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Multifunctional Peptide-Melanin Hybrid Nanodots with Robust Anti-Cutaneous Photoaging Activity

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Journal of Analysis and Testing 2024年第3期8卷 395-401页

作者： Peizhe li Qiming Zhu Baozhu Wang Shanshan He Qi Xu kaiyan li Yongmiao Shen Miao Su Zhijun Zhang Key Laboratory of Surface&Interface Science of Polymer Materials of Zhejiang Province School of Chemistry and Chemical EngineeringZhejiang Sci-Tech UniversityHangzhou310018China College of Textile Science and Engineering(International Silk Institute) Zhejiang Sci-Tech UniversityHangzhou310018China Shanghai Beautyart Biotechnology Co. LtdShanghai200438China Shengzhou Innovation Research Institute of Zhejiang Sci-Tech University Shengzhou312400China

Skin aging is a systematic and complex process,mainly including intrinsic aging caused by time change and extrinsic aging caused by environmental *** caused by ultraviolet(UV)irradiation is the principle extrinsic factor of skin aging,which can directly or indirectly cause damage to DNA and other biomolecules,generate reactive oxygen species(ROS),and induce a decrease in collagen synthesis and other adverse ***,to address the causative factors and multiple side effects of skin photoaging,we constructed multifunctional peptide-melanin hybrid nanodots(PMHDs)to achieve multifaceted synergistic anti-skin aging by using melanin-like nanodots(MDs)and functional peptides as active *** them,the peptide has the activity of promoting collagen synthesis,while the MDs have the function of absorbing UV light and scavenging free ***,the MDs also act as a carrier to increase the cellular uptake of the *** anti-photoaging effects of the PMHDs were systematically verified in a multidimensional manner at the biochemical,cellular and small animal levels,respectively.

关键词： aging Skin ultraviolet

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我国铁路桥梁的发展与对策

中国铁路 2002年第4期 48-50页

作者：李开言中铁五局集团有限公司

回顾和概述了我国铁路桥梁活载标准和设计规范的演变、动力设计问题以及桥梁建设发展的历程,分别从钢桥、预应力混凝土桥、拱桥以及桥梁设计理论等方面对我国铁路桥梁的发展现状进行简略的评述,探讨在新世纪我国铁路桥梁要从设计理论到... 详细信息

回顾和概述了我国铁路桥梁活载标准和设计规范的演变、动力设计问题以及桥梁建设发展的历程,分别从钢桥、预应力混凝土桥、拱桥以及桥梁设计理论等方面对我国铁路桥梁的发展现状进行简略的评述,探讨在新世纪我国铁路桥梁要从设计理论到建设水平赶超世界一流水平应该注意的几个问题。

关键词：铁路桥梁动力设计发展中国活载标准设计规范

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局灶性肝脂肪变性特殊超声造影表现1例

中华超声影像学杂志 2023年第1期32卷 41-43页

作者：吴晓贝李开艳华中科技大学同济医学院附属同济医院超声影像科武汉430030

患者女,22岁,体检发现肝脏占位1个月余入院,未诉特殊不适,否认乙肝、结核等传染病史,否认外伤输血史。体格检查、血常规、肝肾功能检查正常,HBV、HCV检测及肿瘤标志物(AFP、CEA、CA-199)均为阴性。门诊增强CT显示肝右叶类圆形强化影,动... 详细信息

患者女,22岁,体检发现肝脏占位1个月余入院,未诉特殊不适,否认乙肝、结核等传染病史,否认外伤输血史。体格检查、血常规、肝肾功能检查正常,HBV、HCV检测及肿瘤标志物(AFP、CEA、CA-199)均为阴性。门诊增强CT显示肝右叶类圆形强化影,动脉期明显强化,门脉期及延迟期呈低密度,考虑为肿瘤性病变。入院后超声检查显示肝Ⅵ段见一个边界清楚的稍高回声实性结节,大小约6 cm×5 cm(图1A)。彩色多普勒超声显示病灶周边及内部可见丰富血流信号(图1B)。经肘静脉注射2.4 ml SonoVue(Bracco公司)行超声造影(contrast-enhanced ultrasound,CEUS)检查:病灶动脉期呈快速整体高增强(图1C),门静脉期呈稍高增强,延迟期呈等增强(图1D)。

关键词：传染病史肝肾功能检查肝右叶输血史血流信号彩色多普勒超声肝脂肪变性超声检查

Ultrasound-guided percutaneous microwave ablationfor small liver cancers adjacent to large vessels：long-term outcomes and strategies

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Oncology and Translational Medicine 2017年第2期3卷 57-64页

作者： Ruobing liu kaiyan li Hongchang Luo Wei Zhang Tingting Zhang Meng Gao Wenhui Zha Xinwu Cui Youbin Deng Department of Medical Ultrasound Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

Objective The aim of the study was to evaluate the long-term efficacy and safety of percutaneous microwave ablation(MWA) for small hepatic cancers adjacent to large vessels and to investigate the treatment *** From March 2009 to July 2015,a total of 86 patients with 94 tumors underwent ultrasound(US)-guided percutaneous MWA,with pathologically proven or clinically diagnosed liver cancers measuring ≤ 3 cm in diameter and located ≤ 10 mm from a major vessel(n = 94).Regular follow-up after MWA was performed to assess treatment efficacy and perioperative *** The complete ablation rate at 1 month after MWA was 93.3%(84/90).The 6-,9-,12-,24-,36-,48-,60-,72-,and 84-month local recurrence rates were 2.4%,2.4%,3.7%,6.6%,8.4%,8.4%,8.4%,8.4%,and 8.4%,*** were no major *** perioperative special complication rate was 5.32%(5/94),including 3 cases of moderate liver function damage and 2 cases of limited sub-capsular *** Percutaneous MWA for small hepatic cancers adjacent to large vessels is feasible,effective,and safe with an acceptable rate of *** key point is to strictly follow operative indications and adopt proper treatment strategies.

关键词： ultrasound (US) liver cancer percutaneous microwave ablation (MWA)

基于改进灰狼优化算法的边缘计算任务调度方法

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信息与控制 2022年第4期51卷 489-497,512页

作者：李开言王亚刚张涛上海理工大学光电信息与计算机工程学院上海200093

针对边缘计算在离散制造业数据处理过程中存在的时延和资源消耗大的问题,提出了一种基于改进灰狼优化(IGWO)算法的边缘计算任务调度方法。该方法通过对非线性收敛因子以及动态权重的改进,提高了灰狼算法的优化速度和精度,有效降低了终... 详细信息

针对边缘计算在离散制造业数据处理过程中存在的时延和资源消耗大的问题,提出了一种基于改进灰狼优化(IGWO)算法的边缘计算任务调度方法。该方法通过对非线性收敛因子以及动态权重的改进,提高了灰狼算法的优化速度和精度,有效降低了终端设备和边缘端的资源损耗以及任务处理的时延。基于不同数据任务量下的处理时延与资源消耗实验,证明了所提模型的有效性,与3种主流任务调度算法相比,数据处理资源消耗和时延最低。将边缘计算任务调度与智能寻优算法相结合并运用到离散制造业,可以提高设备任务的处理速度、降低能耗,为离散制造业智能化转型提供借鉴。

关键词：离散制造业灰狼优化算法任务调度边缘计算时延资源消耗

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肝脏肝样腺癌超声及Sonazoid造影表现1例

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中华超声影像学杂志 2021年第10期30卷 910-911页

作者：黄哲周萍萍李开艳华中科技大学同济医学院附属同济医院超声影像科武汉430030

患者女,52岁,2周前因跌倒出现右上腹间断性疼痛,遂来我院检查,其间无其他治疗,无恶心、呕吐,无腹泻,无其他不适症状。既往无特殊病史。患者于门诊行增强CT检查,可见肝右前叶下段一动脉期显著强化肿块影,强化欠均,静脉期及延迟期强化减弱... 详细信息

患者女,52岁,2周前因跌倒出现右上腹间断性疼痛,遂来我院检查,其间无其他治疗,无恶心、呕吐,无腹泻,无其他不适症状。既往无特殊病史。患者于门诊行增强CT检查,可见肝右前叶下段一动脉期显著强化肿块影,强化欠均,静脉期及延迟期强化减弱,考虑肿瘤性病变。门诊以"肝肿物"收入院。

关键词：特殊病史肿瘤性病变肝右前叶周前静脉期肿块影肝样腺癌延迟期

Gene Transfection Mediated by Ultrasound and Pluronic P85 in HepG2 Cells

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第6期27卷 700-702页

作者：王芬李开艳陈云超邓远洪恺 Department of Medical Ultrasound Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

In order to assess whether gene transfection could be mediated by ultrasound in association with P85 and find the appropriate parameters of ultrasound irradiation, the effects of ultrasound with or without P85 on gene transfection of HepG2 cells were examined. The HepG2 cells were irra- diated by ultrasound at 1 MHz, 0.4-2.0 W/cm2 and 50% duty cycle with plasmid encoding enhanced green fluorescent protein （EGFP） as a report gene. Forty-eight h later, the expression of EGFP was detected under the fluorescence microscopy. Transfection efficacy was quantitatively assessed by flow cytometry, and cell viability was evaluated by trypan blue exclusion. The results showed that the transfection efficacy was increased with the increases in ultrasound output power and the ideal transfection efficacy was achieved in HepG2 cells irradiated by ultrasound at 0.8 W/cm2 for 30 s. The transfection efficacy in ulstrasound＋P85 group was three times higher than in single ultrasound group [（17.63±1.07）% vs （5.57±0.56）%, P〈0.05]. The cell viability was about 81% and 62% in ultrasound group and ultrasound＋P85 group respectively. It was concluded that ultrasound in combination with P85 could mediate the gene transfection of HepG2 cells, ideal transfection efficacy was achieved by ultrasound irradiation at 0.8 W/cm2 for 30 s, and P85 could somewhat increase the damage to cells caused by ultrasound.

关键词： ultrasound P85 gene transfection HepG2

超声在肝脏微小占位病变诊断和治疗中的应用及评价

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中国实用外科杂志 2006年第9期26卷 657-659页

作者：李开艳张青萍华中科技大学同济医学院附属同济医院湖北武汉430030

随着高品质超声仪的普及,尤其是近几年超声造影技术的临床应用,大大提高了肝内微小占位病变(直径≤2cm)的检出率及病变性质诊断的敏感性和特异性.同时,超声技术在微小肝癌的诊断及局部微创治疗和手术中具有重要的作用.本文对此作一介绍.

关键词：微小占位病变病变诊断微创治疗超声仪肝脏超声造影技术临床应用病变性质微小肝癌超声技术

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修文县猕猴桃果园土壤养分的丰缺状况

贵州农业科学 2024年第1期52卷 42-49页

作者：李铠妍华南农业大学资源环境学院广东广州510642

【目的】探明修文县猕猴桃果园土壤养分的丰缺状况,为果园合理施肥,促进猕猴桃养分吸收及提高产质量提供参考。【方法】以修文县久长街道猕猴桃果园土壤为研究对象,采用野外调查与室内分析相结合的方法,测定耕地土壤pH、有机质和全氮等1... 详细信息

【目的】探明修文县猕猴桃果园土壤养分的丰缺状况,为果园合理施肥,促进猕猴桃养分吸收及提高产质量提供参考。【方法】以修文县久长街道猕猴桃果园土壤为研究对象,采用野外调查与室内分析相结合的方法,测定耕地土壤pH、有机质和全氮等11个指标含量,并对土壤养分指标进行相关性分析和分级诊断。【结果】修文县久长街道不同施肥方式或同一施肥方式的猕猴桃果园土壤养分均存在差异,且不同养分间存在不同程度相关性。土壤pH为4.5~5.0,均值为4.8,属酸性土壤,不利于猕猴桃生长;土壤有机质、全氮和阳离子交换量含量均值分别为54.62 g/kg、2.91 g/kg和31.44 cmol/kg,均属1级水平,弱变异(变异系数90%)。【结论】修文县久长街道2个猕猴桃果园分别采用不施基肥、追施无机肥和基施有机肥、追施有机肥的方式均呈现土壤酸化严重,全钾、全磷含量较低,作物产质量较低等现象,且对调控土壤营养元素、改善土壤团粒结构、提高土壤有机质含量及构建健康土壤环境均无促进作用。建议采用有机-无机肥配施的方式,适当施用石灰、翻压绿肥等措施改善土壤理化性质,促进土壤营养均衡,从而促进作物生长,提高猕猴桃产质量。

关键词：土壤猕猴桃果园养分丰缺评价修文贵州