the Medicinal Synthetic Aluminum-Magnesium Silicate {Al₄(SiO₄)₃ + 3Mg₂SiO₄ → 2Al₂Mg₃(SiO₄)₃}

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World Journal of AIDS 2016年第2期6卷 74-80页

作者： Maduike C. O. Ezeibe Dahiru Aleeyu Nnaemeka K. Aneke Thompson N. Obarezi Ijeoma J. Ogbonna Ekenma kalu College of Veterinary Medicine Michael Okpara University of Agriculture Umudike Nigeria Basic Health Clinic Abuja Nigeria Medical Centre Michael Okpara University of Agriculture Umudike Nigeria

HIV/AIDS patients were treated, daily, with MSAMS (50 mg/kg), MSAMS-stabilized Ampicillin trihydrate (7.5 mg/kg) and immunace extra-protectionM? (1 tablet), for one month and then, with only MSAMS and the immune stimulants. They were tested, monthly, for viral loads and CD4- lymphocytes counts. Those whose viral loads became undetectable were tested for HIV confirmation (antigens/antibody). Their mean-viral load increased (P = 0.020) from 1820.30 ± 868.75 to 2855.90 ± 960.98 after first month, before reducing (P = 0.0.030) to: 1565.20 ± 743.17;759.20 ± 473.65;345.50 ± 115.01;192.80 ± 97.40;95.00 ± 55.80;37.40 ± 26.46;17.50 ± 16.88 (undetectable). Their mean-CD4 count was 496.80 ± 194.39 (lymphopenia). It reduced (P = 0.008) to 263.90 ± 149.26 after first month, before increasing (P = 0.001) to: 507.90 ± 133.19;692.70 ± 113.34;840.20 ± 139.41;1007.30 ± 163.50;1537.10 ± 302.10;1924.60 ± 247.45;2707.00 ± 837.87 (lymphocytosis). Patients whose viral loads became undetectable tested HIV-negative, one month after. CD4-lymphocytes count, approximating to zero-viral load, calculated from equation (Y = 2297.80 - 1.4731X) of line of best fit of graph of their viral loads onCD4-lymphocytes counts, was 1559.84/ml.

关键词： HIV MSAMS-Nanoparticles Opposite Electrical Charges HIV-Positive Lymphopenia HIV-Antigens/Antibody Negative Lymphocytosis

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Indigenous Fruit Trees of Tropical Africa: Status, Opportunity for Development and Biodiversity Management

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Agricultural Sciences 2015年第1期6卷 31-41页

作者： Rasheed Olufemi Awodoyin Oluseun Sunday Olubode Justin Ugochukwu Ogbu Rasheed Babatunde Balogun Jonah U. Nwawuisi kalu O. Orji Department of Crop Protection and Environmental Biology University of Ibadan Ibadan Nigeria Department of Horticulture and Landscape Technology Federal College of Agriculture (FCA) Ishiagu Nigeria Department of Pest Management Technology Federal College of Agriculture (FCA) Ishiagu Nigeria Department of Agronomy Michael Okpara University of Agriculture (MOUA) Umuahia Nigeria

Tropical fruit trees constitute important biological resources in the global agrobiodiversity context. Unlike the tropical fruit trees of American and Asian origin, indigenous fruit trees (IFT) of tropical Africa have scarcely achieved the status of international recognition in commodity markets and research arena outside Africa. This paper presented a critical review of the status of IFT in the Tropical African sub-regions (of West Africa, Central Africa, East Africa, Southern Africa and the Indian Ocean Islands) in relation to the introduced naturalised fruit trees from tropical America and Asia, threats to the diversity and sustainable use of IFT, analysis of the opportunities and challenges of developing IFT, as well as targets for crop improvement of the rich IFT of Tropical Africa. Domestication programme via relevant vegetative propagation techniques for priority IFT of the sub-regions was examined and advocated, in addition to the adoption of complementary conservation strategies, including Field geneBanks in the management of the continent’s IFT diversity.

关键词： Biodiversity Conservation Crop Improvement Domestication Indigenous Fruit Trees Introduced Species Tropical Africa

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结核分枝杆菌Ag85A DNA的克隆与原核表达

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微生物学杂志 2007年第3期27卷 16-20页

作者：姜燕 Azuma kalu 吕昌龙单风平中国医科大学基础医学院免疫学研究室辽宁沈阳110001

抗原85(Ag85)复合体是BCg合成分泌的可刺激机体产生细胞免疫和体液免疫应答。Ag85A是抗原85复合体组成成分之一,可显著刺激细胞免疫功能增强。研究构建了高效表达的pTrcHisB-Ag85A基因重组质粒,并将其转化至大肠埃希菌TOP10中进行重组... 详细信息

抗原85(Ag85)复合体是BCg合成分泌的可刺激机体产生细胞免疫和体液免疫应答。Ag85A是抗原85复合体组成成分之一,可显著刺激细胞免疫功能增强。研究构建了高效表达的pTrcHisB-Ag85A基因重组质粒,并将其转化至大肠埃希菌TOP10中进行重组蛋白的表达,筛选转化物,SDS-PAgE进行蛋白表达的分子量检测,并通过Western Blotting方法,应用抗Ag85A的单克隆抗体进一步确认重组Ag85A蛋白的表达,建立了Ag85A的原核表达体系,为进一步制备出有效的重组Ag85A疫苗奠定基础。

关键词：重组DNA Ag85A 结核分枝杆菌表达载体

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应用新一代目标区域捕获测序揭示视网膜色素变性患者的EYS基因突变

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中华眼视光学与视觉科学杂志 2016年第1期18卷 25-28页

作者：金卡露章峥嵘王毅嘉兴学院南湖学院 314000 嘉兴学院附属第一医院眼科 314000

目的应用新一代测序技术研究一例散发视网膜色素变性（RP）患者的致病基因突变位点及其临床表型。方法实验研究。收集一散发的RP家系，共3名家庭成员参与研究。其中1名患者，2名正常家属。采集3ml外周静脉血，提取基因组DNA，运用目标... 详细信息

目的应用新一代测序技术研究一例散发视网膜色素变性（RP）患者的致病基因突变位点及其临床表型。方法实验研究。收集一散发的RP家系，共3名家庭成员参与研究。其中1名患者，2名正常家属。采集3ml外周静脉血，提取基因组DNA，运用目标区域捕获测序技术来筛查目前已报道的201个遗传性视网膜疾病的致病基因，测序结果运用生物信息学分析得到候选基因，最后用Sanger测序验证。结果临床检查结果显示患者呈现典型的RP临床症状。遗传学筛查结果证实患者在EYS基因上存在2个复合杂合突变：1个杂合的错义突变（c．6416g〉A，P．C2139Y），1个杂合的无义突变（c．8012T〉A，p．L2671X）。Sanger测序结果证实为阳性并且分别遗传自父亲母亲，为常染色体隐性遗传。EYS基因被报道为RP的主要致病基因之一。结论本例患者的EYS基因存在2个杂合突变，是导致RP的致病原因。

关键词：视网膜炎色素性目标区域捕获测序 EYS基因基因突变

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