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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong Kai kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria v.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“varieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase vrcA and the cytochrome P450 ***,the replacement of vrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases variecolin

Flexible unimodal strain sensors for human motion detection and differentiation

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npj Flexible Electronics 2022年第1期6卷 708-717页

作者： Lu Jin Zhenhong Li Zekun Liu Bethany Richardson Yan Zheng Lulu Xu Zhongda Chen Heng Zhai Hongdoo Kim Qingwen Song Pengfei Yue sheng Quan Xie kap Jin Kim Yi Li Department of Materials School of Natural SciencesThe University of ManchesterManchesterUK College of Textile Science and Engineering Xi’an Polytechnic UniversityXi’anChina School of Electronic and Electrical Engineering University of LeedsLeedsUK Department of Advanced Materials Engineering for Information and Electronics Kyung Hee UniversityYonginSouth Korea Institute of Rehabilitation Engineering Binzhou Medical UniversityYantaiChina

Multiple strain sensors are required to identify individual forces/stresses on human joints and recognize how they work together in order to determine the motion’s direction and ***,current sensors cannot detect and differentiate the individual forces/stresses and their contributions to the motion from the sensors’electrical *** address this critical issue,we propose a concept of unimodal tension,bend,shear,and twist strain sensors with piezoelectric poly L-lactic acid *** then construct an integrated unimodal sensor(i-US)using the unimodal sensors and prove that the i-US can detect and differentiate individual strain modes,such as tensioning,bending,shearing,and twisting in complex *** demonstrate the potential impact of unimodal sensors,we design a sleeve and a glove with the i-US that can capture wrist motions and finger ***,we expect unimodal strain sensors to provide a turning point in developing motion recognition and control systems.

关键词： motion strain shearing

西伯利亚地台西南部地区金矿带的地质环境和形成条件(英文)

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成都理工学院学报 2002年第2期29卷 119-130页

作者： v.E.Kirillov N.v.Berdnikov v.A.Guryanov 阳正熙俄罗斯科学院远东分院地质研究所俄罗斯科学院远东分院大地构造和地球物理研究所俄罗斯联邦地质采矿企业成都理工大学

在阿尔丹 -斯坦洛沃依地盾的西伯利亚地台西南部地区划分出四个金矿带 :(1 ) Ket-Kep带 (主要由矽卡岩型、石英脉和网脉型、碳酸岩中的伊利石 -褐铁矿型以及伊利石 -绢云母交代型矿床或矿点构成 ) ;(2 ) Ulkan带 (伊利石 -云母交代型和... 详细信息

在阿尔丹 -斯坦洛沃依地盾的西伯利亚地台西南部地区划分出四个金矿带 :(1 ) Ket-Kep带 (主要由矽卡岩型、石英脉和网脉型、碳酸岩中的伊利石 -褐铁矿型以及伊利石 -绢云母交代型矿床或矿点构成 ) ;(2 ) Ulkan带 (伊利石 -云母交代型和石英脉型 ) ;(3 ) Dzhugdzhur带 (石英脉型和矽卡岩型 ) ;(4 ) Dzhugdyr带 (石英 -硫化物脉型 )。含矿矽卡岩成矿时代为中生代 ,而与石英和石英 -硫化物脉型有关的矿化形成于晚元古代、古生代和中生代。大多数中生代的金矿化都与岩浆作用有关。含金岩石的流体包裹体研究结果表明 ,高温成矿过程主要发生在 Dzhugdzhur带的矽卡岩 (5 0 0～ 71 5℃ )和 Ket-Kep带的热液交代型岩石 (5 1 0～ 5 3 0℃ )中 ,这些岩石的矿物流体包裹体中的水溶液盐度高达 40 % Na Cl当量 ,其子矿物主要为 Na,K,Ca的氯化物 ,并以存在 CO2 为特征。Ket-Kep带内高温 (高达 465℃ )和中温条件形成的石英脉和网脉中的流体包裹体盐度达 3 2 % Na Cl当量 ,包裹体中有时含低密度的 CO2 。 Dzhugdzhur带中的含金石英脉形成于 2 2 5～ 2 3 0℃ ,为低盐度成矿溶液 (1 %～ 2 % Na Cl当量 )。 Dzhugdyr带中含金石英 -硫化物脉的成矿温度为 2 60～ 3 90℃ ,成矿溶液为低盐度(1 .5 %～ 7.5 % Na Cl当量 ) KCl水?

关键词：西伯利亚地台阿尔丹-斯坦洛沃依地盾金成矿规律形成条件金矿床流体包裹体成矿温度

Prevalence and intensity of soil-transmitted helminth infections among school-age children in the Cagayan valley, the Philippines

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Asian Pacific Journal of Tropical Medicine 2021年第3期14卷 113-121页

作者： Ryan v.Labana vimar A.Romero Analette M.Guinto Alvin N.Caril Kimberly D.Untalan Alejandro Jose C.Reboa Khristine L.Sandoval Kristel Joy S.Cada Gary Antonio C.Lirio Iris Rowena A.Bernardo Lanieleen Jerah Mae Arocha Julieta Z.Dungca Department of Biology College of SciencePolytechnic University of the PhilippinesSta.MesaManilathe Philippines Graduate School Centro Escolar UniversityManilathe Philippines Center for Life Sciences Research Institute of Science and Technology ResearchPolytechnic University of the PhilippinesSta.MesaManilathe Philippines Department of Nutrition and Dietetics College of SciencePolytechnic University of the PhilippinesSta.MesaManilathe Philippines School of Science and Technology Centro Escolar UniversityManilathe Philippines

Objective:To identify the prevalence of soil-transmitted helminthiasis(STH)among school-age children in the Cagayan valley,the Philippines,assess their level of awareness on the disease,and determine predisposing factors of the ***:A total of 478 GradesⅢ-Ⅴschool-age children in Pamplona and Sanchez-Mira School Districts in the Cagayan valley answered the questionnaire assessing their knowledge,attitude,and practices on STH,subjected to anthropometric measurements,and provided faecal samples for parasitologic assessment(direct smear,Kato-Katz,and formol-ether concentration techniques).Results:The participants of the study,with 55.86%females,were 8 to 14 years *** nutritional status was assessed‘normal’(84.31%),‘severely wasted’(6.49%),‘wasted’(5.23%),‘overweight’(2.72%),and‘obese’(1.26%).The prevalence of infection with at least 1 STH species was 25.99%in Pamplona and 19.40%in ***,the prevalence of heavy intensity was 7.11%for Ascaris lumbricoides and 1.67%for Trichuris *** hookworm infections had light *** majority of the school-age children had a low score in the kap *** knowledge of STH,‘stunted growth as a symptom of infection’was associated with a lower risk of Ascaris lumbricoides infection(OR 0.448;95%CI 0.212,0.945;P=0.035)while‘playing with soil as a mode of transmission’was associated with an increased risk of Ascaris lumbricoides infection(OR 2.067;95%CI 1.014,4.212;P=0.046).In attitude towards STH,‘I think I have intestinal worm now’was associated with a higher risk of Ascaris lumbricoides infection(OR 1.681;95%CI 1.061,2.662;P=0.027).Conclusions:The prevalence rate of Ascaris lumbricoides among the school-age children in the Cagayan valley shows the need to further intensify intervention in the area to meet the threshold set by the World Health *** identified predictors of infection,which concerns the school-age children’s knowledge and attitude toward STH,can be used in augmenting

关键词： Intestinal worms War on worms Infectious disease Neglected tropical diseases

医科大学新生生殖健康问题的知识、态度、行为研究──性别因素应为制订生殖健康教育规划所考虑

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中国校医 1998年第4期12卷 241-245页

作者：于虹钱汉竹赵鹏飞顾世光 R.v.short 高源上海市计划生育科学研究所 200032 中华预防医学会 DepartmentofPerinatalMedicine RoyalWomen'sHospitalMelbourne3053Australia

目的探讨性别因素对大中学生性病／艾滋病／安全性行为生殖健康教育的影响。方法于1997年6月，对上海某医科大学266名年龄在16～23岁的新生（其中男性130名，女性136名）进行问卷调查。结果男生对绝大多数有关性生理、避孕、艾滋病和性... 详细信息

目的探讨性别因素对大中学生性病／艾滋病／安全性行为生殖健康教育的影响。方法于1997年6月，对上海某医科大学266名年龄在16～23岁的新生（其中男性130名，女性136名）进行问卷调查。结果男生对绝大多数有关性生理、避孕、艾滋病和性病问题的正确回答率明显较高。男生对婚前性行为持更宽容的态度，而对同性恋现象较多地持“应惩罚”的强硬态度。男生手淫、饮酒吸烟率高于女生。女生对性传播疾病的预防及性生理发育知识的需求大于男生，且较多地认为由专家教授和家长来传播生殖健康知识更合适，而男生更倾向于从同伴处获取信息。男女性行为发生率未见统计学差别，99％的男女学生认为有必要开展安全性行为教育。结论在制订生殖健康教育规划时应考虑性别因素。

关键词：生殖健康教育性别大学生新生

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医科大学新生生殖健康问题的kap研究

中国校医 1999年第4期13卷 245-247页

作者：钱汉竹赵鹏飞于虹顾世光 R.v.short 高源上海市计划生育科学研究所 200032 中华预防医学会 DepartmentofPerinatalMedicine

目的为了更好地在大中学生中开展预防性病／艾滋病／安全性行为的教育规划。方法于１９９７年６月对上海２６６名医科大学新生（年龄１６～２３岁，男１３０、女１３６）进行了问卷调查。结果发现对生理、艾滋病和性病知识的正确... 详细信息

目的为了更好地在大中学生中开展预防性病／艾滋病／安全性行为的教育规划。方法于１９９７年６月对上海２６６名医科大学新生（年龄１６～２３岁，男１３０、女１３６）进行了问卷调查。结果发现对生理、艾滋病和性病知识的正确了解率分别为６２％、７３％和５６％；恋爱、接吻、性交、手淫、使用避孕套、购买过避孕套等行为的发生率分别为２９％、１５％、１．２％、４５％、０．７％和４％。

关键词：生殖健康需求大学新生性病艾滋病

医科大学新生生殖健康问题的kap研究———艾滋病知识、态度的调查及启示

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生殖医学杂志 1998年第4期7卷 222-226页

作者：赵鹏飞钱汉竹于虹顾世光高源上海市计划生育科学研究所中国预防医学会

为了解低年级医科大学生的艾滋病知识和态度，以及他们对在大学生中开展预防艾滋病教育的看法，１９９７年６月对２６６名上海某医科大学一年级学生（年龄１６～２３岁，男１３０名、女１３６名）进行了问卷调查。调查显示，由于近年来... 详细信息

为了解低年级医科大学生的艾滋病知识和态度，以及他们对在大学生中开展预防艾滋病教育的看法，１９９７年６月对２６６名上海某医科大学一年级学生（年龄１６～２３岁，男１３０名、女１３６名）进行了问卷调查。调查显示，由于近年来大众媒体对艾滋病的广泛报道，大学新生对艾滋病有一般性了解，但不能正确判断接种疫苗、被蚊虫叮咬、共用坐厕、共用饮食器皿等途径能否传播艾滋病的比例，约为６９％、４８％、３８％和３０％；知道正确使用避孕套能降低感染艾滋病危险性的占６７％。提示，在一年级大学生中应加强艾滋病预防教育，澄清误解，对保护他们自己免受艾滋病威胁，以及在全社会开展控制艾滋病疫情的活动具重要意义。

关键词：医科大学新生生殖健康教育艾滋病