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Two types of uranium mineralization in Gulcheru quartzite:Fracture-controlled in Ambakapalle area and litho-controlled in Tummalapalle area,Cuddapah Basin,Andhra pradesh,India

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China Geology 2019年第2期2卷 142-156页

作者： Sukanta Goswami pradeep Kumar upadhyay Bhaskaran Saravanan V Natarajan Mohan Babu Verma Atomic Minerals Directorate for Exploration and Research Department of Atomic EnergyBangalore 560072India Atomic Minerals Directorate for Exploration and Research Department of Atomic Energy BegumpetHyderabad 500016India

The Cuddapah Basin in southern India has a potential for uranium mineralization due to some favorable factors such as its temporal, stratigraphic and tectonic settings. Systematic exploration program conducted by the Atomic Minerals Directorate for Exploration and Research (AMD) within the Cuddapah Basin resulting in the recognition of distinct types of uranium mineralization, viz., strata bound type, fracture/shear-controlled type and tabular type. The Gulcheru Formation which is the lowermost unit of the Cuddapah Basin is dominantly arenitic in nature. During the exploration works, a number of uranium anomalies were identified with dimensions ranging from 1 m to 1.5 km. Gulcheru quartzite hosted uranium mineralization is intermittent and inconsistent in nature. The anomalous outcrops are distributed over a strike length of ca. 60 km between Gandi in the SE and Ambakapallein the NW. presently, two different types of uranium mineralization are characterized on the basis of field observations, mapping and structural interpretation, petro-mineralogy and geochemistry. Although the host rock is same for both types, the mechanism of uranium enrichment is totally different. The Ambakapalle uranium mineralization is controlled by fault zone and associated hydrothermal activity. Whereas, the Tummalapalle uranium mineralization is litho-controlled in nature influenced by suitable four ‘p’ factors, i.e., provenance, porositypermeability, precipitation and preservation. The geochemical characterization of Gulcheru quartzite suggest a passive margin type of provenance setting. petro-mineralogically the quartz arenite suggests enough textural as well as mineralogical maturity. Ambakapalle quartzite is slightly strained and deformed due to faulting. Analysis of selected samples recorded 0.01% to 0.048% U3O8 and petrographic observation revealed that the anomalies were appeared due to secondary uranium minerals occurring as surficial encrustations, fracture filling an

关键词： Uranium mineralization Fracture-controlled mineralization Litho-contralled mineralization Gulcheru quartzite Hydrothermal alteration Andhra pradesh India

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Effect of purified paper Wasp Ropalidia marginata Venom Toxins on Different Biomolecules in Mice Serum

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Journal of Biosciences and Medicines 2023年第5期11卷 55-75页

作者： Simran Sharma Ravi Kant upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

This study evaluated the effects of purified paper wasp Ropalidia marginata venoms on various biomolecules in the blood serum of albino mice. Changes in the concentration of some important macromolecules, i.e., proteins, free amino acids, uric acid, cholesterol, pyruvic acid, total lipids and glucose were noted down. These alterations were measured after intraperitoneal injection of 40% and 80% 24-hour LD50 purified Ropalidia marginata venom toxin. Serum total protein levels were found to decrease to 78% after 6 hrs, while serum free amino acid levels were significantly increased to 117% 6 hrs after venom injection compared to control. It was also found that serum uric acid levels increased to 138% after 8 hrs of venom injection compared to control. The increase in serum cholesterol i.e. (101% and 106%) and pyruvic acid increased significantly to a maximum value of 106% after 6 hrs of treatment at 40% LD50. Glycogen levels in the gastrocnemius muscle were found to decrease significantly (p-0.05) to 43% and 92% at LD50 after injection of purified Ropalidia marginata venom after 8 h and 80% at LD50 compared to control. Moreover, up to 71% and 81% were obtained at 10 hrs of treatment with the same dose. In the present study, the purified toxins significantly changed the levels of biomolecules in blood serum, indicating their wider effects on cellular physiology due to toxic effects and stress on the animal. These toxins can be good antigens and stimulate immune responses in experimental mice.

关键词： paper Wasp Venom and Toxin Lethal Effects Blood Serum Biomolecules

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Effect of purified paper Wasp Ropalidia marginata Venom Toxin Enzyme Activity in Blood Serum, Liver, and Gastrocnemius Muscle of Albino Mice

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Advances in Enzyme Research 2023年第3期11卷 113-145页

作者： Simran Sharma Ravi Kant upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In the present, investigation effects of sub-lethal dose of purified paper wasp Ropalidia marginata venom toxins were evaluated on important metabolic enzymes i.e. ALp ACp, GpT, GOT, LDH, and AchE enzyme activity in serum, liver, and gastrocnemius muscles of albino mice. Alkaline phosphatase was found to be increased up to 119.9% at the 6p>thp> hr of the toxin injection in comparison to control. This elevation may be due to cytolysis. Maximum increase i.e., 153.33% level of glutamate pyruvate transaminase (GpT) was found at 6 hrs of 40% of 24-h LD50 treatment while it was found to be 151.1% at 6 hrs of 24 hr 80% of LD50, venom injection. A significant elevation was observed in LDH activity in serum, liver, and muscles, while the activity of AchE was decreased in serum, liver, and gastrocnemius muscles of albino mice after injecting the sub-lethal dose of Ropalidia marginata venom. This increase in the activity of LDH produces liver damage, massive disintegration and necrosis of hepatic cells. This elevation in LDH level led to a significant increase in the glucose catabolism and elevated oxidative stress in muscle and liver cells. It also displays insufficient oxygen supply and consequently leads to cell death. In experimental animals, venom toxin treatment decreased AchE level, and animals showed muscular paralysis. When mice were treated with 40% and 80% of 24-h LD50 of purified venom caused a significant (p p, GOT, GpT, and LDH while the reduction in ALp and AChE level. present study will be useful in the development of prototypes for study of pharmacological and therapeutic effects of various venom toxins. For this purpose structure activity relationship of enzyme and venom toxin, its due interaction to various metabolic enzymes and receptors must be explored.

关键词： Ropalidia marginata Serum Liver and Rectus Abdominis Gastrocnemius Muscle Atria and Ventricle Acid phosphatase (ACp) Alkaline phosphatase (ALp) Glutamate pyruvate Transaminase (GpT) and Glutamate Oxaloacetate Transaminase (GOT) Lactic Dehydrogenase (LDH) Acetylcholinesterase (AchE)

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Toxicity of Tagetes erecta Essential Oil Based Combinatorial Formulations on Various Metabolic Enzymes in Indian White Termite Odontotermes obesus

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Advances in Enzyme Research 2023年第2期11卷 58-81页

作者： Susheel Kumar Ravi Kant upadhyay Department of Zoology (Environmental Science) Deen Dayal Upadhyaya Gorakhpur University Uttar Pradesh India

plant essential oils and their constituents have proven to be very effective against insects, especially termites. They are the best alternative to synthetic pesticides that are harmless to the environment and human health. In the present study, different enzymes, namely alkaline phosphatase, acid phosphatase, glutamate-oxaloacetate transaminase, glutamate-pyruvate transaminase and acetylcholinesterase, were evaluated in Indian termite Odontotermes obesus in a combination preparation based on Tagetes erecta essential oil. For the study of anti-termite effects against worker termites were treated topically with 40% and 80% of the 24-hour LD50 values of various combination formulations. Subsequent bioassays at 40% and 80% of LD50 of combinatorial preparations S-AST-A, S-AST-B, and S-AST-C resulted in a significant (p > 0.05) decrease in glutamate-oxaloacetate transaminase. After 16 hours of treatment, they were 87.92%, 80.17%, 89.30%, 79.17%, 81.92% and 73.17% respectively. In vivo exposures of 40% and 80% of the LD50 of the combination formulation caused a highly significant (p > 0.05) reduction (p > 0.05) of all test enzymes tested compared to controls. The effects of different oil formulations exhibited time- and dose-dependent responses, resulting in physiological changes in the concentrations of various enzymes. The combined mixture of Tagetes erecta essential oils has significantly better anti-termite ability compared to inorganic insecticides. Findings from this study will help support termite control in fields, gardens and homes in a sustainable way, without the downsides of insecticide resistance and pollution. These could potentially be used to produce commercial formulations for use against pests.

关键词： Tagetes erecta Essential Oils Odontotermes obesus Enzymes Inhibition Termiticidal Action

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Biochemical Alterations and Termiticidal Activity of Combinatorial Essential Oil Ingredients of Citrus maxima on Indian White Termite Odontotermes obesus

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Journal of Biosciences and Medicines 2023年第4期11卷 60-81页

作者： Lokpriy pandey Ravi Kant upadhyay Department of Zoology (Environmental Science) Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

Essential oils are better alternative for synthetic termiticides with the inherent resistance by insects, environmental and health effects on humans. In present investigation, various bio-molecules i.e. glycogen, protein, amino acid, DNA, RNA and lipid were evaluated to determine the anti-termite efficacy of Citrus maxima essential oil based combinatorial formulations against Indian white termite Odontotermes obesus. For this purpose, termites were treated topically with 40% and 80% of 24 hr LD50 values of various combinatorial formulations. A significant (p > 0.05) alteration was noted in all the above biomolecules at various time intervals. Both dose response and time period was found important in physiological alteration in levels of various bio-molecules. Combinatorial mixtures of Citrus essential oils have shown synergistic activity against termites. The research outcomes of present investigation would help to open sustainable way to termite control in crop field, gardens and houses.

关键词： Citrus maxima Essential Oils Odontotermes obesus Bio-Molecules Inhibition Termiticidal Action

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Toxic Effects of Citrus maxima Based Combinatorial Formulations on Important Metabolic Enzymes in Indian White Termite Odontotermes obesus

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Advances in Enzyme Research 2023年第2期11卷 11-33页

作者： Lokpriy pandey Ravi Kant upadhyay Department of Zoology (Environmental Science) Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In the present study, Citrus maxima essential crude oil extract was used to prepare combinatorial formulations and workers of Indian white termite Odontotermes obesus were treated topically with 40% and 80% of 24 hr LD50 values of these formulations. In subsequent bioassays levels of various enzymes i.e. alkaline phosphatase, acid phosphatase, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and acetylcholinesterase were evaluated to determine the anti-termite efficacy of Citrus maxima essential oil based combinatorial formulations. S-RET-A, S-RET-B and S-RET-C caused significant (p > 0.05) decrease in glutamate oxaloacetate transaminase i.e. 87.47%, 86.81% and 81.77% & 82.04%, 79.39% and 74.75% respectively at 16 h treatment. In vivo exposure of 40% and 80% of LD50 of combinatorial formulations caused very significant (p > 0.05) reduction in all the test enzymes i.e. alkaline phosphatase, acid phosphatase, glutamate oxaloacetate transaminase and glutamate pyruvate transaminase expect acetylcholinesterase levels after 16 h all tested treatments in comparison to control. Both dose-response and time period were found important in physiological alteration in levels of various enzymes. Combinatorial mixtures of Citrus essential oils have shown synergistic activity against termites. The research findings of the present study would help termite control in crop fields, gardens and houses in a sustainable way.

关键词： Citrus maxima Essential Oils Odontotermes obesus Enzymes Inhibition Termiticidal Action

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Termiticidal and Biochemical Activity of Combinatorial Essential Oil Ingredients of Tagetes erecta on Indian White Termite Odontotermes obesus

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Journal of Biosciences and Medicines 2023年第4期11卷 114-136页

作者： Susheel Kumar Ravi Kant upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In present investigation, various bio-molecular parameters i.e. glycogen, protein, amino acid, DNA, RNA and lipid, were determined for evaluation of anti-termite efficacy of Tagetes erecta essential oil based combinatorial formulations against Indian white termite Odontotermes obesus. For this purpose, 40% and 80% of 24 hrs of LD50 values of various formulations were provided for treatment of termite workers. Observations were taken at 4 hrs time interval up to 16 hrs to know inhibitory activity of these combinatorial mixtures on termite species Odontotermes obesus. Significant (p > 0.05) alterations were observed in the level above mentioned bio-molecules when termites were treated with different combinatorial essential oils ingredients of Citrus maxima. Combinatorial mixtures of Tagetes erecta essential oils have shown synergistic activity against termites. This study will provide an overall sustainable way to termite control in crop field, gardens and houses. It also suggests use of essential oils as better alternative of synthetic termiticides as these are safer for environmental and human health.

关键词： Tagetes erecta Odontotermes obesus plant Essential Oils Termiticides Bio-Molecules Inhibition Sustainable

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Effect of Ficus benghalensis Latex Based Combinatorial Formulations on Various Bio-Molecules in Indian White Termite Odontotermes obesus

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Journal of Biosciences and Medicines 2023年第4期11卷 82-102页

作者： Abhishek Kumar Tripathi Ravi Kant upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In present investigation, various bioassays were conducted to evaluate the alteration in levels of certain biomolecules, such as glycogen, protein, amino acid, DNA, RNA and lipids. For this purpose, worker termites were treated with sub-lethal dose 40% and 80% of 24 hrs LD50 values and observations were taken at 4 hrs interval up to 24 hrs. Crude latex and its combinatorial mixtures, like S-MLT-A, B-MLT-A, C-MLT-A, CU-MLT-A, AQ-MLT significantly altered level of bio-molecules in Odontotermes obesus. This effect was found time and dose dependent. Reduction or increase in biomolecules was calculated by using corresponding control. Maximum decrease in glycogen level was observed at 16 h when termites were treated with 80% of LD50 of Ficus benghalensis aqueous extract i.e. 56.88% at 16 h of treatment. A similar dose caused very slight decrease in lipid contents at 4 h of treatment but it was found further significantly (p > 0.05) decreased in other successive treatments. 40% and 80% of LD50 of C-MLT-B mixture caused significant (p > 0.05) decrease in DNA and RNA level at 16 h treatment. The level of DNA and RNA level was recorded 83.90%, 90.18% and 85.42% and 74.05% respectively. Similarly, total proteins were also found to be decreased with 40% and 80% of LD50 of C-MLT-B mixture i.e. 71.47% and 66.45% respectively. All these alterations found in levels of various bio-molecules confirm the action of latex ingredients on worker termites that was antifeedant or deterrent types. These ingredients can be used to control not only termites but also other phytophagous insects in a sustainable and eco-friendly way.

关键词： Ficus benghalensis Odontotermes obesus Latexes Antifeedant or Deterrent Termiticides

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Toxic Effects of Ficus benghalensis Latex Based Combinatorial Formulations on Various Enzymatic parameters in Indian White Termite Odontotermes obesus

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Advances in Enzyme Research 2023年第2期11卷 34-57页

作者： Abhishek Kumar Tripathi Ravi Kant upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In the present investigation, various bioassays were conducted to evaluate the alteration in levels of various enzymes i.e. alkaline phosphatase, acid phosphatase, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and acetylcholinesterase. For this purpose worker termites were treated with sub-lethal doses of 40% and 80% of 24 hrs LD50 of latex-based combinatorial formulations and observations were taken at 4 hours intervals up to 24 hours. Ficus benghalensis crude latex and its combinatorial mixtures, like C-MLT-A, CU-MLT-A, AQ-MLT, p-MLT and EA-MLT significantly altered the level of enzymes in Odontotermes obesus and this effect found time and dose-dependent. Reduction or increase in enzymes was calculated by using the corresponding control. The maximum decrease in acid phosphatase level was observed at 16 h when termites were treated with 80% of LD50 of B-MLT-B and p-MLT i.e. 82.84% at 16 h of treatment. A similar dose caused a very slight decrease in glutamate pyruvate transaminase at 4 h of treatment but with the increase in time. Further decrease was noted in other successive treatments that were significant at p > 0.05. Similarly, 40% and 80% of LD50 of the C-MLT-B mixture caused significant (p > 0.05) decrease in alkaline phosphatase and acid phosphatase level at 16 h treatment i.e. 93.42%, 89.46% and 95.89%, 88.17% respectively. The level of acetylcholinesterase was also found to be decreased when termites were treated with 40% and 80% of LD50 of C-MLT-B mixture i.e. 92.72% and 97.27% respectively. All the above alterations noted in levels of various enzymes confirm the action of latex ingredients on worker termites that were anti-feedant or deterrent types. These ingredients can be used to control not only termites but also other phytophagous insects.

关键词： Ficus benghalensis Enzymes Alteration Odontotermes obesus Latexes Anti-Feedant Termiticides

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Effect of Helicobacter pylori-eradication therapy on hepatic steatosis in patients with non-alcoholic fatty liver disease:a randomized–controlled pilot study

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Gastroenterology Report 2020年第2期8卷 104-110,I0001,I0002页

作者： Vikas Maharshi pooja Gupta Vijay L.Kumar Ashish Datt upadhyay prasenjit Das Rajni Yadav Baibaswata Nayak Ramesh Kumar Shalimar Department of pharmacology All India Institute of Medical SciencesNew DelhiIndia Department of Biostatistics All India Institute of Medical SciencesNew DelhiIndia Department of pathology All India Institute of Medical SciencesNew DelhiIndia Department of Gastroenterology All India Institute of Medical SciencesNew DelhiIndia

Background:Helicobacter pylori infection has been associated with insulin resistance and non-alcoholic fatty liver disease(NAFLD).This study was done to evaluate the effect of ***-eradication therapy(HpET)in patients with NAFLD compared to standard management therapy(SMT).Methods:Eighty NAFLD patients with *** co-infection were randomized into SMT(diet and exercise,n=36)and HpET(SMT plus amoxicillin,clarithromycin,and pantoprazole,n=44)*** controlled attenuation parameter(CAp),anthropometric parameters,liver enzymes,lipid profile,and glycemic parameters including homeostasis model assessment-insulin resistance(HOMA-IR)were measured and compared between two groups at the baseline and 24 ***:Sixty-four participants(SMT group[n=28]and HpET group[n=36])were included in amodified intention-to-treat *** the SMT group and the HpET group had a significant reduction in CAp scores at 24weeks(p=0.002 and ppectively),but the change between the groups was insignificant(p=0.213).Successful eradication of *** occurred in 68%of the HpET group and led to greater improvement in HOMA-IR at 24weeks compared to SMT or non-responder patients(p=0.007).The liver enzymes reduced significantly at 24weeks in both groups,but the changes between the groups were *** lipid parameters remained unchanged within the groups and between the groups at 24weeks.A significant increase in the levels of reduced glutathione was noted in the HpET group,but the change between the two groups was not statistically ***:HpET was found to be comparable to SMT alone in reducing hepatic steatosis and liver enzymes at 24 weeks in NAFLD ***,successful eradication of *** led to greater improvement in HOMA-IR(Trial registration CTRI/2017/05/008608).

关键词： non-alcoholic fatty liver disease H.pylori infection H.pylori-eradication therapy controlled attenuation parameter insulin resistance

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