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Metagenomic insights into seasonal variations in the soil microbial community and function in a Larix gmelinii forest of Mohe,China

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Journal of Forestry Research 2021年第1期32卷 371-383页

作者： Tong Bao Shilin Deng kaiyue yu Weiyi Li Airong Dong Department of Forest Protection College of ForestryNortheast Forestry UniversityHarbin 150040People’s Republic of China

The eff ect of seasons on the soil microbiome in a Larix gmelinii forest of Mohe,China,where winter temperatures are generally below−40°C,was evaluated with metagenomics *** profi ling using sequencing information revealed that Proteobacteria,Actinobacteria,Acidobacteria and Verrucomicrobia were the dominant phyla in spring,summer,and fall,as were Bradyrhizobium,Chthoniobacter,Streptomyces,Acid Candidatus Koribacter at the genus *** species that were abundant in spring and fall greatly diminished in abundance in *** of orthologous groups(COG)of proteins,carbohydrate-active enzymes(CAZy),Kyoto Encyclopedia of Genes and Genomes(KEGG)and NCBI databases were used to elucidate the function of diverse proteins and metabolites of the microbial community of *** *** analysis showed that fewer genes were detected in spring than in fall and summer,indicating that many soil microbes in the *** forest were not tolerant to *** on KEGG analysis,some pathways in the soil microbes were activated in spring and autumn and deactivated in *** analysis revealed that most CAZy were more active in summer than in spring or autumn and were severely inhibited in the *** functional pathways,proteins,and CAZy involved in the community changes were concerned with cold or heat ***,the soil in the *** forest can be a valuable resource for further research on heat and cold tolerance of soil microbes.

关键词： Soil microbial community Microbial function Metagenomic Seasonal variation

Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis

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Acta Pharmaceutica Sinica B 2021年第2期11卷 505-519页

作者： kaiyue yu Xiuming yu Sisi Cao Yixuan Wang yuanhao Zhai Fengdie Yang Xiaoyuan Yang Yi Lu Chuanbin Wu yuehong Xu School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China

Psoriatic arthritis(PsA)is a complicated psoriasis comorbidity with manifestations of psoriatic skin and arthritic joints,and tailoring specific treatment strategies for simultaneously delivering different drugs to different action sites in PsA remains *** developed a need-based layered dissolving microneedle(MN)system loading immunosuppressant tacrolimus(TAC)and antiinflammatory diclofenac(DIC)in different layers of MNs,i.e.,TD-MN,which aims to specifically deliver TAC and DIC to skin and articular cavity,achieving simultaneous alleviation of psoriatic skin and arthritic joint lesions in *** vitro and in vivo skin permeation demonstrated that the inter-layer retained TAC within the skin of~100μm,while the tip-layer delivered DIC up to~300μm into the articular ***-MN not only efficiently decreased the psoriasis area and severity index scores and recovered the thickened epidermis of imiquimod-induced psoriasis but also alleviated carrageenan/kaolin-induced arthritis even better than DIC injection through reducing joint swelling,muscle atrophy,and cartilage ***,TD-MN significantly inhibited the serum TNF-αand IL-17 A in psoriatic and arthritic *** results support that this approach represents a promising alternative to multi-administration of different drugs for comorbidity,providing a convenient and effective strategy for meeting the requirements of PsA treatment.

关键词： Layered microneedles Need-based drug delivery Tacrolimus Diclofenac sodium Psoriasis Psoriatic arthritis

Menthol based microemulsion and gel containing tacrolimus for atopic dermatitis therapy: Enhancing the percutaneous delivery and antipruritic efficacy

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Menthol based microemulsion and gel containing tacrolimus fo...

Combination of hydroxypropyl-β-cyclodextrin with nanoemulsion for enhancing resveratrol percutaneous delivery and treatment in skin photoaging

2018年第十二届中国药物制剂大会

作者：王艺璇 Sisi Cao kaiyue yu yuehong Xu School of Pharmaceutical Sciences Sun Yat-sen University

Objective: Menthol, originating from natural plant, is widely used in dermatology as antipruritic, analgesic and cooling formulations. Pruritus is an emblematical feature of atopic dermatitis（AD） that triggers scratch resulting in exacerbation of AD symptoms. In this study, menthol mixed with camphor forming eutectic was first applied in oil phase of microemulsion（ME） and ME-Gel loaded tacrolimus（FK506）, which promoted to solubilize FK506, enhance percutaneous penetration and retention of FK506, effectively contributing to AD therapy and pruritic relief. Methods: ME and ME-Gel containing tacrolimus were performed for skin permeation studies in vitro. The MTT assay certificated security of ME. The AD-like symptoms of DNCB-induced BALB/c mice were treated with ME and ME-Gel, appraised by dermatitis score, TEWL, histopathological studies, NF-?B and serum IgE expression. Antipruritic efficacy was demonstrated by immunofluorescent staining of substance P. Results: ME and ME-Gel groups increased approximately 1.5-fold higher than commercial preparation group in skin retention. Blank vehicle was confirmed without cytotoxicity. Attributing to inhibition of NF-?B expression, serum IgE and substance P, topical administration of ME and ME-Gel could visibly alleviate AD symptoms. In addition, scratching frequency induced by pruritus was reduced dramatically. Conclusions: Menthol based ME and ME-Gel containing FK506 were prepared to increase the solubility of drug, enhance its permeation and retention into skin. The topical administration of ME and ME-Gel could visibly alleviate inflammation response of AD-like skin lesions in BALB/c mice. Moreover, menthol played a significant role in anti-itching and adjuvant therapy.

关键词： Tacrolimus Microemulsion Menthol Atopic dermatitis Transdermal delivery Antipruritic

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Combination of hydroxypropyl-β-cyclodextrin with nanoemulsi...

国外马克思主义的中国特色社会主义道路性质观辨析

2018年第十二届中国药物制剂大会

作者：曹思思 yueming Long Yixuan Wang kaiyue yu yuanhao Zhai yuehong Xu School of Pharmaceutical Sciences Sun Yat-sen University

Repeated UV exposure can cause cutaneous oxidative stress and inflammation, resulting in premature skin photoaging, and even skin cancer. Resveratrol（RES） has arisen increasing attention due to its antioxidant and anti-inflammatory properties in addition to its amicable safety profile. However, the shortcomings such as its poor solubility, chemical instability, and low oral bioavailability have limited its application. This study was to prepare a hydroxypropyl-β-cyclodextrin（HP-β-CD） combined with nanoemulsion（NE） formulation to encapsulate resveratrol（RES-CD-NE）, increasing the solubility and the stability of resveratrol. RES-CD-NE consisted of oil phase（Labrafil M 1994 CS）, surfactant and co-surfactant（Solutol HS15 and Transcutol P）, 15%（w/w） HP-β-CD solution and 1%（w/w） RES. 1 H NMR spectra strongly confirmed the inclusion complex formation of RES and HP-β-CD. RES was encapsulated effectively and the stability was improved, resulting in the excellent transdermal efficiency both in vitro and in vivo skin permeation studies. The cell experiment verified that RES-CD-NE had higher cellular uptake efficiency, thus reducing the level of ROS and enhancing skin permeation. The wrinkles, roughness, dryness and laxity caused by photoaging were prevented and the activity of antioxidant enzymes superoxide dismutase（SOD） in the skin was improved after RES-CD-NE treatment. In conclusion, HP-β-CD combined with NE could encapsulate resveratrol effectively. The solubility and the stability of RES were improved. RES-CD-NE showed a promising prospect in photoaging treatment.

关键词： Resveratrol nanoemulsion hydroxypropyl-β-cyclodextrin transdermal drug delivery system photoaging

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海派经济学 2022年第4期20卷 170-185页

作者：马津润余凯月丁晓钦上海财经大学马克思主义学院中国政治经济学学会海派经济学专业委员会上海财经大学海派经济学研究院世界政治经济学学会上海市习近平新时代中国特色社会主义思想研究中心

改革开放四十余年来,中国取得的成就举世瞩目。中国特色社会主义道路成为国外马克思主义学者关注的焦点。但是对于如何判断中国特色社会主义道路性质,国外学者存在着一定的分歧和误解。国外马克思主义学者对于中国特色社会主义道路性质... 详细信息

改革开放四十余年来,中国取得的成就举世瞩目。中国特色社会主义道路成为国外马克思主义学者关注的焦点。但是对于如何判断中国特色社会主义道路性质,国外学者存在着一定的分歧和误解。国外马克思主义学者对于中国特色社会主义道路性质的认识主要有以下四种错误观点:一是“市场社会主义”观;二是“资本主义”观;三是“多种经济体制结合”观;四是“第三条道路”观。究其原因,在于国外马克思主义学者对于社会主义的认识及评判标准存在偏差,对中国特色社会主义道路性质的研究存在片面性,并忽视中国共产党在中国特色社会主义道路中发挥的作用。正确认识中国特色社会主义道路性质,应从中国特色社会主义道路的目标、领导力量、经济建设、政治建设、文化建设、社会建设以及生态文明建设七个方面的视角进行深入分析。

关键词：中国特色社会主义道路国外马克思主义科学社会主义

基于数据挖掘探讨中药治疗妊娠恶阻的用药规律

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世界中医药 2024年第3期19卷 403-409页

作者：王凯悦常惠王宇朱梦一吴效科黑龙江中医药大学哈尔滨150040 黑龙江中医药大学附属第一医院哈尔滨150040 黑龙江省医院哈尔滨150030

目的:借助于中医传承辅助平台系统(V2.5)与数据挖掘技术,探讨现代临床研究文献中,中药治疗妊娠恶阻的用药规律,为临床实践诊疗提供理论依据。方法:检索中文数据库中临床研究文献,提取文献数据,建立数据库,通过中医传承辅助平台系统(V2.5... 详细信息

目的:借助于中医传承辅助平台系统(V2.5)与数据挖掘技术,探讨现代临床研究文献中,中药治疗妊娠恶阻的用药规律,为临床实践诊疗提供理论依据。方法:检索中文数据库中临床研究文献,提取文献数据,建立数据库,通过中医传承辅助平台系统(V2.5)对用药进行频次统计、关联规则分析、聚类分析等。结果:本研究共纳入文献121篇,纳入处方139首,涉及中药99味;平均使用频次为12.22次,使用频次≥13次的中药有22味,前5味中药分别是半夏、陈皮、甘草、竹茹、白术;使用中药四气顺序为:温性、寒性、平性、凉性、热性;五味顺序为:甘、辛、苦、酸、涩、咸;归经顺序为:脾经、胃经、肺经、心经、肾经、肝经、大肠经、胆经、小肠经和三焦经。通过关联规则对组方规律进行分析,得出常见药对及药物组合,其中核心药物组合为“半夏,陈皮,甘草”;通过复杂系统熵层次聚类分析得出潜在核心药物组合16个(8组),在此基础上进行无监督的熵层次聚类分析得出潜在新方组合8个。结论:治疗妊娠恶阻的高频中药多以补虚、化痰、理气、化湿药为主,且多具有止呕、保护胃黏膜、调节肠道菌群、调节胃肠道功能等作用;核心药物组合及潜在新方多以健脾益气、清热泻火、化痰行滞、养阴生津安胎为主。

关键词：妊娠恶阻中医传承辅助平台数据挖掘用药规律健脾益气清热泻火化痰行滞养阴生津安胎

气候变化背景下珠江口地区台风风暴潮和流域洪水遭遇事件的风险探究

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中国水利 2024年第14期 27-32页

作者：余锡平张安一方单楷越南方科技大学深圳518055 清华大学北京100084

珠江三角洲是我国开放程度最高、经济活力最强的区域之一,该地区易受超强台风风暴潮和流域特大洪水等极端事件的侵袭,其复合作用的风险也不可忽视。全球气候变化更是增添了珠江三角洲地区防洪安全的复杂性。系统分析珠江口地区复合洪水... 详细信息

珠江三角洲是我国开放程度最高、经济活力最强的区域之一,该地区易受超强台风风暴潮和流域特大洪水等极端事件的侵袭,其复合作用的风险也不可忽视。全球气候变化更是增添了珠江三角洲地区防洪安全的复杂性。系统分析珠江口地区复合洪水的发生条件与致灾风险,提出精准防灾减灾措施,对保障珠江三角洲地区的长治久安和可持续发展具有重要意义。本研究表明,珠江口地区的台风风暴潮和流域洪水的间隔窗口期呈逐步缩小趋势,二者叠加产生复合灾害的潜在风险呈逐步增加趋势。

关键词：珠江口台风风暴潮流域洪水复合灾害气候变化

滨海海底边界层对底栖微体化石仿真模拟的影响

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地学前缘 2024年第2期31卷 410-422页

作者：张毅恒张涛雍媛媛鱼驰洋肖巨月何凯悦王邓王星王宾杨晓光韩健西北大学信息科学与技术学院陕西西安710069 西北大学地质学系大陆动力学国家重点实验室/早期生命与环境陕西省重点实验室陕西西安710069 临沂大学生命科学学院山东临沂276000

计算流体力学CFD(computational fluid dynamics)近年来在古生物学研究中已有大量应用。该方法在研究生物化石的个体形态、器官功能,以及其与生存环境之间的关系方面具有重要意义。目前古生物领域的CFD仿真对象多为厘米级别体型的生物,... 详细信息

计算流体力学CFD(computational fluid dynamics)近年来在古生物学研究中已有大量应用。该方法在研究生物化石的个体形态、器官功能,以及其与生存环境之间的关系方面具有重要意义。目前古生物领域的CFD仿真对象多为厘米级别体型的生物,而对于毫米级别大小的微体生物的仿真则相对较少。区别于厘米级别的宏体生物,底栖型微体生物的生活环境局限于海床上方垂直高度较小的区域,受海底黏性边界层低流速区域的影响更为明显,因而在设置这类化石仿真的水流环境时应当考虑对于边界层流域水体流速以及海床表面地理环境的还原。本文基于随机表面生成的方法,构建了不平坦的滨海海床表面模型,并模拟了水流在海底边界层附近受海床表面地形影响的流动状态;基于获得的仿真流速数据,我们仿真了寒武纪微型底栖刺细胞动物化石Quadrapyrgite在起伏的海床表面环境中四个不同位置的受水流阻力情况。仿真结果显示,近海床表面处的水体流动可形成明显的低流速区域,且低流速区域的厚度随着入口速度增大而变薄。在起伏表面的凹凸区域中,凸起地带的迎水面形成的低流速区域较薄,流速变化较快;而在凸起地带背水面以及凹陷地带形成的低流速区域较厚,流速较缓且易形成涡旋。流速的差异体现在不同位置的Quadrapyrgite的受阻力大小不同上,其差值可达数倍到数十倍。这种量级的受阻力差值可以在毫米级到厘米级尺度上塑造、影响底栖型生物的分布甚至其自身的摄食行为。本文的研究为CFD方法模拟底栖微型化石的生存环境提供了更加深入的思路和方法。

关键词：底栖微体化石计算流体力学海底边界层傅里叶变换随机表面产生方法

体质指数正常的多囊卵巢综合征女性发生高脂血症的影响因素研究

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中国全科医学 2024年第6期27卷 717-722页

作者：刘洋王宇丛晶宫艺韩布威王凯悦朱梦一张蓓吴效科黑龙江中医药大学研究生院黑龙江省哈尔滨市150040 黑龙江中医药大学附属第一医院妇科一科黑龙江省哈尔滨市150040 浙江省宁波市北仑区人民医院中医科 315000 江苏省徐州市中心医院妇产科 221000

背景近年来多囊卵巢综合征(PCOS)女性的脂质代谢紊乱发生率较高,与肥胖、胰岛素抵抗(IR)的关系密切。BMI正常的PCOS女性也有较高的脂质代谢水平,但目前对该类人群中血脂异常的研究较少。目的探讨BMI正常的PCOS女性发生高脂血症的影响因... 详细信息

背景近年来多囊卵巢综合征(PCOS)女性的脂质代谢紊乱发生率较高,与肥胖、胰岛素抵抗(IR)的关系密切。BMI正常的PCOS女性也有较高的脂质代谢水平,但目前对该类人群中血脂异常的研究较少。目的探讨BMI正常的PCOS女性发生高脂血症的影响因素。方法基于“针刺和克罗米芬对多囊卵巢综合征妇女活产率的影响(PCOSAct)”临床试验数据,选取基线较完整且符合研究标准的受试者428例。判断高脂血症的评价标准:总胆固醇(TC)≥6.22 mmol/L和/或三酰甘油(TG)≥2.26 mmol/L和/或低密度脂蛋白(LDL)≥4.14 mmol/L和/或高密度脂蛋白(HDL)<1.04 mmol/L,并据此进行分组。比较两组患者在人体测量学、性激素、糖脂代谢以及心肌酶、肝功能方面的差异,采用多因素Logistic回归分析探究BMI正常的PCOS女性高脂血症的影响因素。结果BMI正常的PCOS女性合并高脂血症的发生率为32.24%(138/428),最常见的血脂异常类型是HDL水平降低;单一表型异常率较高[21.73%(93/428)]。高脂血症组138例、无高脂血症组290例。高脂血症组年龄、糖尿病家族史占比、体质量、腰围、BMI、腰臀比(WHR)较大,尝试妊娠时间较长,游离雄激素指数、空腹胰岛素、胰岛素抵抗指数(HOMA-IR)、LDL、TC、TG、载脂蛋白B、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、乳酸脱氢酶(LDH)水平比无高脂血症组高,性激素结合球蛋白、抗米勒管激素、HDL、载脂蛋白A、总胆红素、直接胆红素水平较无高脂血症组低(P<0.05)。多因素Logistic回归分析发现年龄、BMI、HOMA-IR、LDH是正常BMI的PCOS患者发生高脂血症的独立危险因素(OR=1.170、1.348、1.172、1.009),性激素结合球蛋白是独立保护因素(OR=0.979,P<0.05)。结论BMI正常的PCOS女性合并高脂血症发生率为32.24%,年龄、BMI、HOMA-IR、LDH、SHBG均是PCOS女性发生高脂血症的影响因素,临床上应该根据各诱因采取相应措施防治及延缓PCOS女性高脂血症的发生与发展。

关键词：多囊卵巢综合征高脂血症胰岛素抵抗体质量指数影响因素分析

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