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Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah E.Est-Witte Sydney R.Shannon Dennis H.Gong kaitlyn G.Calabresi Jawaun J.Harris kaitlyn storm Edwin J.Yoo Ariel Isser Vivek P.Jani Natalie K.Livingston Mary O.Omotoso Kelly Rhodes Elana Ben-Akiva Randall A.Meyer Zoe T.Hsieh Simone Sidoli Stephany Y.Tzeng Jonathan P.Schneck Jordan J.Green Translational Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aAPC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

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Stubborn Hypoxia in Neonates with D-Transposition of the Great Arteries after Arterial Switch Operation: Central Sleep Apnea as the Cause and Potential Indicator of Brain Immaturity

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Congenital Heart Disease 2024年第2期19卷 185-195页

作者： Camden L.Hebson Kyle Bliton Amr Y.Hammouda kaitlyn Barr W.Hampton Gray Mohini Gunnett Waldemar F.Carlo Department of Pediatrics Division of Pediatric CardiologyUniversity of Alabama BirminghamBirmingham35233USA Department of Pediatrics Division of Pediatric PulmonologyUniversity of Alabama BirminghamBirmingham35233USA Department of Pediatrics University of Alabama BirminghamBirmingham35233USA Department of Surgery Division of Cardiothoracic SurgeryUniversity of Alabama BirminghamBirmingham35233USA

D-transposition of the great arteries(d-TGA)is surgically repaired with the arterial switch operation(ASO)with excellent results,however short and long-term morbidities still develop including neurocognitive *** significant central sleep apnea is uncommon in non-premature infants,but when present indicates immature autonomic control of respiration likely due to a neurologic *** report the unanticipatedfinding of central sleep apnea in four-term neonates with d-TGA after uncomplicated ASO,with the short-term complication of delayed hospital discharge and long-term concerns regarding this early marker of brain immaturity and its hindrance to normal *** this report,we will review each patient’s clinical course and then examine the literature on pediatric central sleep apnea,neurodevelopmental outcomes after ASO,and the important overlap of these entities in the care of patients going forward.

关键词： Transposition congenital heart disease sleep apnea polysomnography

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Hydrocephalus Secondary to Intraventricular Myxopapillary Ependymoma: Case Report

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World Journal of Neuroscience 2024年第3期14卷 85-91页

作者： Juan Carlos Ayala-Alvarez Onyekachi Emmanuel Anyagwa Fátima Gabriela Macías-Ortiz Oluwatoyin Adalia Dairo Courtney storm Truebody Reza Badrnejad Aishwarya Bhuta Shashwat Sandeep Phade Srushti Kishor Jamdar Mostafa Yassin Vismaja Vijayan Neurology Department Hospital Civil Fray Antonio Alcalde Guadalajara Jalisco Mxico School of Medicine New Vision University Tbilisi Georgia

Ependymomas are a somewhat diverse category of glial tumors that often develop from the lining of the brain’s ventricles, or the spinal cord’s central canal. They make up 5% of all neuroepithelial tumors, 10% of paediatric brain tumors, and up to 33% of brain tumors in children under the age of three. Hydrocephalus is one of the complications, and it can be identified as progressive macrocephaly or increasing head circumference crossing percentiles, nausea, vomiting, poor appetite, irritability, and regression of developmental milestones.

关键词： Hydrocephalus Myxopapillary Ependymoma (MPE) Paediatrics Neurosurgery Glioma Intracranial Hypertension

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Bile acids and sphingolipids in non-alcoholic fatty liver disease

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Chinese Medical Journal 2022年第10期135卷 1163-1171页

作者： kaitlyn G.Jackson Grayson W.Way Huiping Zhou Department of Microbiology and Immunology Virginia Commonwealth University School of MedicineRichmondVA 23298USA Center for Clinical and Translational Research Virginia Commonwealth University School of MedicineRichmondVA 23298USA Central Virginia Veterans Healthcare System RichmondVA 23249USA.

Non-alcoholic fatty liver disease (NAFLD) is one of the fastest-growing diseases, and its global prevalence is estimated to increase >50% by 2030. NAFLD is comorbid with metabolic syndrome, obesity, type 2 diabetes, and insulin resistance. Despite extensive research efforts, there are no pharmacologic or biological therapeutics for the treatment of NAFLD. Bile acids and sphingolipids are well-characterized signaling molecules. Over the last few decades, researchers have uncovered potential mechanisms by which bile acids and sphingolipids regulate hepatic lipid metabolism. Dysregulation of bile acid and sphingolipid metabolism has been linked to steatosis, inflammation, and fibrosis in patients with NAFLD. This clinical observation has been recapitulated in animal models, which are well-accepted by experts in the hepatology field. Recent transcriptomic and lipidomic studies also show that sphingolipids are important players in the pathogenesis of NAFLD. Moreover, the identification of bile acids as activators of sphingolipid-mediated signaling pathways established a novel theory for bile acid and sphingolipid biology. In this review, we summarize the recent advances in the understanding of bile acid and sphingolipid-mediated signaling pathways as potential contributors to NAFLD. A better understanding of the pathologic effects mediated by bile acids and sphingolipids will facilitate the development of new diagnostic and therapeutic strategies for NAFLD.

关键词： Bile acids Sphingolipids Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis

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Endoscopic ultrasound-guided techniques for diagnosing pancreatic mass lesions: Can we do better?

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World Journal of Gastroenterology 2016年第39期22卷 8658-8669页

作者： Andrew C storm Linda S Lee Division of Gastroenterology Hepatology and Endoscopy Brigham and Women’s Hospital Harvard Medical School

The diagnostic approach to a possible pancreatic mass lesion relies first upon various non-invasive imaging modalities, including computed tomography, ultrasound, and magnetic resonance imaging techniques. Once a suspect lesion has been identified, tissue acquisition for characterization of the lesion is often paramount in developing an individualized therapeutic approach. Given the high prevalence and mortality associated with pancreatic cancer, an ideal approach to diagnosing pancreatic mass lesions would be safe, highly sensitive, and reproducible across various practice settings. Tools, in addition to radiologic imaging, currently employed in the initial evaluation of a patient with a pancreatic mass lesion include serum tumor markers, endoscopic retrograde cholangiopancreatography, and endoscopic ultrasound-guided fine needle aspiration(EUS-FNA). EUS-FNA has grown to become the gold standard in tissue diagnosis of pancreatic lesions.

关键词： Endoscopic ultrasound Fine needle aspiration Pancreatic cancer Pancreatic mass Endoscopy

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Adult hippocampal neurogenesis and its impairment in Alzheimer's disease

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Zoological Research 2022年第3期43卷 481-496页

作者： Thomas A.Kim Michelle DSyty kaitlyn Wu Shaoyu Ge Department of Neurobiology&Behavior SUNY at Stony BrookStony BrookNY 11794USA Medical Scientist Training Program(MSTP) Renaissance School of Medicine at SUNYStony BrookStony BrookNY 11794USA

Adult neurogenesis is the creation of new neurons which integrate into the existing neural circuit of the adult *** evidence suggests that adult hippocampal neurogenesis(AHN)persists throughout life in mammals,including *** newborn neurons have been implicated to have a crucial role in brain functions such as learning and ***,studies have also found that hippocampal neurogenesis is impaired in neurodegenerative and neuropsychiatric ***’s disease(AD)is one of the most common forms of dementia affecting millions of *** dysfunction is a common symptom of AD patients and progressive memory loss has been attributed to the degeneration of the ***,there has been growing interest in identifying how hippocampal neurogenesis is affected in ***,the link between cognitive decline and changes in hippocampal neurogenesis in AD is poorly *** this review,we summarized the recent literature on AHN and its impairments in AD.

关键词： Hippocampal function Adult hippocampal neurogenesis Cognitive function Alzheimer’s disease Alzheimer’s disease animal models

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Additive manufacturing and 3D printing of metallic biomaterials

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Engineered Regeneration 2021年第1期2卷 288-299页

作者： kaitlyn Chua Irfaan Khan Raoul Malhotra Donghui Zhu Department of Biomedical Engineering Stony Brook UniversityStony BrookNYUnited States

The advancements of 3D printing technology have been combined with the use of metallic biomaterials to cre-ate devices and products for the biomedical field.3D printing has been a revolutionary process that makes the fabrication of metallic biomedical devices highly specific and simultaneously easier than other fabrication *** purpose and overall function of each medical device created is dependent on the type of metal used along with its fabrication *** this review paper,the major characteristics of metallic biomaterials,includ-ing iron,magnesium,zinc,titanium,cobalt,and stainless steel,will be *** considerations of these metallic biomaterials include degradation rate,biocompatibility,and mechanical properties will be ***,various additive manufacturing processes will be *** on the 3D printing method and the use of specific alloys,these properties can be altered to optimize their functionality for purposes such as bone implants,stents,and other devices.

关键词： 3D bioprinting Metallic biomaterials Alloys Biodegradable Implants

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Mathematical modelling of the spread of COVID-19 on a university campus

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Infectious Disease Modelling 2021年第1期6卷 1025-1045页

作者： kaitlyn Muller Peter A.Muller 800 E.Lancaster Avenue Department of Mathematics and StatisticsVillanova UniversityVillanovaPAUSA

In this paper we present a deterministic transmission dynamic compartmental model for the spread of the novel coronavirus on a college campus for the purpose of analyzing strategies to mitigate an *** goal of this project is to determine and compare the utility of certain containment strategies including gateway testing,surveillance testing,and contact tracing as well as individual level control measures such as mask wearing and social *** modify a standard SEIR-type model to reflect what is currently known about *** also modify the model to reflect the population present on a college campus,separating it into students and *** is done in order to capture the expected different contact rates between groups as well as the expected difference in outcomes based on age known for *** aim to provide insight into which strategies are most effective,rather than predict exact numbers of *** analyze effectiveness by looking at relative changes in the total number of cases as well as the effect a measure has on the estimated basic reproductive *** find that the total number of infections is most sensitive to parameters relating to student *** also find that contact tracing can be an effective control strategy when surveillance testing is ***,we validate the model using data from Villanova University's online COVID-19 Dashboard from Fall 2020 and find good agreement between model and data when superspreader events are incorporated in the model as shocks to the number of infected individuals approximately two weeks after each superspreader event.

关键词： Coronavirus COVID-19 University/college campus Epidemiological models SEIR Contact tracing Surveillance testing 2010 MSC:92-10

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Stakeholder analysis of the governance framework of a national SDI dataset-whose needs are met in the buildings and address register of the Netherlands?

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International Journal of Digital Earth 2020年第3期13卷 355-373页

作者： Serena Coetzee Martijn Odijk Bastiaan van Loenen Janette storm Jantien Stoter Centre for Geoinformation Science Department of GeographyGeoinformatics and MeteorologyUniversity of PretoriaPretoriaSouth Africa Ministerie van Binnenlandse Zaken en Koninkrijksrelaties Den Haagthe Netherlands Knowledge Centre Open Data OTB Research for the Built EnvironmentFaculty of Architecture and the Built EnvironmentDelft University of TechnologyDelftthe Netherlands Kadaster Apeldoornthe Netherlands Department of Urbanism Delft University of TechnologyDelftthe Netherlands

National spatial data infrastructures are key to achieving the Digital Earth *** many cases,national datasets are integrated from local datasets created and maintained by *** are address,building and topographic *** of local datasets may result in a dataset satisfying the needs of users of national datasets,but is it productive for those who create and maintain the data?This article presents a stakeholder analysis of the Basisregistratie Adressen en Gebouwen(BAG),a collection of base information about addresses and buildings in the *** information is captured and maintained by municipalities and integrated into a national base register by Kadaster,the Cadastre,Land Registry and Mapping Agency of the *** stakeholder analysis identifies organisations involved in the BAG governance framework,describes their interests,rights,ownerships and responsibilities in the BAG,and maps the relationships between *** results indicate that Kadaster and the municipalities have the highest relative importance in the governance framework of the *** study reveals challenges of setting up a governance framework that maintains the delicate balance between the interests of all *** results provide guidance for SDI role players setting up governance frameworks for national or global datasets.

关键词： Address data data governance spatial data infrastructure SDI stakeholder analysis Netherlands

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Role of spleen tyrosine kinase in liver diseases

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World Journal of Gastroenterology 2020年第10期26卷 1005-1019页

作者： Dhadhang Wahyu Kurniawan Gert storm Jai Prakash Ruchi Bansal Department of Biomaterials Science and Technology Faculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteEnschede 7500the Netherlands Department of Pharmacy Universitas Jenderal SoedirmanPurwokerto 53132Indonesia Department of Pharmaceutics University of UtrechtUtrecht 3454the Netherlands Department of Pharmacokinetics Toxicology and TargetingGroningen Research Institute of PharmacyUniversity of GroningenEnschede 7500the Netherlands

Spleen tyrosine kinase (SYK),a non-receptor tyrosine kinase,is expressed in most hematopoietic cells and non-hematopoietic cells and play a crucial role in both immune and non-immune biological *** mediate diverse cellular responses via an immune-receptor tyrosine-based activation motifs (ITAMs)-dependent signalling pathways,ITAMs-independent and ITAMs-semidependent signalling *** liver,SYK expression has been observed in parenchymal (hepatocytes) and non-parenchymal cells (hepatic stellate cells and Kupffer cells) and found to be positively correlated with the disease *** implication of SYK pathway has been reported in different liver diseases including liver fibrosis,viral hepatitis,alcoholic liver disease,non-alcoholic steatohepatitis and hepatocellular *** of SYK pathway using kinase inhibitors have shown to attenuate the progression of liver diseases thereby suggesting SYK as a highly promising therapeutic *** review summarizes the current understanding of SYK and its therapeutic implication in liver diseases.

关键词： Spleen tyrosine kinase Liver diseases Inflammation Targeted therapeutics Spleen tyrosine kinase inhibitors

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