检索结果-南通市图书馆

convergence of human and veterinary medicine:leveraging canine naturally occurring neurological disorders to develop regenerative treatments

引用

Neural Regeneration Research 2023年第3期18卷 541-542页

作者： kaitlin c.clark Ashley Amador Aijun Wang center for Surgical Bioengineering Department of SurgeryUniversity of CaliforniaDavis School of MedicineSacramentoCAUSA Institute for Pediatric Regenerative Medicine Shriners Hospital for ChildrenSacramentoCAUSA Department of Biomedical Engineering University of California DavisDavisCAUSA

In recent years,large animal models of naturally occurring diseases have become increasingly studied,with the rationale that their disease attributes may better recapitulate the pathological features of corresponding human diseases as compared to induced disease models(Hoffman and Dow,2016).Of the available naturally occurring disease models,the canine is increasingly recognized as a valuable pre-clinical animal model in translational medicine for numerous human diseases,including cancer.

关键词： diseases clinical treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exosomal microRNAs from mesenchymal stem/stromal cells: Biology and applications in neuroprotection

引用

World Journal of Stem cells 2021年第7期13卷 776-794页

作者： Aida Nasirishargh Priyadarsini Kumar Lalithasri Ramasubramanian kaitlin clark Dake Hao Sabrina V Lazar Aijun Wang Surgical Bioengineering Laboratory Department of SurgeryUniversity of CaliforniaDavis School of MedicineSacramentoCA 95817United States Institute for Pediatric Regenerative Medicine Shriners Hospitals for ChildrenSacramentoCA 95817United States Department of Biomedical Engineering University of California DavisDavisCA 95616United States

Mesenchymal stem/stromal cells(MScs)are extensively studied as cell-therapy agents for neurological *** studies consider exosomes secreted by MScs as important mediators for MScs’neuroprotective *** transfer functional molecules including proteins,lipids,metabolites,DNAs,and coding and non-coding RNAs from MScs to their target *** evidence shows that exosomal microRNAs(miRNAs)play a key role in the neuroprotective properties of these exosomes by targeting several genes and regulating various biological *** exosomal miRNAs have been identified to have neuroprotective effects by promoting neurogenesis,neurite remodeling and survival,and ***,exosomal miRNAs have significant therapeutic potential for neurological disorders such as stroke,traumatic brain injury,and neuroinflammatory or neurodegenerative diseases and *** review discusses the neuroprotective effects of selected miRNAs(miR-21,miR-17-92,miR-133,miR-138,miR-124,miR-30,miR146a,and miR-29b)and explores their mechanisms of action and applications for the treatment of various neurological disease and *** also provides an overview of state-of-the-art bioengineering approaches for isolating exosomes,optimizing their yield and manipulating the miRNA content of their cargo to improve their therapeutic potential.

关键词： Mesenchymal stromal cells Mesenchymal stromal cell-derived exosomes Exosomal microRNAs Neuroprotective effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Use of the V.A.c. RX-4 for Multiple Soft Tissue Wound Application in the Single Patient: A case Report

引用

Surgical Science 2022年第3期13卷 155-163页

作者： Emily R. Kindal kaitlin J. Larson Luis G. Fernandez Sean F. O’Keefe Marc R. Matthews Medical Student IV Royal College of Surgeons in Ireland Dublin Ireland Surgical Resident The Arrowhead Surgical Residency Glendale Arizona Department of Surgery University of Texas Health Science Center Tyler USA Trauma Wound care UT Health East Tyler USA Department of Surgery University of Texas Medical Branch Galveston USA Business Development Manager Saint Paul US University of Arizona & creighton University Schools of Medicine The Arizona Burn Center Phoenix Arizona

contact burn injuries account for a considerable proportion of admissions that frequently require debridement. Such debridements of these multiple open wounds might benefit from the application of negative pressure wound therapy (NPWT) for the removal of proinflammatory mediators and to promote granulation tissue with macrostrain and microstrain. Having four or more Vacuum Assist closure (V.A.c.) Ulta devices connected to the same patient for adequate wound coverage is cumbersome in the management of the patient’s wound care and tethers the patient to the bed. The V.A.c. RX-4 is a multichannel device that can deliver NPWT with a smaller footprint. In addition, the V.A.c. RX-4 has a weight of 16 lbs. versus one V.A.c Ulta which is 7.4 lbs. Therefore, collectively, four V.A.c. Ultas would equal 29.6 lbs. or almost double the weight of a single V.A.c. RX-4. Use of the V.A.c. RX-4 by healthcare providers can mean greater mobility for the patient and easier transport between patient destinations within the hospital. This case report demonstrates the utility of the V.A.c. RX-4 for open and freshly debrided, large soft tissue wounds in a burn patient.

关键词： V.A.c. RX-4 Negative Pressure Wound Therapy Wounds V.A.c. Ulta Footprint Burns

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nature：大规模研究揭示生命所必需的基因

引用

现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, Mary E. Flenniken, Ann M. Ji, Xiao Teboul, Lydia Wong, Michael D. White, Jacqueline K. Meehan, Terrence F. Weninger, Wolfgang J. Westerberg, Henrik Adissu, Hibret Baker, candice N. Bower, Lynette Brown, James M. caddle, L. Brianna chiani, Francesco clary, Dave cleak, James Daly, Mark J. Denegre, James M. Doe, Brendan Dolan, Mary E. Edie, Sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, Juan Guo, Shiying Horner, Neil R. Hsu, chih-Wei Johnson, Sara J. Kalaga, Sowmya Keith, Lance c. Lanoue, Louise Lawson, Thomas N. Lek, Monkol Mark, Manuel Arschall, Susan M. Mason, Jeremy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. J. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Samocha, kaitlin E. Seavitt, John R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, Jonathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William c. Justice, Monica J. Parkinson, Helen E. Moore, Mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David J. Lloyd, K. c. Kent McKerlie, colin Beaudet, Arthur L. Bucan, Maja Murray, Stephen A. Dept Mol Physiol & Biophys Houston TX 77030 USA Toronto ctr Phenogen Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon ctr Harwell OX11 0RD Oxon England Hosp Sick children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick children 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res council cNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mouse clin D-85764 Neuherberg Germany Baylor coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan childrens Hosp Oakland Res Inst Oakland CA 94609 USA IMPc San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German ctr Diabet Res DZD D-85764 Neuherberg Germany Francis crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：